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The Veterinary record2016; 178(4); 91-92; doi: 10.1136/vr.i123

Strangles: a pathogenic legacy of the war horse.

Abstract: Strangles, characterised by pyrexia followed by abscessation of the lymph nodes of the head and neck, was first described in 1251 (Rufus 1251) and the causative agent, Streptococcus equi, was identified in 1888 (Schutz 1888). However, despite more than a century of research into this disease, strangles remains the most frequently diagnosed infection of horses with over 600 outbreaks being identified in the UK alone each year (Parkinson and others 2011). Here, Andrew Waller reviews some of the recent advances in the understanding of the evolution of S equi and puts this into the context of preventing and resolving outbreaks of infection.
Publication Date: 2016-01-23 PubMed ID: 26795860DOI: 10.1136/vr.i123Google Scholar: Lookup
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  • Journal Article
  • Review

Summary

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The research paper focuses on strangles, a common infection among horses caused by the Streptococcus equi bacteria, and discusses recent advancements in understanding the evolution of this bacteria, in the context of preventing and resolving outbreaks of the infection.

Review of Research on Strangles

The research paper by Andrew Waller begins by detailing the history of the condition, Strangles, which has been prevalent amongst horses since 1251. Despite advancements in veterinary science, it remains one of the most frequently diagnosed infections in horses, with more than 600 outbreaks detected in the UK yearly.

  • The disease typically manifests as fever, which is later followed by the formation of abscesses in the lymph nodes of the horse’s head and neck.
  • The bacteria responsible for causing Strangles – Streptococcus equi, was identified in 1888.

Evolution of Streptococcus equi

The paper also delves into the evolution of the causative agent of Strangles – Streptococcus equi.

  • This is crucial in understanding why the bacteria continue to affect horses and contribute to large-scale infectious disease outbreaks.
  • The research paper does not provide specifics on the evolutionary advances of this bacteria; instead, it implies a review of recent research and theories on this subject.

Preventing and Resolving Outbreaks

The research transitions into the practical implications of understanding the evolution of Streptococcus equi and channels this knowledge towards proposing solutions to prevent and manage Strangles outbreaks effectively.

  • Prevention strategies for managing strangles usually involve isolation and treatment of infected horses. However, new insights into the bacteria’s evolution could provide more effective measures for both prevention and cure.
  • The actual steps or strategies for preventing and resolving Strangles outbreaks using this evolutionary understanding are not expressly covered in the abstract, suggesting that further exploration is provided in the full research article.

Cite This Article

APA
Waller AS. (2016). Strangles: a pathogenic legacy of the war horse. Vet Rec, 178(4), 91-92. https://doi.org/10.1136/vr.i123

Publication

ISSN: 2042-7670
NlmUniqueID: 0031164
Country: England
Language: English
Volume: 178
Issue: 4
Pages: 91-92

Researcher Affiliations

Waller, Andrew S
  • Animal Health Trust, Lanwades Park, Newmarket, Suffolk CB8 7UU.

MeSH Terms

  • Animals
  • Carrier State / veterinary
  • Disease Outbreaks / veterinary
  • Horse Diseases / epidemiology
  • Horse Diseases / microbiology
  • Horses
  • Sentinel Surveillance / veterinary
  • Streptococcal Infections / epidemiology
  • Streptococcal Infections / microbiology
  • Streptococcal Infections / veterinary
  • Streptococcus equi / genetics
  • Streptococcus equi / pathogenicity
  • United Kingdom / epidemiology
  • World War I

Citations

This article has been cited 7 times.
  1. Knox A, Zerna G, Beddoe T. Current and Future Advances in the Detection and Surveillance of Biosecurity-Relevant Equine Bacterial Diseases Using Loop-Mediated Isothermal Amplification (LAMP). Animals (Basel) 2023 Aug 18;13(16).
    doi: 10.3390/ani13162663pubmed: 37627456google scholar: lookup
  2. Jaramillo-Morales C, James K, Barnum S, Vaala W, Chappell DE, Schneider C, Craig B, Bain F, Barnett DC, Gaughan E, Pusterla N. Voluntary Biosurveillance of Streptococcus equi Subsp. equi in Nasal Secretions of 9409 Equids with Upper Airway Infection in the USA. Vet Sci 2023 Jan 20;10(2).
    doi: 10.3390/vetsci10020078pubmed: 36851382google scholar: lookup
  3. Frosth S, Morris ERA, Wilson H, Frykberg L, Jacobsson K, Parkhill J, Flock JI, Wood T, Guss B, Aanensen DM, Boyle AG, Riihimäki M, Cohen ND, Waller AS. Conservation of vaccine antigen sequences encoded by sequenced strains of Streptococcus equi subsp. equi. Equine Vet J 2023 Jan;55(1):92-101.
    doi: 10.1111/evj.13552pubmed: 35000217google scholar: lookup
  4. Dominguez-Medina CC, Rash NL, Robillard S, Robinson C, Efstratiou A, Broughton K, Parkhill J, Holden MTG, Lopez-Alvarez MR, Paillot R, Waller AS. SpeS: A Novel Superantigen and Its Potential as a Vaccine Adjuvant against Strangles. Int J Mol Sci 2020 Jun 23;21(12).
    doi: 10.3390/ijms21124467pubmed: 32586031google scholar: lookup
  5. Léon A, Castagnet S, Maillard K, Paillot R, Giard JC. Evolution of In Vitro Antimicrobial Susceptibility of Equine Clinical Isolates in France between 2016 and 2019. Animals (Basel) 2020 May 7;10(5).
    doi: 10.3390/ani10050812pubmed: 32392891google scholar: lookup
  6. Widagdo W, Sooksawasdi Na Ayudhya S, Hundie GB, Haagmans BL. Host Determinants of MERS-CoV Transmission and Pathogenesis. Viruses 2019 Mar 19;11(3).
    doi: 10.3390/v11030280pubmed: 30893947google scholar: lookup
  7. Wilson HJ, Dong J, van Tonder AJ, Ruis C, Lefrancq N, McGlennon A, Bustos C, Frosth S, Léon A, Blanchard AM, Holden M, Waller AS, Parkhill J. Progressive evolution of Streptococcus equi from Streptococcus equi subsp. zooepidemicus and adaption to equine hosts. Microb Genom 2025 Mar;11(3).
    doi: 10.1099/mgen.0.001366pubmed: 40152912google scholar: lookup