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Home / Equine Research Bank / Parasitol Res / The equine ascarids: resuscitating historic model organisms ...
Parasitology research2022; 121(10); 2775-2791; doi: 10.1007/s00436-022-07627-z

The equine ascarids: resuscitating historic model organisms for modern purposes.

Abstract: The equine ascarids, Parascaris spp., are important nematode parasites of juvenile horses and were historically model organisms in the field of cell biology, leading to many important discoveries, and are used for the study of chromatin diminution. In veterinary parasitology, Parascaris spp. are important not only because they can cause clinical disease in young horses but also because they are the only ascarid parasites to have developed widespread anthelmintic resistance. Despite this, much of the general biology and mechanisms of anthelmintic resistance are poorly understood. This review condenses known basic biological information and knowledge on the mechanisms of anthelmintic resistance in Parascaris spp., highlighting the importance of foundational research programs. Although two variants of this parasite were recognized based on the number of chromosomes in the 1870s and suggested to be two species in 1890, one of these, P. univalens, appears to have been largely forgotten in the veterinary scientific literature over the past 100 years. We describe how this omission has had a century-long effect on nomenclature and data analysis in the field, highlighting the importance of proper specimen identification in public repositories. A summary of important basic biology, including life cycle, in vitro maintenance, and immunology, is given, and areas of future research for the improvement of knowledge and development of new systems are given. Finally, the limited knowledge regarding anthelmintic resistance in Parascaris spp. is summarized, along with caution regarding assumptions that resistance mechanisms can be applied across clades.
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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Publication Date: 2022-08-20 PubMed ID: 35986167PubMed Central: PMC9391215DOI: 10.1007/s00436-022-07627-zGoogle Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article examines the biology of equine ascarids (a type of equine parasite) and aspects of anthelmintic resistance found in these organisms. The study focuses on the importance of revitalizing historical models for modern research and highlights gaps in knowledge related to the biology of these parasites and resistance to treatments.

Background of the Research

  • The study focuses on Equine ascarids (Parascaris spp.) which are nematode parasites affecting young horses. These organisms were historically used as models in cell biology research, offering significant insights, particularly in chromatin diminution studies.
  • Notably, these parasites are the only ascarid species known to have developed widespread resistance to anthelmintics – drugs used to treat parasitic infections.
  • Despite their relevance, there is limited understanding of the general biology of these parasites and the mechanisms underlying their anthelmintic resistance. The research aims to condense known information on these salient aspects, underlining the necessity for foundational research programs.

Two Variants: Importance of Correct Identification

  • Around the 1870s, two variants of this parasite, based on their chromosome number, were identified and even suggested as two separate species by 1890. However, one variant, Parascaris univalens, has been largely overlooked in veterinary scientific literature over the past century.
  • The omission of this variant has greatly impacted nomenclature and data analysis in this field of study, underlining the importance of correct identification of specimens in public repositories.

Aspects of Basic Biology of Equine Ascarids

  • The research provides an overview of the basic biology of these parasites, including their life cycle, in vitro maintenance, and immunology.
  • It highlights areas for future research that could help in enhancing knowledge and in the development of new systems.

Anthelmintic Resistance in Parascaris Spp.

  • The study also delves into the limited existing knowledge regarding anthelmintic resistance in Parascaris spp.
  • It cautions against the assumption that resistance mechanisms can be universally applied across different clades – groups of organisms descending from a common ancestor.

Cite This Article

APA
Cain JL, Nielsen MK. (2022). The equine ascarids: resuscitating historic model organisms for modern purposes. Parasitol Res, 121(10), 2775-2791. https://doi.org/10.1007/s00436-022-07627-z

Publication

Parasitology research
ISSN: 1432-1955
NlmUniqueID: 8703571
Country: Germany
Language: English
Volume: 121
Issue: 10
Pages: 2775-2791

Researcher Affiliations

Cain, Jennifer L
  • M.H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, 1400 Nicholasville Rd., Lexington, KY, 40546, USA. jennifer.cain@uky.edu.
Nielsen, Martin K
  • M.H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, 1400 Nicholasville Rd., Lexington, KY, 40546, USA.

MeSH Terms

  • Animals
  • Anthelmintics / therapeutic use
  • Ascaridida Infections / veterinary
  • Ascaridoidea / genetics
  • Drug Resistance
  • Horse Diseases / parasitology
  • Horses

Conflict of Interest Statement

Dr. Martin Nielsen holds stock in and Jennifer Cain is an employee of Parasight System, Inc., a company that is manufacturing an automated parasite egg counting technique.

