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Animals : an open access journal from MDPI2024; 14(14); 2062; doi: 10.3390/ani14142062

The Most Common Environmental Risk Factors for Equine Asthma-A Narrative Review.

Abstract: Equine asthma is a popular subject of research. Many factors influencing the methods used to improve the welfare of asthmatic horses remain unclear. This study reviews scientific articles published after 2000 to collect the most important information on the terminology, symptoms, and potential environmental factors influencing the development and course of equine asthma. Our work highlights the impact of environmental factors on the severity of equine asthma and why these factors should be controlled to improve treatment outcomes. The present article provides horse owners and veterinarians with valuable information on how to improve the well-being of horses that are at risk of developing asthma symptoms.
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Publication Date: 2024-07-14 PubMed ID: 39061524PubMed Central: PMC11273653DOI: 10.3390/ani14142062Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article reviews recent scientific literature to better understand environmental risk factors for equine asthma. It aims to provide useful insight for improving the welfare of horses at risk of this condition.

Overview of the Research Study

  • The authors of the study embark on a review of literature to examine the environmental risk factors influencing equine asthma. The research specifically focuses on peer-reviewed scientific articles published past the year 2000.
  • The study is aimed towards stakeholders in the horse industry, especially horse owners and veterinarians, providing them with crucial insights that can be put to practice for their horses’ health and welfare.

Challenges in Equine Asthma Research

  • Equine asthma is a prevalent subject of research, yet significant aspects of the condition remain under-examined.
  • The current understanding of various elements such as disease terminology, symptoms exhibited by affected horses, and environmental factors affecting the onset and progression of asthma is lacking in clarity.
  • The absence of comprehensive knowledge on these components can hinder the effectiveness of attempts aimed at ameliorating the condition in horses and improving their quality of life.

The Significance of Environmental Factors

  • This research highlights the impact of environmental elements on exacerbating equine asthma. It underscores that control over these factors is crucial for effective treatment and positive outcomes.
  • These factors are significant not just in the causation but additionally influence the severity of the asthma episode and the trajectory of the disease.

Implications of the Study

  • The findings of this review article will equip horse owners and veterinarians with valuable information to bolster the well-being of their horses.
  • By controlling or modifying the particular environmental factors identified in the study, it might be possible to mitigate the risk of horses developing asthma or help manage the symptoms more effectively in those that already suffer from the condition.

Cite This Article

APA
Mańkowska A, Witkowska D. (2024). The Most Common Environmental Risk Factors for Equine Asthma-A Narrative Review. Animals (Basel), 14(14), 2062. https://doi.org/10.3390/ani14142062

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 14
Issue: 14
PII: 2062

Researcher Affiliations

Mańkowska, Anna
  • Department of Animal Welfare and Research, Faculty of Animal Bioengineering, University of Warmia and Mazury, 10-719 Olsztyn, Poland.
Witkowska, Dorota
  • Department of Animal Welfare and Research, Faculty of Animal Bioengineering, University of Warmia and Mazury, 10-719 Olsztyn, Poland.

Conflict of Interest Statement

The authors declare no conflicts of interest.

