Systemic candidiasis in four foals.
Abstract: Four foals were admitted to the neonatal intensive care unit in the first 2 days of life with problems related to birth hypoxia (neonatal maladjustment syndrome, renal failure, necrotizing enterocolitis) and sepsis. Foals were hospitalized for an extended period (35 to 70 days) and received treatment with several broad spectrum antimicrobial agents. Invasive monitoring and treatment procedures included intravenous catheterization, urinary catheterization, and parenteral nutritional and ventilatory support. In each foal, infections of undetermined cause developed, and systemic candidiasis was diagnosed after Candida albicans was isolated from specimens obtained from 1 or more internal sites. The 3 foals in which treatment was attempted responded well to IV administration of amphotericin B and/or oral administration of fluconazole, and were discharged from the hospital.
Publication Date: 1994-08-01 PubMed ID: 7961075
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Summary
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This research article pertains to the systemic candidiasis infection in four foals. The foals were treated with broad spectrum antibiotics for birth hypoxia-related problems and sepsis and later diagnosed with systemic candidiasis. Three of the foals responded positively to the treatment and were discharged.
Study Background
- The study focused on four foals admitted to a neonatal intensive care unit due to issues related to birth hypoxia, such as neonatal maladjustment syndrome, renal failure, and necrotizing enterocolitis, all of which are potential complications of the birth process.
- The foals also suffered from sepsis, a severe and life-threatening response to infection which can result in multiple organ failure.
Study Methodology
- The foals were hospitalized for an extensive period ranging from 35 to 70 days during which, they were treated with various broad spectrum antimicrobial agents to help combat their initial health problems.
- Moreover, invasive monitoring and treatment procedures were conducted, which included intravenous and urinary catheterization, as well as parenteral nutritional support and ventilatory assistance, all imperative to maintain the foals’ health and ensure their survival through the initial weak phase.
Candidiasis Infection
- During their hospital stay, the foals developed infections of an undetermined cause. These infections were later diagnosed as systemic candidiasis.
- Systemic candidiasis is a severe infection caused by the Candida albicans fungus. This infection was diagnosed after the fungus was isolated from samples taken from one or more internal sites in each foal.
Treatment and Results
- The treatment undertaken for systemic candidiasis involved intravenous administration of amphotericin B and/or oral administration of fluconazole, both known antifungal medications.
- These treatment approaches were effective for three of the four foals. They responded positively and were eventually discharged from the hospital.
- The research does not provide information on the condition or progress of the fourth foal following diagnosis and treatment.
Cite This Article
APA
Reilly LK, Palmer JE.
(1994).
Systemic candidiasis in four foals.
J Am Vet Med Assoc, 205(3), 464-466.
Publication
Researcher Affiliations
- New Bolton Center, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Kennett Square 19348.
MeSH Terms
- Amphotericin B / therapeutic use
- Animals
- Animals, Newborn
- Candidiasis / drug therapy
- Candidiasis / etiology
- Candidiasis / veterinary
- Catheterization, Peripheral / adverse effects
- Catheterization, Peripheral / veterinary
- Gram-Negative Bacterial Infections / complications
- Gram-Negative Bacterial Infections / drug therapy
- Gram-Negative Bacterial Infections / veterinary
- Horse Diseases / drug therapy
- Horse Diseases / etiology
- Horses
- Intubation, Intratracheal / adverse effects
- Intubation, Intratracheal / veterinary
- Male
- Risk Factors
- Urinary Catheterization / adverse effects
- Urinary Catheterization / veterinary
Citations
This article has been cited 6 times.- Jaishi VL, Parajuli R, Dahal P, Maharjan R. Prevalence and Risk Factors of Superficial Fungal Infection among Patients Attending a Tertiary Care Hospital in Central Nepal.. Interdiscip Perspect Infect Dis 2022;2022:3088681.
- Merchán A, Voss JK, Dubois MS. Fungal osteitis of the axial aspect of the mid body of the medial proximal sesamoid bone in a horse.. Can Vet J 2021 Aug;62(8):867-871.
- Dalvand A, Katiraee F, Jafari Joozani R, Shokri H. Genotyping of Candida albicans isolated from animals using 25S ribosomal DNA and ALT repeats polymorphism in repetitive sequence.. Curr Med Mycol 2018 Dec;4(4):12-19.
- Bufalari A, Maggio C, Moretti G, Crovace A, Stefanetti V, Straubinger RK, Passamonti F. Management of Candida guilliermondii joint infection in a dog.. Acta Vet Scand 2016 Jul 8;58(1):47.
- Różański P, Slaska B, Różańska D. Prevalence of yeasts in English full blood mares.. Mycopathologia 2013 Apr;175(3-4):339-44.
- Edelmann A, Krüger M, Schmid J. Genetic relationship between human and animal isolates of Candida albicans.. J Clin Microbiol 2005 Dec;43(12):6164-6.
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