References

This article includes 232 references
  1. Afzal J, Burke AB, Batten PL, DeLay RL, Miller P. Moxidectin: metabolic fate and blood pharmacokinetics of 14C-labeled moxidectin in horses.. J Agric Food Chem 1997;45(9):3627–3633.
    doi: 10.1021/jf960981sgoogle scholar: lookup
  2. Alanazi AD, Mukbel RM, Alyousif MS, AlShehri ZS, Alanazi IO, Al-Mohammed HI. A field study on the anthelmintic resistance of Parascaris spp. in Arab foals in the Riyadh region, Saudi Arabia.. Vet Q 2017;37(1):200–205.
    pubmed: 28537782
  3. Anderson RR. The use of ivermectin in horses: research and clinical observations.. Compend Contin Educ Vet 1984;6(9):s516–s521.
  4. Armstrong SK, Woodgate RG, Gough S, Heller J, Sangster NC, Hughes KJ. The efficacy of ivermectin, pyrantel and fenbendazole against Parascaris equorum infection in foals on farms in Australia.. Vet Parasitol 2014;205(3–4):575–580.
    doi: 10.1016/j.vetpar.2014.08.028pubmed: 25224788google scholar: lookup
  5. Avery RH, Wall LA, Verhoeve VI, Gipson KS, Malone JB. Molecular Confirmation of Ascaris suum: further investigation into the Zoonotic origin of infection in an 8-year-old boy with Loeffler syndrome.. Vector Borne Zoonotic Dis 2018;18(11):638–640.
    doi: 10.1089/vbz.2018.2306pubmed: 30085905google scholar: lookup
  6. Bachmann-Waldmann C, Jentsch S, Tobler H, Müller F. Chromatin diminution leads to rapid evolutionary changes in the organization of the germ line genomes of the parasitic nematodes A. suum and P. univalens.. Mol Biochem 2004;134(1):53–64.
    pubmed: 14747143
  7. Beasley A, Coleman G, Kotze AC. Suspected ivermectin resistance in a south-east Queensland Parascaris equorum population.. Aust Vet J 2015;93(9):305–307.
    doi: 10.1111/avj.12352pubmed: 26313207google scholar: lookup
  8. Beech RN, Neveu C. The evolution of pentameric ligand-gated ion-channels and the changing family of anthelmintic drug targets.. Parasitol 2015;142(2):303–317.
    doi: 10.1017/S003118201400170Xpubmed: 25354656google scholar: lookup
  9. Beech RN, Prichard RK, Scott ME. Genetic variability of the beta-tubulin genes in benzimidazole-susceptible and -resistant strains of Haemonchus contortus.. Genetics 1994;138(1):103–110.
    doi: 10.1093/genetics/138.1.103pmc: PMC1206121pubmed: 8001777google scholar: lookup
  10. Beech RN, Skuce P, Bartley DJ, Martin RJ, Prichard RK, Gilleard JS. Anthelmintic resistance: markers for resistance, or susceptibility?. Parasitol 2010;138(2):160–174.
    doi: 10.1017/S0031182010001198pmc: PMC3064440pubmed: 20825689google scholar: lookup
  11. Bellaw JB, Pagan J, Cadell S, Phethean E, Donecker JM, Nielsen MK. Objective evaluation of two deworming regimens in young thoroughbreds using parasitological and performance parameters.. Vet Parasitol 2016;221:69–75.
    doi: 10.1016/j.vetpar.2016.03.018pubmed: 27084476google scholar: lookup
  12. Bello TR. The insidious invasive verminous antigens of the horse.. J Equine Vet Sci 1985;5(3):163–167.
    doi: 10.1016/S0737-0806(85)80023-Xgoogle scholar: lookup
  13. Bethony J, Brooker S, Albonico M, Geiger SM, Loukas A, Diemert D, Hotez PJ. Soil-transmitted heliminth infections: ascariasis, trichuriasis, and hookworm.. Lancet 2006;367(9521):1521–1532.
    doi: 10.1016/S0140-6736(06)68653-4pubmed: 16679166google scholar: lookup
  14. Biocca E, Nascetti G, Iori A, Constantini R, Bullini L. Descrizione di Parascaris univalens, parassita degli equini, e suo differenziamento da Parascaris equorum.. Atti della Accademia Nazionale dei Lincei: Classe di Scienze Fisiche, Matematiche e Naturali 1978;65(3–4):133–140.
  15. Bishop RM, Scott I, Gee EK, Rogers CW, Pomroy WE, Mayhew IG. Sub-optimal efficacy of ivermectin against Parascaris equorum in foals on three Thoroughbred stud farms in the Manawatu region of New Zealand.. N Z Vet J 2014;62(2):91–95.
    doi: 10.1080/00480169.2013.843146pubmed: 24151853google scholar: lookup
  16. Blaxter M, Koutsovoulos G. The evolution of parasitism in Nematoda.. Parasitol 2015;142(Suppl 1):S26–S39.
    doi: 10.1017/S0031182014000791pmc: PMC4413787pubmed: 24963797google scholar: lookup
  17. Blaxter ML, De Ley P, Garey JR, Liu LX, Scheldeman P, Vierstraete A, Vanfleteren JR, Mackey LY, Dorris M, Frisse LM, Vida JT, Thomas WK. A molecular evolutionary framework for the phylum Nematoda.. Nature 1998;392(6671):71–75.
    doi: 10.1038/32160pubmed: 9510248google scholar: lookup
  18. Boersema JH, Eysker M, Nas JWM. Apparent resistance of Parascaris equorum to macrocylic lactones.. Vet Rec 2002;150(9):279–281.
    doi: 10.1136/vr.150.9.279pubmed: 11924584google scholar: lookup
  19. Boraski EA. Efficacy of oral ivermectin against ascarids in horses.. Mod Vet Prac 1987;68:486–488.
  20. Borgsteede FHM, Deleeuw WA, Dijikstra T, Alsma G, de Vries W. Ascaris suum infections causing clinical problems in cattle.. Tijdschr Diergeneeskd 1992;117(10):296–298.
    pubmed: 1604447
  21. Boveri T. Über Differenzierung der Zellkerne während der Furchung des Eies von Ascaris megalocephala.. Anat Anz 1887;2:688–693.
  22. Boveri T. Zellen-Studien: Die Befruchtung und Teilung des Eies von Ascaris megalocephala.. Zeitschrift Für Naturwissenschaften 1888;22:685–882.
  23. Brown PJ, Clayton HM. Hepatic pathology of experimental Parascaris equorum infection in worm-free foals.. J Comp Path 1979;89(1):115–123.
    doi: 10.1016/0021-9975(79)90015-Xpubmed: 570571google scholar: lookup
  24. Brown HD, Matzuk AR, Ilves IR, Peterson LH, Harris SA, Sarett LH, Egerton JR, Yakstis JJ, Campbell WC, Cuckler AC. Antiparasitic drugs. IV. 2-(4′-Thiazolyl)-benzimidazole, a new anthelmintic.. JACS 1961;83(7):1764–1765.
  25. Bullini L, Nascetti G, Carrè S, Rumore F, Biocca E. Ricerche cariologiche ed elettroforetiche su Parascaris univalens e Parascaris equorum.. Atti della Accademia Nazionale dei Lincei. Classe di Scienze Fisiche, Matematiche e Naturali. Rendiconti Serie 8 1978;65:151–156.
  26. Burk SV, Dangoudoubiyam S, Brewster-Barnes T, Bryant UK, Howe DK, Carter CN, Vanzant ES, Harmon RJ, Kazacos KR, Rossano MG. In vitro culture of Parascaris equorum larvae and initial investigation of parasite excretory-secretory products.. Parasitol Res 2014;113(11):4217–4224.
    doi: 10.1007/s00436-014-4097-0pubmed: 25209615google scholar: lookup
  27. Burk SV, Dangoudoubiyam S, Brewster-Barnes T, Howe DK, Carter CN, Bryant UK, Rossano MG. Equine antibody response to larval Parascaris equorum excretory-secretory products.. Vet Parasitol 2016;226:83–87.
    doi: 10.1016/j.vetpar.2016.06.036pubmed: 27514890google scholar: lookup
  28. Campbell WC, Fisher MH, Stapley O, Albers-Schönberg G, Jacob TA. Ivermectin: A potent new antiparasitic agent.. Science 1983;221(4613):823–828.
    doi: 10.1126/science.6308762pubmed: 6308762google scholar: lookup
  29. Carmichael I, Visser R, Schneider D, Stoll M. Haemonchus contortus resistance to ivermectin.. J S Afr Vet Assoc 1987;58(2):93.
    pubmed: 3681886
  30. Carnoy JB. La cellule, recueil de cytologie et d’histologie générale. T. III. I. La vésicule germinative et les globules polaires chez divers nématodes. IL La segmentation chez les nématodes. Heft 1. 1886. Conférence donnée à la société belge de microscopic Les globules polaires de l’Ascaris clavata. Heft II. 1887. 1886/1887.
  31. Carter GT, Neitsche JA, Hertz MR, Williams DR, Siegel MM, Morton GO, James JC, Borders JD. LL-F28249 antibiotic complex: a new family of antiparasitic macrocyclic lactones.. J Antibiot 1988;41(4):519–529.
    doi: 10.7164/antibiotics.41.519pubmed: 3372359google scholar: lookup
  32. Charvet CL, Guégnard F, Courtot E, Cortet J, Neveu C. Nicotine-sensitive acetylcholine receptors are relevant pharmacological targets for the control of multidrug resistant parasitic nematodes.. Int J Parasitol Drugs Drug Resist 2018;8(3):540–549.
    doi: 10.1016/j.ijpddr.2018.11.003pmc: PMC6287576pubmed: 30502120google scholar: lookup
  33. Chelladurai JJ, Brewer MT. Detection and quantification of Parascaris P-glycoprotein drug transporter expression with a novel mRNA hybridization technique.. Vet Parasitol 2019;267:75–83.
    doi: 10.1016/j.vetpar.2019.02.002pubmed: 30878090google scholar: lookup
  34. Chelladurai JJ, Bader C, Snobl T, Magstadt D, Cooper V, Brewer MT. Toxocara vitulorum infection in a cohort of beef calves in Iowa.. Vet Parasitol 2015;214(1–2):96–99.
    doi: 10.1016/j.vetpar.2015.10.004pubmed: 26518643google scholar: lookup