References

This article includes 144 references
  1. Sheats M.K., Davis K.U., Poole J.A.. Comparative review of asthma in farmers and horses. Curr. Allergy Asthma. Rep. 2019;19:50.
    doi: 10.1007/s11882-019-0882-2pmc: PMC9116535pubmed: 31599358google scholar: lookup
  2. Kozłowska N., Wierzbicka M., Pawliński B., Domino M.. Co-Occurrence of Severe Equine Asthma and Palatal Disorders in Privately Owned Pleasure Horses. Animals 2023;13:1962.
    doi: 10.3390/ani13121962pmc: PMC10295701pubmed: 37370472google scholar: lookup
  3. Lange-Consiglio A., Stucchi L., Zucca E., Lavoie J.P., Cremonesi F., Ferrucci F.. Insights into animal models for cell-based therapies in translational studies of lung diseases: Is the horse with naturally occurring asthma the right choice?. Cytotherapy 2019;21:525–534.
    doi: 10.1016/j.jcyt.2019.02.010pubmed: 30929991google scholar: lookup
  4. Ivester K.M., Couëtil L.L., Moore G.E.. An observational study of environmental exposures, airway cytology, and performance in racing thoroughbreds. J. Vet. Intern. Med. 2018;32:1754–1762.
    doi: 10.1111/jvim.15226pmc: PMC6189343pubmed: 30222207google scholar: lookup
  5. White S.J., Moore-Colyer M., Marti E., Hannant D., Gerber V., Coüetil L., Richard E.A., Alcocer M.. Antigen array for serological diagnosis and novel allergen identification in severe equine asthma. Sci. Rep. 2019;9:15170.
    doi: 10.1038/s41598-019-51820-7pmc: PMC6811683pubmed: 31645629google scholar: lookup
  6. Bond S.L., Léguillette R., Richard E.A., Couetil L., Lavoie J.P., Martin J.G., Pirie R.S.. Equine asthma: Integrative biologic relevance of a recently proposed nomenclature. J. Vet. Intern. Med. 2018;32:2088–2098.
    doi: 10.1111/jvim.15302pmc: PMC6271326pubmed: 30294851google scholar: lookup
  7. Bond S.L., Timsit E., Workentine M., Alexander T., Léguillette R.. Upper and lower respiratory tract microbiota in horses: Bacterial communities associated with health and mild asthma (inflammatory airway disease) and effects of dexamethasone. BMC Microbiol. 2017;17:184.
    doi: 10.1186/s12866-017-1092-5pmc: PMC5569571pubmed: 28835202google scholar: lookup
  8. Ceriotti S., Bullone M., Leclere M., Ferrucci F., Lavoie J.P.. Severe asthma is associated with a remodeling of the pulmonary arteries in horses. PLoS ONE 2020;15:e0239561.
    doi: 10.1371/journal.pone.0239561pmc: PMC7580920pubmed: 33091038google scholar: lookup
  9. Davis K.U., Sheats M.K.. Bronchoalveolar lavage cytology characteristics and seasonal changes in a herd of pastured teaching horses. Front. Vet. Sci. 2019;6:74.
    doi: 10.3389/fvets.2019.00074pmc: PMC6426765pubmed: 30923711google scholar: lookup
  10. Kinnison T., McGilvray T.A., Couëtil L.L., Smith K.C., Wylie C.E., Bacigalupo S.A., Gomez-Grau E., Cardwell J.M.. Mild-moderate equine asthma: A scoping review of evidence supporting the consensus definition. Vet. J. 2022;286:105865.
    doi: 10.1016/j.tvjl.2022.105865pubmed: 35817389google scholar: lookup
  11. Borowska A., Wolska D., Niedzwiedz A., Borowicz H., Jaworski Z., Siemieniuch M., Szwaczkowski T.. Some genetic and environmental effects on equine asthma in polish konik horses. Animals 2021;11:2285.
    doi: 10.3390/ani11082285pmc: PMC8388498pubmed: 34438743google scholar: lookup
  12. Leclere M., Lavoie-Lamoureux A., Lavoie J.P.. Heaves, an asthma-like disease of horses. Respirology 2011;16:1027–1046.
    doi: 10.1111/j.1440-1843.2011.02033.xpubmed: 21824219google scholar: lookup
  13. Couëtil L.L., Ward M.P.. Analysis of risk factors for recurrent airway obstruction in North American horses: 1,444 cases (1990–1999). J. Am. Vet. Med. Assoc. 2003;223:1645–1650.
    doi: 10.2460/javma.2003.223.1645pubmed: 14664454google scholar: lookup
  14. Gerber V., De Feijter-Rupp H., Wagner J., Venta P., Harkema J.R., Robinson N.E.. Differential association of MUC5AC and CLCA1 expression in small cartilaginous airways of RAO-affected and control horses. Equine Vet. J. 2009;41:817–823.
    doi: 10.2746/042516409X443305pubmed: 20095232google scholar: lookup
  15. Gy C., Leclere M., Vargas A., Grimes C., Lavoie J.P.. Investigation of blood biomarkers for the diagnosis of mild to moderate asthma in horses. J. Vet. Intern. Med. 2019;33:1789–1795.
    doi: 10.1111/jvim.15505pmc: PMC6639487pubmed: 31099114google scholar: lookup
  16. Pirie R.S.. Recurrent airway obstruction: A review. Equine Vet. J. 2014;46:276–288.
    doi: 10.1111/evj.12204pubmed: 24164473google scholar: lookup
  17. Simões J., Batista M., Tilley P.. The Immune Mechanisms of Severe Equine Asthma—Current Understanding and What Is Missing. Animals 2022;12:744.
    doi: 10.3390/ani12060744pmc: PMC8944511pubmed: 35327141google scholar: lookup
  18. Costa L.R., Johnson J.R., Baur M.E., Beadle R.E.. Temporal clinical exacerbation of summer pasture-associated recurrent airway obstruction and relationship with climate and aeroallergens in horses. Am. J. Vet. Res. 2006;67:1635–1642.
    doi: 10.2460/ajvr.67.9.1635pubmed: 16948614google scholar: lookup
  19. Bullone M., Murcia R.Y., Lavoie J.P.. Environmental heat and airborne pollen concentration are associated with increased asthma severity in horses. Equine Vet. J. 2016;48:479–484.
    doi: 10.1111/evj.12559pubmed: 26708931google scholar: lookup
  20. Bullone M., Lavoie J.P.. Recurrent Airway Obstruction and Summer Pasture-Associated Obstructive Pulmonary Disease. Equine Clinical. Immunol. 2016:127–144.
    doi: 10.1002/9781119086512.ch16google scholar: lookup
