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Tachykinin receptors in the equine pelvic flexure.
Abstract: Tachykinins, of which substance P (SP) is the prototype, are neuropeptides which are widely distributed in the nervous systems. In the equine gut, SP is present in enteric nerves and is a powerful constrictor of enteric muscle; in other species, SP is also known to have potent vasodilatory and pro-inflammatory effects. The specific effects of SP are determined by the subtype of receptor present in the target tissue. There are 3 known subtypes of tachykinin receptors, distinguished by their relative affinities for SP and other tachykinins. The distribution of SP binding sites in the equine pelvic flexure was determined using 125I-Bolton Hunter SP (I-BHSP) autoradiography. Most I-BHSP binding sites were determined to be saturable and specific, therefore presumably representing tachykinin receptors. The greatest degree of I-BHSP binding occurred over very small vessels, and over the muscularis mucosae; I-BHSP binding was also intense over the circular muscle of the muscularis externa and mucosa, and present, although less intense, over the longitudinal muscle of the muscularis externa. Competition of I-BHSP with specific receptor agonists for binding sites in the equine pelvic flexure were used to determine the subtypes of tachykinin receptors present. The neurokinin-1 receptor subtype predominated in the equine pelvic flexure, followed by the neurokinin-3 receptor subtype.
Publication Date: 1997-07-01 PubMed ID: 15338912DOI: 10.1111/j.2042-3306.1997.tb03128.xGoogle Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Research Support
- Non-U.S. Gov't
- Research Support
- U.S. Gov't
- Non-P.H.S.
Summary
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The study investigates the presence and distribution of Tachykinin receptors, especially those of Substance P (SP), in the equine pelvic flexure. The findings reveal that the predominant subtype of these receptors in the equine pelvic flexure is the neurokinin-1, followed by neurokinin-3.
Overview of the Research
In this research, the authors conducted a detailed investigation of the presence and distribution of Tachykinin receptors in the equine pelvic flexure. Tachykinins are neuropeptides, and substance P (SP) is the prototype among these. These are found widely in nervous systems. Particularly in the equine gut, SP is found in enteric nerves and has been observed to constrict enteric muscle.
- The effects of substance P are determined by the variant of receptor present in the target tissue.
- Three known subtypes of these receptors exist and are distinguishable based on their relative affinities towards SP and other Tachykinins.
Methodology and Findings
The researchers used 125I-Bolton Hunter SP (I-BHSP) autoradiography to identify SP binding sites in the equine pelvic flexure.
- The majority of the I-BHSP binding sites were found to be saturable and specific, which suggests that they represent Tachykinin receptors.
- The highest degree of I-BHSP binding was observed over very small vessels and the muscularis mucosae.
- I-BHSP binding was also significantly present over the circular muscle of the muscularis externa and mucosa, but found less intense over the longitudinal muscle of the muscularis externa.
The researchers also analyzed the competition of I-BHSP with specific receptor agonists for binding sites in the equine pelvic flexure to determine the subtypes of tachykinin receptors present.
Conclusion of the Research
The findings indicated the predominant receptor subtype in the equine pelvic flexure is neurokinin-1, followed by neurokinin-3. This detailed understanding of the distribution and types of Tachykinin receptors can have important implications for understanding related physiological processes and potential treatments.
Cite This Article
APA
Sonea IM, Wilson DV, Bowker RM, Robinson NE.
(1997).
Tachykinin receptors in the equine pelvic flexure.
Equine Vet J, 29(4), 306-312.
https://doi.org/10.1111/j.2042-3306.1997.tb03128.x Publication
Researcher Affiliations
- Department of Anatomy, Michigan State University, East Lansing, Michigan 48824, USA.
MeSH Terms
- Animals
- Autoradiography / veterinary
- Binding Sites
- Colon / innervation
- Colon / metabolism
- Densitometry / veterinary
- Female
- Horses / metabolism
- Horses / physiology
- Iodine Radioisotopes
- Male
- Pelvis / innervation
- Receptors, Neurokinin-1 / metabolism
- Receptors, Tachykinin / metabolism
- Substance P / metabolism
- Tachykinins / metabolism
Citations
This article has been cited 1 times.- Sonea IM, Palmer MV, Akili D, Harp JA. Treatment with neurokinin-1 receptor antagonist reduces severity of inflammatory bowel disease induced by Cryptosporidium parvum. Clin Diagn Lab Immunol 2002 Mar;9(2):333-40.
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