  35. Choi YJ, Bisset SA, Doyle SR, Hallsworth-Pepin K, Martin J, Grant WN, Mitreva M. Genomic introgression mapping of field-derived multiple-anthelmintic resistance in Teladorsagia circumcincta.. PLoS Genet 2017;13(6):e1006857.
    doi: 10.1371/journal.pgen.1006857pmc: PMC5507320pubmed: 28644839google scholar: lookup
  36. Cirak VY, Kar S, Girişgin O. A survey on anthelmintic resistance in strongyles to ivermectin and pyrantel and macrocyclic lactone-resistance in Parascaris equorum.. Turkiye Paraziol Derg 2010;34(1):35–39.
    pubmed: 20340086
  37. Clayton HM, Duncan JL. Clinical signs associated with Parascaris equorum infection in worm-free pony foals and yearlings.. Vet Parasitol 1978;4(1):69–78.
    doi: 10.1016/0304-4017(78)90037-7google scholar: lookup
  38. Clayton HM, Duncan JL. The migration and development of Parascaris equorum in the horse.. Int J Parasitol 1979;9(4):285–292.
    doi: 10.1016/0020-7519(79)90076-6pubmed: 489235google scholar: lookup
  39. Clayton HM, Duncan JL. The development of immunity to Parascaris equorum infection in the foal.. Res Vet Sci 1979;26(3):383–384.
    doi: 10.1016/S0034-5288(18)32899-6pubmed: 574660google scholar: lookup
  40. Collins JB, Jordan B, Baldwin L, Hebron C, Paras K, Vidyaskankar AN, Kaplan RM. Resistance to fenbendazole in Ascaridia dissimilis, an important nematode parasite of turkeys.. Poult Sci 2019;98(11):5412–5415.
    doi: 10.3382/ps/pez379pubmed: 31328783google scholar: lookup
  41. Collins JB, Jordan B, Bishop A, Kaplan RM. Fenbendazole resistance in Heterakis gallinarum, the vector of Histomonas meleagridis, the causative agent of blackhead disease in poultry.. bioRxiv Preprint 2021.
  42. Cooper LG, Caffe G, Cerutti J, Nielsen MK, Anziani OS. Reduced efficacy of ivermectin and moxidectin against Parascaris spp. in foals from Argentina.. Vet Parasitol Reg Stud Rep 2020;20:100388.
    pubmed: 32448542
  43. Courtot E, Charvet CL, Beech RN, Harmache A, Wolstenholme AJ, Holden-Dye L, O’Connor V, Peineau N, Woods DJ, Neveu C. Functional characterization of a novel class of morantel-sensitive acetylcholine receptors in nematodes.. PLoS Path 2015;11(12):e1005267.
    doi: 10.1371/journal.ppat.1005267pmc: PMC4666645pubmed: 26625142google scholar: lookup
  44. Cox FEG. History of human parasitology.. Clin Microbiol Rev 2002;15(4):595–612.
    doi: 10.1128/CMR.15.4.595-612.2002pmc: PMC126866pubmed: 12364371google scholar: lookup
  45. Craig TM, Diamond PL, Ferwerda NS, Thompson JA. Evidence of ivermectin resistance by Parascaris equorum on a Texas horse farm.. J Equine Vet Sci 2007;27(2):67–71.
    doi: 10.1016/j.jevs.2006.12.002google scholar: lookup
  46. Cribb NC, Cote NM, Boure LP, Peregrine AS. Acute small intestinal obstruction associated with Parascaris equorum infection in young horses: 25 cases (1985–2004). N Z Vet J 2006;54(6):338–343.
    doi: 10.1080/00480169.2006.36721pubmed: 17151735google scholar: lookup
  47. Curtis SE, Tisch DA, Todd KS, Simon J. Pulmonary bacterial deposition and clearance during ascarid larval migration in weanling pigs.. Can J Vet Res 1987;51(4):525–527.
    pmc: PMC1255378pubmed: 3330966
  48. Deslyper G, Colgan TJ, Cooper AJR, Holland CV, Carolan JC. A proteomic investigation of hepatic resistance to Ascaris in a murine model.. PLoS Negl Trop Dis 2016;10(8):e0004837.
    doi: 10.1371/journal.pntd.0004837pmc: PMC4974003pubmed: 27490109google scholar: lookup
  49. Deslyper G, Holland CV, Colgan TJ, Carolan JC. The liver proteome in a mouse model for Ascaris suum resistance and susceptibility: evidence for an altered innate immune response.. Parasit Vectors 2019;12(1):402.
    doi: 10.1186/s13071-019-3655-9pmc: PMC6693097pubmed: 31412915google scholar: lookup
  50. Diawara A, Drake LJ, Suswillo RR, Kihara J, Bundy DAP, Scott ME, Halpenny C, Stothard JR, Prichard RK. Assays to detect beta-tubulin codon 200 polymorphism in Trichuris trichiura and Ascaris lumbricoides.. PLoS Negl Trop Dis 2009;3(3):e397.
    doi: 10.1371/journal.pntd.0000397pmc: PMC2654341pubmed: 19308251google scholar: lookup
  51. Diawara A, Schwenkenbecher JM, Kaplan RM, Prichard RK. Molecular and biological diagnostic test for monitoring benzimidazole resistance in human soil-transmitted helminths.. Am J Top Med Hyg 2013;88(6):1052–1061.
    doi: 10.4269/ajtmh.12-0484pmc: PMC3752802pubmed: 23458960google scholar: lookup
  52. Donoghue EM, Lyons ET, Bellaw JL, Nielsen MK. Biphasic appearance of corticated and decorticated ascarid egg shedding in untreated horse foals.. Vet Parasitol 2015;214(1–2):114–117.
    doi: 10.1016/j.vetpar.2015.09.003pubmed: 26391818google scholar: lookup
  53. Doyle SR, Cotton JA. Genome-wide approaches to investigate anthelmintic resistance.. Trends Parasitol 2019;35(4):289–301.
    doi: 10.1016/j.pt.2019.01.004pubmed: 30733094google scholar: lookup
  54. Drudge JH, Lyons ET. Control of internal parasites of the horse.. J Am Vet Med Assoc 1966;148(4):378–383.
    pubmed: 5950040
  55. Drudge JH, Szanto J, Wyant ZN, Elam G. Field studies on parasite control in sheep: comparison of thiabendazole, ruelene, and phenothiazine.. A J Vet Res 1964;25:1512–1518.
    pubmed: 14204835
  56. Eberhard ML, Alfano E. Adult Toxocara cati infections in U.S. children: report of four cases.. Am J Trop Med Hyg 1998;59(3):404–406.
    pubmed: 9749634
  57. Ellingson J, Coates-Markle L. Managing your pregnant mare and her foal.. Oregon State University Extension Service 1996.
  58. ESCCAP. A guide to the treatment and control of equine gastrointestinal parasite infections.. European Scientific Counsel Companion Animal Parasites 2019.
  59. Fabiani JV, Lyons ET, Nielsen MK. Dynamics of Parascaris and Strongylus spp. parasites in untreated juvenile horses.. Vet Parasitol 2016;230:62–66.
    doi: 10.1016/j.vetpar.2016.11.002pubmed: 27884444google scholar: lookup
  60. Faust EC. The use of anthelmintics.. JAMA 1937;108(5):386–392.
    doi: 10.1001/jama.1937.92780050002013google scholar: lookup
  61. Fleischmann RD, Adams MD, White O, Clayton RA, Kirkness EF, Kerlavage AR, Bult CJ, Tomb JF, Dougherty BA, Merrick JM, McKenney K, Sutton G, Fitzhugh W, Fields C, Gocayne JD. Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.. Science 1995;269(5223):496–512.
    doi: 10.1126/science.7542800pubmed: 7542800google scholar: lookup
  62. Fleming SA, Craig T, Kaplan RM, Miller JE, Navarre C, Rings M. Anthelmintic resistance of gastrointestinal parasites in small ruminants.. J Vet Intern Med 2006;20(2):435–444.
    doi: 10.1111/j.1939-1676.2006.tb02881.xpubmed: 16594607google scholar: lookup
  63. Friedman PA, Platzer EG. Interaction of anthelmintic benzimidazoles and benzimidazole derivatives with bovine brain tubulin.. Biochim Biophys Acta 1978;544(3):605–614.
    doi: 10.1016/0304-4165(78)90334-3pubmed: 728472google scholar: lookup
  64. Gakosso LGC, Baadi F, Abakka FZ, Basraoui D. The visceral larva migrans caused by Toxocara canis: a case report.. Pan Afr Med J 2020;36:150.
    doi: 10.11604/pamj.2020.36.150.24176pmc: PMC7436642pubmed: 32874414google scholar: lookup
  65. Gao JF, Zhang XX, Wang XX, Li Q, Li Y, Xu WW, Gao Y, Wang CR. According to mitochondrial DNA evidence, Parascaris equorum and Parascaris univalens may represent the same species.. J Helminthol 2019;93(3):383–388.
    doi: 10.1017/S0022149X18000330pubmed: 29792237google scholar: lookup
  66. Geary TG, Thompson DP. Caenorhabditis elegans: how good a model for veterinary parasites?. Vet Parasitol 2001;101(3–4):371–386.
    doi: 10.1016/S0304-4017(01)00562-3pubmed: 11707307google scholar: lookup
  67. Geerts S, Gryseels B. Drug resistance in human helminths: current situation and lessons from livestock.. Clin Microbiol Rev 2000;13(2):207–222.
    doi: 10.1128/CMR.13.2.207pmc: PMC100151pubmed: 10755998google scholar: lookup
  68. Geerts S, Gryseels B. Anthelmintic resistance in human helminths: a review.. Trop Med Int Health 2002;6(11):915–921.
    doi: 10.1046/j.1365-3156.2001.00774.xpubmed: 11703846google scholar: lookup
  69. Geerts S, Coles GC, Gryseels B. Anthelmintic resistance in human helminths: learning from the problems with worm control in livestock.. Parasitol Today 1997;13(4):149–151.
    doi: 10.1016/S0169-4758(97)01024-7pubmed: 15275102google scholar: lookup
  70. Gerhard AP, Krücken J, Heitlinger E, Janssen IJI, Besiaga M, Kornaś S, Beier C, Nielsen MK, Davis RE, Wang J, von Samson-Himmelstjerna G. The P-glycoprotein repertoire of the equine parasitic nematode Parascaris univalens.. Sci Rep 2020;10(1):13586.
    doi: 10.1038/s41598-020-70529-6pmc: PMC7423980pubmed: 32788636google scholar: lookup