  21. Mair T.S.. Obstructive pulmonary disease in 18 horses at summer pasture. Vet. Rec. 1996;138:89–91.
    doi: 10.1136/vr.138.4.89pubmed: 8650894google scholar: lookup
  22. Eaton S.. Management of equine allergic airway disease: A review of conventional and complementary therapies. Am. J. Trad. Chin. Vet. Med. 2023;18:43–53.
    doi: 10.59565/001c.84481google scholar: lookup
  23. Berndt A., Derksen F.J., Edward Robinson N.. Endotoxin concentrations within the breathing zone of horses are higher in stables than on pasture. Vet. J. 2010;183:54–57.
    doi: 10.1016/j.tvjl.2008.09.001pubmed: 18930664google scholar: lookup
  24. Simões J., Sales Luís J.P., Tilley P.. Owner compliance to an environmental management protocol for severe equine asthma syndrome. J. Equine Vet. Sci. 2020;87:102937.
    doi: 10.1016/j.jevs.2020.102937pubmed: 32172903google scholar: lookup
  25. Bosshard S., Gerber V.. Evaluation of Coughing and Nasal Discharge as Early Indicators for An Increased Risk to Develop Equine Recurrent Airway Obstruction (RAO). JVIM 2014;28:618–623.
    doi: 10.1111/jvim.12279pmc: PMC4858023pubmed: 24417562google scholar: lookup
  26. Gehlen H., Oey L., Rohn K., Bilzer T., Stadler P.. Pulmonary Dysfunction and Skeletal Muscle Changes in Horses with RAO. JVIM 2008;22:1014–1021.
    doi: 10.1111/j.1939-1676.2008.0111.xpubmed: 18498323google scholar: lookup
  27. Herszberg B., Ramos-Barbón D., Tamaoka M., Martin J.G., Lavoie J.P.. Heaves, an asthma-like equine disease, involves airway smooth muscle remodeling. J. Allergy Clin. Immunol. 2006;118:382–388.
    doi: 10.1016/j.jaci.2006.03.044pubmed: 16890762google scholar: lookup
  28. Hotchkiss J.W., Reid S.W.J., Christley R.M.. A survey of horse owners in Great Britain regarding horses in their care. Part 1: Horse demographic characteristics and management. Equine Vet. J. 2007;39:294–300.
    doi: 10.2746/042516407X177538pubmed: 17722719google scholar: lookup
  29. Ramseyer A., Gaillard C., Burger D., Straub R., Jost U., Boog C., Marti E., Gerber V.. Effects of genetic and environmental factors on chronic lower airway disease in horses. J. Vet. Intern. Med. 2007;21:149–156.
    doi: 10.1111/j.1939-1676.2007.tb02941.xpubmed: 17338163google scholar: lookup
  30. Couëtil L.L., Cardwell J.M., Gerber V., Lavoie J.P., Leguillette R., Richard E.A.. Inflammatory airway disease of horses-revised consensus statement. J. Vet. Intern. Med. 2016;30:503–515.
    doi: 10.1111/jvim.13824pmc: PMC4913592pubmed: 26806374google scholar: lookup
  31. Bullone M., Lavoie J.P.. Science-in-brief: Equine asthma diagnosis: Beyond bronchoalveolar lavage cytology. Equine Vet. J. 2017;49:263–265.
    doi: 10.1111/evj.12679pubmed: 28387029google scholar: lookup
  32. Ter Woort F., Caswell J.L., Arroyo L.G., Viel L.. Histologic investigation of airway inflammation in postmortem lung samples from racehorses. Am. J. Vet. Res. 2018;79:342–347.
    doi: 10.2460/ajvr.79.3.342pubmed: 29466041google scholar: lookup
  33. Couëtil L.L., Ivester K., Barnum S., Pusterla N.. Equine respiratory viruses, airway inflammation and performance in thoroughbred racehorses. Vet. Microbiol. 2021;257:109070.
    doi: 10.1016/j.vetmic.2021.109070pubmed: 33865081google scholar: lookup
  34. Stucchi L., Alberti E., Stancari G., Conturba B., Zucca E., Ferrucci F.. The relationship between lung inflammation and aerobic threshold in standardbred racehorses with mild-moderate equine asthma. Animals 2020;10:1278.
    doi: 10.3390/ani10081278pmc: PMC7459439pubmed: 32727062google scholar: lookup
  35. Mellor D.J., Beausoleil N.J.. Equine welfare during exercise: An evaluation of breathing, breathlessness and bridles. Animals 2017;7:41.
    doi: 10.3390/ani7060041pmc: PMC5483604pubmed: 28587125google scholar: lookup
  36. Morini M., Gobbo F., Rinnovati R., Romagnoli N., Peli A., Massarenti C., Spadari A., Pietra M.. Bronchoalveolar Lavage Cytology in Severe Equine Asthma: Cytocentrifugated versus Sediment Smear Preparations. Vet. Sci. 2023;10:527.
    doi: 10.3390/vetsci10080527pmc: PMC10459724pubmed: 37624314google scholar: lookup
  37. Karagianni A.E., Eaton S.L., Kurian D., Cillán-Garcia E., Twynam-Perkins J., Raper A., Wishart T.M., Pirie S.R.. Application across species of a one health approach to liquid sample handling for respiratory based -omics analysis. Sci. Rep. 2021;11:14292.
    doi: 10.1038/s41598-021-93839-9pmc: PMC8275668pubmed: 34253818google scholar: lookup
  38. Kozłowska N., Wierzbicka M., Jasiński T., Domino M.. Advances in the Diagnosis of Equine Respiratory Diseases: A Review of Novel Imaging and Functional Techniques. Animals 2022;12:381.
    doi: 10.3390/ani12030381pmc: PMC8833607pubmed: 35158704google scholar: lookup
  39. Lascola K.M., Joslyn S.. Diagnostic imaging of the lower respiratory tract in neonatal foals: Radiography and computed Tomography. Vet. Clin. N. Am. Equine Pract. 2015;31:497–514.
    doi: 10.1016/j.cveq.2015.08.003pubmed: 26612745google scholar: lookup
  40. Smith S.. Interpretation of tracheal wash samples in horses. Practice 2019;41:220–226.
    doi: 10.1136/inp.12075google scholar: lookup
  41. Rossi H., Virtala A.M., Raekallio M., Rahkonen E., Rajamaki M.M., Mykkanen A.. Comparison of tracheal wash and bronchoalveolar lavage cytology in 154 horses with and without respiratory signs in a referral hospital over 2009–2015. Front. Vet. Sci. 2018;5:61.
    doi: 10.3389/fvets.2018.00061pmc: PMC5879091pubmed: 29632867google scholar: lookup
