Strangles: a pathogenic legacy of the war horse.
- Journal Article
- Review
- Diagnosis
- Disease control
- Disease Diagnosis
- Disease Etiology
- Disease Management
- Disease Outbreaks
- Disease Prevention
- Disease Treatment
- Epidemiology
- Equine Diseases
- Equine Health
- Evolutionary Biology
- Horses
- Infection
- Infectious Disease
- Pathogenesis
- Pathogens
- Strangles
- Streptococcus
- Veterinary Medicine
- Veterinary Research
Summary
The research paper focuses on strangles, a common infection among horses caused by the Streptococcus equi bacteria, and discusses recent advancements in understanding the evolution of this bacteria, in the context of preventing and resolving outbreaks of the infection.
Review of Research on Strangles
The research paper by Andrew Waller begins by detailing the history of the condition, Strangles, which has been prevalent amongst horses since 1251. Despite advancements in veterinary science, it remains one of the most frequently diagnosed infections in horses, with more than 600 outbreaks detected in the UK yearly.
- The disease typically manifests as fever, which is later followed by the formation of abscesses in the lymph nodes of the horse’s head and neck.
- The bacteria responsible for causing Strangles – Streptococcus equi, was identified in 1888.
Evolution of Streptococcus equi
The paper also delves into the evolution of the causative agent of Strangles – Streptococcus equi.
- This is crucial in understanding why the bacteria continue to affect horses and contribute to large-scale infectious disease outbreaks.
- The research paper does not provide specifics on the evolutionary advances of this bacteria; instead, it implies a review of recent research and theories on this subject.
Preventing and Resolving Outbreaks
The research transitions into the practical implications of understanding the evolution of Streptococcus equi and channels this knowledge towards proposing solutions to prevent and manage Strangles outbreaks effectively.
- Prevention strategies for managing strangles usually involve isolation and treatment of infected horses. However, new insights into the bacteria’s evolution could provide more effective measures for both prevention and cure.
- The actual steps or strategies for preventing and resolving Strangles outbreaks using this evolutionary understanding are not expressly covered in the abstract, suggesting that further exploration is provided in the full research article.
Cite This Article
Publication
Researcher Affiliations
- Animal Health Trust, Lanwades Park, Newmarket, Suffolk CB8 7UU.
MeSH Terms
- Animals
- Carrier State / veterinary
- Disease Outbreaks / veterinary
- Horse Diseases / epidemiology
- Horse Diseases / microbiology
- Horses
- Sentinel Surveillance / veterinary
- Streptococcal Infections / epidemiology
- Streptococcal Infections / microbiology
- Streptococcal Infections / veterinary
- Streptococcus equi / genetics
- Streptococcus equi / pathogenicity
- United Kingdom / epidemiology
- World War I
Citations
This article has been cited 7 times.- Knox A, Zerna G, Beddoe T. Current and Future Advances in the Detection and Surveillance of Biosecurity-Relevant Equine Bacterial Diseases Using Loop-Mediated Isothermal Amplification (LAMP). Animals (Basel) 2023 Aug 18;13(16).
- Jaramillo-Morales C, James K, Barnum S, Vaala W, Chappell DE, Schneider C, Craig B, Bain F, Barnett DC, Gaughan E, Pusterla N. Voluntary Biosurveillance of Streptococcus equi Subsp. equi in Nasal Secretions of 9409 Equids with Upper Airway Infection in the USA. Vet Sci 2023 Jan 20;10(2).
- Frosth S, Morris ERA, Wilson H, Frykberg L, Jacobsson K, Parkhill J, Flock JI, Wood T, Guss B, Aanensen DM, Boyle AG, Riihimäki M, Cohen ND, Waller AS. Conservation of vaccine antigen sequences encoded by sequenced strains of Streptococcus equi subsp. equi. Equine Vet J 2023 Jan;55(1):92-101.
- Dominguez-Medina CC, Rash NL, Robillard S, Robinson C, Efstratiou A, Broughton K, Parkhill J, Holden MTG, Lopez-Alvarez MR, Paillot R, Waller AS. SpeS: A Novel Superantigen and Its Potential as a Vaccine Adjuvant against Strangles. Int J Mol Sci 2020 Jun 23;21(12).
- Léon A, Castagnet S, Maillard K, Paillot R, Giard JC. Evolution of In Vitro Antimicrobial Susceptibility of Equine Clinical Isolates in France between 2016 and 2019. Animals (Basel) 2020 May 7;10(5).
- Widagdo W, Sooksawasdi Na Ayudhya S, Hundie GB, Haagmans BL. Host Determinants of MERS-CoV Transmission and Pathogenesis. Viruses 2019 Mar 19;11(3).
- Wilson HJ, Dong J, van Tonder AJ, Ruis C, Lefrancq N, McGlennon A, Bustos C, Frosth S, Léon A, Blanchard AM, Holden M, Waller AS, Parkhill J. Progressive evolution of Streptococcus equi from Streptococcus equi subsp. zooepidemicus and adaption to equine hosts. Microb Genom 2025 Mar;11(3).