  71. Gerhard AP, Krücken J, Neveu C, Charvet CL, Harmache A, von Samson-Himmelstjerna G. Pharyngeal pumping and tissue-specific transgenic P-glycoprotein expression influence macrocyclic lactone susceptibility in Caenorhabditis elegans.. Pharmaceuticals 2021;14(2):153.
    doi: 10.3390/ph14020153pmc: PMC7917992pubmed: 33668460google scholar: lookup
  72. Getachew AM, Innocent GT, Trawford AF, Feseha G, Reid SJW, Love S. Equine parascarosis under the tropical weather conditions of Ethiopia: a coprological and postmortem study.. Vet Rec 2008;162(6):177–180.
    doi: 10.1136/vr.162.6.177pubmed: 18263917google scholar: lookup
  73. Getachew M, Trawford A, Feseha G, Reid SWJ. Gastrointestinal parasites of working donkeys in Ethiopia.. Trop Anim Health Prod 2010;42(1):27–33.
    doi: 10.1007/s11250-009-9381-0pubmed: 19548106google scholar: lookup
  74. Geurden T, Betsch JM, Maillard K, Vanimisetti B, D’Espois M, Besognet B. Determination of anthelmintic efficacy against equine cyathostomins and Parascaris equorum in France.. Equine Vet Ed 2013;25:304–307.
    doi: 10.1111/j.2042-3292.2012.00454.xgoogle scholar: lookup
  75. Ghisi M, Kaminsky R, Mäser P. Phenotyping and genotyping of Haemonchus contortus isolates reveals a new putative candidate mutation for benzimidazole resistance in nematodes.. Vet Parasitol 2007;144(3–4):313–320.
    doi: 10.1016/j.vetpar.2006.10.003pubmed: 17101226google scholar: lookup
  76. Goday C, Pimpinelli S. Chromosome organization and heterochromatin elimination in Parascaris.. Science 1984;224(4647):411–413.
    doi: 10.1126/science.224.4647.411pubmed: 17741221google scholar: lookup
  77. Goday C, Pimpinelli S. Cytological analysis of chromosomes in the two species Parascaris univalens and P. equorum.. Chromosoma 1986;94:1–10.
    doi: 10.1007/BF00293524google scholar: lookup
  78. Goday C, Ciofi-Luzzatto A, Pimpinelli S. Centromere ultrastructure in germ-line chromosomes of Parascaris.. Chromosoma 1985;91(2):121–125.
    doi: 10.1007/BF00294055pubmed: 4039246google scholar: lookup
  79. Goeze JAE. Versuch einer Naturgeschichte der Eingeweidewürmer thierischer Körper.. 1782.
  80. Gundran RS, More SJ. Health and growth of water-buffalo calves in Nueva Ecija, the Philippines.. Prev Vet Med 1999;40(2):87–100.
    doi: 10.1016/S0167-5877(99)00034-3pubmed: 10384946google scholar: lookup
  81. Hamoir G. The discovery of meiosis by E. Van Beneden, a breakthrough in the morphological phase of heredity.. Int J Dev Biol 1992;36(1):9–15.
    pubmed: 1627480
  82. Han L, Lan T, Lu Y, Zhou M, Li H, Lu H, Wang Q, Li X, Du S, Guan C, Zhang Y, Sahu SK, Qian P, Zhang S, Zhou H. Equus roundworms (Parascaris univalens) are undergoing rapid divergence while genes involved in metabolic as well as anthelminic resistance are under positive selection.. BMC Genomics 2022;23(1):489.
    doi: 10.1186/s12864-022-08702-6pmc: PMC9252044pubmed: 35787772google scholar: lookup
  83. Hansen EP, Fromm B, Andersen SD, Marcilla A, Andersen KL, Borup A, Williams AR, Jex AR, Gasser RB, Young ND, Hall RS, Stensballe A, Ovchinnikov V, Yan Y, Fredholm M. Exploration of extracelluar vesicles from Ascaris suum provides evidence of parasite-host cross talk.. J Extracell Vesicles 2019;8(1):1578116.
    doi: 10.1080/20013078.2019.1578116pmc: PMC6383609pubmed: 30815237google scholar: lookup
  84. Harder A. Chemotherapeutic approaches to nematodes: current knowledge and outlook.. Parasitol Res 2002;88(3):272–277.
    doi: 10.1007/s00436-001-0535-xpubmed: 11954915google scholar: lookup
  85. Harrow ID, Gration AF. Mode of action of the anthelmintics morantel, pyrantel and levamisole on muscle cell membrane of the nematode Ascaris suum.. Pestic Sci 1985;16(6):662–672.
    doi: 10.1002/ps.2780160612google scholar: lookup
  86. Hautala K, Näreaho A, Kauppinen O, Nielsen MK, Sukura A, Rajala-Schultz PJ. Risk factors for equine intestinal parasite infections and reduced efficacy of pyrantel embonate against Parascaris sp.. Vet Parasitol 2019;273:52–59.
    doi: 10.1016/j.vetpar.2019.08.004pubmed: 31442894google scholar: lookup
  87. Hearn FPD, Peregrine AS. Identification of foals infected with Parascaris equorum apparently resistant to ivermectin.. J Am Vet Med Assoc 2003;223(4):482–485.
    doi: 10.2460/javma.2003.223.482pubmed: 12930086google scholar: lookup
  88. Hertwig O. Vergleich der Ei- und Samenbildung bei Nematoden.. Arch Mikrosk Anat 1890;36:1–138.
    doi: 10.1007/BF02955994google scholar: lookup
  89. Hill IR, Denham DA, Scholtz CL. Toxocara canis larvae in the brain of a British child.. Trans R Soc Trop Med Hyg 1985;79(3):351–354.
    doi: 10.1016/0035-9203(85)90378-5pubmed: 4035735google scholar: lookup
  90. Holland C. Impact of Ascaris suum in livestock.. Ascaris: the neglected parasite. Elsevier, Amsterdam 2013;pp 363–382.
  91. Horton J. Global anthelmintic chemotherapy programs: learning from history.. Trend Parasitol 2003;19(9):405–409.
    doi: 10.1016/S1471-4922(03)00171-5pubmed: 12957517google scholar: lookup
  92. International Helminth Genomes Consortium. Comparative genomics of the major parasitic worms.. Nat Genet 2019;51(1):163–174.
    doi: 10.1038/s41588-018-0262-1pmc: PMC6349046pubmed: 30397333google scholar: lookup
  93. Islam MK, Miyoshi T, Yokomizo Y, Tsuji N. The proteome expression patterns in adult Ascaris suum under exposure to aerobic/anaerobic environments analyzed by two-dimensional electrophoresis.. Parasitol Res 2004;93(2):96–101.
    doi: 10.1007/s00436-004-1101-0pubmed: 15114481google scholar: lookup
  94. James CE, Hudson AL, Davey MW. Drug resistance mechanisms in helminths: is it survival of the fittest?. Trends Parasitol 2009;25(7):328–335.
    doi: 10.1016/j.pt.2009.04.004pubmed: 19541539google scholar: lookup
  95. Janssen IJI, Krücken J, Demeler J, Basiaga M, Kornaś S, von Samson-Himmelstjerna G. Genetic variants and increased expression of Parascaris equorum P-glycoprotein-11 in populations with decreased ivermectin susceptibility.. PLoS ONE 2013;8(4):e61635.
    doi: 10.1371/journal.pone.0061635pmc: PMC3634834pubmed: 23637871google scholar: lookup
  96. Janssen IJI, Krücken J, Demeler J, von Samson-Himmelstjerna G. Transgenically expressed Parascaris P-glycoprotein-11 can modulate ivermectin susceptibility in Caenorhabditis elegans.. Int J Parasitol Drugs Drug Resist 2015;5(2):44–47.
    doi: 10.1016/j.ijpddr.2015.03.003pmc: PMC4401813pubmed: 25905032google scholar: lookup
  97. Jimenez Castro PD, Howell SB, Schaefer JJ, Avramenko RW, Gilleard JS, Kaplan RM. Multiple drug resistance in the canine hookworm Ancylostoma caninum: an emerging threat?. Parasit Vectors 2019;12(1):576.
    doi: 10.1186/s13071-019-3828-6pmc: PMC6902405pubmed: 31818311google scholar: lookup
  98. Jimenez Castro PD, Venkatesan A, Redman E, Chen R, Malatesta A, Huff H, Zuluaga Salazar DA, Avramenko R, Gilleard JS, Kaplan RM. Multiple drug resistance in hookworms infecting greyhound dogs in the USA.. Int J Parasitol Drugs Drug Resist 2021;17:107–117.
    doi: 10.1016/j.ijpddr.2021.08.005pmc: PMC8426179pubmed: 34492564google scholar: lookup
  99. Jones WE. Anthelmintic rotation.. Equine Vet Data 1985;6:97–100.
  100. Kaplan RM. Biology, epidemiology, diagnosis, and management of anthelmintic resistance in gastrointestinal nematodes of livestock.. Vet Clin North Am Food Anim Pract 2020;36(1):17–30.
    doi: 10.1016/j.cvfa.2019.12.001pubmed: 32029182google scholar: lookup
  101. Kaplan RM, Vidyashankar AN. An inconvenient truth: global worming and anthelmintic resistance.. Vet Parasitol 2012;186(1–2):70–78.
    doi: 10.1016/j.vetpar.2011.11.048pubmed: 22154968google scholar: lookup
  102. Kaufmann F, Das G, Sohnrey B, Gauly M. Helminth infections in laying hens kept in organic free range systems in Germany.. Livest Sci 2011;141(2–3):182–187.
    doi: 10.1016/j.livsci.2011.05.015google scholar: lookup
  103. Kelly TG, Madhavan VL, Peters JM, Kazacos KR, Silvera VM. Spinal cord involvement in a child with raccoon roundworm (Baylisascaris procyonis) meningoencephalitis.. Pediatr Radiol 2012;42(3):369–373.
    doi: 10.1007/s00247-011-2151-ypubmed: 21629989google scholar: lookup
  104. Khan S, Nisar A, Yuan J, Luo X, Dou X, Liu F, Zhao X, Li J, Ahmad H, Mehmood SA, Feng X. A whole genome re-sequencing based GWA analysis reveal candidate genes associated with ivermectin resistance in Haemonchus contortus.. Genes 2020;11(4):367.
    doi: 10.3390/genes11040367pmc: PMC7230667pubmed: 32231078google scholar: lookup
