Thrombocytopenia in horses: 35 cases (1989-1994).
Abstract: The records of 3,952 equine patients presenting to the Veterinary Teaching Hospital at North Carolina State University College of Veterinary Medicine were evaluated to determine risk factors associated with thrombocytopenia. Of 2,346 horses from which a CBC was obtained, 35 (1.49%) were thrombocytopenic (platelet count < 75,000/microL). A reference population of 189 horses with normal platelet counts (75,000 to 300,000/microL) was also studied. Standardbred horses were at increased risk for thrombocytopenia, but age and gender were not identified as significant risk factors. Horses with infectious or inflammatory diseases were at increased risk for thrombocytopenia. The potential association of clinical and clinicopathologic factors with thrombocytopenia were assessed by reviewing a series of multiple logistic regression models. Clinical and clinicopathologic variables significantly associated with thrombocytopenia in the final model included increased PCV, increased band neutrophil count, increased total WBC, and decreased plasma protein concentration. Increased mature neutrophil count was associated with normal platelet counts. Thrombocytopenic horses were significantly more likely to die to be euthanized than were horses with normal platelet counts.
Publication Date: 1996-05-01 PubMed ID: 8743211DOI: 10.1111/j.1939-1676.1996.tb02044.xGoogle Scholar: Lookup
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- Journal Article
Summary
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This research article analyzes the risk factors associated with thrombocytopenia, a condition characterized by low platelet count, in horses. The study uses data from 3,952 equine patients and identifies factors such as breed, presence of infectious or inflammatory diseases, and various clinical variables as significant.
Introduction
In this research, the authors studied the medical records of 3,952 equine patients from North Carolina State University College of Veterinary Medicine. The goal was to identify any potential risk factors that could be associated with thrombocytopenia, a condition resulting from an exceptionally low number of platelets (less than 75,000/microL) in the blood.
Methodology and Findings
- The study focused on 2,346 horses for which a CBC (Complete Blood Count) was available. Out of these, 35 horses (1.49%) were identified as thrombocytopenic.
- The researchers compared this group with a reference population consisting of 189 horses with a normal platelet count (within the range of 75,000 to 300,000/microL).
- It was found that Standardbred horses were at an increased risk for thrombocytopenia. However, no significant risk was associated with factors like age and gender.
- Horses suffering from infectious or inflammatory diseases also showed a higher risk for thrombocytopenia.
Association with Clinical Variables
- Different clinical and clinicopathologic factors were also analyzed using a series of multiple logistic regression models.
- In the final model, variables that had a significant association with thrombocytopenia included an increased packed cell volume (PCV), increased band neutrophil count, higher total WBC (white blood cell) count, and a decreased plasma protein concentration.
- On the other hand, a high count of mature neutrophils in the blood was found to be associated with normal platelet counts.
Consequences of Thrombocytopenia
- The research found that horses diagnosed with thrombocytopenia were significantly more likely to die or be euthanized than horses with normal platelet counts. This suggests that thrombocytopenia can potentially be a life-threatening condition in horses.
Cite This Article
APA
Sellon DC, Levine J, Millikin E, Palmer K, Grindem C, Covington P.
(1996).
Thrombocytopenia in horses: 35 cases (1989-1994).
J Vet Intern Med, 10(3), 127-132.
https://doi.org/10.1111/j.1939-1676.1996.tb02044.x Publication
Researcher Affiliations
- Department of Food Animal and Equine Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA.
MeSH Terms
- Animals
- Communicable Diseases / complications
- Communicable Diseases / veterinary
- Female
- Horse Diseases / epidemiology
- Horse Diseases / physiopathology
- Horses
- Inflammation / complications
- Inflammation / veterinary
- Male
- Prevalence
- Retrospective Studies
- Risk Factors
- Thrombocytopenia / epidemiology
- Thrombocytopenia / etiology
- Thrombocytopenia / physiopathology
- Thrombocytopenia / veterinary
Citations
This article has been cited 3 times.- Bozorgmanesh R, Magdesian KG, Sutton-Burges JW, Owens SD, Tablin F. Equine platelet concentrate preparation and validation.. J Vet Intern Med 2019 May;33(3):1500-1506.
- Broeckx SY, Seys B, Suls M, Vandenberghe A, Mariën T, Adriaensen E, Declercq J, Van Hecke L, Braun G, Hellmann K, Spaas JH. Equine Allogeneic Chondrogenic Induced Mesenchymal Stem Cells Are an Effective Treatment for Degenerative Joint Disease in Horses.. Stem Cells Dev 2019 Mar 15;28(6):410-422.
- Nunez R, Gomes-Keller MA, Schwarzwald C, Feige K. Assessment of Equine Autoimmune Thrombocytopenia (EAT) by flow cytometry.. BMC Blood Disord 2001;1(1):1.
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