Journal of molecular biology1976; 102(1); 27-59; doi: 10.1016/0022-2836(76)90072-3

Three-dimensional structure of horse liver alcohol dehydrogenase at 2-4 A resolution.

Abstract: No abstract available
Publication Date: 1976-03-25 PubMed ID: 178875DOI: 10.1016/0022-2836(76)90072-3Google Scholar: Lookup
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Cite This Article

APA
Eklund H, Nordstru00f6m B, Zeppezauer E, Su00f6derlund G, Ohlsson I, Boiwe T, Su00f6derberg BO, Tapia O, Bru00e4ndu00e9n CI, Akeson A. (1976). Three-dimensional structure of horse liver alcohol dehydrogenase at 2-4 A resolution. J Mol Biol, 102(1), 27-59. https://doi.org/10.1016/0022-2836(76)90072-3

Publication

ISSN: 0022-2836
NlmUniqueID: 2985088R
Country: Netherlands
Language: English
Volume: 102
Issue: 1
Pages: 27-59

Researcher Affiliations

Eklund, H
    Nordstru00f6m, B
      Zeppezauer, E
        Su00f6derlund, G
          Ohlsson, I
            Boiwe, T
              Su00f6derberg, B O
                Tapia, O
                  Bru00e4ndu00e9n, C I
                    Akeson, A

                      MeSH Terms

                      • Adenine
                      • Adenosine Diphosphate Sugars
                      • Alcohol Oxidoreductases
                      • Animals
                      • Binding Sites
                      • Diphosphates
                      • Fourier Analysis
                      • Horses
                      • Liver / enzymology
                      • Models, Molecular
                      • Niacinamide
                      • Protein Binding
                      • Protein Conformation
                      • Ribose
                      • X-Ray Diffraction

                      Citations

                      This article has been cited 92 times.
                      1. Plapp BV, Kratzer DA, Souhrada SK, Warth E, Jacobi T. Specific base catalysis by yeast alcohol dehydrogenase I with substitutions of histidine-48 by glutamate or serine residues in the proton relay system.. Chem Biol Interact 2023 Sep 1;382:110558.
                        doi: 10.1016/j.cbi.2023.110558pubmed: 37247811google scholar: lookup
                      2. Ren Y, Eronen V, Blomster Andberg M, Koivula A, Hakulinen N. Structure and function of aldopentose catabolism enzymes involved in oxidative non-phosphorylative pathways.. Biotechnol Biofuels Bioprod 2022 Dec 28;15(1):147.
                        doi: 10.1186/s13068-022-02252-5pubmed: 36578086google scholar: lookup
                      3. Stark F, Loderer C, Petchey M, Grogan G, Ansorge-Schumacher MB. Advanced Insights into Catalytic and Structural Features of the Zinc-Dependent Alcohol Dehydrogenase from Thauera aromatica.. Chembiochem 2022 Aug 3;23(15):e202200149.
                        doi: 10.1002/cbic.202200149pubmed: 35557486google scholar: lookup
                      4. Pal S, Plapp BV. The Thr45Gly substitution in yeast alcohol dehydrogenase substantially decreases catalysis, alters pH dependencies, and disrupts the proton relay system.. Chem Biol Interact 2021 Nov 1;349:109650.
                        doi: 10.1016/j.cbi.2021.109650pubmed: 34529977google scholar: lookup
                      5. Petratos K, Gessmann R, Daskalakis V, Papadovasilaki M, Papanikolau Y, Tsigos I, Bouriotis V. Structure and Dynamics of a Thermostable Alcohol Dehydrogenase from the Antarctic Psychrophile Moraxella sp. TAE123.. ACS Omega 2020 Jun 23;5(24):14523-14534.
                        doi: 10.1021/acsomega.0c01210pubmed: 32596590google scholar: lookup
                      6. Yi SY, Ku SS, Sim HJ, Kim SK, Park JH, Lyu JI, So EJ, Choi SY, Kim J, Ahn MS, Kim SW, Park H, Jeong WJ, Lim YP, Min SR, Liu JR. An Alcohol Dehydrogenase Gene from Synechocystis sp. Confers Salt Tolerance in Transgenic Tobacco.. Front Plant Sci 2017;8:1965.