  42. Mahalingam-Dhingra A., Bedenice D., Mazan M.R.. Bronchoalveolar lavage hemosiderosis in lightly active or sedentary horses. J. Vet. Intern. Med. 2023;37:1243–1249.
    doi: 10.1111/jvim.16692pmc: PMC10229344pubmed: 36975043google scholar: lookup
  43. Lo Feudo C.M., Stucchi L., Alberti E., Stancari G., Conturba B., Zucca E., Ferrucci F.. The role of thoracic ultrasonography and airway endoscopy in the diagnosis of equine asthma and exercise-induced pulmonary hemorrhage. Vet. Sci. 2021;8:276.
    doi: 10.3390/vetsci8110276pmc: PMC8619806pubmed: 34822649google scholar: lookup
  44. Bullone M., Lavoie J.P.. The equine asthma model of airway remodeling: From a veterinary to a human perspective. Cell Tissue Res. 2020;380:223–236.
    doi: 10.1007/s00441-019-03117-4pubmed: 31713728google scholar: lookup
  45. . Diagnosis of Mild to Moderate Equine Asthma in Australian Horses: Investigation of the Diagnostic Confirmatory Tests of Bronchoalveolar Lavage Cytology and Pulmonary Function Testing. .
  46. Słowikowska M., Bajzert J., Miller J., Stefaniak T., Niedzwiedz A.. The dynamics of circulating immune complexes in horses with severe equine asthma. Animals 2021;11:1001.
    doi: 10.3390/ani11041001pmc: PMC8066133pubmed: 33918401google scholar: lookup
  47. Simões J., Luís J.S., Tilley P.. Contribution of lung function tests to the staging of severe equine asthma syndrome in the field. Res. Vet. Sci. 2019;123:112–117.
    doi: 10.1016/j.rvsc.2018.12.014pubmed: 30616173google scholar: lookup
  48. Decloedt A., Borowicz H., Slowikowska M., Chiers K., van Loon G., Niedzwiedz A.. Right ventricular function during acute exacerbation of severe equine asthma. Equine Vet. J. 2017;49:603–608.
    doi: 10.1111/evj.12675pubmed: 28132404google scholar: lookup
  49. Laumen E., Doherr M.G., Gerber V.. Relationship of horse owner assessed respiratory signs index to characteristics of recurrent airway obstruction in two Warmblood families. Equine Vet. J. 2010;42:142–148.
    doi: 10.2746/042516409X479586pubmed: 20156250google scholar: lookup
  50. Gressler A.E., Lübke S., Wagner B., Arnold C., Lohmann K.L., Schnabel C.L.. Comprehensive Flow Cytometric Characterization of Bronchoalveolar Lavage Cells Indicates Comparable Phenotypes between Asthmatic and Healthy Horses But Functional Lymphocyte Differences. Front. Immunol. 2022;13:896255.
    doi: 10.3389/fimmu.2022.896255pmc: PMC9296846pubmed: 35874777google scholar: lookup
  51. Wyler M., Sage S.E., Marti E., White S., Gerber V.. Protein microarray allergen profiling in bronchoalveolar lavage fluid and serum of horses with asthma. J. Vet. Intern. Med. 2023;37:328–337.
    doi: 10.1111/jvim.16600pmc: PMC9889601pubmed: 36479920google scholar: lookup
  52. Sperl C., Gerber V., Drießlein D., Klima A., Becher A.M.. Are respiratory clinical signs in horses associated with Strongyle egg shedding rates on farmfs with varying egg shedding levels?. J. Equine Vet. Sci. 2019;75:104–111.
    doi: 10.1016/j.jevs.2019.01.006pubmed: 31002083google scholar: lookup
  53. Herteman N., Mosing M., Waldmann A.D., Gerber V., Schoster A.. Exercise-induced airflow changes in horses with asthma measured by electrical impedance tomography. J. Vet. Intern. Med. 2021;35:2500–2510.
    doi: 10.1111/jvim.16260pmc: PMC8478024pubmed: 34505734google scholar: lookup
  54. . The Effect of Different Bedding Materials Used in Stable on Elected Equine Welfare Indicators. .
  55. Bright L.A., Dittmar W., Nanduri B., McCarthy F.M., Mujahid N., Costa L.R.R., Burgess S.C., Swiderski C.E.. Modeling the pasture-associated severe equine asthma bronchoalveolar lavage fluid proteome identifies molecular events mediating neutrophilic airway inflammation. Vet. Med. 2019;10:43–63.
    doi: 10.2147/VMRR.S194427pmc: PMC6504673pubmed: 31119093google scholar: lookup
  56. Swiderski C.E., Hunter C.L., Bowser J.E., Costa L.R., Cooley A.J., Claude A., Eddy A.L., Bright L.A.. Deciphering the Role of Bronchial Hyper-Responsiveness in Equine Pasture Asthma. JEVS 2017;52:29–35.
    doi: 10.1016/j.jevs.2017.03.219google scholar: lookup
  57. Secombe C.J., Lester G.D., Robertson I.D., Cullimore A.M.. Retrospective survey of bronchoalveolar lavage fluid cytology in Western Australian horses presented for evaluation of the respiratory tract: Effect of season on relative cell percentages. Aust. Vet. J. 2015;93:152156.
    doi: 10.1111/avj.12315pubmed: 25939261google scholar: lookup
  58. Davis M.S., Malayer J.R., Vandeventer L., Royer C.M., McKenzie E.C., Williamson K.K.. Cold weather exercise and airway cytokine expression. J. Appl. Physiol. 2005;98:2132–2136.
    doi: 10.1152/japplphysiol.01218.2004pubmed: 15705724google scholar: lookup
  59. Hansen S., Honoré M.L., Riihimaki M., Pringle J., Ammentorp A.H., Fjeldborg J.. Seasonal Variation in Tracheal Mucous and Bronchoalveolar Lavage Cytology for Adult Clinically Healthy Stabled Horses. JEVS 2018;71:1–5.
    doi: 10.1016/j.jevs.2018.09.001google scholar: lookup
  60. Pirie R.S., Collie D.D., Dixon P.M., McGorum B.C.. Evaluation of nebulised hay dust suspensions (HDS) for the diagnosis and investigation of heaves. 2: Effects of inhaled HDS on control and heaves horses. Equine Vet. J. 2002;34:337–342.
    doi: 10.2746/042516402776249074pubmed: 12117104google scholar: lookup
  61. Ward M.P., Couetil L.L.. Climatic and aeroallergen risk factors for chronic obstructive pulmonary disease in horses. Am. J. Vet. Res. 2005;66:818–824.
