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Home / Equine Research Bank / Cell Tissue Res / The ultrastructure of the cell types in the endocrine pancre...
Cell and tissue research1976; 167(2); 179-195; doi: 10.1007/BF00224326

The ultrastructure of the cell types in the endocrine pancreas of the horse.

Abstract: The islets of Langerhans of the equine pancreas were examined with the electron microscope after immersion or perfusion fixation. Five cell types could be distinguished after fixation by either technique: 1. A-cells, situated at the center of the islets, 2. B-cells, containing mostly "pale granules" and constituting the principal cell type of the periphery of the islets, 3. D-cells, also located mainly at the periphery of the islets, 4. G-cells, found at the edge of the islets and in the exocrine pancreas, and 5. S-cells, (small granule cells), which are relatively few in number and occur only in the islets. The function and age-dependent modifications of these cells are discussed. The formation of light and dark cells and of "mixed cells" are regarded as artifact, since cells of this type occur only under the condition of immersion fixation.
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Publication Date: 1976-03-16 PubMed ID: 769989DOI: 10.1007/BF00224326Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study examines and details the ultrastructure of five different types of cells found in the endocrine pancreas or Islets of Langerhans of horses, exploring their location, characteristics, and potential changes due to aging.

Research Methods

  • The study used electron microscopy to examine the Islets of Langerhans in the pancreas of horses.
  • Two types of fixation techniques were used: immersion and perfusion fixation. Both techniques help to preserve the structure of the cells for accurate observation.

Findings

  • Five distinct types of cells were identified in the endocrine part of the equine pancreas:
  • A-cells, which are primarily located at the center of the islets.
  • B-cells, identified by their “pale granules”, are the primary cell type found at the periphery of the islets.
  • D-cells are similarly mainly found at the periphery of the islets.
  • G-cells can be found both at the edge of the islets and in the exocrine part of the pancreas, which are associated with digestive enzyme production in mammals.
  • S-cells, or “small granule cells”, are fewer in number and are found solely within the islets.

Discussion

  • The functions and age-related changes of these cells in the horse pancreas were addressed.
  • The researchers stipulate that the formation of light and dark cells and “mixed cells” could be artifacts caused by the immersion fixation process, as they were not observed when other fixation methods were used.

Cite This Article

APA
Forssmann A. (1976). The ultrastructure of the cell types in the endocrine pancreas of the horse. Cell Tissue Res, 167(2), 179-195. https://doi.org/10.1007/BF00224326

Publication

Cell and tissue research
ISSN: 0302-766X
NlmUniqueID: 0417625
Country: Germany
Language: English
Volume: 167
Issue: 2
Pages: 179-195

Researcher Affiliations

Forssmann, A

    MeSH Terms

    • Aging
    • Animals
    • Cytoplasmic Granules / ultrastructure
    • Female
    • Histological Techniques
    • Horses / anatomy & histology
    • Islets of Langerhans / ultrastructure
    • Lipofuscin / analysis
    • Male

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    Citations

    This article has been cited 8 times.
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