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The effect of omeprazole paste on intragastric pH in clinically ill neonatal foals.
Abstract: Administration of omeprazole paste per os to healthy neonatal foals has been shown to effectively increase intragastric pH, but has not been evaluated in sick neonatal foals. Objective: To determine the effect of orally administered omeprazole paste on intragastric pH in clinically ill neonatal foals requiring nasogastric intubation. Methods: Intragastric pH was measured continuously for 24 h using an indwelling electrode and continuous data recording system in hospitalised neonatal foals age < or =2 days. Intragastric pH was measured for 12 h prior to (pretreatment period) and 12 h following (post treatment period) treatment with omeprazole paste (4 mg/kg bwt per os). All foals displayed periods of acidity (pH <4) prior to treatment. Statistical analysis compared pre- and post treatment mean and median intragastric pH, and percentage of time below pH 4. Results: Eight foals were evaluated age 1-3 days, a gestational age of at least 320 days or reported to be full term. The mean (3.19 +/- 1.50 vs. 6.20 +/- 0.93) and median (4.6 +/- 1.7 vs. 6.86 +/- 0.89) pH were significantly higher and the percentage of time below pH 4 (32.25 vs. 1.1%) was significantly lower in the post treatment compared to the pretreatment period. Conclusions: Omeprazole paste effectively increases intragastric pH in clinically ill neonatal foals after one dose at 4 mg/kg bwt orally.
Publication Date: 2007-12-18 PubMed ID: 18083658DOI: 10.2746/042516407X235803Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This research project investigates the impact of a medication called omeprazole paste on stomach acidity in sick newborn horses. The findings suggest that the medication successfully reduces stomach acidity in these animals after a single dose.
Objective and Methodology:
The study aimed to pinpoint the effects of orally given omeprazole paste on the stomach pH levels (a measure of acidity) in sick newborn horses (neonatal foals) that required nasogastric intubation (a tube passed through the nose into the stomach). Researchers continuously tracked stomach pH levels for a full day using an internal electrode and a continuous data recording system. The foals in the study were all hospitalised, aged 2 days or less, and displayed periods of high acidity (pH lower than 4) before the treatment. The study measured pH levels for 12 hours before and after the treatment. Omeprazole paste was administered at a dose of 4 mg per kg of body weight to the foals.
- The study aimed to understand the impact of omeprazole paste on the gastrointestinal pH level of sick young horses that required a nasogastric tube.
- The researchers monitored the stomach pH level of the foals continuously for 24 hours before and after administering the medication.
- They noticed that all foals showed episodes of high acidity before the treatment.!
Results:
The research included eight foals aged between 1-3 days, had a gestational period of at least 320 days, or were reported to be full term. The findings indicated that the average and median pH levels were significantly higher, and the percentage of time with a pH below 4 was considerably smaller after the treatment compared to before.
- Eight young horses aged 1 to 3 days were part of the research.
- The research indicated that both average and median pH levels in the stomach were significantly higher after the treatment.
- Moreover, the time when the foals had a pH level below 4 was also considerably lower after the treatment.
Conclusions:
The research concluded that omeprazole paste effectively raises stomach pH levels in sick newborn horses. This conclusion is based on the evidence of elevated stomach pH levels in foals, following a single dose of the medication at 4 mg per kg orally.
- The study concluded that omeprazole was successful in increasing the stomach pH level in sick newborn horses.
- A single oral dose of 4 mg per kg was demonstrated to be effective.
Cite This Article
APA
Javsicas LH, Sanchez LC.
(2007).
The effect of omeprazole paste on intragastric pH in clinically ill neonatal foals.
Equine Vet J, 40(1), 41-44.
https://doi.org/10.2746/042516407X235803 Publication
Researcher Affiliations
- Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA.
MeSH Terms
- Administration, Oral
- Animals
- Animals, Newborn
- Anti-Ulcer Agents / therapeutic use
- Female
- Gastric Acid / chemistry
- Gastric Acid / metabolism
- Gastric Acidity Determination / veterinary
- Horse Diseases / prevention & control
- Horses
- Hydrogen-Ion Concentration / drug effects
- Intubation, Gastrointestinal / veterinary
- Male
- Omeprazole / therapeutic use
- Stomach / chemistry
- Stomach / drug effects
- Stomach Ulcer / prevention & control
- Stomach Ulcer / veterinary
- Time Factors
- Treatment Outcome
Citations
This article has been cited 2 times.- Wise JC, Raidal SL, Wilkes EJA, Hughes KJ. Intragastric pH of foals admitted to the intensive care unit. J Vet Intern Med 2020 Nov;34(6):2719-2726.
- Mullen KR, Yasuda K, Divers TJ, Weese JS. Equine faecal microbiota transplant: Current knowledge, proposed guidelines and future directions. Equine Vet Educ 2018 Mar;30(3):151-160.
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