    doi: 10.2460/ajvr.2005.66.818pubmed: 15934609google scholar: lookup
  62. Araneda O.F., Cavada G.. Atmospheric Pollutants Affect Physical Performance: A Natural Experiment in Horse Racing Studied by Principal Component Analysis. Biology 2022;11:687.
    doi: 10.3390/biology11050687pmc: PMC9138079pubmed: 35625415google scholar: lookup
  63. Zhou W., Chen C., Lei L., Fu P., Sun Y.. Temporal variations and spatial distributions of gaseous and particulate air pollutants and their health risks during 2015–2019 in China. Environ. Pollut. 2021;272:116031.
    doi: 10.1016/j.envpol.2020.116031pubmed: 33261960google scholar: lookup
  64. Fleming K., Hessel E.F., Van den Weghe H.F.A.. Generation of airborne particles from different bedding materials used for horse keeping. JEVS 2008;28:408–418.
    doi: 10.1016/j.jevs.2008.05.004google scholar: lookup
  65. Kwiatkowska-Stenzel A., Sowińska J., Witkowska D.. Analysis of noxious gas pollution in horse stable air. JEVS 2014;34:249–256.
    doi: 10.1016/j.jevs.2013.05.006google scholar: lookup
  66. Tainio M., Jovanovic Andersen Z., Nieuwenhuijsen M.J., Hu L., de Nazelle A., An R., Garcia L.M.T., Goenka S., Zapata-Diomedi B., Bull F.. Air pollution, physical activity and health: A mapping review of the evidence. Environ. Int. 2021;147:105954.
    doi: 10.1016/j.envint.2020.105954pmc: PMC7816214pubmed: 33352412google scholar: lookup
  67. Daigle C.C., Chalupa D.C., Gibb F.R., Morrow P.E., Oberdörster G., Utell M.J., Frampton M.W.. Ultrafine Particle Deposition in Humans during Rest and Exercise. Inhal. Toxicol. 2003;15:539–552.
    doi: 10.1080/08958370304468pubmed: 12692730google scholar: lookup
  68. Witkowska D., Sowinska J.. Identification of microbial and gaseous contaminants in poultry farms and developing methods for contamination prevention at the source. .
  69. Lawrence L., Bicudo J.R., Wheeler E.. Horse manure characteristics literature and data base review. .
  70. Hesterberg T.W., Bunn W.B., McClellan R.O., Hamade A.K., Long C.M., Valberg P.A.. Critical review of the human data on short-term nitrogen dioxide (NO2) exposures: Evidence for NO2 no-effect levels. Crit. Rev. Toxicol. 2009;39:743–781.
    doi: 10.3109/10408440903294945pubmed: 19852560google scholar: lookup
  71. Piantadosi C.A.. Carbon monoxide poisoning. N. Engl. J. Med. 2002;347:1054–1055.
    doi: 10.1056/NEJMp020104pubmed: 12362005google scholar: lookup
  72. Lippi G., Rastelli G., Meschi T., Borghi L., Cervellin G.. Pathophysiology, clinics, diagnosis and treatment of heart involvement in carbon monoxide poisoning. Clin. Biochem. 2012;45:1278–1285.
    doi: 10.1016/j.clinbiochem.2012.06.004pubmed: 22705450google scholar: lookup
  73. Lu X., Li R., Yan X.. Airway hyperresponsiveness development and the toxicity of PM2.5. Environ. Sci. Pollut. Res. Int. 2021;28:6374–6391.
    doi: 10.1007/s11356-020-12051-wpubmed: 33394441google scholar: lookup
  74. Hernandez J., Hawkins D.L.. Race-start characteristics and risk of catastrophic musculoskeletal injury in Thoroughbred racehorses. J. Am. Vet. Med. Assoc. 2001;218:83–86.
    doi: 10.2460/javma.2001.218.83pubmed: 11149721google scholar: lookup
  75. Elfman L., Riihimäki M., Pringle J., Wålinder R.. Influence of horse stable environment on human airways. J. Occup. Med. Toxicol. 2009;4:10–16.
    doi: 10.1186/1745-6673-4-10pmc: PMC2693518pubmed: 19467158google scholar: lookup
  76. Seedorf J., Schröder M., Kohler L., Hartung L.. Sustability of biocompost as bedding material for stabled horses: Respiratory hygiene and management practicalities. Equine Vet. J. 2007;39:129–135.
    doi: 10.2746/042516407X170085pubmed: 17378441google scholar: lookup
  77. Fleming K., Hessel E.F., Van den Weghe H.. Evaluation of factor influencing the generation of ammonia in different bedding materials used for horse keeping. J. Equine Vet. Sci. 2008;28:223–231.
    doi: 10.1016/j.jevs.2008.02.008google scholar: lookup
  78. Elfman L., Wålinder R., Riihimäki M., Pringle J.. Air Quality in Horse Stables. .
    doi: 10.5772/18228google scholar: lookup
  79. Samadi S., Wouters I.M., Wouters I., Houben R., Jamshidifard A., Eerdenburg F., Heederik D.J.J.. Exposure to inhalable dust, endotoxins, beta(1-3)-glucans, and airborne microorganisms in horse stables. Ann. Occup. Hyg. 2009;53:595–603.
    doi: 10.1093/annhyg/mep040pubmed: 19561032google scholar: lookup
  80. Wickens C., Weir J., Li H.. Strategies for Reducing Ammonia in Horse Barns. South. Equine Consort. 2016;1:1–2.
  81. Saastamoinen M., Särkijärvi S., Hyyppä S.. Reducing respiratory health risks to horses and workers: A comparison of two stall bedding materials. Animals 2015;5:965–977.
    doi: 10.3390/ani5040394pmc: PMC4693198pubmed: 26479479google scholar: lookup
  82. Witkowska D., Kwiatkowska-Stenzel A., Jóźwiak A., Chorąży Ł., Wójcik A.. Microbiological Contamination of Air Inside and Around Stables during Different Seasons of the Year. Pol. J. Environ. Stud. 2012;21:1061–1066.
  83. Dutkiewicz J., Pomorski Z.J.H., Sitkowska J., Krysińska-Traczyk E., Skórska C., Prażmo Z., Cholewa G., Wójtowicz H.. Airborne microorganisms and endotoxin in animal houses. Grana 1994;33:85–90.
    doi: 10.1080/00173139409427837google scholar: lookup
  84. Nardoni S., Mancianti F., Sgorbini M., Taccini F., Corazza M.. Identification and seasonal distribution of airborne fungi in three horse stables in Italy. Mycopathologia 2005;160:29–34.
