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Home / Equine Research Bank / Vet Rec / Temporal efficacy of antimicrobials against aerobic bacteria...
The Veterinary record2019; 185(19); 598; doi: 10.1136/vr.105413

Temporal efficacy of antimicrobials against aerobic bacteria isolated from equine endometritis: an Italian retrospective analysis (2010-2017).

Abstract: This study aimed to describe bacteria isolated from the reproductive tract of mares and to identify changes in antimicrobial susceptibility patterns to those antibiotics commonly used for the treatment of equine endometritis. A total of 4122 equine uterine swabs were collected from mares suffering from reproductive tract disorders in the period 2010-2017. Aerobic culture and antimicrobial susceptibility testing using agar disc diffusion were performed on each sample. Aerobic bacteria were isolated from 3171 of 4122 (76.9 per cent) samples. The most frequently isolated microorganisms were (885/3171, 27.9 per cent) and subspecies (791/3171, 24.9 per cent), confirming previous findings from the literature. Antimicrobial susceptibility patterns of , subspecies and changed over time. A statistically significant decrease in antimicrobial efficacy of cefquinome against was observed over the years, as well as of ampicillin, cefquinome and penicillin against subspecies The high frequency of resistant bacteria isolated in the present work proceeds in the same way as indicated by surveillance data on the huge antibiotic use in Italy. As a result, testing and monitoring programmes of antimicrobial efficacy are crucial to consciously using antibiotics and preserving their effectiveness both for veterinary and human medicine.
© British Veterinary Association 2019. No commercial re-use. See rights and permissions. Published by BMJ.
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Publication Date: 2019-08-13 PubMed ID: 31409748DOI: 10.1136/vr.105413Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article investigates the bacteria present in the reproductive tract of mares and how these bacteria have changed their resistance to common antibiotics for endometritis in horses. Understanding this can help optimize the use of antibiotics in veterinary medicine.

Study Overview

  • This study focuses on bacteria found in the reproductive tract of mares, with a particular emphasis on those contributing to equine endometritis, an infection of the uterine lining in horses.
  • The research was performed using data gathered from 4,122 uterine swabs collected from horses with reproductive system issues between 2010 and 2017 in Italy.

Methodology

  • Each sample went through an aerobic culture and antimicrobial susceptibility test using agar disc diffusion, a method used to determine the antibiotic susceptibility of bacteria.
  • The team identified aerobic bacteria in 76.9%, or 3,171, of the samples.

Findings

  • The two most commonly found microorganisms were Enterobacteriaceae family bacteria (27.9% of cases) and Streptococcus equi subspecies zooepidemicus (24.9% of cases), a finding that aligns with previous studies.
  • The research showed changes in how these bacteria responded to certain antibiotics over time.
  • A significant reduction in the effectiveness of the antibiotic cefquinome against Enterobacteriaceae was noticed, as well as decreased effectiveness of the antibiotics ampicillin, cefquinome, and penicillin against Streptococcus equi subspecies zooepidemicus.

Implications

  • The high frequency of antibiotic-resistant bacteria found in this study mirrors patterns observed in data tracking extensive antibiotic use in Italy.
  • These results highlight the importance of testing and monitoring programs for determining antibiotic efficacy, which can help guide the responsible use of antibiotics in both veterinary and human medicine and preserve their effectiveness in the long run.

Cite This Article

APA
Pisello L, Rampacci E, Stefanetti V, Beccati F, Hyatt DR, Coletti M, Passamonti F. (2019). Temporal efficacy of antimicrobials against aerobic bacteria isolated from equine endometritis: an Italian retrospective analysis (2010-2017). Vet Rec, 185(19), 598. https://doi.org/10.1136/vr.105413

Publication

The Veterinary record
ISSN: 2042-7670
NlmUniqueID: 0031164
Country: England
Language: English
Volume: 185
Issue: 19
Pages: 598

Researcher Affiliations

Pisello, Lorenzo
  • Veterinary Medicine, University of Perugia, Perugia, Italy.
Rampacci, Elisa
  • Veterinary Medicine, University of Perugia, Perugia, Italy.
Stefanetti, Valentina
  • Veterinary Medicine, University of Perugia, Perugia, Italy.
Beccati, Francesca
  • Veterinary Medicine, University of Perugia, Perugia, Italy.
Hyatt, Doreene Rose
  • Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
Coletti, Mauro
  • Veterinary Medicine, University of Perugia, Perugia, Italy.
Passamonti, Fabrizio
  • Veterinary Medicine, University of Perugia, Perugia, Italy fabrizio.passamonti@unipg.it.

