The pathophysiology of wound repair.
Abstract: The equine practitioner who is presented with a wounded horse should fully understand the physiologic mechanisms involved in repair so as to design an appropriate treatment plan. In the following articles of this issue,experienced authors share their thoughts on the management of specific injuries, and the reader should benefit from acquisition of knowledge about the different phases of healing as well as the cytokines that regulate them,because these data dictate the approach to follow, particularly in com-plicated wounds, such as those afflicted by chronic inflammation and/or an excessive proliferative response.
Publication Date: 2005-02-05 PubMed ID: 15691596DOI: 10.1016/j.cveq.2004.11.001Google Scholar: Lookup
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Summary
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This research paper provides insights into how understanding the pathophysiology of wound repair can aid equine practitioners in designing effective treatment plans for wounded horses, with a focus on complicated wounds such as those with chronic inflammation or excessive proliferative response.
Understanding Pathophysiology of Wound Repair
In this paper, the authors delve into the pathophysiology, or the physical processes associated with disease and injury, of wound repair in horses. They suggest:
- A thorough understanding of the physiological mechanisms involved in wound repair is vital when designing a treatment plan for wounded horses.
- This knowledge enables the equine practitioner to determine the best approach to treat complicated wounds such as those affected by chronic inflammation or an excessive proliferative response.
The Three Phases of Healing
The authors put emphasis on the understanding of the different phases of healing as part of healing pathophysiology. This includes:
- Inflammation Phase: The initial phase of the healing process where the body responds to control bleeding and limit infection.
- Proliferation Phase: The body starts to repair the damaged tissue by replacing it with new granulation tissue.
- Remodeling Phase: Also known as the maturation phase, during which the body continues to build and remodel new tissue.
Role of Cytokines in Wound Healing
Cytokines, being the proteins that facilitate interactions and communication between cells, are central to wound repair. Their role in healing includes:
- Promoting inflammation and proliferation in initial healing stages.
- Regulating immune cells and other physiological processes that help in injury recovery.
Application to Equine Practice
As a call to action, they stress that understanding the pathophysiology of wound repair will significantly benefit equine practitioners, especially while dealing with specific injuries.
- The knowledge of healing process and the role of cytokines allows for the determination of an appropriate treatment plan.
- This can lead to better outcomes in equine wound management, particularly for complicated wounds.
Cite This Article
APA
Theoret CL.
(2005).
The pathophysiology of wound repair.
Vet Clin North Am Equine Pract, 21(1), 1-13.
https://doi.org/10.1016/j.cveq.2004.11.001 Publication
Researcher Affiliations
- Département de biomédecine vétérinaire, Faculté de médecine vétérinaire, Université de Montréal, CP 5000, St-Hyacinthe, Québec J2S 7C6, Canada. christine.theoret@umontreal.ca
MeSH Terms
- Animals
- Cytokines / physiology
- Growth Substances / physiology
- Horses / injuries
- Inflammation / veterinary
- Skin Physiological Phenomena
- Wound Healing / physiology
- Wounds and Injuries / pathology
- Wounds and Injuries / physiopathology
- Wounds and Injuries / veterinary
References
This article includes 59 references
Citations
This article has been cited 14 times.- Mu Y, Zhang X, Zhang L, Luo R, Zhang Y, Wang M. MSC Exosomes Containing Valproic Acid Promote Wound Healing by Modulating Inflammation and Angiogenesis. Molecules 2024 Sep 9;29(17).
- Iacopetti I, Perazzi A, Patruno M, Contiero B, Carolo A, Martinello T, Melotti L. Assessment of the quality of the healing process in experimentally induced skin lesions treated with autologous platelet concentrate associated or unassociated with allogeneic mesenchymal stem cells: preliminary results in a large animal model. Front Vet Sci 2023;10:1219833.
- Su CY, Liu TY, Wang HV, Yang WC. Histopathological Study on Collagen in Full-Thickness Wound Healing in Fraser's Dolphins (Lagenodelphis hosei). Animals (Basel) 2023 May 18;13(10).
- Rai V, Moellmer R, Agrawal DK. Stem Cells and Angiogenesis: Implications and Limitations in Enhancing Chronic Diabetic Foot Ulcer Healing. Cells 2022 Jul 25;11(15).
- Ishida Y, Nosaka M, Kondo T. Bone Marrow-Derived Cells and Wound Age Estimation. Front Med (Lausanne) 2022;9:822572.
- Despoudi K, Mantzoros I, Ioannidis O, Loutzidou L, Christidis P, Chatzakis C, Gkasdaris G, Raptis D, Pramateftakis MG, Angelopoulos S, Zaraboukas T, Koliakos G, Tsalis K. Healing of colonic anastomosis in rats under obstructive ileus conditions. Discoveries (Craiova) 2021 Apr-Jun;9(2):e129.
- Zhang Y, Li T, Zhao C, Li J, Huang R, Zhang Q, Li Y, Li X. An Integrated Smart Sensor Dressing for Real-Time Wound Microenvironment Monitoring and Promoting Angiogenesis and Wound Healing. Front Cell Dev Biol 2021;9:701525.
- Guillamat-Prats R. The Role of MSC in Wound Healing, Scarring and Regeneration. Cells 2021 Jul 8;10(7).
- Melotti L, Martinello T, Perazzi A, Iacopetti I, Ferrario C, Sugni M, Sacchetto R, Patruno M. A Prototype Skin Substitute, Made of Recycled Marine Collagen, Improves the Skin Regeneration of Sheep. Animals (Basel) 2021 Apr 23;11(5).
- Iacopetti I, Patruno M, Melotti L, Martinello T, Bedin S, Badon T, Righetto EM, Perazzi A. Autologous Platelet-Rich Plasma Enhances the Healing of Large Cutaneous Wounds in Dogs. Front Vet Sci 2020;7:575449.
- Kotwal GJ, Chien S. Macrophage Differentiation in Normal and Accelerated Wound Healing. Results Probl Cell Differ 2017;62:353-364.
- Partlow J, Blikslager A, Matthews C, Law M, Daniels J, Baker R, Labens R. Effect of topically applied Saccharomyces boulardii on the healing of acute porcine wounds: a preliminary study. BMC Res Notes 2016 Apr 11;9:210.
- Perazzi A, Busetto R, Martinello T, Drigo M, Pasotto D, Cian F, Patruno M, Iacopetti I. Description of a double centrifugation tube method for concentrating canine platelets. BMC Vet Res 2013 Jul 22;9:146.
- Saarto EE, Hielm-Björkman AK, Hette K, Kuusela EK, Brandão CV, Luna SP. Effect of a single acupuncture treatment on surgical wound healing in dogs: a randomized, single blinded, controlled pilot study. Acta Vet Scand 2010 Oct 15;52(1):57.
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