The effect of single pretreatment with salbutamol on recovery of bronchoalveolar lavage fluid in horses with suspected or confirmed severe equine asthma.
Abstract: Bronchoalveolar lavage (BAL) is a method for the recovery of respiratory secretion from the lower airways. Objective: To investigate if the administration of a single dose of a bronchodilatator in horses with a suspected or confirmed severe equine asthma could improve recovery of bronchoalveolar lavage fluid (BALF). Methods: Twenty-eight horses with severe equine asthma. Methods: Horses were divided into 2 groups: group "treated" was given salbutamol before endoscopic examination and BALF collection, whereas group "not treated" was not given. BAL was performed with BAL-catheter by instilling 350 mL of sterile saline. Amount of recovered fluid was recorded. Statistical analysis was performed with a two-tailed Student's t test. Results: The average fluid recovery in the horses treated with salbutamol was 52% ± 15% (mean +/- SD), compared with 38% ± 13% for the group of horses not treated with salbutamol (P = 0.013). Conclusions: Clinicians should consider administration of salbutamol before performing BAL on horses with asthma.
© 2018 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
Publication Date: 2019-02-01 PubMed ID: 30707780PubMed Central: PMC6430915DOI: 10.1111/jvim.15359Google Scholar: Lookup
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Summary
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This study investigates whether giving a single dose of a bronchodilator to horses with severe equine asthma can enhance the recovery of bronchoalveolar lavage fluid, which is a respiratory secretion from the lower airways. The results showed that horses who received the bronchodilator had a higher average of fluid recovery than those who did not.
Explanation of Research
The objective of this study was to determine if a single dose of a bronchodilator specifically, salbutamol, could enhance the recovery of bronchoalveolar lavage fluid (BALF) in horses who have severe equine asthma.
- The methods involved taking 28 horses with confirmed severe equine asthma, and dividing them into two groups “treated” and “not treated”.
- The treated group was given salbutamol before undergoing an endoscopic examination and collection of BALF, while the not treated group did not receive this treatment.
- Bronchoalveolar lavage (BAL) was performed on these horses using a special catheter, and involved the instillation of 350 mL of sterile saline into the lung and then collection of the fluid. The amount of fluid recovered was recorded.
Results and Conclusions
- The results of the study revealed that the average fluid recovery for horses that were treated with salbutamol was approximately 52% (plus or minus 15% standard deviation), as compared to 38% (plus or minus 13% standard deviation) for the untreated horses. This difference was statistically significant (P = 0.013).
- These findings suggest that the use of salbutamol before performing BAL on horses with severe asthma can improve the recovery of bronchoalveolar lavage fluid.
- Therefore, the clinicians should consider administering salbutamol before performing bronchoalveolar lavage in horses suffering from severe asthma.
Cite This Article
APA
Varegg MS, Kløverød KM, Austnes MK, Siwinska N, Slowikowska M, Zak A, Niedzwiedz A.
(2019).
The effect of single pretreatment with salbutamol on recovery of bronchoalveolar lavage fluid in horses with suspected or confirmed severe equine asthma.
J Vet Intern Med, 33(2), 976-980.
https://doi.org/10.1111/jvim.15359 Publication
Researcher Affiliations
- Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland.
- Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland.
- Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland.
- Department of Internal Diseases with Clinic for Horses, Dogs and Cats, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland.
- Department of Internal Diseases with Clinic for Horses, Dogs and Cats, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland.
- Department of Internal Diseases with Clinic for Horses, Dogs and Cats, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland.
- Department of Internal Diseases with Clinic for Horses, Dogs and Cats, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland.
MeSH Terms
- Albuterol / administration & dosage
- Animals
- Asthma / diagnosis
- Asthma / drug therapy
- Asthma / veterinary
- Bronchoalveolar Lavage / methods
- Bronchoalveolar Lavage / veterinary
- Bronchoalveolar Lavage Fluid
- Bronchodilator Agents / administration & dosage
- Endoscopy / veterinary
- Female
- Horse Diseases / diagnosis
- Horses
- Male
Conflict of Interest Statement
Authors declare no conflict of interest.
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