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Home / Equine Research Bank / Muscles Ligaments Tendons J / Stem cell therapy of tendinopathies: suggestions from veteri...
Muscles, ligaments and tendons journal2012; 2(3); 187-192;

Stem cell therapy of tendinopathies: suggestions from veterinary medicine.

Abstract: The ideal strategy for tendon healing has not been identified to date. Recently, the use of stem cells based therapy has been proposed, due to their ability to proliferate and to differentiate towards specific connective tissues lineages. Embryonic stem cells should be considered the ideal cell source for regenerative therapies, but ethical factors limit their use in humans. Mesenchymal stem cells are more easily available and can be obtained by different sources. Amnion derived stem cells can differentiate towards all three germ layers, and can be used for allogeneic transplantation and stored thanks to cryopreservation. In veterinary medicine, stem cells have been used with encouraging results for the treatment of the Superficial Digital Flexor tendinopathy in the horses. Considering that Superficial Digital Flexor tendinopathy is similar for pathogenesis and histopathology to Achilles tendinopathy in man, this experience can provide supportive data to encourage the use of regenerative therapy in humans.
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Publication Date: 2012-10-16 PubMed ID: 23738296PubMed Central: PMC3666520
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses the potential use of stem cell therapy in treating tendinopathies, a type of tendon disorder. It mentions examples from veterinary medicine where the treatment has yielded promising results and encourages its application in humans.

Background of the Study

  • The research opens with a discussion on the challenge in finding the ideal treatment strategy for tendinopathies.
  • It also introduces the concept of stem cell therapy as a potential solution, given these cells’ ability to proliferate and differentiate into specific connective tissue types.

The Role of Stem Cells in Regenerative Medicine

  • Embryonic stem cells are presented as the ideal cell source for regenerative therapies. However, their usage is limited in human treatments due to ethical considerations.
  • An alternative to embryonic stem cells are Mesenchymal stem cells. These cells can be obtained more easily and from different sources compared to their embryonic counterparts.
  • The paper also mentions Amnion-derived stem cells, which can differentiate into all three germ layers, making them a promising source for stem cell therapy. These cells also have the advantage of being used for allogeneic transplantation and being preserved through cryopreservation.

Application in Veterinary Medicine

  • The study outlines the beneficial results of stem cell therapy in treating Superficial Digital Flexor tendinopathy in horses.

Potential Human Applications

  • The article concludes by drawing comparisons between Superficial Digital Flexor tendinopathy in horses and Achilles tendinopathy in humans. These similarities suggest that the positive results obtained in veterinary medicine may offer valuable data for the potential use of stem cell therapy in human treatments.

Cite This Article

APA
Muttini A, Salini V, Valbonetti L, Abate M. (2012). Stem cell therapy of tendinopathies: suggestions from veterinary medicine. Muscles Ligaments Tendons J, 2(3), 187-192.

Publication

Muscles, ligaments and tendons journal
ISSN: 2240-4554
NlmUniqueID: 101600853
Country: Italy
Language: English
Volume: 2
Issue: 3
Pages: 187-192

Researcher Affiliations

Muttini, Aurelio
  • Department of Comparative Biomedical Sciences, University of Teramo, Italy ; Stem TeCh group, Chieti Scalo, Italy.
Salini, Vincenzo
    Valbonetti, Luca
      Abate, Michele