                        doi: 10.3389/fpls.2017.01965pubmed: 29204151google scholar: lookup
                      7. Plapp BV, Savarimuthu BR, Ferraro DJ, Rubach JK, Brown EN, Ramaswamy S. Horse Liver Alcohol Dehydrogenase: Zinc Coordination and Catalysis.. Biochemistry 2017 Jul 18;56(28):3632-3646.
                        doi: 10.1021/acs.biochem.7b00446pubmed: 28640600google scholar: lookup
                      8. Gaona-Lu00f3pez C, Juliu00e1n-Su00e1nchez A, Riveros-Rosas H. Diversity and Evolutionary Analysis of Iron-Containing (Type-III) Alcohol Dehydrogenases in Eukaryotes.. PLoS One 2016;11(11):e0166851.
                        doi: 10.1371/journal.pone.0166851pubmed: 27893862google scholar: lookup
                      9. u00d6stberg LJ, Persson B, Hu00f6u00f6g JO. Computational studies of human class V alcohol dehydrogenase - the odd sibling.. BMC Biochem 2016 Jul 25;17(1):16.
                        doi: 10.1186/s12858-016-0072-ypubmed: 27455956google scholar: lookup
                      10. Raj SB, Ramaswamy S, Plapp BV. Yeast alcohol dehydrogenase structure and catalysis.. Biochemistry 2014 Sep 16;53(36):5791-803.
                        doi: 10.1021/bi5006442pubmed: 25157460google scholar: lookup
                      11. Zastrow ML, Pecoraro VL. Designing hydrolytic zinc metalloenzymes.. Biochemistry 2014 Feb 18;53(6):957-78.
                        doi: 10.1021/bi4016617pubmed: 24506795google scholar: lookup
                      12. Lakowicz JR, Kierdaszuk B, Gryczynski I, Malak H. Fluorescence of horse liver alcohol dehydrogenase using one- and two-photon excitation.. J Fluoresc 1996 Mar;6(1):51-9.
                        doi: 10.1007/BF00726726pubmed: 24226997google scholar: lookup
                      13. Vitale A, Thorne N, Lovell S, Battaile KP, Hu X, Shen M, D'Auria S, Auld DS. Physicochemical characterization of a thermostable alcohol dehydrogenase from Pyrobaculum aerophilum.. PLoS One 2013;8(6):e63828.
                        doi: 10.1371/journal.pone.0063828pubmed: 23755111google scholar: lookup
                      14. Liu X, Bastian S, Snow CD, Brustad EM, Saleski TE, Xu JH, Meinhold P, Arnold FH. Structure-guided engineering of Lactococcus lactis alcohol dehydrogenase LlAdhA for improved conversion of isobutyraldehyde to isobutanol.. J Biotechnol 2012 Dec 15;164(2):188-95.
                        doi: 10.1016/j.jbiotec.2012.08.008pubmed: 22974724google scholar: lookup
                      15. Carrigan MA, Uryasev O, Davis RP, Zhai L, Hurley TD, Benner SA. The natural history of class I primate alcohol dehydrogenases includes gene duplication, gene loss, and gene conversion.. PLoS One 2012;7(7):e41175.
                        doi: 10.1371/journal.pone.0041175pubmed: 22859968google scholar: lookup
                      16. Weaver MN, Yang Y, Merz KM Jr. Assessment of the CCSD and CCSD(T) coupled-cluster methods in calculating heats of formation for Zn complexes.. J Phys Chem A 2009 Sep 17;113(37):10081-8.
                        doi: 10.1021/jp904241vpubmed: 19691272google scholar: lookup
                      17. Plapp BV. Conformational changes and catalysis by alcohol dehydrogenase.. Arch Biochem Biophys 2010 Jan 1;493(1):3-12.
                        doi: 10.1016/j.abb.2009.07.001pubmed: 19583966google scholar: lookup
                      18. Knoll M, Pleiss J. The Medium-Chain Dehydrogenase/reductase Engineering Database: a systematic analysis of a diverse protein family to understand sequence-structure-function relationship.. Protein Sci 2008 Oct;17(10):1689-97.
