Studies on the pathogenesis of equine tendonitis following collagenase injury.
Abstract: The histological and morphological characteristics of the scar tissue formed during healing after traumatic equine tendon injury have been compared with those of scar tissue produced in response to an enzyme-induced pony tendon injury. Several techniques are currently in use in the treatment of equine tendon sprain and this work formed part of a study of their respective efficacy. It was concluded that the enzyme-induced lesion is resolved by a reparative process very similar in its prognosis and extent to that following a naturally occurring tendon sprain. It may therefore justifiably be used as a model of naturally occurring tendon sprain in the comparative study of treatment methods.
Publication Date: 1984-05-01 PubMed ID: 6087432
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research article explores how the scar tissue produced after a horse tendon injury, inflicted by an enzyme or trauma, heals. The goal is to compare the efficacy of various treatment methods for equine tendon sprain.
Opening and Objectives
- The researchers looked at the process of healing in horse tendons following an injury. Specifically, they compared the scar tissue developed after a traumatic injury with the one formed after an enzyme-induced injury.
- The project’s objective was part of a broader study investigating the effectiveness of different existing treatment techniques for equine tendon sprains.
Comparative Study and Conclusion
- The team concluded that both types of injuries result in a healing process that produces similar scar tissue in scope and prognoses. The enzymatic injury was found to mimic the natural healing process seen in naturally occurring tendon sprains.
- This similarity led the researchers to propose the justification of using the enzyme-induced lesion as a model for natural tendon sprains. This can be used in further comparative studies aiming to evaluate the effectiveness of different treatment methods for tendon sprains in horses.
Significance
- This research plays a crucial role in furthering our understanding of equine tendonitis, its treatment strategies, and the rehabilitation process. By providing a reliable model of a naturally occurring tendon sprain, the study aids future research in comparing the effectiveness of different treatment methods.
- By understanding the similarities in healing processes between natural and enzyme-induced injuries, medical professionals can make more informed decisions about equine health and injury treatment. This could potentially lead to improved treatment methods in the future.
Cite This Article
APA
Williams IF, McCullagh KG, Goodship AE, Silver IA.
(1984).
Studies on the pathogenesis of equine tendonitis following collagenase injury.
Res Vet Sci, 36(3), 326-338.
Publication
Researcher Affiliations
MeSH Terms
- Animals
- Collagen / metabolism
- Female
- Forelimb
- Horse Diseases / chemically induced
- Horse Diseases / metabolism
- Horse Diseases / pathology
- Horses
- Male
- Microbial Collagenase / adverse effects
- Tendinopathy / chemically induced
- Tendinopathy / metabolism
- Tendinopathy / pathology
- Tendinopathy / veterinary
- Tendons / pathology
Citations
This article has been cited 19 times.- Gaesser AM, Underwood C, Linardi RL, Even KM, Reef VB, Shetye SS, Mauck RL, King WJ, Engiles JB, Ortved KF. Evaluation of Autologous Protein Solution Injection for Treatment of Superficial Digital Flexor Tendonitis in an Equine Model.. Front Vet Sci 2021;8:697551.
- Wagner FC, Gerlach K, Geiger SM, Gittel C, Böttcher P, Mülling CKW. Biplanar High-Speed Fluoroscopy of Pony Superficial Digital Flexor Tendon (SDFT)-An In Vivo Pilot Study.. Vet Sci 2021 May 27;8(6).
- Pownder SL, Hayashi K, Lin BQ, Meyers KN, Caserto BG, Breighner RE, Potter HG, Koff MF. Differences in the magnetic resonance imaging parameter T2* may be identified during the course of canine patellar tendon healing: a pilot study.. Quant Imaging Med Surg 2021 Apr;11(4):1234-1246.
- Ribitsch I, Baptista PM, Lange-Consiglio A, Melotti L, Patruno M, Jenner F, Schnabl-Feichter E, Dutton LC, Connolly DJ, van Steenbeek FG, Dudhia J, Penning LC. Large Animal Models in Regenerative Medicine and Tissue Engineering: To Do or Not to Do.. Front Bioeng Biotechnol 2020;8:972.