    doi: 10.1007/s11046-005-2669-3pubmed: 16160766google scholar: lookup
  85. Wolny-Koładka K.. Microbiological quality of air in free-range and box-stall stable horse keeping systems. Environ. Monit. Assess. 2018;190:269.
    doi: 10.1007/s10661-018-6644-0pmc: PMC5889767pubmed: 29627901google scholar: lookup
  86. Mostafa E., Szabo E., Gates R.S., Buescher W.. Identification of airborne particles and fungus spores concentrations within horses stables. Atmos. Pollut. Res. 2021;12:93–103.
    doi: 10.1016/j.apr.2020.10.012google scholar: lookup
  87. Lenart-Boroń A., Bajor A., Tischner M., Kulik K., Kabacińska J.. Particulate matter concentrations and fungal aerosol in horse stables as potential causal agents in recurrent airway disease in horses and human asthma and allergies. Appl. Sci. 2022;12:9375.
    doi: 10.3390/app12189375google scholar: lookup
  88. Dauvillier J., ter Woort F., van Erck-Westergren E.. Fungi in respiratory samples of horses with inflammatory airway disease. JVIM 2019;33:968–975.
    doi: 10.1111/jvim.15397pmc: PMC6430897pubmed: 30576012google scholar: lookup
  89. Houtsma A., Bedenice D., Pusterla N., Pugliese B., Mapes S., Hoffman A.M., Paxson J., Rozanski E., Mukherjee J., Wigley M.. Association between inflammatory airway disease of horses and exposure to respiratory viruses: A case control study. Multidiscip. Respir. Med. 2015;10:33.
    doi: 10.1186/s40248-015-0030-3pmc: PMC4630835pubmed: 26535117google scholar: lookup
  90. Bond S.L., McMullen C., Timsit E., Léguillette R.. Topography of the respiratory, oral, and guttural pouch bacterial and fungal microbiotas in horses. J. Vet. Intern. Med. 2023;37:349–360.
    doi: 10.1111/jvim.16612pmc: PMC9889660pubmed: 36607177google scholar: lookup
  91. Wood J.L., Newton J.R., Chanter N., Mumford J.A.. Association between respiratory disease and bacterial and viral infections in British racehorses. J. Clin. Microbiol. 2005;43:120–126.
    doi: 10.1128/JCM.43.1.120-126.2005pmc: PMC540098pubmed: 15634959google scholar: lookup
  92. Mete A., Özgür N.Y.. Investigation of the presence of Mycoplasma as an etiologic agent of inflammatory airway diseases in thoroughbred racehorses in İstanbul Province. Turk. J. Vet. Anim. Sci. 2017;41:365–371.
    doi: 10.3906/vet-1606-90google scholar: lookup
  93. Fillion-Bertrand G., Dickson R.P., Boivin R., Lavoie J.P., Huffnagle G.B., Leclere M.. Lung microbiome is influenced by the environment and asthmatic status in an equine model of asthma. Am. J. Respir. Cell Mol. Biol. 2019;60:189197.
    doi: 10.1165/rcmb.2017-0228OCpubmed: 30183323google scholar: lookup
  94. Xavier M.O., Nogueira C.E.W., Meirelles M., Fernandes W.R., Andreolla H., Severo L.C., Pasqualotto A.C., Meireles M.C.A.. Fungi in the respiratory tract of horses with recurrent airway obstruction. Arq. Bras. Med. Vet. Zootec. 2014;66:1457–1463.
    doi: 10.1590/1678-6552google scholar: lookup
  95. . Ventilation and Air Hygiene Parameters in Horse Stables. .
  96. Lühe T., Volkmann N., Probst J., Dreyer-Rendelsmann C., Schulz J., Kemper N.. Bacterial Burden in the Air of Indoor Riding Arenas. Agriculture 2022;12:2111.
    doi: 10.3390/agriculture12122111google scholar: lookup
  97. Glatter M., Bochnia M., Wensch-Dorendorf M., Greef J.M., Zeyner A.. Feed Intake Parameters of Horses Fed Soaked or Steamed Hay and Hygienic Quality of Hay Stored Following Treatment. Animals 2021;11:2729.
    doi: 10.3390/ani11092729pmc: PMC8471832pubmed: 34573695google scholar: lookup
  98. Hayes D., Jr., Collins P.B., Khosravi M., Lin R.L., Lee L.Y.. Bronchoconstriction triggered by breathing hot humid air in patients with asthma: Role of cholinergic reflex. Am. J. Respir. Crit. Care Med. 2012;185:1190–1196.
    doi: 10.1164/rccm.201201-0088OCpmc: PMC3373066pubmed: 22505744google scholar: lookup
  99. Hsu C.C., Lin R.L., Lin Y.S., Lee L.Y.. Bronchoconstriction induced by increasing airway temperature in ovalbumin-sensitized rats: Role of tachykinins. J. Appl. Physiol. 2013;115:688–696.
    doi: 10.1152/japplphysiol.00491.2013pmc: PMC3763070pubmed: 23845978google scholar: lookup
  100. Ruan T., Gu Q., Kou Y.R., Lee L.Y.. Hyperthermia increases sensitivity of pulmonary C-fibre afferents in rats. J. Physiol. 2005;565:295–308.
    doi: 10.1113/jphysiol.2005.084319pmc: PMC1464481pubmed: 15760937google scholar: lookup
  101. Ivester K.M., Couëtil L.L.. Management of chronic airway inflammation in the horse: A systematic review. Equine Vet. Educ. 2014;26:647–656.
    doi: 10.1111/eve.12238google scholar: lookup
  102. Claußen G., Hessel E.F.. Particulate Matter in Equestrian Stables and Riding Arenas. JEVS 2017;55:60–70.
    doi: 10.1016/j.jevs.2017.04.004google scholar: lookup
  103. Vincent J.H.. Aerosol exposure: Concepts, criteria, standards and applications. J. Phys. Conf. Ser. 2009;151:012003.
    doi: 10.1088/1742-6596/151/1/012003google scholar: lookup
  104. Brankston G., Greer A.L., Marshall Q., Lang B., Moore K., Hodgins D., Hennessey J.T.G., Beeler-Marfisi J.. Increased weekly mean PM2. 5, and no2 are associated with increased proportions of lower airway granulocytes in Ontario horses. Front. Vet. Sci. 2020;7:185.
    doi: 10.3389/fvets.2020.00185pmc: PMC7214617pubmed: 32432128google scholar: lookup
  105. Bond S.L., Workentine M., Hundt J., UCVM Class of 2019. Gilkerson J.R., Léguillette R.. Effects of nebulized dexamethasone on the respiratory microbiota and mycobiota and relative equine herpesvirus-1, 2, 4, 5 in an equine model of asthma. J. Vet. Intern. Med. 2020;34:307–321.
