The use of mitomycin C as an adjunctive treatment for equine ocular squamous cell carcinoma.
Abstract: To assess the effectiveness of topical mitomycin C application as an alternative adjunctive therapy to CO2 laser ablation in the treatment of equine ocular squamous cell carcinoma. Methods: A retrospective clinical study of eight client owned horses in which 10 affected eyes were treated for ocular squamous cell carcinoma over a 17 month period. (March 2003 to August 2004). Methods: Each horse was given a general anaesthetic to allow CO2 laser ablation of the lesion(s). Mitomycin C at a concentration of 0.4 mg/mL was then applied intraoperatively to the affected areas for 1 or 5 minutes. Postoperatively a triple antibiotic eye ointment was applied to the eye twice daily and each horse was treated with systemic non-steroidal anti-inflammatory drugs for 7 days. Results: Recurrence following treatment was noted in three eyes. Two of these were retreated and no further signs developed. The remaining eye was enucleated at the request of the owner. Overall 90% of treated eyes appeared free of tumour a minimum of 11 months post treatment. Conclusions: In this case series mitomycin C appeared to offer a valid alternative to other adjunctive therapies currently employed in the treatment of equine ocular squamous cell carcinoma.
Publication Date: 2006-02-28 PubMed ID: 16498834DOI: 10.1111/j.1751-0813.2006.tb13124.xGoogle Scholar: Lookup
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- Journal Article
Summary
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The research study explores the usefulness of mitomycin C as a supporting treatment for horse ocular squamous cell carcinoma post CO2 laser surgery, with promising results reported.
Research Background
- This research work looks into a different supplemental treatment option for equine ocular squamous cell carcinoma – a prevalent ocular tumor in horses, which was earlier addressed with CO2 laser surgery and supplementary therapies such as cryotherapy and brachytherapy. This study envisages topical application of mitomycin C as a viable alternative supplementary treatment.
Research Methodology
- The research was a retrospection of clinical study involving 10 eyes of 8 horses over 17 months starting March 2003 until August 2004.
- Each horse was put under general anesthesia and treated with a CO2 laser to ablate the tumor.
- Post-ablation, 0.4 mg/mL of mitomycin C was topically applied to the treated regions for 1 or 5 minutes. Following the surgery, each horse was treated with triple antibiotic eye ointment twice a day and non-steroidal anti-inflammatory drugs systemically for 7 days.
Research Findings
- The main finding of this research work was that 90% of the treated eyes seemed to be void of tumor at least 11 months after the treatment.
- Tumor recurrence was observed in three eyes following the treatment. Two were re-treated without further complications, while the remaining one was enucleated (removed) per the owner’s request.
Conclusions
- The results highlighted the potential of mitomycin C as a valid adjunctive (supporting) therapy following CO2 laser surgery for equine ocular squamous cell carcinoma (eye tumor in horses).
- The study suggests that mitomycin C can be an effective substitute to other supporting therapies used in the treatment of the said condition.
Cite This Article
APA
Rayner SG, Van Zyl N.
(2006).
The use of mitomycin C as an adjunctive treatment for equine ocular squamous cell carcinoma.
Aust Vet J, 84(1-2), 43-46.
https://doi.org/10.1111/j.1751-0813.2006.tb13124.x Publication
Researcher Affiliations
- Oakey Veterinary Hospital, PO Box 2, Oakey, Queensland 4401.
MeSH Terms
- Animals
- Antibiotics, Antineoplastic / therapeutic use
- Carcinoma, Squamous Cell / drug therapy
- Carcinoma, Squamous Cell / surgery
- Carcinoma, Squamous Cell / veterinary
- Eye Neoplasms / drug therapy
- Eye Neoplasms / surgery
- Eye Neoplasms / veterinary
- Female
- Horse Diseases / drug therapy
- Horse Diseases / surgery
- Horses
- Intraoperative Care / methods
- Intraoperative Care / veterinary
- Male
- Mitomycin / therapeutic use
- Neoplasm Recurrence, Local / veterinary
- Retrospective Studies
- Treatment Outcome
Citations
This article has been cited 4 times.- Condello M, D'Avack G, Vona R, Spugnini EP, Scacco L, Meschini S. Electrochemotherapy with Mitomycin C Potentiates Apoptosis Death by Inhibiting Autophagy in Squamous Carcinoma Cells. Cancers (Basel) 2021 Jul 31;13(15).
- Balagholi S, Aletaha M, Kanavi MR, Karami S, Dabbaghi R, Nakhaie PA. Optimizing the effective doses of mitomycin C, 5-fluorouracil, and their combination on cultivated basal cell carcinoma. Arq Bras Oftalmol 2021;84(5):481-489.
- Jeanes EC, Koll-Hampp S, Dawson C, Dunkel B, Tetas Pont R. Rhomboid blepharoplasty and cryotherapy for the treatment of a squamous cell carcinoma on the lower eyelid in a horse. Clin Case Rep 2019 Jan;7(1):40-46.
- Buss DG, Sharma A, Giuliano EA, Mohan RR. Efficacy and safety of mitomycin C as an agent to treat corneal scarring in horses using an in vitro model. Vet Ophthalmol 2010 Jul;13(4):211-8.
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