  105. Kim SB, Goodfellow M. Streptomyces avermitilis sp. nov., nom. rev., a taxonomic home for the avermectin-producing streptomycetes.. Int J Syst Evol Micr 2002;52(6):2011–2014.
    pubmed: 12508861
  106. Kojima G, Usuki S, Mizokami K, Tanabe M, Machi J. Intestinal anisakiasis as a rare cause of small bowel obstruction.. Am J Emerg Med 2013;31(9):1422.e1–1422.e2.
    doi: 10.1016/j.ajem.2013.05.015pubmed: 23786678google scholar: lookup
  107. Kotze AC, Prichard AK. Anthelmintic resistance in Haemonchus contortus: history, mechanisms and diagnosis.. Adv Parasitol 2016;93:397–428.
    doi: 10.1016/bs.apar.2016.02.012pubmed: 27238009google scholar: lookup
  108. Kotze AC, Cowling K, Bagnall NH, Hines BM, Ruffell AP, Hunt PW, Coleman GT. Relative level of thiabendazole resistance associated with the E198A and F200Y SNPs in larvae of a multi-drug resistant isolate of Haemonchus contortus.. Int J Parasitol Drugs Drug Resist 2012;2:92–97.
    doi: 10.1016/j.ijpddr.2012.02.003pmc: PMC3862426pubmed: 24533269google scholar: lookup
  109. Kotze AC, Hunt PW, Skuce P, von Samson-Himmelstjera G, Martin RJ, Sager H, Krücken J, Hodgkinson J, Lespine A, Jex AR, Gilleard JS, Beech RN, Wolstenholme AJ, Demeler J, Robertson A. Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions.. Int J Parasitol Drugs Drug Resist 2014;4(3):164–184.
    doi: 10.1016/j.ijpddr.2014.07.007pmc: PMC4266812pubmed: 25516826google scholar: lookup
  110. Krücken J, Fraundorfer K, Mugisha JC, Ramünke S, Sifft KC, Geus D, Habarugira F, Ndoli J, Sendegeya A, Mukampunga C, Bayingana C, Aebischer T, Demeler J, Gahutu JB, Mockenhaupt FP, von Samson-Himmelstjerna G. Reduced efficacy of albendazole against Ascaris lumbricoides in Rwandan schoolchildren.. Int J Parasitol Drugs Drug Resist 2017;7(3):262–271.
    doi: 10.1016/j.ijpddr.2017.06.001pmc: PMC5503839pubmed: 28697451google scholar: lookup
  111. Lacey E. The role of the cytoskeletal protein, tubulin, in the mode of action and mechanism of drug resistance to benzimidazoles.. Int J Parasitol 1988;18(7):885–936.
    doi: 10.1016/0020-7519(88)90175-0pubmed: 3066771google scholar: lookup
  112. Lacey E. Mode of action of benzimidazoles.. Parasitol Today 1990;6(4):112–115.
    doi: 10.1016/0169-4758(90)90227-Upubmed: 15463312google scholar: lookup
  113. Lacey E, Gill JH. Biochemistry of benzimidazole resistance.. Acta Trop 1994;56(2–3):245–262.
    doi: 10.1016/0001-706X(94)90066-3pubmed: 8203306google scholar: lookup
  114. Laing R, Maitland K, Lecová L, Skuce PJ, Tait A, Devaney E. Analysis of putative resistance gene loci in UK field populations of Haemonchus contortus after 6 years of macrocyclic lactone use.. Int J Parasitol 2016;46(10):621–630.
    doi: 10.1016/j.ijpara.2016.03.010pmc: PMC5011429pubmed: 27179994google scholar: lookup
  115. Lassen B, Peltola SM. Anthelmintic resistance of intestinal nematodes to ivermectin and pyrantel in Estonian horses.. J Helminthol 2014;89(6):760–763.
    doi: 10.1017/S0022149X14000510pubmed: 25007041google scholar: lookup
  116. Laugier C, Sevin C, Ménard S, Maillard K. Prevalence of Parascaris equorum infection in foals on French stud farms and first report of ivermectin-resistant P. equorum populations in France.. Vet Parasitol 2012;188(1–2):185–189.
    pubmed: 22494940
  117. Lem MF, Vincent KP, Pone JW, Joseph T. Prevalence and intensity of gastro-intestinal helminths in horses in the Sudano-Guinean climatic zone of Cameroon.. Trop Parasitol 2012;2(1):45–48.
    doi: 10.4103/2229-5070.97239pmc: PMC3593501pubmed: 23508513google scholar: lookup
  118. Lespine A, Ménez C, Bourguinat C, Prichard RK. P-glycoproteins and other multidrug resistance transporters in the pharmacology of anthelmintics: Prospects for reversing transport-dependent anthelmintic resistance.. Int J Parasitol Drugs Drug Resist 2011;2:58–75.
    pmc: PMC3862436pubmed: 24533264
  119. Li JC. A six-chromosome Ascaris in Chinese horses.. Science 1937;86(2222):101–102.
    doi: 10.1126/science.86.2222.101.bpubmed: 17733944google scholar: lookup
  120. Li L, Lü L, Nadler SA, Gibson DI, Zhang LP, Chen HX, Zhao WT, Guo YN. Molecular phylogeny and dating reveal a terrestrial origin in the early carboniferous for Ascaridoid nematodes.. Syst Biol 2018;67(5):888–900.
    doi: 10.1093/sysbio/syy018pubmed: 29528459google scholar: lookup
  121. Lightowlers MW, Rickard MD. Excretory–secretory products of helminth parasites: effects on host immune responses.. Parasitology 1988;96:S123–S166.
    doi: 10.1017/S0031182000086017pubmed: 3287288google scholar: lookup
  122. Lin TP. The chromosomal cycle in Parascaris equorum (Ascaris megalocephala); oogenesis and diminution.. Chromosoma 1954;6(3):175–198.
    pubmed: 13172849
  123. Lind EO, Christensson D. Anthelmintic efficacy on Parascaris equorum in foals on Swedish studs.. Acta Vet Scand 2009;51(1):45.
    doi: 10.1186/1751-0147-51-45pmc: PMC2788565pubmed: 19930608google scholar: lookup
  124. Lindgren K, Ljungvall Ö, Nilsson O, Ljungström BL, Lindahl C, Höglund J. Parascaris equorum in foals and in their environment on a Swedish stud farm, with notes on treatment failure of ivermectin.. Vet Parasitol 2008;151(2–4):337–343.
    doi: 10.1016/j.vetpar.2007.10.014pubmed: 18077096google scholar: lookup
  125. Linnaeus C. Systema naturæ per regna tria naturæ, secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis. Tomus I. Editio decima, reformata.. 1758.
  126. Liu GH, Nadler SA, Liu SS, Podolska M, D’Amelio S, Shao R, Gasser RB, Zhu XQ. Mitochondrial phylogenomics yields strongly supported hypotheses for Ascaridomorph nematodes.. Sci Rep 2016;6:39248.
    doi: 10.1038/srep39248pmc: PMC5159812pubmed: 27982084google scholar: lookup
  127. Lubega GW, Prichard RK. Specific interaction of benzimidazole anthelmintics with tubulin: high-affinity binding and benzimidazole resistance in Haemonchus contortus.. Mol Biochem Parasitol 1990;38(2):221–232.
    doi: 10.1016/0166-6851(90)90025-Hpubmed: 2325707google scholar: lookup
  128. Lubega GW, Klein RD, Geary TG, Prichard RK. Haemonchus contortus: the role of two beta-tubulin gene subfamilies in the resistance to benzimidazole anthelmintics.. Biochem Pharmacol 1994;47(9):1705–1715.
    doi: 10.1016/0006-2952(94)90551-7pubmed: 7910461google scholar: lookup
  129. Lyons ET, Drudge JH, Tolliver SC. Prevalence of some internal parasites found (1971–1989) in horses born on a farm in Central Kentucky.. J Equine Vet Sci 1990;10(2):99–107.
    doi: 10.1016/S0737-0806(06)80114-0google scholar: lookup
  130. Lyons ET, Tolliver SC, Drudge JH. Critical and controlled tests of activity of moxidectin (CL 301,423) against natural infections of internal parasites of equids.. Vet Parasitol 1992;41(3–4):255–284.
    doi: 10.1016/0304-4017(92)90086-Opubmed: 1502789google scholar: lookup
  131. Lyons ET, Tolliver SC, Ionita M, Collins SS. Evaluation of parasiticidal activity of fenbendazole, ivermectin, oxibendazole, and pyrantel pamoate in horse foals with emphasis on ascarids (Parascaris equorum) in field studies on five farms in Central Kentucky in 2007.. Parasitol Res 2008;103(2):287–291.
    doi: 10.1007/s00436-008-0966-8pubmed: 18470536google scholar: lookup
  132. Lyons ET, Tolliver SC, Kuzmina TA, Collins SS. Further evaluation in field tests of the activity of three anthelmintics (fenbendazole, oxibendazole, and pyrantel pamoate) against the ascarid Parascaris equorum in horse foals on eight farms in Central Kentucky (2009–2010). Parasitol Res 2011;109(4):1193–1197.
    doi: 10.1007/s00436-011-2379-3pubmed: 21499750google scholar: lookup
  133. Malekpour SH, Rakhshandehroo E, Yekaseresht A. Molecular characterization of β-tubulin gene associated with benzimidazole resistance in larvae of field isolates of Parascaris (Nematoda: Ascarididae). J Parasi Dis 2019;43(4):672–678.
    doi: 10.1007/s12639-019-01146-ypmc: PMC6841862pubmed: 31749539google scholar: lookup
  134. Martin F, Höglund J, Bergström TF, Lindsjö OK, Tydén E. Resistance to pyrantel embonate and efficacy of fenbendazole in Parascaris univalens on Swedish stud farms.. Vet Parasitol 2018;264:69–73.
    doi: 10.1016/j.vetpar.2018.11.003pubmed: 30503095google scholar: lookup
  135. Martin F, Dube F, Lindsjö OK, Eydal M, Höglund J, Bergström TF, Tydén E. Transcriptional responses in Parascaris univalens after in vitro exposure to ivermectin, pyrantel citrate and thiabendazole.. Parasit Vectors 2020;13(1):342.
    doi: 10.1186/s13071-020-04212-0pmc: PMC7346371pubmed: 32646465google scholar: lookup
