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Journal of veterinary internal medicine2019; 33(2); 976-980; doi: 10.1111/jvim.15359

The effect of single pretreatment with salbutamol on recovery of bronchoalveolar lavage fluid in horses with suspected or confirmed severe equine asthma.

Abstract: Bronchoalveolar lavage (BAL) is a method for the recovery of respiratory secretion from the lower airways. Objective: To investigate if the administration of a single dose of a bronchodilatator in horses with a suspected or confirmed severe equine asthma could improve recovery of bronchoalveolar lavage fluid (BALF). Methods: Twenty-eight horses with severe equine asthma. Methods: Horses were divided into 2 groups: group "treated" was given salbutamol before endoscopic examination and BALF collection, whereas group "not treated" was not given. BAL was performed with BAL-catheter by instilling 350 mL of sterile saline. Amount of recovered fluid was recorded. Statistical analysis was performed with a two-tailed Student's t test. Results: The average fluid recovery in the horses treated with salbutamol was 52% ± 15% (mean +/- SD), compared with 38% ± 13% for the group of horses not treated with salbutamol (P = 0.013). Conclusions: Clinicians should consider administration of salbutamol before performing BAL on horses with asthma.
© 2018 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
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Publication Date: 2019-02-01 PubMed ID: 30707780PubMed Central: PMC6430915DOI: 10.1111/jvim.15359Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study investigates whether giving a single dose of a bronchodilator to horses with severe equine asthma can enhance the recovery of bronchoalveolar lavage fluid, which is a respiratory secretion from the lower airways. The results showed that horses who received the bronchodilator had a higher average of fluid recovery than those who did not.

Explanation of Research

The objective of this study was to determine if a single dose of a bronchodilator specifically, salbutamol, could enhance the recovery of bronchoalveolar lavage fluid (BALF) in horses who have severe equine asthma.

  • The methods involved taking 28 horses with confirmed severe equine asthma, and dividing them into two groups “treated” and “not treated”.
  • The treated group was given salbutamol before undergoing an endoscopic examination and collection of BALF, while the not treated group did not receive this treatment.
  • Bronchoalveolar lavage (BAL) was performed on these horses using a special catheter, and involved the instillation of 350 mL of sterile saline into the lung and then collection of the fluid. The amount of fluid recovered was recorded.

Results and Conclusions

  • The results of the study revealed that the average fluid recovery for horses that were treated with salbutamol was approximately 52% (plus or minus 15% standard deviation), as compared to 38% (plus or minus 13% standard deviation) for the untreated horses. This difference was statistically significant (P = 0.013).
  • These findings suggest that the use of salbutamol before performing BAL on horses with severe asthma can improve the recovery of bronchoalveolar lavage fluid.
  • Therefore, the clinicians should consider administering salbutamol before performing bronchoalveolar lavage in horses suffering from severe asthma.

Cite This Article

APA
Varegg MS, Kløverød KM, Austnes MK, Siwinska N, Slowikowska M, Zak A, Niedzwiedz A. (2019). The effect of single pretreatment with salbutamol on recovery of bronchoalveolar lavage fluid in horses with suspected or confirmed severe equine asthma. J Vet Intern Med, 33(2), 976-980. https://doi.org/10.1111/jvim.15359

Publication

Journal of veterinary internal medicine
ISSN: 1939-1676
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 33
Issue: 2
Pages: 976-980

Researcher Affiliations

Varegg, Mathilde S
  • Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland.
Kløverød, Kine M
  • Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland.
Austnes, Malin K
  • Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland.
Siwinska, Natalia
  • Department of Internal Diseases with Clinic for Horses, Dogs and Cats, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland.
Slowikowska, Malwina
  • Department of Internal Diseases with Clinic for Horses, Dogs and Cats, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland.
Zak, Agnieszka
  • Department of Internal Diseases with Clinic for Horses, Dogs and Cats, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland.
Niedzwiedz, Artur
  • Department of Internal Diseases with Clinic for Horses, Dogs and Cats, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland.

