The role of nutritional therapy in the treatment of equine Cushing’s syndrome and laminitis.
Abstract: Equine Cushing's syndrome, a relatively common and complex condition, is difficult to treat with conventional medicine. Cushing's syndrome involves a hyperplasia or adenoma of the anterior pituitary gland. Biochemical alterations include increased endogenous cortisol, insulin resistance, elevated adrenocorticotrophic hormone, and decreased thyroid hormone levels. Symptoms include hirsutism with no loss of the winter coat in summer, refractory laminitis, weight problems (over- or underweight), polyuria/polydipsia (Pu/Pd), frequent infections, lowered immunity to intestinal parasites, decreased intestinal wall integrity, and infertility. Laminitis (an inflammation of the laminae of the foot) is a common and often fatal complication of Cushing's syndrome that tends to be refractory to conventional treatment. One of the most common therapies is phenylbutazone, a non-steroidal anti-inflammatory drug (NSAID) known to cause significant changes in the permeability of the intestinal wall. Recent research has shown an intestinal bacterial exotoxin to be one of the triggering factors in laminitis. By removing phenylbutazone and healing the intestinal wall, laminitis becomes more responsive to treatment. Good hoof-care combined with nutritional management and the application of other modalities, including acupuncture and Chinese and Western herbs, can complete the healing process. The successful treatment of equine Cushing's syndrome is one of the best examples of treating a disease using the holistic approach. While each case requires different combinations of modalities, the outcome is usually positive with individually selected treatments.
Publication Date: 2001-10-10 PubMed ID: 11591169
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Summary
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Equine Cushing’s syndrome, a common disease in horses characterized by a hyperactive pituitary gland and resulting hormonal imbalance, and its common complication, laminitis, are challenging to treat with traditional medicine. This research investigates the potential of a multifaceted holistic approach, featuring nutritional therapy, hoof-care, acupuncture, and both Western and Chinese herbs.
Understanding Equine Cushing’s Syndrome and Laminitis
- Equine Cushing’s Syndrome is a complex illness affecting horses, associated with an overactive pituitary gland and the resulting hormonal changes. This manifests in increased cortisol, insulin resistance, raised adrenocorticotrophic hormone, and diminished thyroid hormone levels.
- The disease can result in a variety of symptoms, such as long-lasting winter coat, weight issues, excessive urination and drinking, frequent infections, lowered immune response to intestinal parasites, diminished intestinal wall strength, and infertility.
- Laminitis, a condition causing inflammation in the foot’s laminae, is a frequent and often deadly complication of Equine Cushing’s syndrome. Conventional treatments often struggle to successfully treat this issue.
The Conventional Treatment and its Challenges
- Phenylbutazone, an NSAID, is often used to treat laminitis. However, this treatment can lead to significant changes in the intestinal wall’s permeability.
- Recent research highlighted that an intestinal bacterial exotoxin is a trigger point for laminitis. Therefore, the side-effects of phenylbutazone present a significant obstacle in treating this condition.
A Holistic Approach to Treatment
- By removing Phenylbutazone and instead focusing on the healing of the intestinal wall, the research found that laminitis shows improved responsiveness to treatment.
- This research argues for a holistic approach to treating Equine Cushing’s syndrome and its complications. The proposed treatment strategy includes good hoof-care, nutritional management, and the use of both traditional Chinese and Western herbs, aided by acupuncture.
- The researchers postulate that this integrated approach often leads to positive outcomes, although the specific combination of treatments needs to be selected based on the individual requirements of the case.
Cite This Article
APA
Harman J, Ward M.
(2001).
The role of nutritional therapy in the treatment of equine Cushing’s syndrome and laminitis.
Altern Med Rev, 6 Suppl, S4-S16.
Publication
Researcher Affiliations
- Harmany Equine Clinic, Ltd, Washington, Virginia 22747, USA.
MeSH Terms
- Animal Nutritional Physiological Phenomena
- Animals
- Complementary Therapies / veterinary
- Cushing Syndrome / diagnosis
- Cushing Syndrome / physiopathology
- Cushing Syndrome / therapy
- Cushing Syndrome / veterinary
- Diet Therapy / veterinary
- Hoof and Claw / pathology
- Horse Diseases / diagnosis
- Horse Diseases / physiopathology
- Horse Diseases / therapy
- Horses
- Inflammation / etiology
- Inflammation / therapy
- Inflammation / veterinary
Citations
This article has been cited 2 times.- Zhou K, Zhang J, Xu L, Lim CED. Chinese herbal medicine for subfertile women with polycystic ovarian syndrome. Cochrane Database Syst Rev 2021 Jun 4;6(6):CD007535.
- Zhou K, Zhang J, Xu L, Wu T, Lim CE. Chinese herbal medicine for subfertile women with polycystic ovarian syndrome. Cochrane Database Syst Rev 2016 Oct 12;10(10):CD007535.
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