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Frontiers in veterinary science2022; 8; 753796; doi: 10.3389/fvets.2021.753796

The Effects of Prostaglandin E2 Treatment on the Secretory Function of Mare Corpus Luteum Depends on the Site of Application: An in vivo Study.

Abstract: We examined the effect of prostaglandin (PG) E on the secretory function of equine corpus luteum (CL), according to the application site: intra-CL injection vs. an intrauterine (intra-U) administration. Moreover, the effect of intra-CL injection vs. intra-U administration of both luteotropic factors: PGE and human chorionic gonadotropin (hCG) as a positive control, on CL function was additionally compared. Mares were assigned to the groups ( = 6 per group): (1) an intra-CL saline injection (control); (2) an intra-CL injection of PGE (5 mg/ml); (3) an intra-CL injection of hCG (1,500 IU/ml); (4) an intra-U saline administration (control); (5) an intra-U administration of PGE (5 mg/5 ml); (6) an intra-U administration of hCG (1,500 IU/5 ml). Progesterone (P) and PGE concentrations were measured in blood plasma samples collected at -2, -1, and 0 (pre-treatment), and at 1, 2, 3, 4, 6, 8, 10, 12, and 24 h after treatments. Moreover, effects of different doses of PGE application on the concentration of total PGF (PGF and its main metabolite 13,14-dihydro-15-keto-prostaglandin F- PGFM) was determined. The time point of PGE, hCG, or saline administration was defined as hour "0" of the experiment. An intra-CL injection of PGE increased P and PGE concentrations between 3 and 4 h or at 3 and 12 h, respectively ( < 0.05). While intra-U administration of PGE elevated P concentrations between 8 and 24 h, PGE was upregulated at 1 h and between 3 and 4 h ( < 0.05). An intra-CL injection of hCG increased P concentrations at 1, 6, and 12 h ( < 0.05), while its intra-U administration enhanced P and PGE concentrations between 1 and 12 h or at 3 h and between 6 and 10 h, respectively ( < 0.05). An application of PGE, dependently on the dose, supports equine CL function, regardless of the application site, consequently leading to differences in both P and PGE concentrations in blood plasma.
Copyright © 2022 Piotrowska-Tomala, Jonczyk, Szóstek-Mioduchowska, Żebrowska, Ferreira-Dias and Skarzynski.
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Publication Date: 2022-02-15 PubMed ID: 35242830PubMed Central: PMC8885592DOI: 10.3389/fvets.2021.753796Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research investigates the varying impacts of prostaglandin E2 treatment on the hormonal secretions of the Corpus Luteum in mares; findings suggest the effects are dependent on the site of application. The study also compares these effects with the introduction of human chorionic gonadotropin (hCG) as a control.

Study Methodology

  • The researchers sought to understand the influence of prostaglandin E (PGE) on the secretory activities of the equine corpus luteum (CL), a temporary endocrine structure involved in the menstrual and estrous cycles in females.
  • The focus was on whether the impact varied based on where the PGE was applied – specifically, whether it was injected directly into the CL (intra-CL) or administered intrauterine (intra-U).
  • They also compared the effect of intra-CL injection versus intra-U administration of both PGE and human chorionic gonadotropin (hCG, a hormone produced in the placenta that maintains the corpus luteum during the early stages of pregnancy) on CL function.
  • For this purpose, the mares were assigned to six groups for the administration of different combinations of PGE, hCG, or saline (used as a control). The same amounts of PGE and hCG were used for intra-CL and intra-U administration.

Observations and Findings

  • Progesterone (P, a hormone produced by the CL) and PGE concentrations were measured in blood plasma samples collected at various intervals before and after the treatments.
  • The researchers also studied the effects of different doses of PGE on the concentration of total PGF (a variant of prostaglandin) and its main metabolite, 13,14-dihydro-15-keto-prostaglandin F (PGFM).
  • The observation revealed that an intra-CL injection of PGE increased P and PGE concentrations at specific times, while intra-U administration of PGE elevated P concentrations over a longer period. PGE was upregulated at certain times post treatment in both cases.
  • Similar observations with varying timings were made for intra-CL and intra-U administration of hCG.
  • The study concluded that the application of PGE, depending on the dosage, supports equine CL function, regardless of the application site, thereby leading to differences in blood plasma concentrations of both P and PGE.
  • The findings suggest that the hormonal response to PGE treatment in the equine CL depends on the site of application, highlighting the need for a nuanced understanding of how this and similar substances interact with equine reproductive biology.

Cite This Article

APA
Piotrowska-Tomala KK, Jonczyk AW, Szóstek-Mioduchowska AZ, Żebrowska E, Ferreira-Dias G, Skarzynski DJ. (2022). The Effects of Prostaglandin E2 Treatment on the Secretory Function of Mare Corpus Luteum Depends on the Site of Application: An in vivo Study. Front Vet Sci, 8, 753796. https://doi.org/10.3389/fvets.2021.753796

Publication

Frontiers in veterinary science
ISSN: 2297-1769
NlmUniqueID: 101666658
Country: Switzerland
Language: English
Volume: 8
Pages: 753796
PII: 753796

Researcher Affiliations

Piotrowska-Tomala, Katarzyna K
  • Department Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland.
Jonczyk, Agnieszka W
  • Department Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland.
Szóstek-Mioduchowska, Anna Z
  • Department Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland.
Żebrowska, Ewelina
  • Department Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland.
Ferreira-Dias, Graca
  • Faculty of Veterinary Medicine, CIISA - Centre for Interdisciplinary Research in Animal Health, University of Lisbon, Lisbon, Portugal.
Skarzynski, Dariusz J
  • Department Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland.

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Citations

This article has been cited 3 times.
  1. Diel de Amorim M, Dong L, Byron M, Foster RA, Klein C, Saleh M, Saleh T, Card C. Characterization of serum and tissue oxytocinase and tissue oxytocin in the pregnant and non-pregnant mare. Sci Rep 2023 Mar 21;13(1):4616.
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  2. Afzal A. Melatonin as a multifunctional modulator: emerging insights into its role in health, reproductive efficiency, and productive performance in livestock. Front Physiol 2024;15:1501334.
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  3. Piotrowska-Tomala KK, Jonczyk AW, Szóstek-Mioduchowska A, Hojo T, Żebrowska E, Katila T, Ferreira-Dias G, Skarzynski DJ. Intrauterine devices influence prostaglandin secretion by equine uterus: in vitro and in vivo studies. BMC Vet Res 2024 Feb 3;20(1):46.
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