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Home / Equine Research Bank / Front Microbiol / The Composition and Predictive Function of the Fecal Microbi...
Frontiers in microbiology2020; 11; 596394; doi: 10.3389/fmicb.2020.596394

The Composition and Predictive Function of the Fecal Microbiota Differ Between Young and Adult Donkeys.

Abstract: The community of microorganisms inhabiting the gastrointestinal tract of monogastric herbivores played critical roles in the absorption of nutrients and keeping the host healthy. However, its establishment at different age groups has not been quantitatively and functionally examined. The knowledge of microbial colonization and its function in the intestinal tract of different-age donkeys is still limited. By applying the V3-V4 region of the bacterial 16S rRNA gene and functional prediction on fecal samples from different-age donkeys, we characterized the gut microbiota during the different age groups. In contrast to the adult donkeys, the gut microbiota diversity and richness of the young donkeys showed significantly less resemblance. The microbial data showed that diversity and richness increased with age, but a highly individual variation of microbial composition was observed at month 1. Principal coordinate analysis (PCoA) revealed a significant difference across five time points in the feces. The abundance of , , and tended to decrease, while the proportion of was significantly increased with age. For functional prediction, the relative abundance of pathways had a significant difference in the feces across different age groups, for example, Terpenoids and Polyketides and Folding, Sorting, and Degradation ( < 0.05 or < 0.01). The analysis of beta diversity (PCoA and LEfSe) and microbial functions predicted with PICRUSt (NSTIs) clearly divided the donkeys into foals (≤3 months old) and adults (≥7 months old). Microbial community composition and structure had distinctive features at each age group, in accordance with functional stability of the microbiota. Our findings established a framework for understanding the composition and function of the fecal microbiota to differ between young and adult donkeys.
Copyright © 2020 Xing, Liu, Zhang, Bai, Yu, Li, Wang, Su, Zhao, Bou and Dugarjaviin.
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Publication Date: 2020-12-03 PubMed ID: 33343537PubMed Central: PMC7744375DOI: 10.3389/fmicb.2020.596394Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research study examined the differences in microbial composition and functionality in the gastrointestinal tract of young and adult donkeys. Significant variations were found, including age-related changes in gut microbiota diversity, richness, and predicted functions.

Research Methodology

  • The research utilized the V3-V4 region of the bacterial 16S rRNA gene to characterize the gut microbiota in different age groups of donkeys.
  • Fecal samples were obtained from the donkeys and subjected to functional prediction algorithms to study the gut microbiota at different stages of life.

Findings

  • The researchers discovered a lower similarity in gut microbiota diversity and richness between adult and young donkeys. Additionally, they found the diversity and richness to increase with age. However, at one-month-old, there was a high individual variation in microbial composition.
  • The Principal Coordinate Analysis (PCoA) showed significant differences in the fecal samples obtained at five different time points.
  • Some species, including , , and , were found to decrease in abundance with age. In contrast, the proportion of significantly increased.
  • Functional prediction exposed a notable difference in the relative abundance of certain function pathways in different age groups. For instance, Terpenoids and Polyketides and Folding, Sorting, and Degradation were significantly varied across the age groups.

Conclusion

  • The research’s analysis of beta diversity and microbial functions, using PCoA, LEfSe, and PICRUSt, identified clear divisions between foals (≤3 months old) and adults (≥7 months old) in terms of microbial community composition and structure. Given this distinctive feature at each age group aligned with the functional stability of the microbiota, the authors concluded that the composition and function of the fecal microbiota differ between young and adult donkeys.
  • These findings serve as a foundation for a better understanding of the relationship between gut microbiota and the age of a donkey, helping to further the potential implications for health and disease development in monogastric herbivores.

Cite This Article

APA
Xing J, Liu G, Zhang X, Bai D, Yu J, Li L, Wang X, Su S, Zhao Y, Bou G, Dugarjaviin M. (2020). The Composition and Predictive Function of the Fecal Microbiota Differ Between Young and Adult Donkeys. Front Microbiol, 11, 596394. https://doi.org/10.3389/fmicb.2020.596394

Publication

Frontiers in microbiology
ISSN: 1664-302X
NlmUniqueID: 101548977
Country: Switzerland
Language: English
Volume: 11
Pages: 596394
PII: 596394

Researcher Affiliations

Xing, Jingya
  • Inner Mongolia Key Laboratory of Equine Genetics, Breeding and Reproduction, College of Animal Science, Equine Research Center, Inner Mongolia Agricultural University, Hohhot, China.
Liu, Guiqin
  • Inner Mongolia Key Laboratory of Equine Genetics, Breeding and Reproduction, College of Animal Science, Equine Research Center, Inner Mongolia Agricultural University, Hohhot, China.
  • College of Agronomy, Shandong Engineering Technology Research Center for Efficient Breeding and Ecological Feeding of Black Donkey, Shandong Donkey Industry Technology Collaborative Innovation Center, Liaocheng University, Liaocheng, China.
Zhang, Xinzhuang
  • Inner Mongolia Key Laboratory of Equine Genetics, Breeding and Reproduction, College of Animal Science, Equine Research Center, Inner Mongolia Agricultural University, Hohhot, China.
Bai, Dongyi
  • Inner Mongolia Key Laboratory of Equine Genetics, Breeding and Reproduction, College of Animal Science, Equine Research Center, Inner Mongolia Agricultural University, Hohhot, China.
Yu, Jie
  • National Engineering Research Center for Gelatin-based Traditional Chinese Medicine, Dong-E-E-Jiao Co., Ltd., Liaocheng, China.
Li, Lanjie
  • College of Agronomy, Shandong Engineering Technology Research Center for Efficient Breeding and Ecological Feeding of Black Donkey, Shandong Donkey Industry Technology Collaborative Innovation Center, Liaocheng University, Liaocheng, China.
Wang, Xisheng
  • Inner Mongolia Key Laboratory of Equine Genetics, Breeding and Reproduction, College of Animal Science, Equine Research Center, Inner Mongolia Agricultural University, Hohhot, China.
Su, Shaofeng
  • Inner Mongolia Key Laboratory of Equine Genetics, Breeding and Reproduction, College of Animal Science, Equine Research Center, Inner Mongolia Agricultural University, Hohhot, China.
Zhao, Yiping
  • Inner Mongolia Key Laboratory of Equine Genetics, Breeding and Reproduction, College of Animal Science, Equine Research Center, Inner Mongolia Agricultural University, Hohhot, China.
Bou, Gerelchimeg
  • Inner Mongolia Key Laboratory of Equine Genetics, Breeding and Reproduction, College of Animal Science, Equine Research Center, Inner Mongolia Agricultural University, Hohhot, China.
Dugarjaviin, Manglai
  • Inner Mongolia Key Laboratory of Equine Genetics, Breeding and Reproduction, College of Animal Science, Equine Research Center, Inner Mongolia Agricultural University, Hohhot, China.

Conflict of Interest Statement

JY was employed by the company Dong-E-E-Jiao Co., Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors declare that this study received samples from Dong-E-E-Jiao Co., Ltd. Dong-E-E-Jiao Co., Ltd was not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication.

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