                        doi: 10.1110/ps.035428.108pubmed: 18614751google scholar: lookup
                      19. Klimacek M, Hellmer H, Nidetzky B. Catalytic mechanism of Zn2+-dependent polyol dehydrogenases: kinetic comparison of sheep liver sorbitol dehydrogenase with wild-type and Glu154-->Cys forms of yeast xylitol dehydrogenase.. Biochem J 2007 Jun 15;404(3):421-9.
                        doi: 10.1042/BJ20061384pubmed: 17343568google scholar: lookup
                      20. Manru00edquez D, El-Sharkawy I, Flores FB, El-Yahyaoui F, Regad F, Bouzayen M, Latchu00e9 A, Pech JC. Two highly divergent alcohol dehydrogenases of melon exhibit fruit ripening-specific expression and distinct biochemical characteristics.. Plant Mol Biol 2006 Jul;61(4-5):675-85.
                        doi: 10.1007/s11103-006-0040-9pubmed: 16897483google scholar: lookup
                      21. Papanikolau Y, Tsigos I, Papadovasilaki M, Bouriotis V, Petratos K. Crystallization and preliminary X-ray diffraction studies of an alcohol dehydrogenase from the Antarctic psychrophile Moraxella sp. TAE123.. Acta Crystallogr Sect F Struct Biol Cryst Commun 2005 Feb 1;61(Pt 2):246-8.
                        doi: 10.1107/S1744309105002253pubmed: 16511007google scholar: lookup
                      22. Schneider G, Lindqvist Y, Bru00e4ndu00e9n CI, Lorimer G. Three-dimensional structure of ribulose-1,5-bisphosphate carboxylase/oxygenase from Rhodospirillum rubrum at 2.9 A resolution.. EMBO J 1986 Dec 20;5(13):3409-15.
                      23. Yoshida K, Miyashita NT. Nucleotide polymorphism in the Adh2 region of the wild rice Oryza rufipogon.. Theor Appl Genet 2005 Oct;111(6):1215-28.
                        doi: 10.1007/s00122-005-0054-8pubmed: 16133310google scholar: lookup
                      24. Welin M, Kosinska U, Mikkelsen NE, Carnrot C, Zhu C, Wang L, Eriksson S, Munch-Petersen B, Eklund H. Structures of thymidine kinase 1 of human and mycoplasmic origin.. Proc Natl Acad Sci U S A 2004 Dec 28;101(52):17970-5.
                        doi: 10.1073/pnas.0406332102pubmed: 15611477google scholar: lookup
                      25. Reimers MJ, Hahn ME, Tanguay RL. Two zebrafish alcohol dehydrogenases share common ancestry with mammalian class I, II, IV, and V alcohol dehydrogenase genes but have distinct functional characteristics.. J Biol Chem 2004 Sep 10;279(37):38303-12.
                        doi: 10.1074/jbc.M401165200pubmed: 15231826google scholar: lookup
                      26. Levin I, Meiri G, Peretz M, Burstein Y, Frolow F. The ternary complex of Pseudomonas aeruginosa alcohol dehydrogenase with NADH and ethylene glycol.. Protein Sci 2004 Jun;13(6):1547-56.
                        doi: 10.1110/ps.03531404pubmed: 15152088google scholar: lookup
                      27. Shimomura Y, Kakuta Y, Fukuyama K. Crystal structures of the quinone oxidoreductase from Thermus thermophilus HB8 and its complex with NADPH: implication for NADPH and substrate recognition.. J Bacteriol 2003 Jul;185(14):4211-8.
                      28. Luo J, Bruice TC. Ten-nanosecond molecular dynamics simulation of the motions of the horse liver alcohol dehydrogenase.PhCH2O- complex.. Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16597-600.
                        doi: 10.1073/pnas.262667599pubmed: 12481026google scholar: lookup
                      29. Scarborough GA. Molecular mechanism of the P-type ATPases.. J Bioenerg Biomembr 2002 Aug;34(4):235-50.
                        doi: 10.1023/a:1020211016696pubmed: 12392187google scholar: lookup
                      30. Niederhut MS, Gibbons BJ, Perez-Miller S, Hurley TD. Three-dimensional structures of the three human class I alcohol dehydrogenases.. Protein Sci 2001 Apr;10(4):697-706.
                        doi: 10.1110/ps.45001pubmed: 11274460google scholar: lookup
                      31. Xie PT, Hurley TD. Methionine-141 directly influences the binding of 4-methylpyrazole in human sigma sigma alcohol dehydrogenase.. Protein Sci 1999 Dec;8(12):2639-44.
