Subtourniquet pressures generated by application of wide-rubber tourniquets in standing, sedated horses.
Abstract: To determine the influence of location and movement on subtourniquet pressure (STP) generated by application of a wide-rubber tourniquet (WRT) on equine limbs. Methods: Randomized experimental cross-over design. Methods: Six standing, sedated horses. Methods: Horses were sedated with detomidine hydrochloride (0.2 μg/kg IV), and 4 investigators applied WRTs to the antebrachium (AB), gaskin (GK), and midmetacarpus (MC) of each horse in a predetermined, randomized order. Subtourniquet pressure was consequently measured at 10-minute intervals (T0, T10, T20, T30) for 30 minutes. Indirect systolic blood pressure (SBP) was measured presedation, postsedation, and throughout the tourniquet application period. Target STP was established as SBP + 100 mm Hg. Limb movements at each location were classified as none, low, moderate, or high, on the basis of counts and magnitude. Results: Mean STP did not change with time (P = .93) and exceeded SBP by 163 mm Hg (95% CI 122-205), 185 mm Hg (95% CI 156-214), and 402 mm Hg (95% CI 351-454) at the AB, GK, and MC, respectively. Mean STP at each location exceeded the target STP in 59 of 70 (81%) of the trials. Limb movements affected STP generated by tourniquets at the AB (P = .04) and MC (P 100 mm Hg above SBP for 30 minutes in standing, sedated horses. Conclusions: Wide-rubber tourniquets as applied in this study can achieve and maintain the current recommended STP (SBP + 100 mm Hg) for equine IV regional limb perfusion. Number and magnitude of limb movement can decrease STP over time, potentially reducing the efficacy of a WRT.
© 2019 The American College of Veterinary Surgeons.
Publication Date: 2019-02-17 PubMed ID: 30773652DOI: 10.1111/vsu.13181Google Scholar: Lookup
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- Clinical Trial
- Veterinary
- Journal Article
Summary
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The research is about the effect of tourniquet location and movement of horses on subtourniquet pressure (STP) when a wide-rubber tourniquet (WRT) is applied. The study found that the STP exceeded the systolic blood pressure (SBP) by various amounts depending on the location, and that limb movements can decrease the STP over time.
Methods
- The study involved six standing, sedated horses. They used detomidine hydrochloride to sedate the horses.
- Four researchers applied WRTs to the antebrachium (AB), gaskin (GK), and midmetacarpus (MC) of each horse in a predetermined, randomized order.
- They measured the STP at 10-minute intervals for 30 minutes.
- Indirect systolic blood pressure (SBP) was measured before sedation, after sedation, and during the period when the tourniquet was applied. The target STP was established as SBP + 100mm Hg.
- Limb movements at each location were classified as none, low, moderate, or high, based on counts and magnitude.
Results
- The average STP did not change with time and exceeded the SBP by 163mm Hg (95% CI 122-205), 185mm Hg (95% CI 156-214), and 402mm Hg (95% CI 351-454) at the AB, GK, and MC respectively.
- The mean STP at each location exceeded the target STP in 81% of the trials.
- Limb movements affected the STP generated by tourniquets at the AB (P = .04) and MC (P < .0001) but not at the GK (P = .67).
Conclusions
- Wide-rubber tourniquets applied at the AB, GK, and MC generated STP more than 100mm Hg above SBP for 30 minutes in standing, sedated horses.
- Wide-rubber tourniquets applied during the study can achieve and maintain the current recommended STP (SBP + 100mm Hg) for equine IV regional limb perfusion.
- The number and magnitude of limb movement can decrease STP over time, potentially reducing the efficacy of a WRT.
Cite This Article
APA
Plunkett AH, Schoonover MJ, Young JM, Taylor JD, Holbrook TC.
(2019).
Subtourniquet pressures generated by application of wide-rubber tourniquets in standing, sedated horses.
Vet Surg, 48(3), 417-423.
https://doi.org/10.1111/vsu.13181 Publication
Researcher Affiliations
- Department of Veterinary Clinical Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma.
- Department of Veterinary Clinical Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma.
- Department of Veterinary Clinical Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma.
- Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma.
- Department of Veterinary Clinical Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma.
MeSH Terms
- Animals
- Blood Pressure
- Conscious Sedation
- Cross-Over Studies
- Female
- Horses
- Hypnotics and Sedatives / pharmacology
- Imidazoles / administration & dosage
- Imidazoles / pharmacology
- Male
- Perfusion / veterinary
- Pressure
- Random Allocation
- Rubber
- Tourniquets / veterinary
- Vascular Surgical Procedures
Grant Funding
- Department of Veterinary Clinical Sciences and the June Jacobs Endowed Chair in Equine Medicine, Center for Veterinary Health Sciences, Oklahoma State University
Citations
This article has been cited 3 times.- O'Brien M, Mochel JP, Kersh K, Wang C, Troy J. Phenylbutazone concentrations in synovial fluid following administration via intravenous regional limb perfusion in the forelimbs of six adult horses. Front Vet Sci 2023;10:1236976.
- Bonilla AG, Causeret L, Torrent-Crosa A. Pharmacokinetics of ceftiofur in the metacarpophalangeal joint after standing intravenous regional limb perfusion in horses. Can Vet J 2021 Sep;62(9):975-981.
- Guillot M, Mespoulhes-Rivière C, Bousquet-Mélou A, Lacroix MZ, Roques BB, Lallemand EA. Pharmacokinetics, pharmacodynamics, and local tolerance at injection site of penicillin and gentamicin administered by intravenous regional limb perfusion in standing horses: comparison between weightbearing and flexed limbs. BMC Vet Res 2025 Nov 7;21(1):650.
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