MeSH Terms

  • Albuterol / administration & dosage
  • Animals
  • Asthma / diagnosis
  • Asthma / drug therapy
  • Asthma / veterinary
  • Bronchoalveolar Lavage / methods
  • Bronchoalveolar Lavage / veterinary
  • Bronchoalveolar Lavage Fluid
  • Bronchodilator Agents / administration & dosage
  • Endoscopy / veterinary
  • Female
  • Horse Diseases / diagnosis
  • Horses
  • Male

Conflict of Interest Statement

Authors declare no conflict of interest.

References

This article includes 21 references
  1. Couëtil LL, Cardwell JM, Gerber V, Lavoie JP, Léguillette R, Richard EA. Inflammatory Airway Disease of Horses--Revised Consensus Statement.. J Vet Intern Med 2016 Mar-Apr;30(2):503-15.
    pmc: PMC4913592pubmed: 26806374doi: 10.1111/jvim.13824google scholar: lookup
  2. Pirie RS, Couëtil LL, Robinson NE, Lavoie JP. Equine asthma: An appropriate, translational and comprehendible terminology?. Equine Vet J 2016 Jul;48(4):403-5.
    pubmed: 27292020doi: 10.1111/evj.12586google scholar: lookup
  3. Leclere M, Lavoie-Lamoureux A, Lavoie JP. Heaves, an asthma-like disease of horses.. Respirology 2011 Oct;16(7):1027-46.
    pubmed: 21824219doi: 10.1111/j.1440-1843.2011.02033.xgoogle scholar: lookup
  4. Léguillette R. Recurrent airway obstruction--heaves.. Vet Clin North Am Equine Pract 2003 Apr;19(1):63-86, vi.
    pubmed: 12747662doi: 10.1016/s0749-0739(02)00067-6google scholar: lookup
  5. Hoffman AM. Bronchoalveolar lavage: sampling technique and guidelines for cytologic preparation and interpretation.. Vet Clin North Am Equine Pract 2008 Aug;24(2):423-35, vii-viii.
    pubmed: 18652963doi: 10.1016/j.cveq.2008.04.003google scholar: lookup
  6. Roy MF, Lavoie JP. Tools for the diagnosis of equine respiratory disorders.. Vet Clin North Am Equine Pract 2003 Apr;19(1):1-17, v.
    pubmed: 12747658doi: 10.1016/s0749-0739(02)00063-9google scholar: lookup
  7. McGorum BC, Dixon PM, Halliwell RE, Irving P. Comparison of cellular and molecular components of bronchoalveolar lavage fluid harvested from different segments of the equine lung.. Res Vet Sci 1993 Jul;55(1):57-9.
    pubmed: 8378614doi: 10.1016/0034-5288(93)90034-dgoogle scholar: lookup
  8. Finley TN, Swenson EW, Curran WS, Huber GL, Ladman AJ. Bronchopulmonary lavage in normal subjects and patients with obstructive lung disease.. Ann Intern Med 1967 Apr;66(4):651-8.
    pubmed: 6023531doi: 10.7326/0003-4819-66-4-651google scholar: lookup
  9. Koblinger K, Hecker K, Nicol J, Wasko A, Fernandez N, Léguillette R. Bronchial collapse during bronchoalveolar lavage in horses is an indicator of lung inflammation.. Equine Vet J 2014 Jan;46(1):50-5.
    pubmed: 23662631doi: 10.1111/evj.12096google scholar: lookup
  10. Jean D, Vrins A, Beauchamp G, Lavoie JP. Evaluation of variations in bronchoalveolar lavage fluid in horses with recurrent airway obstruction.. Am J Vet Res 2011 Jun;72(6):838-42.
    pubmed: 21627532doi: 10.2460/ajvr.72.6.838google scholar: lookup
  11. Maestrelli P, Saetta M, Di Stefano A, Calcagni PG, Turato G, Ruggieri MP, Roggeri A, Mapp CE, Fabbri LM. Comparison of leukocyte counts in sputum, bronchial biopsies, and bronchoalveolar lavage.. Am J Respir Crit Care Med 1995 Dec;152(6 Pt 1):1926-31.
    pubmed: 8520757doi: 10.1164/ajrccm.152.6.8520757google scholar: lookup