- Tondelli T, Götschi T, Camenzind RS, Snedeker JG. Assessing the effects of intratendinous genipin injections: Mechanical augmentation and spatial distribution in an ex vivo degenerative tendon model.. PLoS One 2020;15(4):e0231619.
- Ahrberg AB, Horstmeier C, Berner D, Brehm W, Gittel C, Hillmann A, Josten C, Rossi G, Schubert S, Winter K, Burk J. Effects of mesenchymal stromal cells versus serum on tendon healing in a controlled experimental trial in an equine model.. BMC Musculoskelet Disord 2018 Jul 18;19(1):230.
- Camenzind RS, Tondelli TO, Götschi T, Holenstein C, Snedeker JG. Can Genipin-coated Sutures Deliver a Collagen Crosslinking Agent to Improve Suture Pullout in Degenerated Tendon? An Ex Vivo Animal Study.. Clin Orthop Relat Res 2018 May;476(5):1104-1113.
- Watts AE, Millar NL, Platt J, Kitson SM, Akbar M, Rech R, Griffin J, Pool R, Hughes T, McInnes IB, Gilchrist DS. MicroRNA29a Treatment Improves Early Tendon Injury.. Mol Ther 2017 Oct 4;25(10):2415-2426.
- Perucca Orfei C, Lovati AB, Viganò M, Stanco D, Bottagisio M, Di Giancamillo A, Setti S, de Girolamo L. Dose-Related and Time-Dependent Development of Collagenase-Induced Tendinopathy in Rats.. PLoS One 2016;11(8):e0161590.
- Kamineni S, Butterfield T, Sinai A. Percutaneous ultrasonic debridement of tendinopathy-a pilot Achilles rabbit model.. J Orthop Surg Res 2015 May 20;10:70.
- de Mattos LH, Álvarez LE, Yamada AL, Hussni CA, Rodrigues CA, Watanabe MJ, Alves AL. Effect of phototherapy with light-emitting diodes (890 nm) on tendon repair: an experimental model in sheep.. Lasers Med Sci 2015 Jan;30(1):193-201.
- Rio E, Moseley L, Purdam C, Samiric T, Kidgell D, Pearce AJ, Jaberzadeh S, Cook J. The pain of tendinopathy: physiological or pathophysiological?. Sports Med 2014 Jan;44(1):9-23.
- Södersten F, Hultenby K, Heinegård D, Johnston C, Ekman S. Immunolocalization of collagens (I and III) and cartilage oligomeric matrix protein in the normal and injured equine superficial digital flexor tendon.. Connect Tissue Res 2013;54(1):62-9.
- Dakin SG, Werling D, Hibbert A, Abayasekara DR, Young NJ, Smith RK, Dudhia J. Macrophage sub-populations and the lipoxin A4 receptor implicate active inflammation during equine tendon repair.. PLoS One 2012;7(2):e32333.
- Choi S, Cheong Y, Shin JH, Lee HJ, Lee GJ, Choi SK, Jin KH, Park HK. Short-term nanostructural effects of high radiofrequency treatment on the skin tissues of rabbits.. Lasers Med Sci 2012 Sep;27(5):923-33.
- Watts AE, Yeager AE, Kopyov OV, Nixon AJ. Fetal derived embryonic-like stem cells improve healing in a large animal flexor tendonitis model.. Stem Cell Res Ther 2011 Jan 27;2(1):4.
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- Abate M, Silbernagel KG, Siljeholm C, Di Iorio A, De Amicis D, Salini V, Werner S, Paganelli R. Pathogenesis of tendinopathies: inflammation or degeneration?. Arthritis Res Ther 2009;11(3):235.
- Warden SJ. Animal models for the study of tendinopathy.. Br J Sports Med 2007 Apr;41(4):232-40.
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