                        doi: 10.1110/ps.8.12.2639pubmed: 10631979google scholar: lookup
                      32. Ma K, Adams MW. An unusual oxygen-sensitive, iron- and zinc-containing alcohol dehydrogenase from the hyperthermophilic archaeon Pyrococcus furiosus.. J Bacteriol 1999 Feb;181(4):1163-70.
                      33. Gillooly DJ, Robertson AG, Fewson CA. Molecular characterization of benzyl alcohol dehydrogenase and benzaldehyde dehydrogenase II of Acinetobacter calcoaceticus.. Biochem J 1998 Mar 15;330 ( Pt 3)(Pt 3):1375-81.
                        doi: 10.1042/bj3301375pubmed: 9494109google scholar: lookup
                      34. Fliegmann J, Sandermann H Jr. Maize glutathione-dependent formaldehyde dehydrogenase cDNA: a novel plant gene of detoxification.. Plant Mol Biol 1997 Aug;34(6):843-54.
                        doi: 10.1023/a:1005872222490pubmed: 9290637google scholar: lookup
                      35. Li D, Stevenson KJ. Purification and sequence analysis of a novel NADP(H)-dependent type III alcohol dehydrogenase from Thermococcus strain AN1.. J Bacteriol 1997 Jul;179(13):4433-7.
                      36. De Bolle X, Vinals C, Fastrez J, Feytmans E. Bivalent cations stabilize yeast alcohol dehydrogenase I.. Biochem J 1997 Apr 15;323 ( Pt 2)(Pt 2):409-13.
                        doi: 10.1042/bj3230409pubmed: 9163331google scholar: lookup
                      37. Ramaswamy S, el Ahmad M, Danielsson O, Ju00f6rnvall H, Eklund H. Crystal structure of cod liver class I alcohol dehydrogenase: substrate pocket and structurally variable segments.. Protein Sci 1996 Apr;5(4):663-71.
                        doi: 10.1002/pro.5560050410pubmed: 8845755google scholar: lookup
                      38. Dauter Z, Wilson KS, Sieker LC, Moulis JM, Meyer J. Zinc- and iron-rubredoxins from Clostridium pasteurianum at atomic resolution: a high-precision model of a ZnS4 coordination unit in a protein.. Proc Natl Acad Sci U S A 1996 Aug 20;93(17):8836-40.
                        doi: 10.1073/pnas.93.17.8836pubmed: 8799113google scholar: lookup
                      39. Farrar JA, Formicka G, Zeppezauer M, Thomson AJ. Magnetic and optical properties of copper-substituted alcohol dehydrogenase: a bisthiolate copper (II) complex.. Biochem J 1996 Jul 15;317 ( Pt 2)(Pt 2):447-56.
                        doi: 10.1042/bj3170447pubmed: 8713071google scholar: lookup
                      40. Barber RD, Rott MA, Donohue TJ. Characterization of a glutathione-dependent formaldehyde dehydrogenase from Rhodobacter sphaeroides.. J Bacteriol 1996 Mar;178(5):1386-93.
                      41. Gaut BS, Clegg MT. Molecular evolution of the Adh1 locus in the genus Zea.. Proc Natl Acad Sci U S A 1993 Jun 1;90(11):5095-9.
                        doi: 10.1073/pnas.90.11.5095pubmed: 8506356google scholar: lookup
                      42. Hempel J, Nicholas H, Lindahl R. Aldehyde dehydrogenases: widespread structural and functional diversity within a shared framework.. Protein Sci 1993 Nov;2(11):1890-900.
                        doi: 10.1002/pro.5560021111pubmed: 8268800google scholar: lookup
                      43. Kaiser R, Fernu00e1ndez MR, Paru00e9s X, Ju00f6rnvall H. Origin of the human alcohol dehydrogenase system: implications from the structure and properties of the octopus protein.. Proc Natl Acad Sci U S A 1993 Dec 1;90(23):11222-6.
                        doi: 10.1073/pnas.90.23.11222pubmed: 8248232google scholar: lookup
                      44. Bruce NC, Willey DL, Coulson AF, Jeffery J. Bacterial morphine dehydrogenase further defines a distinct superfamily of oxidoreductases with diverse functional activities.. Biochem J 1994 May 1;299 ( Pt 3)(Pt 3):805-11.
