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Veterinary surgery : VS2019; 48(5); 685-693; doi: 10.1111/vsu.13216

Surgical site infection associated with equine orthopedic internal fixation: 155 cases (2008-2016).

Abstract: To determine the prevalence of surgical site infection (SSI) after internal fixation and to identify risk factors for SSI and nonsurvival. Methods: Retrospective study. Methods: One hundred fifty-five horses with long bone fractures or arthrodesis treated by internal fixation at 1 hospital between 2008-2016. Methods: Signalment, diagnosis, surgical repair, surgeon, surgical time, antimicrobial use, SSI onset, bacterial identification, and adjunct treatments were recorded. Perioperative variables were analyzed to identify risk factors associated with outcomes. Results: Surgical-site infection was reported in 22 of 155 (14.2%) horses, which is lower than what has been previously reported (P = .003). Horses with fetlock arthrodesis or ulnar fracture were more likely to develop SSI. Local prophylactic antimicrobial therapy was associated with an increased risk of SSI. Horses with SSI were 12 times (P < .0001) less likely to survive to discharge than horses without SSI. Horses with a fetlock or carpal arthrodesis or those with radial/humeral/femoral fractures were less likely to survive. No association was identified between open fractures, open reduction and internal fixation, or surgical times and SSI. Conclusions: The prevalence of SSI in this population was lower than what has been previously reported. Horses with fetlock or carpal arthrodesis or radial/humeral/femoral fractures were at increased risk for SSI and/or nonsurvival to discharge. A protective role of local antimicrobial therapy for SSI could not be established. Conclusions: The impact of SSI on outcomes of cases of equine internal fixation remains substantial. Identification of cases at higher risk of SSI should influence surgical technique, postoperative management, and early intervention when SSI is suspected. Additional investigation is warranted regarding local antimicrobial therapy.
Publication Date: 2019-04-16 PubMed ID: 30993777DOI: 10.1111/vsu.13216Google Scholar: Lookup
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  • Journal Article

Summary

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The research paper details a study concerning equine orthopedic internal fixation, looking specifically at the prevalence of surgical site infection (SSI) and associated risk factors. The study spanned from 2008 to 2016 and found that the prevalence of SSIs in this context is lower than previously reported, but horses with certain medical conditions were at increased risk of developing SSIs.

Study Details

  • The research was a retrospective study that included 155 horses that underwent orthopedic internal fixation surgeries at a single hospital between the years 2008 and 2016.
  • Data collected included the horse’s diagnosis, the method of surgical repair, the operating surgeon, surgical time, the use of antimicrobial substances, onset of SSI, bacterial identification, and additional treatments.
  • Various perioperative variables were analyzed to identify potential risk factors connected to surgical outcomes.

Key Findings

  • Out of the 155 horses, 22 (14.2%) developed an SSI, a rate lower than what previous research has shown.
  • Horses with fetlock arthrodesis (fusion of the fetlock joint) or ulnar fractures were more likely to develop an SSI.
  • The administration of local prophylactic antimicrobial therapy was associated with an increased risk of SSIs.
  • Horses that developed an SSI were 12 times less likely to survive to discharge than horses that didn’t develop an SSI.
  • In terms of survival, horses with fetlock or carpal arthrodesis or fractures in the radial/humeral/femoral bones were at higher risk.
  • No associations were found between open fractures, open reduction, internal fixation, surgical times, and SSI.

Conclusions

  • The researchers concluded that the prevalence of SSIs in such cases was lower than previously reported, but equine patients with fetlock or carpal arthrodesis and radial/humeral/femoral fractures were at increased risk of SSI and/or nonsurvival.
  • The study could not establish a protective role of local antimicrobial therapy for SSI, implying that further investigation is required for this particular treatment.
  • The authors suggest that these findings should influence surgical techniques, postoperative management strategies, and promote early interventions when SSI is suspected in equine patients undergoing orthopedic internal fixation.