  12. Li X, Ward C, Thien F, Bish R, Bamford T, Bao X, Bailey M, Wilson JW, Haydn Walters E. An antiinflammatory effect of salmeterol, a long-acting beta(2) agonist, assessed in airway biopsies and bronchoalveolar lavage in asthma.. Am J Respir Crit Care Med 1999 Nov;160(5 Pt 1):1493-9.
    pubmed: 10556111doi: 10.1164/ajrccm.160.5.9811052google scholar: lookup
  13. Barnes PJ. Pharmacology of airway smooth muscle.. Am J Respir Crit Care Med 1998 Nov;158(5 Pt 3):S123-32.
    pubmed: 9817735doi: 10.1164/ajrccm.158.supplement_2.13tac800google scholar: lookup
  14. Derksen FJ, Olszewski MA, Robinson NE, Berney C, Hakala JE, Matson CJ, Ruth DT. Aerosolized albuterol sulfate used as a bronchodilator in horses with recurrent airway obstruction.. Am J Vet Res 1999 Jun;60(6):689-93.
    pubmed: 10376893
  15. Rush BR. Treatment of inflammatory airway disease: aerosol delivery devices and medications. AAEP Proceedings 2002:218–227.
  16. Cooper AE, Ferguson D, Grime K. Optimisation of DMPK by the inhaled route: challenges and approaches.. Curr Drug Metab 2012 May 1;13(4):457-73.
    pubmed: 22299825doi: 10.2174/138920012800166571google scholar: lookup
  17. Tilley P, Sales Luis JP, Branco Ferreira M. Correlation and discriminant analysis between clinical, endoscopic, thoracic X-ray and bronchoalveolar lavage fluid cytology scores, for staging horses with recurrent airway obstruction (RAO).. Res Vet Sci 2012 Oct;93(2):1006-14.
    pubmed: 22136797doi: 10.1016/j.rvsc.2011.10.024google scholar: lookup
  18. Fernandez NJ, Hecker KG, Gilroy CV, Warren AL, Léguillette R. Reliability of 400-cell and 5-field leukocyte differential counts for equine bronchoalveolar lavage fluid.. Vet Clin Pathol 2013 Mar;42(1):92-8.
    pubmed: 23289790doi: 10.1111/vcp.12013google scholar: lookup
  19. Barton AK, Gehlen H. Pulmonary Remodeling in Equine Asthma: What Do We Know about Mediators of Inflammation in the Horse?. Mediators Inflamm 2016;2016:5693205.
    doi: 10.1155/2016/5693205pmc: PMC5174180pubmed: 28053371google scholar: lookup
  20. Sweeney CR, Rossier Y, Ziemer EL, Lindborg S. Effects of lung site and fluid volume on results of bronchoalveolar lavage fluid analysis in horses.. Am J Vet Res 1992 Aug;53(8):1376-9.
    pubmed: 1510313
  21. Pickles K, Pirie RS, Rhind S, Dixon PM, McGorum BC. Cytological analysis of equine bronchoalveolar lavage fluid. Part 1: Comparison of sequential and pooled aliquots.. Equine Vet J 2002 May;34(3):288-91.
    pubmed: 12108749doi: 10.2746/042516402776186137google scholar: lookup

Citations

This article has been cited 2 times.
  1. Meiseberg LK, Delarocque J, de Buhr N, Ohnesorge B. Clinical variability of equine asthma phenotypes and analysis of diagnostic steps in phenotype differentiation. Acta Vet Scand 2024 Sep 18;66(1):51.
    doi: 10.1186/s13028-024-00773-7pubmed: 39294710google scholar: lookup
  2. Lapsina S, Riond B, Hofmann-Lehmann R, Stirn M. Comparison of Sysmex XN-V body fluid mode and deep-learning-based quantification with manual techniques for total nucleated cell count and differential count for equine bronchoalveolar lavage samples. BMC Vet Res 2024 Feb 5;20(1):48.
    doi: 10.1186/s12917-024-03884-5pubmed: 38317167google scholar: lookup
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