The effect of milk basic protein supplementation on bone metabolism during training of young thoroughbred racehorses.
Abstract: In laboratory animals, man and cell culture experiments, milk basic protein was reported to suppress bone resorption and promote bone formation. However, no studies in horses have previously examined the effect of milk basic protein. Objective: To evaluate the effect of milk basic protein supplementation on bone metabolism in young Thoroughbred horses in training. Methods: Twenty 2-year-old horses in training were used for 90 days in this study. The treatment group was fed a basal diet with 1 g of milk basic protein and the control group a basal diet only. Blood samples were collected on Days 0, 45 and 90 to determine serum calcium (Ca) and biochemical markers of bone metabolism. Radiographs were taken at the start and end of the study to determine radiographic bone aluminium equivalence (RBAE). Results: Serum osteocalcin (OC) was significantly higher at Day 45 after the beginning of the study in the treatment group compared to that in the control group. The treatment group showed a greater increase in the total RBAE change at the end of this study compared to that in the control group. However, there were no significant differences in serum Ca and carboxy-terminal telopeptide of type I collagen (ICTP) between groups. Conclusions: These findings provide preliminary evidence that milk basic protein has an effect on bone formation in 2-year-old Thoroughbred horses in training. However, further studies in larger groups of horses are now required to substantiate our findings.
Publication Date: 2007-04-04 PubMed ID: 17402500DOI: 10.1111/j.2042-3306.2006.tb05621.xGoogle Scholar: Lookup
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- Journal Article
- Randomized Controlled Trial
Summary
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The research investigates the impact of milk basic protein supplementation on bone metabolism in young racehorses under training. The study discovered that the protein potentially enhances bone formation.
Objective of the Research
The primary focus of the research was to evaluate the effects of milk basic protein supplementation on bone metabolism in young Thoroughbred horses undergoing training.
Research Methodology
- 20 two-year-old racehorses in training were used in the study which spanned 90 days.
- The horses were split into two groups: the treatment group, which received a regular diet supplemented with 1g of milk basic protein, and the control group, which only received the basal diet.
- Blood samples were collected from the horses at the beginning of the study (Day 0), midway (Day 45), and at the end of the study (Day 90). These samples were utilized to measure serum calcium and other biochemical markers of bone metabolism.
- Radiographs were also taken at the start and end of the experiment to measure radiographic bone aluminium equivalence (RBAE).
Results of the Study
- By Day 45 of the study, serum osteocalcin, a marker of bone formation, was found to be significantly higher in the group receiving milk basic protein supplementation as compared to the control group.
- The horses receiving the milk basic protein supplementation exhibited a greater increase in overall RBAE change at the end of the study than the control group horses.
- However, there were no considerable differences between the two groups in terms of serum calcium and carboxy-terminal telopeptide of type I collagen (ICTP), another marker of bone resorption.
Conclusions
While the study provides preliminary evidence that milk basic protein supplementation can have a positive impact on bone formation in young Thoroughbred racehorses, the researchers express the need for larger-scale studies to conclusively establish these findings.
Cite This Article
APA
Inoue Y, Asai Y, Tomita M, Kuribara K, Kobayashi M, Kaneko M, Toba Y.
(2007).
The effect of milk basic protein supplementation on bone metabolism during training of young thoroughbred racehorses.
Equine Vet J Suppl(36), 654-658.
https://doi.org/10.1111/j.2042-3306.2006.tb05621.x Publication
Researcher Affiliations
- Equine Science Division, Hidaka Training and Research Center, Japan Racing Association, 535-13, Aza-Nishicha, Urakawa-cho, Urakawa- gun, Hokkaido, Japan.
MeSH Terms
- Animals
- Bone Density / drug effects
- Bone Density / physiology
- Bone and Bones / diagnostic imaging
- Bone and Bones / drug effects
- Bone and Bones / metabolism
- Calcium / blood
- Dietary Proteins / administration & dosage
- Female
- Horses / metabolism
- Male
- Milk Proteins / administration & dosage
- Osteocalcin / blood
- Osteogenesis / drug effects
- Osteogenesis / physiology
- Physical Conditioning, Animal / physiology
- Radiography
- Time Factors
Citations
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