                        doi: 10.1042/bj2990805pubmed: 8192670google scholar: lookup
                      45. Ito K, Takahashi M, Yoshimoto T, Tsuru D. Cloning and high-level expression of the glutathione-independent formaldehyde dehydrogenase gene from Pseudomonas putida.. J Bacteriol 1994 May;176(9):2483-91.
                      46. Paru00e9s X, Cederlund E, Moreno A, Hjelmqvist L, Farru00e9s J, Ju00f6rnvall H. Mammalian class IV alcohol dehydrogenase (stomach alcohol dehydrogenase): structure, origin, and correlation with enzymology.. Proc Natl Acad Sci U S A 1994 Mar 1;91(5):1893-7.
                        doi: 10.1073/pnas.91.5.1893pubmed: 8127901google scholar: lookup
                      47. Garvin DF, Weeden NF, Doyle JJ. The reduced stability of a plant alcohol dehydrogenase is due to the substitution of serine for a highly conserved phenylalanine residue.. Plant Mol Biol 1994 Oct;26(2):643-55.
                        doi: 10.1007/BF00013750pubmed: 7948919google scholar: lookup
                      48. Ingersoll JC, Rothenberg M, Liedl BE, Folkerts K, Garvin D, Hanson MR, Doyle JJ, Mutschler MA. A novel anther-expressed adh-homologous gene in Lycopersicon esculentum.. Plant Mol Biol 1994 Dec;26(6):1875-91.
                        doi: 10.1007/BF00019500pubmed: 7858224google scholar: lookup
                      49. Hanfstingl U, Berry A, Kellogg EA, Costa JT 3rd, Ru00fcdiger W, Ausubel FM. Haplotypic divergence coupled with lack of diversity at the Arabidopsis thaliana alcohol dehydrogenase locus: roles for both balancing and directional selection?. Genetics 1994 Nov;138(3):811-28.
                        doi: 10.1093/genetics/138.3.811pubmed: 7851777google scholar: lookup
                      50. Yuan HS, Stevens RC, Bau R, Mosher HS, Koetzle TF. Determination of the absolute configuration of (+)-neopentyl-1-d alcohol by neutron and x-ray diffraction analysis.. Proc Natl Acad Sci U S A 1994 Dec 20;91(26):12872-6.
                        doi: 10.1073/pnas.91.26.12872pubmed: 7809138google scholar: lookup
                      51. Glasner JD, Kocher TD, Collins JJ. Caenorhabditis elegans contains genes encoding two new members of the Zn-containing alcohol dehydrogenase family.. J Mol Evol 1995 Jul;41(1):46-53.
                        doi: 10.1007/BF00174040pubmed: 7608988google scholar: lookup
                      52. Hjelmqvist L, Estonius M, Ju00f6rnvall H. The vertebrate alcohol dehydrogenase system: variable class II type form elucidates separate stages of enzymogenesis.. Proc Natl Acad Sci U S A 1995 Nov 21;92(24):10904-8.
                        doi: 10.1073/pnas.92.24.10904pubmed: 7479907google scholar: lookup
                      53. Ju00f6rnvall H, Persson M, Jeffery J. Alcohol and polyol dehydrogenases are both divided into two protein types, and structural properties cross-relate the different enzyme activities within each type.. Proc Natl Acad Sci U S A 1981 Jul;78(7):4226-30.
                        doi: 10.1073/pnas.78.7.4226pubmed: 7027257google scholar: lookup
                      54. Thatcher DR, Sawyer L. Secondary-structure prediction from the sequence of Drosophila melanogaster (fruitfly) alcohol dehydrogenase.. Biochem J 1980 Jun 1;187(3):884-6.
                        doi: 10.1042/bj1870884pubmed: 6821374google scholar: lookup
                      55. Bu00fchler R, Hempel J, Kaiser R, von Wartburg JP, Vallee BL, Ju00f6rnvall H. Human alcohol dehydrogenase: structural differences between the beta and gamma subunits suggest parallel duplications in isoenzyme evolution and predominant expression of separate gene descendants in livers of different mammals.. Proc Natl Acad Sci U S A 1984 Oct;81(20):6320-4.
