The relationship of daily sperm production with number of Sertoli cells and testicular size in adult horses: role of primitive spermatogonia.
Abstract: The number of Sertoli cells is important in spermatogenesis as noted by significant correlations between the number of Sertoli cells and the number of germ cells observed as early as type B2 spermatogonia in the horse. However, the stage within spermatocytogenesis at which these relationships first occur is unclear. The relationships between the number of Sertoli cells and parenchymal weight and the number of germ cells during the mitosis of spermatogenesis were determined in 184 adult horses to identify the developmental stage (that is, the earliest germ cell) at which significant relationships are established. The total numbers of all types of A spermatogonia and of specific subtypes (A1, A2, A3, B1 or B2) of spermatogonia were correlated with the number of Sertoli cells and with parenchymal weight. The number of each cell type was calculated using stereology. The number of Sertoli cells was correlated (P < 0.01) with parenchymal weight (r = 0.85) and with daily sperm production (r = 0.83), and parenchymal weight was correlated (P < 0.01) with daily sperm production (r = 0.89). The number of Sertoli cells was correlated (P < 0.01) with the number of type A (r = 0.81) and A1 (r = 0.74) spermatogonia. Parenchymal weight was correlated with the number of type A (r = 0.80) spermatogonia and with the number of A1 (r = 0.67) spermatogonia.(ABSTRACT TRUNCATED AT 250 WORDS)
Publication Date: 1994-01-01 PubMed ID: 8182606DOI: 10.1530/jrf.0.1000315Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
- Research Support
- U.S. Gov't
- P.H.S.
Summary
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The research investigates the connection between the number of Sertoli cells, essential for sperm production, and testicular size in adult horses, aiming to identify the earliest stage of sperm development where these relationships occur.
Context and Purpose of Study
- The study is based on the relationship of Sertoli cells with spermatogenesis, a process that involves the production of sperm cells.
- Sertoli cells have a significant role to play in the spermatogenesis process, as shown by correlations with the number of germ cells.
- The researchers aim to identify the stage in sperm development (spermatocytogenesis) at which this relationship first becomes noticeable.
Methodology
- The study was conducted on 184 adult horses, focusing on the correlation between the number of Sertoli cells, the parenchymal weight (which encapsulates the functional parts of an organ in the body), and the number of germ cells during the mitosis of spermatogenesis.
- The total numbers of all types of A spermatogonia (the initial or stem cell stage in the male germ cell line) and specific subtypes of spermatogonia were compared to the number of Sertoli cells and parenchymal weight.
- Cells were counted using the stereological method to minimize any potential bias or error.
Findings
- The study finds a significant correlation (p<0.01) between the number of Sertoli cells and parenchymal weight (r= 0.85). The stronger the correlation, the more closely these factors are related.
- There is also a significant correlation between the number of Sertoli cells and daily sperm production (r= 0.83).
- Moreover, the researchers observed that the parenchymal weight also correlates significantly with daily sperm production (r=0.89).
- Finally, the number of Sertoli cells has a significant correlation with the number of Type A (r = 0.81) and A1 (r = 0.74) spermatogonia, with the parenchymal weight correspondingly correlated with these germ cells.
Conclusions
- The study acknowledges the importance and high correlation of Sertoli cells with the process of sperm production and the size of the testis in adult horses.
- The influence of Sertoli cells on the germ cells from the initial stage of development was established, indicating their crucial role in spermatogenesis.
Cite This Article
APA
Johnson L, Carter GK, Varner DD, Taylor TS, Blanchard TL, Rembert MS.
(1994).
The relationship of daily sperm production with number of Sertoli cells and testicular size in adult horses: role of primitive spermatogonia.
J Reprod Fertil, 100(1), 315-321.
https://doi.org/10.1530/jrf.0.1000315 Publication
Researcher Affiliations
- Department of Veterinary Anatomy and Public Health, College of Veterinary Medicine, Texas A & M University, College Station 77843.
MeSH Terms
- Animals
- Cell Count
- Horses / anatomy & histology
- Horses / physiology
- Male
- Organ Size / physiology
- Sertoli Cells / cytology
- Spermatogenesis / physiology
- Spermatogonia / physiology
- Testis / anatomy & histology
Grant Funding
- HD-16773 / NICHD NIH HHS
Citations
This article has been cited 3 times.- Ros-Santaella JL, Kotrba R, Pintus E. High-energy diet enhances spermatogenic function and increases sperm midpiece length in fallow deer (Dama dama) yearlings.. R Soc Open Sci 2019 Jun;6(6):181972.
- Pintus E, Ros-Santaella JL, Garde JJ. Beyond Testis Size: Links between Spermatogenesis and Sperm Traits in a Seasonal Breeding Mammal.. PLoS One 2015;10(10):e0139240.
- Achard V, Weber P, Mercier G, Blanchard MP. High-magnification observation of seminiferous tubules through the tunica albuginea by two-photon laser scanning microscopy.. Asian J Androl 2011 Sep;13(5):774-6.
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