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Home / Equine Research Bank / Wien Klin Wochenschr / [The efficacy of anthelmintic drugs against horse strongyles...
Wiener klinische Wochenschrift2010; 122 Suppl 3; 71-75; doi: 10.1007/s00508-010-1441-y

[The efficacy of anthelmintic drugs against horse strongyles in the area of Salzburg and preliminary results of selective anthelmintic treatment].

Abstract: In recent years more and more cases of anthelmintic resistant equine strongyles were reported. The latest developments are cases of resistance against macrocyclic lactones. In order to delay this process less anthelmintics and only those which have been previously tested for their efficacy on each individual farm should be used. During the grazing season 2008 faecal samples of 281 horses and 5 donkeys from 26 farms were analysed in the area of Salzburg. To 164 of these horses selective anthelmintic treatment was implemented. Every four weeks faecal samples from the 164 horses were quantitatively analysed for strongyle eggs using a modified McMaster technique. When more than 250 eggs per gram (EpG) of faeces were detected in a sample the horse was treated with an oral pyrantel product. In case of a subsequent faecal sample of the same horse with EpG > 250, Ivermectin, and after the third sample with EpG > 250, Moxidectin was administered. In the fall 2008, all 164 horses together with 117 additional horses and 5 donkeys were treated with Moxidectin plus Praziquantel independent of the faecal egg count. After each anthelmintic treatment a faecal egg count reduction test was performed. In total 1521 faecal samples were analysed. In 1065 samples (70%) no strongyle eggs were detected at all and only 109 samples (7%) had EpG > 250 values. After the treatment with Pyrantel a total of 49 faecal egg count reduction tests, after the treatment with Ivermectin 28 and after the administration of Moxidectin totally 109 faecal egg count reduction tests were performed. After the treatment with either Ivermectin or Moxidectin, all faecal egg count reductions were 100%. On one farm however, the mean reduction of strongyle eggs after the administration of pyrantel was 85.4% on day 14 and 74.9% on day 21. Therefore, faecal egg count reduction tests are strongly recommended whenever horses are treated with Pyrantel.
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Publication Date: 2010-10-07 PubMed ID: 20924696DOI: 10.1007/s00508-010-1441-yGoogle Scholar: Lookup
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  • Comparative Study
  • English Abstract
  • Journal Article

Summary

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The study investigates the efficacy of various anthelmintic drugs against horse strongyles in the Salzburg region, and explores outcomes from selective application of these treatments. Results indicate that Ivermectin and Moxidectin were 100% effective, while Pyrantel’s efficacy was lower, suggesting that faecal egg count reduction tests are recommended when using Pyrantel.

Research Context and Aim

  • The research was carried out in the context of increasing instances of equine strongyles demonstrating resistance to anthelmintic drugs. Notably, there have been cases showing resistance to macrocyclic lactones which are important in controlling such infections.
  • The study aims to test the effectiveness of various anthelmintic drugs on horse populations in farms located in the region of Salzburg. The ultimate goal is to determine which drugs are most efficient and consider these for selective use to delay the progress of drug resistance among parasites.

Methodology

  • Sampling was done during the 2008 grazing season, where faecal samples were collected from 281 horses and 5 donkeys across 26 farms in Salzburg.
  • Selective anthelmintic treatment was administered to 164 of these horses which involved treating horses only when more than 250 eggs per gram (EpG) of wastes were detected in their faecal samples. The parasites were treated in a stepwise manner using Pyrantel, Ivermectin, and Moxidectin respectively for first, second and third instance of EpG > 250.
  • At the end of the season, all 164 horses along with additional 117 horses and 5 donkeys were treated with Moxidectin plus Praziquantel, irrespective of their faecal egg count.
  • A faecal egg count reduction test was performed after each treatment.

Results

  • A total of 1521 faecal samples were analyzed. In 70% of the samples, no strongyle eggs were detected and only 7% of the samples showed EpG > 250 values.
  • 49, 28, and 109 faecal egg count reduction tests were performed after the treatment with Pyrantel, Ivermectin and Moxidectin respectively.
  • Both Ivermectin and Moxidectin treatments resulted in 100% reduction in faecal egg counts. Strikingly, there was evidence of significant reduction but not elimination of strongyle eggs after the administration of pyrantel, with the reduction rate standing at 85.4% on day 14 and 74.9% on day 21.

Conclusion

  • The findings of the study indicate that while Ivermectin and Moxidectin remain completely effective against horse strongyles, Pyrantel’s efficacy is reduced. This highlights the importance of regularly conducting faecal egg count reduction tests whenever equine parasites are treated with Pyrantel.

Cite This Article

APA
Becher AM, Pfister K. (2010). [The efficacy of anthelmintic drugs against horse strongyles in the area of Salzburg and preliminary results of selective anthelmintic treatment]. Wien Klin Wochenschr, 122 Suppl 3, 71-75. https://doi.org/10.1007/s00508-010-1441-y

Publication

Wiener klinische Wochenschrift
ISSN: 1613-7671
NlmUniqueID: 21620870R
Country: Austria
Language: ger
Volume: 122 Suppl 3
Pages: 71-75

Researcher Affiliations

Becher, Anne M
  • Equine Practice Dr. Müller, Freilassing, Germany. annebecher@gmx.de
Pfister, Kurt

    MeSH Terms

    • Animals
    • Anthelmintics / administration & dosage
    • Austria
    • Feces / parasitology
    • Horses
    • Pilot Projects
    • Strongyle Infections, Equine / diagnosis
    • Strongyle Infections, Equine / drug therapy
    • Strongyle Infections, Equine / parasitology
    • Treatment Outcome

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    Citations

    This article has been cited 2 times.
    1. Ramalho Sousa S, Anastácio S, Nóvoa M, Paz-Silva A, Madeira de Carvalho LM. Gastrointestinal Parasitism in Miranda Donkeys: Epidemiology and Selective Control of Strongyles Infection in the Northeast of Portugal. Animals (Basel) 2021 Jan 11;11(1).
      doi: 10.3390/ani11010155pubmed: 33440886google scholar: lookup
    2. Buono F, Veneziano V, Veronesi F, Molento MB. Horse and donkey parasitology: differences and analogies for a correct diagnostic and management of major helminth infections. Parasitology 2023 Oct;150(12):1119-1138.
      doi: 10.1017/S0031182023000525pubmed: 37221816google scholar: lookup
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