    doi: 10.1111/jvim.15671pmc: PMC6979091pubmed: 31793692google scholar: lookup
  106. Simões J.D.S.A.. Contribution to the Discriminant Power of Some of the Variables Involved in the Staging of Severe Equine Asthma Syndrome. .
  107. Siegers E.W., Anthonisse M., van Eerdenburg F.J., van den Broek J., Wouters I.M., Westermann C.M.. Effect of ionization, bedding, and feeding on air quality in a horse stable. J. Vet. Intern. Med. 2018;32:1234–1240.
    doi: 10.1111/jvim.15069pmc: PMC5980306pubmed: 29485234google scholar: lookup
  108. Grzyb J., Podstawski Z., Bulski K.. Bacterial aerosol, particulate matter, and microclimatic parameters in the horse stables in Poland. Environ. Sci. Pollut. Res. Int. 2022;29:26992–27006.
    doi: 10.1007/s11356-021-18142-6pmc: PMC8990930pubmed: 34921652google scholar: lookup
  109. Woods P.S., Robinson N.E., Swanson M.C., Reed C.E., Broadstone R.V., Derksen F.J.. Airborne dust and aeroallergen concentration in a horse stable under two different management systems. Equine Vet. J. 1993;25:208–213.
    doi: 10.1111/j.2042-3306.1993.tb02945.xpubmed: 8508749google scholar: lookup
  110. Auger E.J., Moore-Colyer M.J.S.. The effect of management regime on airborne respirable dust concentrations in two different types of horse stable design. JEVS 2017;51:105–109.
    doi: 10.1016/j.jevs.2016.12.007google scholar: lookup
  111. Mönki J., Saastamoinen M., Karikoski N., Norring M., Rajamäki M., Mykkänen A.. Effects of Bedding Material on Equine Lower Airway Inflammation: A Comparison of Two Peat Beddings, Wood Pellet, and Straw Pellet. Front. Vet. Sci. 2021;8:799645.
    doi: 10.3389/fvets.2021.799645pmc: PMC8718510pubmed: 34977227google scholar: lookup
  112. Olave C.J., Ivester K.M., Couetil L.L., Kritchevsky J.E., Tinkler S.H., Mukhopadhyay A.. Dust exposure and pulmonary inflammation in Standardbred racehorses fed dry hay or haylage: A pilot study. Vet. J. 2021;271:105654.
    doi: 10.1016/j.tvjl.2021.105654pubmed: 33840486google scholar: lookup
  113. Clements J.M., Pirie R.S.. Respirable dust concentrations in equine stables. Part 2: The benefits of soaking hay and optimising the environment in a neighbouring stable. Res. Vet. Sci. 2007;83:263–268.
    doi: 10.1016/j.rvsc.2006.12.003pubmed: 17467753google scholar: lookup
  114. Hunt M.A.. Assessment of Dust, Endotoxin, and Fungal Exposures in Horse Confinement Rooms. .
  115. Hessel E.F., Garlipp F., Van den Weghe H.F.A.. Generation of airborne particles from horse feeds depending on type and processing. JEVS 2009;29:665–674.
    doi: 10.1016/j.jevs.2009.07.013google scholar: lookup
  116. Sowińska J., Witkowska D., Bursztynowicz K., Kwiatkowska-Stenzel A., Mituniewicz T., Wojcik A.. Relationship between environmental conditions and physiological indicators of horses’ welfare. Med. Weter. 2015;71:486–492.
  117. McGorum B.C., Ellison J., Cullen R.T.. Total and respirable airborne dust endotoxin concentrations in three equine management systems. Equine Vet. J. 1998;30:430–434.
    doi: 10.1111/j.2042-3306.1998.tb04514.xpubmed: 9758102google scholar: lookup
  118. Barton A.K., Shety T., Bondzio A., Einspanier R., Gehlen H.. Metalloproteinases and their inhibitors are influenced by inhalative glucocorticoid therapy in combination with environmental dust reduction in equine recurrent airway obstruction. BMC Vet. Res. 2016;12:282.
    doi: 10.1186/s12917-016-0915-1pmc: PMC5148864pubmed: 27938355google scholar: lookup
  119. Piecuch A., Cywińska A.. The role of nutrition in prevention and supportive therapy of equine asthma. Med. Weter. 2022;78:263–271.
    doi: 10.21521/mw.6656google scholar: lookup
  120. Séguin V., Lemauviel-Lavenant S., Garon D., Bouchart V., Gallard Y., Blanchet B., Diquélou S., Personeni E., Gauduchon P., Ourry A.. Effect of agricultural and environmental factors on the hay characteristics involved in equine respiratory disease. Agric. Ecosyst. Environ. 2010;135:206–215.
    doi: 10.1016/j.agee.2009.09.012google scholar: lookup
  121. Intemann S., Reckels B., Schubert D., Wolf P., Kamphues J., Visscher C.. The Hygienic Status of Different Forage Types for Horses—A Retrospective Study on Influencing Factors and Associations with Anamnestic Reports. Vet. Sci. 2022;9:226.
    doi: 10.3390/vetsci9050226pmc: PMC9143553pubmed: 35622753google scholar: lookup
  122. Beeler-Marfisi J., Clark M.E., Wen X., Sears W., Huber L., Ackerley C., Viel L., Bienzle D.. Experimental induction of recurrent airway obstruction with inhaled fungal spores, lipopolysaccharide, and silica microspheres in horses. Am. J. Vet. Res. 2010;71:682–689.
    doi: 10.2460/ajvr.71.6.682pubmed: 20513185google scholar: lookup
  123. Ferro E., Ferrucci F., Salimei E., Antoni M., Codazza D., Caniatti M.. Relationship between the conditions of lower airways in healthy horses, environmental factors and air quality in stables. Pferdeheilkunde 2000;16:579–586.
    doi: 10.21836/PEM20000603google scholar: lookup
  124. Orard M., Hue E., Couroucé A., Bizon-Mercier C., Toquet M.P., Moore-Colyer M., Couëtil L., Pronost S., Paillot R., Demoor M.. The influence of hay steaming on clinical signs and airway immune response in severe asthmatic horses. BMC Vet. Res. 2018;14:345.
    doi: 10.1186/s12917-018-1636-4pmc: PMC6236910pubmed: 30442129google scholar: lookup