        References

        This article includes 50 references
        1. Barboni B, Russo V, Curini V. Achilles tendon regeneration can be improved by amniotic epithelial cells allotransplantation.. Cell Transplant 2012.
          pubmed: 22507232
        2. Abate M, Silbernagel KG, Siljeholm C. Pathogenesis of tendinopathies: inflammation or degeneration?. Arthritis Res Ther 2009;11(3):235.
          pmc: PMC2714139pubmed: 19591655
        3. Abate M, Oliva F, Schiavone C, Salini V. Achilles tendinopathy in amateur runners: role of adiposity (Tendinopathies and obesity). MLTJ 2012;2(1):44–48.
          pmc: PMC3666497pubmed: 23738273
        4. Thorpe CT, Clegg PD, Birch HL. A review of tendon injury: why is the equine superficial digital flexor tendon most at risk?. Equine Vet J 2010 Mar;42(2):174–180.
          pubmed: 20156256
        5. Longo UG, Loppini M, Denaro L, Maffulli N, Denaro V. Conservative management of patients with an osteoporotic vertebral fracture: a review of the literature.. J Bone Joint Surg Br 2012;94(2):152–157.
          pubmed: 22323677
        6. Dowling BA, Dart AJ, Hodgson DR, Smith RK. Superficial digital flexor tendonitis in the horse.. Equine Vet J 2000;32(5):369–378.
          pubmed: 11037257
        7. Salini V, Abate M. Percutaneous steroidal treatment in relapses of chronic tendinopathies: a pilot study.. Int J Immunopathol Pharmacol 2011;24(1):211–216.
          pubmed: 21496380
        8. Wilkins R, Bisson LJ. Operative versus nonoperative management of acute achilles tendon ruptures: a quantitative systematic review of randomized controlled trials.. Am J Sports Med 2012;40(9):2154–2160.
          pubmed: 22802271
        9. Friedenstein AJ, Petrakova KV, Kurolesova AI, Frolova GP. Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues.. Transplantation 1968;6(2):230–247.
          pubmed: 5654088
        10. Ryan JM, Barry FP, Murphy JM, Mahon BP. Mesenchymal stem cells avoid allogeneic rejection.. J Inflamm (Lond) 2005;26(2):8.
          pmc: PMC1215510pubmed: 16045800
        11. Le Blanc K, Tammik C, Rosendahl K, Zetterberg E, Ringdén O. HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells.. Exp Hematol 2003;31(10):890–896.
          pubmed: 14550804
        12. Phinney DG, Prockop DJ. Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair—current views.. Stem Cells 2007;25(11):2896–2902.
          pubmed: 17901396
        13. Priya N, Sarcar S, Majumdar AS, Sundarraj S. Explant culture: a simple, reproducible, efficient and economic technique for isolation of mesenchymal stromal cells from human adipose tissue and lipoaspirate.. J Tissue Eng Regen Med 2012;27:1–9.
          pubmed: 22837175
        14. Stillwell C, Wang F, Xiang B. Adipose tissue houses different subtypes of stem cells.. Can J Physiol Pharmacol 2012;90(9):1295–1301.
          pubmed: 22913488
        15. Blaber SP, Webster RA, Hill CJ. Analysis of in vitro secretion profiles from adipose-derived cell populations.. J Transl Med 2012;10(1):172.
          pmc: PMC3479070pubmed: 22913454
        16. Lovati AB, Corradetti B, Lange Consiglio A. Characterization and differentiation of equine tendon-derived progenitor cells.. J Biol Regul Homeost Agents 2011;25(2 Suppl):S75–84.
          pubmed: 22051173
        17. Zhou Z, Akinbiyi T, Xu L. Tendon-derived stem/progenitor cell aging: defective self-renewal and altered fate.. Aging Cell 2010;9(5):911–915.
          pmc: PMC2944918pubmed: 20569237
        18. Saito S, Sawai K, Minamihashi A, Ugai H, Murata T, Yokoyama KK. Derivation, maintenance, and induction of the differentiation in vitro of equine embryonic stem cells.. Methods Mol Biol 2006;329:59–79.
          pubmed: 16845984