Cite This Article

APA
Curtiss AL, Stefanovski D, Richardson DW. (2019). Surgical site infection associated with equine orthopedic internal fixation: 155 cases (2008-2016). Vet Surg, 48(5), 685-693. https://doi.org/10.1111/vsu.13216

Publication

ISSN: 1532-950X
NlmUniqueID: 8113214
Country: United States
Language: English
Volume: 48
Issue: 5
Pages: 685-693

Researcher Affiliations

Curtiss, Alexandra L
  • Department of Clinical Studies, New Bolton Center, University of Pennsylvania, Kennett Square, Pennsylvania.
Stefanovski, Darko
  • Department of Clinical Studies, New Bolton Center, University of Pennsylvania, Kennett Square, Pennsylvania.
Richardson, Dean W
  • Department of Clinical Studies, New Bolton Center, University of Pennsylvania, Kennett Square, Pennsylvania.

MeSH Terms

  • Animals
  • Anti-Bacterial Agents / therapeutic use
  • Arthrodesis / adverse effects
  • Female
  • Forelimb / pathology
  • Forelimb / surgery
  • Fracture Fixation, Internal / adverse effects
  • Fracture Fixation, Internal / veterinary
  • Hindlimb / pathology
  • Hindlimb / surgery
  • Horse Diseases / drug therapy
  • Horse Diseases / etiology
  • Horses
  • Humans
  • Humeral Fractures
  • Male
  • Open Fracture Reduction / adverse effects
  • Open Fracture Reduction / veterinary
  • Operative Time
  • Prevalence
  • Retrospective Studies
  • Risk Factors
  • Surgical Wound Infection / drug therapy
  • Surgical Wound Infection / etiology
  • Surgical Wound Infection / veterinary

Citations

This article has been cited 9 times.
  1. Thurston CC, Stefanovski D, MacKinnon MC, Chapman HS, Richardson DW, Levine DG. Serum amyloid A and fibrinogen as markers for early detection of surgical site infection associated with internal fixation in the horse.. Front Vet Sci 2022;9:960865.
    doi: 10.3389/fvets.2022.960865pubmed: 36299628google scholar: lookup
  2. Qian W, Sun W, Xie S. Risk factors of wound infection after lung transplantation: a narrative review.. J Thorac Dis 2022 Jun;14(6):2268-2275.
    doi: 10.21037/jtd-22-543pubmed: 35813752google scholar: lookup
  3. Daniels A, Pezzanite LM, Griffenhagen GM, Hendrickson DA. Evaluation of factors associated with surgical site infection in equine proximal interphalangeal joint arthrodesis: 54 cases (2010-2019).. Vet Med Sci 2022 Jul;8(4):1478-1488.
    doi: 10.1002/vms3.839pubmed: 35594487google scholar: lookup
  4. Bowers K, Weinhandl JT, Anderson DE. A review of equine tibial fractures.. Equine Vet J 2023 Mar;55(2):171-181.
    doi: 10.1111/evj.13599pubmed: 35569040google scholar: lookup
  5. Marchionatti E, Constant C, Steiner A. Preoperative skin asepsis protocols using chlorhexidine versus povidone-iodine in veterinary surgery: A systematic review and meta-analysis.. Vet Surg 2022 Jul;51(5):744-752.
    doi: 10.1111/vsu.13810pubmed: 35437786google scholar: lookup
  6. Redding LE, Elzer EJ, Ortved KF. Effects of regional limb perfusion technique on concentrations of antibiotic achieved at the target site: A meta-analysis.. PLoS One 2022;17(4):e0265971.
    doi: 10.1371/journal.pone.0265971pubmed: 35363825google scholar: lookup
  7. Gordon J, Álvarez-Narváez S, Peroni JF. Antimicrobial Effects of Equine Platelet Lysate.. Front Vet Sci 2021;8:703414.
    doi: 10.3389/fvets.2021.703414pubmed: 34490395google scholar: lookup
  8. Grzeskowiak RM, Alghazali KM, Hecht S, Donnell RL, Doherty TJ, Smith CK, Anderson DE, Biris AS, Adair HS. Influence of a novel scaffold composed of polyurethane, hydroxyapatite, and decellularized bone particles on the healing of fourth metacarpal defects in mares.. Vet Surg 2021 Jul;50(5):1117-1127.
    doi: 10.1111/vsu.13608pubmed: 33948951google scholar: lookup
  9. Ma R, He J, Xu B, Zhao C, Zhang Y, Li X, Sun S, Zhang Q. Nomogram prediction of surgical site infection of HIV-infected patients following orthopedic surgery: a retrospective study.. BMC Infect Dis 2020 Nov 26;20(1):896.
    doi: 10.1186/s12879-020-05613-3pubmed: 33243159google scholar: lookup