  136. Martin F, Eyda M, Höglund J, Tydén E. Constitutive and differential expression of transport protein genes in Parascaris univalens larvae and adult tissues after in vitro exposure to anthelmintic drugs.. Vet Parasitol 2021;298:109535.
    doi: 10.1016/j.vetpar.2021.109535pubmed: 34340009google scholar: lookup
  137. Martin F, Halvarsson P, Delhomme N, Höglund J, Tydén E. Exploring the β-tubulin gene family in a benzimidazole-resistant Parascaris univalens population.. Int J Parasitol Drugs Drug Resist 2021;17:84–91.
    doi: 10.1016/j.ijpddr.2021.08.004pmc: PMC8406161pubmed: 34467878google scholar: lookup
  138. Martin F, Svansson V, Eydal M, Oddsdóttir C, Ernback M, Persson I, Tydén E. First report of resistance to ivermectin in Parascaris univalens in Iceland.. J Parasitol 2021;107(1):16–22.
    doi: 10.1645/20-91pubmed: 33498083google scholar: lookup
  139. Mateus TL, Cruzeiro ALF, Rocha H, Vieira-Pino MM. Economic impact of hepatic rejections caused by Ascaris suum in swine during post mortem inspection at slaughterhouse.. Safepork 2015 Proceedings Book: epidemiology and control of hazards in pork production chain 2015;pp 269–272.
  140. Matthews JB. Anthelmintic resistance in equine nematodes.. Int J Parasitol Drugs Drug Resist 2014;4(3):310–315.
    doi: 10.1016/j.ijpddr.2014.10.003pmc: PMC4266799pubmed: 25516842google scholar: lookup
  141. Molento MB, Antunes J, Bentes RN, Coles GC. Anthelmintic resistant nematodes in Brazilian horses.. Vet Rec 2008;162(12):384–385.
    doi: 10.1136/vr.162.12.384pubmed: 18359933google scholar: lookup
  142. Morsy K, Fahmy S, Mohamed A, Ali S, El-Garhy M, Shazly M. Optimizing and evaluating the antihelminthic activity of the biocompatible zinc oxide nanoparticles against the ascaridid nematode, Parascaris Equorum in Vitro.. Acta Parasitol 2019;64(4):873–886.
    doi: 10.2478/s11686-019-00111-2pubmed: 31478140google scholar: lookup
  143. Mulcahy G, O’Neill S, Fanning J, McCarthy E, Sekiya M. Tissue migration by parasitic helminths – an immunoevasive strategy?. Trends Parasitol 2005;21(6):273–277.
    doi: 10.1016/j.pt.2005.04.003pubmed: 15922248google scholar: lookup
  144. Muller F, Tobler H. Chromatin diminution in the parasitic nematodes Ascaris suum and Parascaris univalens.. Int J Parasitol 2000;30(4):391–399.
    doi: 10.1016/S0020-7519(99)00199-Xpubmed: 10731562google scholar: lookup
  145. Mullis KB, Faloona FA. Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction.. Methods Enzymol 1987;155:335–350.
    doi: 10.1016/0076-6879(87)55023-6pubmed: 3431465google scholar: lookup
  146. Nadler SA. Biochemical and immunological systematics of some Ascaridoid nematodes: genetic divergence between congeners.. J Parasitol 1987;73(4):811–816.
    doi: 10.2307/3282419pubmed: 3114467google scholar: lookup
  147. Nadler SA, Hudspeth DS. Phylogeny of the Ascaridoidea (Nematoda: Ascaridida) based on three genes and morphology: hypotheses of structural and sequence evolution.. J Parasitol 2000;86(2):380–393.
    doi: 10.1645/0022-3395(2000)086[0380:POTANA]2.0.CO;2pubmed: 10780561google scholar: lookup
  148. Nadler SA, Carreno RA, Mejía-Madrid H, Ullberg J, Pagan C, Houston R, Hugot JP. Molecular phylogeny of clade III nematodes reveals multiple origins of tissue parasitism.. Parasitology 2007;134(Pt 10):1421–1442.
    doi: 10.1017/S0031182007002880pubmed: 17506928google scholar: lookup
  149. Näreaho A, Vainio K, Oksanen A. Impaired efficacy of ivermectin against Parascaris equorum, and both ivermectin and pyrantel against strongyle infections in trotter foals in Finland.. Vet Parasitol 2011;182(2–4):372–377.
    doi: 10.1016/j.vetpar.2011.05.045pubmed: 21689886google scholar: lookup
  150. Nejsum P, Parker ED Jr, Frydenberg J, Roepstorff A, Boes J, Haque R, Astrup I, Prag J, Sørensen UBS. Ascariasis is a zoonosis in Denmark.. J Clin Microbiol 2005;43(3):1142–1148.
    doi: 10.1128/JCM.43.3.1142-1148.2005pmc: PMC1081283pubmed: 15750075google scholar: lookup
  151. Nicholls JM, Clayton HM, Pirie HM, Duncan JL. A pathological study of the lungs of foals infected experimentally with Parascaris equorum.. J Comp Path 1978;88(2):261–274.
    doi: 10.1016/0021-9975(78)90030-0pubmed: 659680google scholar: lookup
  152. Niedermaier J, Moritz KB. Organization and dynamics of satellite and telomere DNAs in Ascaris: implications for formation and programmed breakdown of compound chromosomes.. Chromosoma 2000;109(7):439–452.
    doi: 10.1007/s004120000104pubmed: 11151673google scholar: lookup
  153. Nielsen MK, Wang J, Davis R, Bellaw JL, Lyons ET, Lear TL, Goday C. Parascaris univalens – a victim of large-scale misidentification?. Parasitol Res 2014;113(12):4485–4490.
    doi: 10.1007/s00436-014-4135-ypubmed: 25231078google scholar: lookup
  154. Nielsen MK, Branan MA, Wiedenheft AM, Digianantonio R, Garber LP, Kopral CA, Phillippi-Taylor AM, Traub-Dargatz JL. Parasite control strategies used by equine owners in the United States: a national survey.. Vet Parasitol 2018;250:45–51.
    doi: 10.1016/j.vetpar.2017.12.012pubmed: 29329623google scholar: lookup
  155. Nielsen MK, Gee EK, Hansen A, Waghorn T, Bell J, Leathwick DM. Monitoring equine ascarid and cyathostomin parasites: Evaluating health parameters under different treatment regimens.. Equine Vet J 2021;53(5):902–910.
    doi: 10.1111/evj.13374pubmed: 33119179google scholar: lookup
  156. Nielsen MK, Mittel L, Grice A, Erskine M, Graves E, Vaala W, Tully RC, French DD, Bowman R, Kaplan RM. AAEP parasite control guidelines.. American Association of Equine Practitioners 2019.
  157. Nielsen MK. Evidence-based considerations for control of Parascaris spp. infections in horses.. Equine Vet Ed 2016;28(4):224–231.
  158. Nobel Prize. The Nobel Prize in Physiology or Medicine 2015.. The Nobel Prize 2015.
  159. Özben M, von Samson-Himmelstjerna G, Freiin von Streit MKB, Wilkes EJA, Hughes KJ, Krücken J. Absence of polymorphisms in codons 167, 198 and 200 of all seven β-tubulin isotypes of benzimidazole susceptible and resistant Parascaris spp. specimens from Australia.. Pathogens 2022;11(5):490.
    pmc: PMC9143322pubmed: 35631011
  160. Palma A, Matamoros G, Escobar D, Sánchez AL, Fontecha G. Absence of mutations associated with resistance to benzimidazole in the beta-tubulin gene of Ascaris suum.. Rev De Soc Bras Med Trop 2020;53:e20190155.
    doi: 10.1590/0037-8682-0155-2019pmc: PMC7094045pubmed: 32187331google scholar: lookup
  161. Pape M, Posedi J, Failing K, Schnieder T, von Samson-Himmelstjerna G. Analysis of the beta-tubulin codon 200 genotype distribution in a benzimidazole-susceptible and -resistant cyathostome population.. Parasitology 2003;127(Pt 1):53–59.
    doi: 10.1017/S0031182003003317pubmed: 12885188google scholar: lookup
  162. Peng Z, Shen D, Zhang D, Li X, Wang X, Zhai Q, Hou Z, Li H. Genetic characteristics and phylogenetic relationship of Parascaris spp. from Equus zebra, E. caballus, and E. asinus.. Vet Parasitol 2019;271:76–79.
    doi: 10.1016/j.vetpar.2019.06.013pubmed: 31303209google scholar: lookup
  163. Prichard R. Anthelmintic resistance.. Vet Parasitol 1994;54(1–3):259–268.
    doi: 10.1016/0304-4017(94)90094-9pubmed: 7846855google scholar: lookup
  164. Rakhshandehroo E, Asadpour M, Jafari A, Malekpour SH. The effectiveness of Cinnamomum zeylanicum, Punica granatum flower and Capsicum annuum extracts against Parascaris equorum infective larvae.. Acta Vet Eurasia 2016;42:132–137.
  165. Rakhshandehroo E, Asadpour M, Malekpour SH, Jafari A. The anthelmintic effects of five plant extracts on the viability of Parascaris equorum larvae.. Equine Vet Ed 2017;29(4):219–224.
    doi: 10.1111/eve.12676google scholar: lookup
  166. Rashwan N, Scott M, Prichard R. Rapid genotyping of β-tubulin polymorphisms in Trichuris trichiura and Ascaris lumbricoides.. PLoS Negl Trop Dis 2017;11(1):e0005205.
    doi: 10.1371/journal.pntd.0005205pmc: PMC5230752pubmed: 28081124google scholar: lookup
  167. Read AF, Skorping A. The evolution of tissue migration by parasitic nematode larvae.. Parasitology 1995;111(Pt 3):359–371.
    doi: 10.1017/S0031182000081919pubmed: 7567104google scholar: lookup
  168. Reinemeyer CR. Diagnosis and control of anthelmintic-resistant Parascaris equorum.. Parasit Vectors 2009;2(Suppl 2):S8.
    doi: 10.1186/1756-3305-2-S2-S8pmc: PMC2751844pubmed: 19778469google scholar: lookup
  169. Reinemeyer CR, Nielsen MK. Control of helminth parasites in juvenile horses.. Equine Vet Ed 2017;29(4):225–232.
    doi: 10.1111/eve.12541google scholar: lookup