                        doi: 10.1073/pnas.81.20.6320pubmed: 6387702google scholar: lookup
                      56. Bru00e4ndu00e9n CI, Eklund H, Cambillau C, Pryor AJ. Correlation of exons with structural domains in alcohol dehydrogenase.. EMBO J 1984 Jun;3(6):1307-10.
                      57. Ju00f6rnvall H, Hempel J, Vallee BL, Bosron WF, Li TK. Human liver alcohol dehydrogenase: amino acid substitution in the beta 2 beta 2 Oriental isozyme explains functional properties, establishes an active site structure, and parallels mutational exchanges in the yeast enzyme.. Proc Natl Acad Sci U S A 1984 May;81(10):3024-8.
                        doi: 10.1073/pnas.81.10.3024pubmed: 6374651google scholar: lookup
                      58. Schneider G, Eklund H, Cedergren-Zeppezauer E, Zeppezauer M. Structure of the complex of active site metal-depleted horse liver alcohol dehydrogenase and NADH.. EMBO J 1983;2(5):685-9.
                      59. Schneider G, Eklund H, Cedergren-Zeppezauer E, Zeppezauer M. Crystal structures of the active site in specifically metal-depleted and cobalt-substituted horse liver alcohol dehydrogenase derivatives.. Proc Natl Acad Sci U S A 1983 Sep;80(17):5289-93.
                        doi: 10.1073/pnas.80.17.5289pubmed: 6351056google scholar: lookup
                      60. Dahl KH, Eklund H, McKinley-McKee JS. Enantioselective affinity labelling of horse liver alcohol dehydrogenase. Correlation of inactivation kinetics with the three-dimensional structure of the enzyme.. Biochem J 1983 May 1;211(2):391-6.
                        doi: 10.1042/bj2110391pubmed: 6347187google scholar: lookup
                      61. Tsai CS, White JH. Activation of liver alcohol dehydrogenase by glycosylation.. Biochem J 1983 Feb 1;209(2):309-14.
                        doi: 10.1042/bj2090309pubmed: 6342612google scholar: lookup
                      62. Dennis ES, Gerlach WL, Pryor AJ, Bennetzen JL, Inglis A, Llewellyn D, Sachs MM, Ferl RJ, Peacock WJ. Molecular analysis of the alcohol dehydrogenase (Adh1) gene of maize.. Nucleic Acids Res 1984 May 11;12(9):3983-4000.
                        doi: 10.1093/nar/12.9.3983pubmed: 6328449google scholar: lookup
                      63. Makinen MW, Yim MB. Coordination environment of the active-site metal ion of liver alcohol dehydrogenase.. Proc Natl Acad Sci U S A 1981 Oct;78(10):6221-5.
                        doi: 10.1073/pnas.78.10.6221pubmed: 6273859google scholar: lookup
                      64. Bertini I, Lanini G, Luchinat C, Haas C, Maret W, Zeppezauer M. The influence of anions and inhibitors on the catalytic metal ion in Co(II)-substituted horse liver alcohol dehydrogenase.. Eur Biophys J 1987;14(7):431-9.
                        doi: 10.1007/BF00254867pubmed: 3608931google scholar: lookup
                      65. Rice DW, Baker PJ, Farrants GW, Hornby DP. The crystal structure of glutamate dehydrogenase from Clostridium symbiosum at 0.6 nm resolution.. Biochem J 1987 Mar 15;242(3):789-95.
                        doi: 10.1042/bj2420789pubmed: 3593276google scholar: lookup
                      66. Irish EE, Schwartz D. Activation of low and null activity isozymes of maize alcohol dehydrogenase by antibodies.. Mol Gen Genet 1987 Jun;208(1-2):271-8.
                        doi: 10.1007/BF00330453pubmed: 3475528google scholar: lookup
                      67. Ju00f6rnvall H, Hu00f6u00f6g JO, von Bahr-Lindstru00f6m H, Vallee BL. Mammalian alcohol dehydrogenases of separate classes: intermediates between different enzymes and intraclass isozymes.. Proc Natl Acad Sci U S A 1987 May;84(9):2580-4.