MeSH Terms

  • Animals
  • Anti-Infective Agents / pharmacology
  • Bacteria, Aerobic / drug effects
  • Bacteria, Aerobic / isolation & purification
  • Endometritis / drug therapy
  • Endometritis / microbiology
  • Endometritis / veterinary
  • Female
  • Horse Diseases / drug therapy
  • Horse Diseases / microbiology
  • Horses
  • Italy
  • Retrospective Studies
  • Treatment Outcome

Conflict of Interest Statement

Competing interests: None declared.

Citations

This article has been cited 11 times.
  1. Tyrnenopoulou P, Fthenakis GC. Clinical Aspects of Bacterial Distribution and Antibiotic Resistance in the Reproductive System of Equids.. Antibiotics (Basel) 2023 Mar 28;12(4).
    doi: 10.3390/antibiotics12040664pubmed: 37107026google scholar: lookup
  2. Malaluang P, Wilén E, Frosth S, Lindahl JF, Hansson I, Morrell JM. Antimicrobial Resistance in Vaginal Bacteria in Inseminated Mares.. Pathogens 2023 Feb 24;12(3).
    doi: 10.3390/pathogens12030375pubmed: 36986297google scholar: lookup
  3. Ding X, Cui X, Shi J, Cheng X, Yao D, Gao Y, Zhang Y. Construction of a model of endometritis in domestic rabbits using equine-derived pathogens and evaluation of therapeutic effect of sensitive drugs.. Front Vet Sci 2023;10:1064522.
    doi: 10.3389/fvets.2023.1064522pubmed: 36846263google scholar: lookup
  4. Köhne M, Hofbauer L, Böttcher D, Tönissen A, Hegger A, Görgens A, Ulrich R, Sieme H. Comparison of systemic trimethoprim-sulfadimethoxine treatment and intrauterine ozone application as possible therapies for bacterial endometritis in equine practice.. Front Vet Sci 2023;10:1102149.
    doi: 10.3389/fvets.2023.1102149pubmed: 36777673google scholar: lookup
  5. Malaluang P, Wilén E, Frosth S, Lindahl J, Hansson I, Morrell JM. Vaginal Bacteria in Mares and the Occurrence of Antimicrobial Resistance.. Microorganisms 2022 Nov 8;10(11).
    doi: 10.3390/microorganisms10112204pubmed: 36363796google scholar: lookup
  6. Magnusson U. Antimicrobial use and resistance in food-producing animals-How can we protect the efficacy of antibiotics for reproductive diseases?. Reprod Domest Anim 2022 Sep;57 Suppl 4(Suppl 4):13-20.
    doi: 10.1111/rda.14170pubmed: 35668646google scholar: lookup
  7. Zhao Y, Zhu Y, Liu B, Mi J, Li N, Zhao W, Wu R, Holyoak GR, Li J, Liu D, Zeng S, Wang Y. Antimicrobial Susceptibility of Bacterial Isolates from Donkey Uterine Infections, 2018-2021.. Vet Sci 2022 Feb 5;9(2).
    doi: 10.3390/vetsci9020067pubmed: 35202320google scholar: lookup
  8. Nocera FP, D'Eletto E, Ambrosio M, Fiorito F, Pagnini U, De Martino L. Occurrence and Antimicrobial Susceptibility Profiles of Streptococcus equi subsp. zooepidemicus Strains Isolated from Mares with Fertility Problems.. Antibiotics (Basel) 2021 Dec 27;11(1).
    doi: 10.3390/antibiotics11010025pubmed: 35052902google scholar: lookup
  9. Nielsen SS, Bicout DJ, Calistri P, Canali E, Drewe JA, Garin-Bastuji B, Gonzales Rojas JL, Gortazar Schmidt C, Herskin M, Michel V, Miranda Chueca MA, Padalino B, Pasquali P, Roberts HC, Sihvonen LH, Spoolder H, Stahl K, Velarde A, Viltrop A, Winckler C, Dewulf J, Guardabassi L, Hilbert F, Mader R, Baldinelli F, Alvarez J. Assessment of animal diseases caused by bacteria resistant to antimicrobials: Horses.. EFSA J 2021 Dec;19(12):e07112.
    doi: 10.2903/j.efsa.2021.7112pubmed: 34987627google scholar: lookup
  10. Malaluang P, Wilén E, Lindahl J, Hansson I, Morrell JM. Antimicrobial Resistance in Equine Reproduction.. Animals (Basel) 2021 Oct 22;11(11).
    doi: 10.3390/ani11113035pubmed: 34827768google scholar: lookup
  11. Díaz-Bertrana ML, Deleuze S, Pitti Rios L, Yeste M, Morales Fariña I, Rivera Del Alamo MM. Microbial Prevalence and Antimicrobial Sensitivity in Equine Endometritis in Field Conditions.. Animals (Basel) 2021 May 20;11(5).
    doi: 10.3390/ani11051476pubmed: 34065566google scholar: lookup
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