  170. Relf VE, Lester HE, Morgan ER, Hodgkinson JE, Matthews JB. Anthelmintic efficacy on UK Thoroughbred stud farms.. Int J Parasitol 2014;44(8):507–514.
    doi: 10.1016/j.ijpara.2014.03.006pubmed: 24746779google scholar: lookup
  171. Rendle D, Austin C, Bowen M, Cameron I, Furtado T, Hodgkinson J, McGorum B, Matthews J. Equine de-worming: a consensus on current best practice.. UK-Vet Equine 2019;3:1–14.
  172. Rezansoff AM, Lain R, Gilleard JS. Evidence from two independent backcross experiments supports genetic linkage of microsatellite Hcms8a20, but not other candidate loci, to a major ivermectin resistance locus in Haemonchus contortus.. Int J Parasitol 2016;46(10):653–661.
    doi: 10.1016/j.ijpara.2016.04.007pubmed: 27216082google scholar: lookup
  173. Robert M, Hu W, Nielsen MK, Stowe CJ. Attitudes towards implementation of surveillance-based parasite control on Kentucky thoroughbred farms – current strategies, awareness and willingness-to-pay.. Equine Vet J 2015;47(6):694–700.
    doi: 10.1111/evj.12344pubmed: 25196091google scholar: lookup
  174. Robertson SJ, Pennington AJ, Evans AM, Martin RJ. The action of pyrantel as an agonist and an open channel blocker at acetylcholine receptors in isolated Ascaris suum muscle vesicles.. Eur J Pharmacol 1994;272(2–3):273–282.
    doi: 10.1016/0014-2999(94)90784-6pubmed: 7535704google scholar: lookup
  175. Rose H, Rinaldi L, Bosco A, Mavrot F, de Waal T, Skuce P, Charlier J, Torgerson PR, Hertzberg H, Hendrickx G, Vercruysse J, Morgan ER. Widespread anthelmintic resistance in European farmed ruminants: a systematic review.. Vet Rec 2015;176(21):546.
    doi: 10.1136/vr.102982pubmed: 25762583google scholar: lookup
  176. Saffra NA, Perlman JE, Desai RU, Kazacos KR, Coyle CM, Machado FS, Kedhar SR, Engelbert M, Tanowitz HB. Baylisascaris procyonis induced diffuse unilateral subacute neuroretinitis in New York City.. J Neuroparasitology 2010;1:N100401.
    doi: 10.4303/jnp/N100401pmc: PMC3278166pubmed: 22337758google scholar: lookup
  177. Santschi EM, Slone DE, Embertson RM, Clayton MK, Markel MD. Colic surgery in 206 juvenile thoroughbreds: survival and racing results.. Equine Vet J Suppl 2000;32:32–36.
    doi: 10.1111/j.2042-3306.2000.tb05331.xpubmed: 11202379google scholar: lookup
  178. Saunders GI, Wasmuth JD, Beech R, Laing R, Hunt M, Naghra H, Cotton JA, Berriman M, Britton C, Gilleard JS. Characterization and comparative analysis of the complete Haemonchus contortus β-tubulin gene family and implications for benzimidazole resistance in strongylid nematodes.. 2013;43(6):465–475.
    pubmed: 23416426
  179. Scare JA, Dini P, Norris JK, Steuer AE, Scoggin K, Gravatte HS, Howe DK, Sulsarewicz P, Nielsen MK. Ascarids exposed: a method for in vitro drug exposure and gene expression analysis of anthelmintic naïve Parascaris spp.. Parasitology 2020;147(6):659–666.
    doi: 10.1017/S0031182020000189pmc: PMC10317622pubmed: 32046800google scholar: lookup
  180. Scare JA, Steuer AE, Shaffer CL, Slusarewicz P, Mousley A, Nielsen MK. Long live the worms: methods for maintaining and assessing the viability of intestinal stages of Parascaris spp. in vitro.. Parasitology 2019;146(5):685–693.
    pubmed: 30561286
  181. Schougaard H, Nielsen MK. Apparent ivermectin resistance of Parascaris equorum in Danish foals.. Vet Rec 2007;160(13):439–440.
    doi: 10.1136/vr.160.13.439pubmed: 17400903google scholar: lookup
  182. Sharma N, Hunt PW, Hine BC, Ruhnke I. The impacts of Ascaridia galli on performance, health, and immune responses of laying hens: new insights into an old problem.. Poul Sci 2019;98(12):6517–6526.
    doi: 10.3382/ps/pez422pmc: PMC8914002pubmed: 31504894google scholar: lookup
  183. Slocombe JOD, de Gannes RVG, Lake MC. Macrocyclic lactone resistant Parascaris equorum on stud farms in Canada and effectiveness of fenbendazole and pyrantel pamoate.. Vet Parasitol 2007;145(3–4):371–376.
    doi: 10.1016/j.vetpar.2006.08.008pubmed: 16962243google scholar: lookup
  184. Sohn WM, Na BK, Kim TH, Park TJ. Anisakiasis: Report of 15 gastric cases caused by Anisakis Type I larvae and a brief review of Korean Anisakiasis cases.. Korean J Parasitol 2015;54(4):465–470.
    doi: 10.3347/kjp.2015.53.4.465pmc: PMC4566497pubmed: 26323845google scholar: lookup
  185. Sotilli J, Robinson MW, Kimber MJ, Cucher M, Ancarola ME, Nejsum P, Marcilla A, Eichenberger RM, Tritten L. The protein and microRNA cargo of extracellular vesicles from parasitic helminths – current status and research priorities.. Int J Parasitol 2020;50(9):635–645.
    doi: 10.1016/j.ijpara.2020.04.010pubmed: 32652128google scholar: lookup
  186. Southwood LL, Ragle CA, Snyder S, Hendrickson DA. Surgical treatment of ascarid impactions in horses and foals.. Proc Am Assoc Equine Practnrs 1996;42:258–261.
  187. Stewart TB, Hale OM. Losses to internal parasites in swine production.. J Anim Sci 1988;66(6):1548–1554.
    doi: 10.2527/jas1988.6661548xpubmed: 2969380google scholar: lookup
  188. Stoneham S, Coles G. Ivermectin resistance in Parascaris equorum.. The Vet Rec 2006;158(16):572.
    doi: 10.1136/vr.158.16.572-bpubmed: 16632539google scholar: lookup
  189. Studzińska MB, Sallé G, Roczeń-Karczmarz M, Szczepaniak K, Demkowska-Kutrzepa M, Tomczuk K. A survey of ivermectin resistance in Parascaris species infected foals in south-eastern Poland.. Acta Vet Scand 2020;62(1):28.
    doi: 10.1186/s13028-020-00526-2pmc: PMC7275302pubmed: 32503589google scholar: lookup
  190. Sutherland IA, Leathwick DM. Anthelmintic resistance in nematode parasites of cattle: a global issue?. Trends Parasitol 2011;27(4):176–181.
    doi: 10.1016/j.pt.2010.11.008pubmed: 21168366google scholar: lookup
  191. Takiguchi Y, Mishima H, Okuda M, Terao M, Aoki A, Fukuda R. Milbemycins, a new family of macrolide antibiotcs: fermentation, isolation, and physico-chemical properties.. J Antibiot 1980;33(10):1120–1127.
    doi: 10.7164/antibiotics.33.1120pubmed: 7451362google scholar: lookup
  192. Tatz AJ, Segev G, Steinman A, Berlin D, Milgram J, Kelmer G. Surgical treatment for acute small intestinal obstruction caused by Parascaris equorum infection in 15 horses (2002–2011). Equine Vet J Suppl 2012;43:111–114.
    doi: 10.1111/j.2042-3306.2012.00607.xpubmed: 23447889google scholar: lookup
  193. Tchou S. Une nouvelle race chinoise d’Ascaris megalocephala (type trivalens). Comptes Rendus De L’académie Des Sciences 1937;204:1676–1677.
  194. Thapa S, Hinrichsen LK, Brenninkmeyer C, Gunnarsson S, Heerkens JL, Verwer C, Niebuhr K, Willet A, Grilli G, Thamsborg SM, Sørensen JT. Prevalence and magnitude of helminth infections in organic laying hens (Gallus gallus domesticus) across Europe.. Vet Parasitol 2015;214(1–2):118–125.
    doi: 10.1016/j.vetpar.2015.10.009pubmed: 26518645google scholar: lookup
  195. Thompson RC, Roberts MG. Does pet helminth prophylaxis increase the rate of selection for drug resistance?. Trends Parasitol 2001;17(12):576–578.
    doi: 10.1016/S1471-4922(01)02084-0pubmed: 11756040google scholar: lookup
  196. Tinkler SH. Preventive chemotherapy and anthelmintic resistance of soil-transmitted helminths - can we learn nothing from veterinary medicine?. One Health 2020;9:100106.
    doi: 10.1016/j.onehlt.2019.100106pmc: PMC6957790pubmed: 31956691google scholar: lookup
  197. Townsend LB, Wise DS. The synthesis and chemistry of certain anthelmintic benzimidazoles.. Parasitol Today 1990;6(4):107–112.
    doi: 10.1016/0169-4758(90)90226-Tpubmed: 15463311google scholar: lookup
  198. Trailovic SM, Rajkovic M, Marjanovic DS, Neveu C, Charvet CL. Action of carvacrol on Parascaris sp. and antagonistic effect on nicotinic acetylcholine receptors.. Pharmaceuticals 2021;14(6):505.
    pmc: PMC8226574pubmed: 34073197
  199. Tydén E, Engström A, Morrison DA, Höglund J. Sequencing of the β-tubulin genes in the ascarid nematodes Parascaris equorum and Ascaridia galli.. Mol Biochem 2013;190(1):38–43.
    pubmed: 23685342
  200. Tydén E, Morrison DA, Engström A, Nielsen MK, Edal M, Höglund J. Population genetics of Parascaris equorum based on DNA fingerprinting.. Infect Genet Evol 2013;13:236–241.
    doi: 10.1016/j.meegid.2012.09.022pubmed: 23168211google scholar: lookup
  201. Tydén E, Dahlberg J, Karlberg O, Höglund J. Deep amplicon sequencing of preselected isolates of Parascaris equorum in β-tubulin codons associated with benzimidazole resistance in other nematodes.. Parasit Vectors 2014;7:410.
    doi: 10.1186/1756-3305-7-410pmc: PMC4156605pubmed: 25175357google scholar: lookup