                        doi: 10.1073/pnas.84.9.2580pubmed: 3472225google scholar: lookup
                      68. Edenberg HJ, Zhang K, Fong K, Bosron WF, Li TK. Cloning and sequencing of cDNA encoding the complete mouse liver alcohol dehydrogenase.. Proc Natl Acad Sci U S A 1985 Apr;82(8):2262-6.
                        doi: 10.1073/pnas.82.8.2262pubmed: 3157987google scholar: lookup
                      69. Tsai CS, Godin JR, Wand AJ. Dye-sensitized photo-oxidation of enzymes.. Biochem J 1985 Jan 1;225(1):203-8.
                        doi: 10.1042/bj2250203pubmed: 3156581google scholar: lookup
                      70. Dennis ES, Sachs MM, Gerlach WL, Finnegan EJ, Peacock WJ. Molecular analysis of the alcohol dehydrogenase 2 (Adh2) gene of maize.. Nucleic Acids Res 1985 Feb 11;13(3):727-43.
                        doi: 10.1093/nar/13.3.727pubmed: 2987807google scholar: lookup
                      71. Ikuta T, Fujiyoshi T, Kurachi K, Yoshida A. Molecular cloning of a full-length cDNA for human alcohol dehydrogenase.. Proc Natl Acad Sci U S A 1985 May;82(9):2703-7.
                        doi: 10.1073/pnas.82.9.2703pubmed: 2986130google scholar: lookup
                      72. Duester G, Ju00f6rnvall H, Hatfield GW. Intron-dependent evolution of the nucleotide-binding domains within alcohol dehydrogenase and related enzymes.. Nucleic Acids Res 1986 Mar 11;14(5):1931-41.
                        doi: 10.1093/nar/14.5.1931pubmed: 2938077google scholar: lookup
                      73. Chang C, Meyerowitz EM. Molecular cloning and DNA sequence of the Arabidopsis thaliana alcohol dehydrogenase gene.. Proc Natl Acad Sci U S A 1986 Mar;83(5):1408-12.
                        doi: 10.1073/pnas.83.5.1408pubmed: 2937058google scholar: lookup
                      74. Ikuta T, Szeto S, Yoshida A. Three human alcohol dehydrogenase subunits: cDNA structure and molecular and evolutionary divergence.. Proc Natl Acad Sci U S A 1986 Feb;83(3):634-8.
                        doi: 10.1073/pnas.83.3.634pubmed: 2935875google scholar: lookup
                      75. Trezise AE, Godfrey EA, Holmes RS, Beacham IR. Cloning and sequencing of cDNA encoding baboon liver alcohol dehydrogenase: evidence for a common ancestral lineage with the human alcohol dehydrogenase beta subunit and for class I ADH gene duplications predating primate radiation.. Proc Natl Acad Sci U S A 1989 Jul;86(14):5454-8.
                        doi: 10.1073/pnas.86.14.5454pubmed: 2748595google scholar: lookup
                      76. Osterman JC, Dennis ES. Molecular analysis of the ADH1-Cm allele of maize.. Plant Mol Biol 1989 Aug;13(2):203-12.
                        doi: 10.1007/BF00016138pubmed: 2577507google scholar: lookup
                      77. Xie Y, Wu R. Rice alcohol dehydrogenase genes: anaerobic induction, organ specific expression and characterization of cDNA clones.. Plant Mol Biol 1989 Jul;13(1):53-68.
                        doi: 10.1007/BF00027335pubmed: 2562760google scholar: lookup
                      78. Scarborough GA. Binding energy, conformational change, and the mechanism of transmembrane solute movements.. Microbiol Rev 1985 Sep;49(3):214-31.
                        doi: 10.1128/mr.49.3.214-231.1985pubmed: 2413342google scholar: lookup
                      79. Vanderkooi JM, Englander SW, Papp S, Wright WW, Owen CS. Long-range electron exchange measured in proteins by quenching of tryptophan phosphorescence.. Proc Natl Acad Sci U S A 1990 Jul;87(13):5099-103.
                        doi: 10.1073/pnas.87.13.5099pubmed: 2367526google scholar: lookup
                      80. Dolferus R, Van den Bossche D, Jacobs M. Sequence analysis of two null-mutant alleles of the single Arabidopsis Adh locus.. Mol Gen Genet 1990 Nov;224(2):297-302.