        19. Chen SS, Fitzgerald W, Zimmerberg J, Kleinman HK, Margolis L. Cell-cell and cell-extracellular matrix interactions regulate embryonic stem cell differentiation.. Stem Cells 2007;25(3):553–561.
          pubmed: 17332514
        20. Evangelista M, Soncini M, Parolini O. Placenta-derived stem cells: new hope for cell therapy?. Cytotechnology 2008;58(1):33–42.
          pmc: PMC2593758pubmed: 19002775
        21. Iacono E, Brunori L, Pirrone A. Isolation, characterization and differentiation of mesenchymal stem cells from amniotic fluid, umbilical cord blood and Wharton's jelly in the horse.. Reproduction 2012;143(4):455–468.
          pubmed: 22274885
        22. Miki T, Lehmann T, Cai H, Stolz DB, Strom SC. Stem cell characteristics of amniotic epithelial cells.. Stem Cells 2005;23(10):1549–1559.
          pubmed: 16081662
        23. Ilancheran S, Michalska A, Peh G, Wallace EM, Pera M, Manuelpillai U. Stem cells derived from human fetal membranes display multilineage differentiation potential.. Biol Reprod 2007;77(3):577–588.
          pubmed: 17494917
        24. Parolini O, Alviano F, Bagnara GP. Concise review: isolation and characterization of cells from human term placenta: outcome of the first international Workshop on Placenta Derived Stem Cells.. Stem Cells 2008;26(2):300–311.
          pubmed: 17975221
        25. Lange-Consiglio A, Corradetti B. Characterization and potential applications of progenitor-like cells isolated from horse amniotic membrane.. J Tissue Eng Regen Med 2012;6(8):622–635.
          pubmed: 21948689
        26. Mattioli M, Gloria A, Turriani M. Stemness characteristics and osteogenic potential of sheep amniotic epithelial cells.. Cell Biol Int 2012;36(1):7–19.
          pubmed: 21880014
        27. Parolini O, Soncini M, Evangelista M, Schmidt D. Amniotic membrane and amniotic fluid-derived cells: potential tools for regenerative medicine?. Regen Med 2009;4:275–291.
          pubmed: 19317646
        28. Bailo M, Soncini M, Vertua E. Engraftment potential of human amnion and chorion cells derived from term placenta.. Transplantation 2004;78(10):1439–1448.
          pubmed: 15599307
        29. Hori J, Wang M, Kamiya K, Takahashi H, Sakuragawa N. Immunological characteristics of amniotic epithelium.. Cornea 2006;25(10 Suppl 1):S53–8.
          pubmed: 17001194
        30. Hunt JS, Petroff MG, McIntire RH, Ober C. HLA-G and immune tolerance in pregnancy.. FASEB J 2005;19(7):681–693.
          pubmed: 15857883
        31. Tamagawa T, Ishiwata I, Saito S. Establishment and characterization of a pluripotent stem cell line derived from human amniotic membranes and initiation of germ layers in vitro.. Hum Cell 2004;17(3):125–130.
          pubmed: 15859157
        32. Muttini A, Mattioli M, Petrizzi L. Experimental study on allografts of amniotic epithelial cells in calcaneal tendon lesions of sheep.. Vet Res Commun 2010;34(Suppl 1):S117–120.
          pubmed: 20495868
        33. Butler DL, Juncosa-Melvin N, Boivin GP. Functional tissue engineering for tendon repair: A multi-disciplinary strategy using mesenchymal stem cells, bioscaffolds, and mechanical stimulation.. J Orthop Res 2008;26(1):1–9.
          pubmed: 17676628
        34. Uysal CA, Tobita M, Hyakusoku H, Mizuno H. Adipose-derived stem cells enhance primary tendon repair: Biomechanical and immunohistochemical evaluation.. J Plast Reconstr Aesthet Surg 2012:6.
          pubmed: 22771087
        35. Behfar M, Sarrafzadeh-Rezaei F, Hobbenaghi R, Delirezh N, Dalir-Naghadeh B. Enhanced mechanical properties of rabbit flexor tendons in response to intratendinous injection of adipose derived stromal vascular fraction.. Curr Stem Cell Res Ther 2012;7(3):173–178.
          pubmed: 22329584