  202. Tydén E, Skarin M, Andersson-Franko M, Sjöblom M, Höglund J. Differential expression of β-tubulin isotypes in different life stages of Parascaris spp after exposure to thiabendazole.. Mol Biochem Parasitol 2016;205(1–2):22–28.
    doi: 10.1016/j.molbiopara.2016.02.004pubmed: 26880419google scholar: lookup
  203. Urban Jr JF, Nielsen MK, Gazzola D, Xie Y, Beshah E, Hu Y, Li H, Rus F, Flanagan K, Draper A, Vakalapudi S, Li RW, Ostroff GR, Aroian RV. An inactivated bacterium (paraprobiotic) expressing Bacillus thuringiensis Cry5B as a therapeutic for Ascaris and Parascaris spp. infections in large animals.. One Health 2021;12:100241.
    pmc: PMC8048022pubmed: 33889707
  204. van Beneden E. Recherches sur la Maturation de L’Oeuf, la Fécondation et la Division Cellulaire.. 1883.
  205. van Loon JPAM, Visser EMS, de Mik-van MM, Kerbert P, Huppes T, Menke ES. Colic surgery in horses: a retrospective study into short- and long-term survival rate, complications and rehabilitation toward sporting activity.. J Equine Vet Sci 2020;90:103012.
    doi: 10.1016/j.jevs.2020.103012pubmed: 32534778google scholar: lookup
  206. van Wyk JA, Malan FS, Gerber HM, Alves RM. Two field strains of Haemonchus contortus resistant to rafoxanide.. Onderstepoort J Vet Res 1987;54(2):143–146.
    pubmed: 3306550
  207. Vercruysse J, Harrids EA, Kaboret Y, Pangui LJ, Gibson DI. Gastrointestinal helminths of donkeys in Burkina Faso.. Z Parasitenkd 1986;72:821–825.
    doi: 10.1007/BF00925102pubmed: 3799012google scholar: lookup
  208. Vercruysse J, Albonico M, Behnke JM, Kotze AC, Prichard RK, McCarthy JS, Montresor A, Levecke B. Is anthelmintic resistance a concern for the control of human soil-transmitted helminths?. Int J Parasitol Drugs Drug Resist 2011;1(1):14–27.
    doi: 10.1016/j.ijpddr.2011.09.002pmc: PMC3913213pubmed: 24533260google scholar: lookup
  209. Veronesi F, Moretta I, Moretti A, Fioretti DP, Genchi C. Field effectiveness of pyrantel and failure of Parascaris equorum egg count reduction following ivermectin treatment in Italian horse farms.. Vet Parasitol 2009;161(1–2):138–141.
    doi: 10.1016/j.vetpar.2009.01.004pubmed: 19201100google scholar: lookup
  210. Veronesi F, Fioretti DP, Genchi C. Are macrocyclic lactones useful drugs for the treatment of Parascaris equorum infections in foals?. Vet Parasitol 2010;172(1–2):164–167.
    doi: 10.1016/j.vetpar.2010.04.019pubmed: 20471177google scholar: lookup
  211. Volk N, Tormey L. Not just globetrotters: zoonotic transmission of Ascaris suum in Vermont.. Am J Gastroenterol 2017;112:S1373.
    doi: 10.14309/00000434-201710001-02519google scholar: lookup
  212. von Samson-Himmelstjerna G. Anthelmintic resistance in equine parasites – detection, potential clinical relevance and implications for control.. Vet Parasitol 2012;185(1):2–8.
    doi: 10.1016/j.vetpar.2011.10.010pubmed: 22100141google scholar: lookup
  213. von Samson-Himmelstjerna G, Buschbaum S, Wirtherle N, Pape M, Schnieder T. TaqMan minor groove binder real-time PCR analysis of β-tubulin codon 200 polymorphism in small strongyles (Cyathostomin) indicates that the TAC allele is only moderately selected in benzimidazole-resistant populations.. Parasitology 2003;127(Pt 5):489–496.
    doi: 10.1017/S0031182003003974pubmed: 14653538google scholar: lookup
  214. von Samson-Himmelstjerna G, Blackhall WJ, McCarthy JS, Skuce PJ. Single nucleotide polymorphism (SNP) markers for benzimidazole resistance in veterinary nematodes.. Parasitology 2007;134(Pt 8):1077–1086.
    doi: 10.1017/S0031182007000054pubmed: 17608967google scholar: lookup
  215. von Samson-Himmelstjerna G, Fritzen B, Demeler J, Schurmann S, Rohn K, Schnieder T, Epe C. Cases of reduced cyathostomin egg-reappearance period and failure of Parascaris equorum egg count reduction following ivermectin treatment as well as survey on pyrantel efficacy on German horse farms.. Vet Parasitol 2007;144(1–2):74–80.
    doi: 10.1016/j.vetpar.2006.09.036pubmed: 17112667google scholar: lookup
  216. von Samson-Himmelstjerna G, Janssen IJI, Ramünke S, Goday C, Borges FA, Koudela B, Niedźwiedź A, Tomczuk K, Studzińska B, Kornas S, Krücken J. Very low intraspecific sequence variation in selected nuclear and mitochondrial Parascaris univalens genes.. Infect Genet Evol 2021;95:105035.
    doi: 10.1016/j.meegid.2021.105035pubmed: 34384934google scholar: lookup
  217. von Samson-Himmelstjerna G, Thompson RCA, Krücken J, Grant W, Bowman DD, Schnyder M, Deplazes P. Spread of anthelmintic resistance in intestinal helminths of dogs and cats is currently less pronounced than in ruminants and horses – yet it is of major concern.. Int J Parasitol Drugs Drug Resist 2021;17:36–45.
    doi: 10.1016/j.ijpddr.2021.07.003pmc: PMC8347694pubmed: 34343829google scholar: lookup
  218. Wang J. Genomics of the parasitic nematode Ascaris and its relatives.. Genes 2021;12(4):493.
    doi: 10.3390/genes12040493pmc: PMC8065839pubmed: 33800545google scholar: lookup
  219. Wang J, Davis RE. Programmed DNA elimination in multicellular organisms.. Curr Op Genet Dev 2014;27:26–34.
    doi: 10.1016/j.gde.2014.03.012pmc: PMC4125452pubmed: 24886889google scholar: lookup
  220. Wang J, Gao S, Mostovoy Y, Kang Y, Zagoskin M, Sun Y, Zhang B, White LK, Easton A, Nutman TB, Kwok PY, Hu S, Nielsen MK, Davis DE. Comparative genome analysis of programmed DNA elimination in nematodes.. Genome Res 2017;27(12):2001–2014.
    doi: 10.1101/gr.225730.117pmc: PMC5741062pubmed: 29118011google scholar: lookup
  221. Wells MM. Ascaris megalocephala.. 1924.
  222. Whittaker JH, Carlson SA, Jones DE, Brewer MT. Molecular mechanisms for anthelmintic resistance in strongyle nematode parasites of veterinary importance.. J Vet Pharmacol Ther 2017;40(2):105–115.
    doi: 10.1111/jvp.12330pubmed: 27302747google scholar: lookup
  223. Wilkes EJA, McConaghy FF, Thompson RL, Dawson K, Sangster NC, Hughes KJ. Efficacy of a morantel–abamectin combination for the treatment of resistant ascarids in foals.. Aust Vet J 2017;95(3):85–88.
    doi: 10.1111/avj.12559pubmed: 28239856google scholar: lookup
  224. Wolstenholme AJ. Glutamate-gated chloride channels.. J Biol Chem 2012;287(48):40232–40238.
    doi: 10.1074/jbc.R112.406280pmc: PMC3504739pubmed: 23038250google scholar: lookup
  225. Xinou E, Lefkoupoulos A, Gelagoti M, Drevelegas A, Diakou A, Milonas I, Dimitriadis AS. CT and MR imaging findings in cerebral toxocaral disease.. ANJR Am J Neuroradiol 2003;24(4):714–718.
    pmc: PMC8148679pubmed: 12695211
  226. Xu M, Molento M, Blackhall W, Ribeiro P, Beech R, Prichard R. Ivermectin resistance in nematodes may be cause by alteration of P-glycoprotein homolog.. Mol Biochem Parasitol 1998;91(2):327–335.
    doi: 10.1016/S0166-6851(97)00215-6pubmed: 9566525google scholar: lookup
  227. Xu MJ, Fu JH, Nisbet AJ, Huang SY, Zhou DH, Lin RQ, Song HQ, Zhu XQ. Comparative profiling of microRNAs in male and female adults of Ascaris suum.. Parasitol Res 2013;112(3):1189–1195.
    doi: 10.1007/s00436-012-3250-xpubmed: 23306386google scholar: lookup
  228. Yazwinksi TA, Tucker CA, Wray E, Jones L, Clark FD. Observations of benzimidazole efficacies against Ascaridia dissimilus, Ascaridia galli, and Heterakis gallinarum in naturally infected poultry.. J Appl Poult Res 2013;22(1):75–79.
    doi: 10.3382/japr.2012-00606google scholar: lookup
  229. Yoshihara S, Nakagawa M, Suda H, Ikeda K, Hanashiro K. White spots of the liver in pigs experimentally infected with Ascaris suum.. Natl Inst Anim Health Q 1983;23(4):127–137.
    pubmed: 6680775
  230. Zakeri A, Whitehead BJ, Stensballe A, de Korne C, Williams AR, Everts B, Nejsum P. Parasite worm antigens instruct macrophages to release immunoregulatory extracellular vesicles.. J Extracell Vesicles 2021;10(10):e12131.
    doi: 10.1002/jev2.12131pmc: PMC8365858pubmed: 34429858google scholar: lookup
  231. Zibaei M, Sadjjadi SM, Jahadi-Hosseini SH. Toxocara cati larvae in the eye of a child: a case report.. Asian Pac J Trop Biomed 2014;4(Suppl 1):S53–S55.
    doi: 10.12980/APJTB.4.2014C1281pmc: PMC4025287pubmed: 25183145google scholar: lookup
  232. Zuccherato LW, Furtado LF, Medeiros CdS, Pinheiro CdS, Rabelo ÉM. PCR-RFLP screening of polymorphisms associated with benzimidazole resistance in Necator americanus and Ascaris lumbricoides from different geographical regions in Brazil.. PLoS Negl Trop Dis 2018;12(9):e0006766.
    doi: 10.1371/journal.pntd.0006766pmc: PMC6141064pubmed: 30222749google scholar: lookup
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