                        doi: 10.1007/BF00271565pubmed: 2277648google scholar: lookup
                      81. Johnson MS, Sutcliffe MJ, Blundell TL. Molecular anatomy: phyletic relationships derived from three-dimensional structures of proteins.. J Mol Evol 1990 Jan;30(1):43-59.
                        doi: 10.1007/BF02102452pubmed: 2107323google scholar: lookup
                      82. Gaut BS, Clegg MT. Molecular evolution of alcohol dehydrogenase 1 in members of the grass family.. Proc Natl Acad Sci U S A 1991 Mar 15;88(6):2060-4.
                        doi: 10.1073/pnas.88.6.2060pubmed: 2006143google scholar: lookup
                      83. Chalmers RM, Keen JN, Fewson CA. Comparison of benzyl alcohol dehydrogenases and benzaldehyde dehydrogenases from the benzyl alcohol and mandelate pathways in Acinetobacter calcoaceticus and from the TOL-plasmid-encoded toluene pathway in Pseudomonas putida. N-terminal amino acid sequences, amino acid compositions and immunological cross-reactions.. Biochem J 1991 Jan 1;273(Pt 1)(Pt 1):99-107.
                        doi: 10.1042/bj2730099pubmed: 1989592google scholar: lookup
                      84. Ghosh D, Weeks CM, Grochulski P, Duax WL, Erman M, Rimsay RL, Orr JC. Three-dimensional structure of holo 3 alpha,20 beta-hydroxysteroid dehydrogenase: a member of a short-chain dehydrogenase family.. Proc Natl Acad Sci U S A 1991 Nov 15;88(22):10064-8.
                        doi: 10.1073/pnas.88.22.10064pubmed: 1946424google scholar: lookup
                      85. Ribas De Pouplana L, Atrian S, Gonzu00e0lex-Duarte R, Fothergill-Gilmore LA, Kelly SM, Price NC. Structural properties of long- and short-chain alcohol dehydrogenases. Contribution of NAD+ to stability.. Biochem J 1991 Jun 1;276 ( Pt 2)(Pt 2):433-8.
                        doi: 10.1042/bj2760433pubmed: 1904719google scholar: lookup
                      86. Hurley TD, Bosron WF, Hamilton JA, Amzel LM. Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site substitutions.. Proc Natl Acad Sci U S A 1991 Sep 15;88(18):8149-53.
                        doi: 10.1073/pnas.88.18.8149pubmed: 1896463google scholar: lookup
                      87. Schauerte JA, Steel DG, Gafni A. Time-resolved circularly polarized protein phosphorescence.. Proc Natl Acad Sci U S A 1992 Nov 1;89(21):10154-8.
                        doi: 10.1073/pnas.89.21.10154pubmed: 1438204google scholar: lookup
                      88. Danielsson O, Ju00f6rnvall H. "Enzymogenesis": classical liver alcohol dehydrogenase origin from the glutathione-dependent formaldehyde dehydrogenase line.. Proc Natl Acad Sci U S A 1992 Oct 1;89(19):9247-51.
                        doi: 10.1073/pnas.89.19.9247pubmed: 1409630google scholar: lookup
                      89. Mainigi KD, Sorof S. Evidence for a receptor protein of activated carcinogen.. Proc Natl Acad Sci U S A 1977 Jun;74(6):2293-6.
                        doi: 10.1073/pnas.74.6.2293pubmed: 407575google scholar: lookup
                      90. Luisi PL. Why are enzymes macromolecules?. Naturwissenschaften 1979 Oct;66(10):498-504.
                        doi: 10.1007/BF00404859pubmed: 388239google scholar: lookup
                      91. Richardson JS, Getzoff ED, Richardson DC. The beta bulge: a common small unit of nonrepetitive protein structure.. Proc Natl Acad Sci U S A 1978 Jun;75(6):2574-8.
                        doi: 10.1073/pnas.75.6.2574pubmed: 275827google scholar: lookup
                      92. Parker DM, Hardman MJ, Plapp BV, Holbrook JJ, Shore JD. pH-dependent changes of intrinsic fluorescence of chemically modified liver alcohol dehydrogenases.. Biochem J 1978 Jul 1;173(1):269-75.
                        doi: 10.1042/bj1730269pubmed: 28733google scholar: lookup