        36. Kasashima Y, Takahashi T, Smith RK. Prevalence of superficial digital flexor tendonitis and suspensory desmitis in Japanese Thoroughbred flat racehorses in 1999.. Equine Vet J 2004;36(4):346–350.
          pubmed: 15163043
        37. Ely ER, Avella CS, Price JS, Smith RK, Wood JL, Verheyen KL. Descriptive epidemiology of fracture, tendon and suspensory ligament injuries in National Hunt racehorses in training.. Equine Vet J 2009;41(4):372–378.
          pubmed: 19562899
        38. Smith RK, Birch HL, Goodman S, Heinegård D, Goodship AE. The influence of ageing and exercise on tendon growth and degeneration—hypotheses for the initiation and prevention of strain-induced tendinopathies.. Comp Biochem Physiol A Mol Integr Physiol 2002;133(4):1039–1050.
          pubmed: 12485691
        39. Dahlgren LA, Mohammed HO, Nixon AJ. Temporal expression of growth factors and matrix molecules in healing tendon lesions.. J Orthop Res 2005;23(1):84–92.
          pubmed: 15607879
        40. Bi Y, Ehirchiou D, Kilts TM. Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche.. Nat Med 2007;13(10):1219–1227.
          pubmed: 17828274
        41. Nixon AJ, Dahlgren LA, Haupt JL, Yeager AE, Ward DL. Effect of adipose-derived nucleated cell fractions on tendon repair in horses with collagenase-induced tendinitis.. Am J Vet Res 2008;69(7):928–937.
          pubmed: 18593247
        42. Crovace A, Lacitignola L, Rossi G, Francioso E. Histological and immunohistochemical evaluation of autologous cultured bone marrow mesenchymal stem cells and bone marrow mononucleated cells in collagenase-induced tendinitis of equine superficial digital flexor tendon.. Vet Med Int 2010;2010:250978.
          pmc: PMC2859019pubmed: 20445779
        43. Caniglia CJ, Schramme MC, Smith RK. The effect of intralesional injection of bone marrow derived mesenchymal stem cells and bone marrow supernatant on collagen fibril size in a surgical model of equine superficial digital flexor tendonitis.. Equine Vet J 2012;44(5):587–593.
          pubmed: 22150794
        44. O'Meara B, Bladon B, Parkin TD, Fraser B, Lischer CJ. An investigation of the relationship between race performance and superficial digital flexor tendonitis in the Thoroughbred racehorse.. Equine Vet J 2010;42(4):322–326.
          pubmed: 20525050
        45. Godwin EE, Young NJ, Dudhia J, Beamish IC, Smith RK. Implantation of bone marrow-derived mesenchymal stem cells demonstrates improved outcome in horses with overstrain injury of the superficial digital flexor tendon.. Equine Vet J 2012;44(1):25–32.
          pubmed: 21615465
        46. Marfe G, Rotta G, De Martino L. A new clinical approach: use of blood-derived stem cells (BDSCs) for superficial digital flexor tendon injuries in horses.. Life Sci 2012;690(21–22):825–830.
          pubmed: 22480518
        47. Fulton IC, MacLean AA, O'Rielly JL, Church S. Superior check ligament desmotomy for treatment of superficial digital flexor tendonitis in thoroughbred and standardbred horses.. Aust Vet J 1994;71(8):233–235.
          pubmed: 7986183
        48. Gibson KT, Burbidge HM, Pfeiffer DU. Superficial digital flexor tendonitis in thoroughbred race horses: outcome following non-surgical treatment and superior check desmotomy.. Aust Vet J 1997;75(9):631–635.
          pubmed: 9325536
        49. Muttini A, Valbonetti L, Abate M. Ovine amniotic epithelial cells: In vitro characterization and transplantation into equine superficial digital flexor tendon spontaneous defects.. Res Vet Sci 2012 Sep 3.
          pubmed: 22954787
        50. Ahmad Z, Wardale J, Brooks R, Henson F, Noorani A, Rushton N. Exploring the application of stem cells in tendon repair and regeneration.. Arthroscopy 2012;28(7):1018–1029.
          pubmed: 22381688
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