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Frontiers in veterinary science2018; 5; 178; doi: 10.3389/fvets.2018.00178

The Importance of Subchondral Bone in the Pathophysiology of Osteoarthritis.

Abstract: Subchondral bone plays a critical role in the pathogenesis of osteochondral disease across veterinary species. The subchondral bone is highly adaptable, with the ability to model and remodel in response to loading stresses experienced by the joint. Repetitive stress injuries within the joint can result in primary or secondary pathologic lesions within the subchondral bone, which have been recognized to contribute to the development and progression of osteoarthritis. Recent advances in diagnostic imaging, particularly volumetric imaging modalities have facilitated earlier identification of subchondral bone disease. Despite these advancements, limitations in our knowledge about subchondral bone makes treatment and prevention of these conditions challenging. The purpose of this report is to review our current understanding of subchondral bone and its relationship to osteoarthritis across veterinary species, with a specific focus in the research that has been performed in horses. It can be concluded that our current understanding of subchondral bone is advancing, and future experimental, clinical and pathologic studies will provide additional insight about subchondral bone and its relationship to joint disease.
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Publication Date: 2018-08-28 PubMed ID: 30211173PubMed Central: PMC6122109DOI: 10.3389/fvets.2018.00178Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research paper examines the significant role played by subchondral bone in the development and progression of osteoarthritis, a common joint disease, in different animal species. The study particularly focuses on horses and the advances in understanding its condition through improved diagnostic imaging and existing challenges to pave the way for future studies.

Subchondral Bone and Its Role in Osteoarthritis

  • The paper recognizes the subchondral bone as critical in the pathogenesis of osteochondral diseases among various animal species, including horses. This bone is highly adaptable and able to adjust its structure in response to the stresses placed upon the joint.
  • Continuous stress injuries within the joint can lead to primary or secondary pathologic lesions within the subchondral bone, contributing significantly to the onset and progression of osteoarthritis, which is a degenerative joint disease.

Diagnostic Imaging Advances and Challenges

  • Advancements in diagnostic imaging, especially the use of volumetric imaging modalities, have made it easier to detect subchondral bone diseases earlier. This has greatly improved the chances of successful treatment and disease management.
  • Despite these advances, the paper highlights some limitations in our understanding of subchondral bone. These challenges make it harder to devise effective treatment and preventive measures against these conditions.

Focus on Horses and Future Studies

  • The report has a specific focus on research that has been conducted on horses. This focus is aimed at enhancing our comprehension of the subchondral bone in these animals, and about how this knowledge can be applied to improve the prevention and treatment of osteoarthritis in them.
  • The paper concludes by stating that our understanding of the subchondral bone is improving. However, it proposes that more experimental, clinical and pathologic studies will need to be conducted to expand upon this understanding and to better understand the relationship between the subchondral bone and joint diseases.

Cite This Article

APA
Stewart HL, Kawcak CE. (2018). The Importance of Subchondral Bone in the Pathophysiology of Osteoarthritis. Front Vet Sci, 5, 178. https://doi.org/10.3389/fvets.2018.00178

Publication

Frontiers in veterinary science
ISSN: 2297-1769
NlmUniqueID: 101666658
Country: Switzerland
Language: English
Volume: 5
Pages: 178

Researcher Affiliations

Stewart, Holly L
  • Equine Orthopaedic Research Center, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.
Kawcak, Christopher E
  • Equine Orthopaedic Research Center, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.

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This article has been cited 63 times.
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