  125. Moore-Colyer M.J.S., Lumbis K., Longland A., Harris P.. The effect of five different wetting treatments on the nutrient content and microbial concentration in hay for horses. PLoS ONE 2014;9:e114079.
    doi: 10.1371/journal.pone.0114079pmc: PMC4245254pubmed: 25426729google scholar: lookup
  126. Moore-Colyer M.J.S., Taylor J.L.E., James R.. The effect of steaming and soaking on the respirable particle, bacteria, mould, and nutrient content in hay for horses. JEVS 2016;39:62–68.
    doi: 10.1016/j.jevs.2015.09.006google scholar: lookup
  127. Pisch C., Wensch-Dorendorf M., Schwarzenbolz U., Henle T., Greef J.M., Zeyner A.. Effect of Hay Steaming on the Estimated Precaecal Digestibility of Crude Protein and Selected Amino Acids in Horses. Animals 2022;12:3092.
    doi: 10.3390/ani12223092pmc: PMC9686632pubmed: 36428320google scholar: lookup
  128. Larson J.L.. The Comparison of Airway Responses of Normal Horses Fed Round Bale versus Square Bale Hay. .
  129. Vandenput S., Istasse L., Nicks B., Lekeux P.. Airborne dust and aeroallergen concentrations in different sources of feed and bedding for horses. Vet. Q. 1997;19:154–158.
    doi: 10.1080/01652176.1997.9694762pubmed: 9413111google scholar: lookup
  130. Jochmans-Lemoine A., Picotte K., Beauchamp G., Vargas A., Lavoie J.P.. Effects of a propriety oiled mixed hay feeding system on lung function, neutrophilic airway inflammation and oxidative stress in severe asthmatic horses. Equine Vet. J. 2020;52:564–571.
    doi: 10.1111/evj.13218pubmed: 31802526google scholar: lookup
  131. Intemann S., Reckels B., Schubert D.C., Wolf P., Kamphues J., Visscher C.. The Microbiological Quality of Concentrates for Horses—A Retrospective Study on Influencing Factors and Associations with Clinical Symptoms Reported by Owners or Referring Vets. Vet. Sci. 2022;9:413.
    doi: 10.3390/vetsci9080413pmc: PMC9414818pubmed: 36006328google scholar: lookup
  132. Nogradi N., Couetil L., Messick J., Stochelski M.A., Burgess J.R.. Omega-3 Fatty Acid Supplementation Provides an Additional Benefit to a Low-Dust Diet in the Management of Horses with Chronic Lower Airway Inflammatory Disease. JVIM 2015;29:299–306.
    doi: 10.1111/jvim.12488pmc: PMC4858086pubmed: 25307169google scholar: lookup
  133. Kwiatkowska-Stenzel A., Witkowska D., Sowińska J., Stopyra A.. The effect of stable bedding materials on dust levels, microbial air contamination and equine respiratory health. Res. Vet. Sci. 2017;115:523–529.
    doi: 10.1016/j.rvsc.2017.09.022pubmed: 28972942google scholar: lookup
  134. Werhahn H., Hessel E.F., Bachhausen I., Van den Weghe H.F.. Effects of different bedding materials on the behavior of horses housed in single stalls. JEVS 2010;30:425–431.
    doi: 10.1016/j.jevs.2010.07.005google scholar: lookup
  135. Greening L., Shenton V., Wilcockson K., Swanson J.. Investigating duration of nocturnal ingestive and sleep behaviors of horses bedded on straw versus shavings. J. Vet. Behav. 2013;8:82–86.
    doi: 10.1016/j.jveb.2012.05.003google scholar: lookup
  136. Greening L., Downing J., Amiouny D., Lekang L., Mcbride S.. The effect of altering routine husbandry factors on sleep duration and memory consolidation in the horse. Appl. Anim. Behav. Sci. 2021;236:105229.
    doi: 10.1016/j.applanim.2021.105229google scholar: lookup
  137. Burla J.B., Rufener C., Bachmann I., Gygax L., Patt A., Hillmann E.. Space allowance of the littered area affects lying behavior in group-housed horses. Front. Vet. Sci. 2017;4:23.
    doi: 10.3389/fvets.2017.00023pmc: PMC5339441pubmed: 28326309google scholar: lookup
  138. Prišenk J., Turk J., Rozman Č., Pažek K., Janžekovič M.. Feasibility analysis of different bedding materials for horses. J. Appl. Anim. Res. 2018;46:798–803.
    doi: 10.1080/09712119.2017.1403919google scholar: lookup
  139. Keskinen R., Saastamoinen M., Nikama J., Särkijärvi S., Myllymäki M., Salo T., Uusi-Kämppä J.. Recycling nutrients from horse manure: Effects of bedding type and its compostability. Agric. Food Sci. 2017;26:68–79.
    doi: 10.23986/afsci.60443google scholar: lookup
  140. Bambi G., Rossi G., Barbari M.. Comparison between different types of bedding materials for horses. Agron. Res. 2018;16:646–655.
    doi: 10.15159/AR.18.124google scholar: lookup
  141. Yarnell K., Le Bon M., Turton N., Savova M., McGlennon A., Forsythe S.. Reducing exposure to pathogens in the horse: A preliminary study into the survival of bacteria on a range of equine bedding types. J. Appl. Microbiol. 2017;122:23–29.
    doi: 10.1111/jam.13298pubmed: 27659898google scholar: lookup
  142. Airaksinen S., Heinonen-Tanski H., Heiskanen M.L.. Quality of different bedding materials and their influence on the compostability of horse manure. JEVS 2001;21:125–130.
    doi: 10.1016/S0737-0806(01)70108-6google scholar: lookup
  143. Mönki J., Saastamoinen M., Karikoski N., Rajamäki M., Raekallio M., Junnila J., Särkijärvi S., Norring M., Valros A., Oranen Ben Fatma S.. Effects of bedding material on equine lower airway inflammation: A crossover study comparing peat and wood shavings. Front. Vet. Sci. 2021;8:656814.
    doi: 10.3389/fvets.2021.656814pmc: PMC8062776pubmed: 33898547google scholar: lookup
  144. Ward P.L., Wohlt J.E., Katz S.E.. Chemical, physical, and environmental properties of pelleted newspaper compared to wheat straw and wood shavings as bedding for horses. J. Anim. Sci. 2001;79:1359–1369.
    doi: 10.2527/2001.7961359xpubmed: 11424670google scholar: lookup

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