Treatment of Infiltrative Superficial Tumors in Awake Standing Horses Using Novel High-Frequency Pulsed Electrical Fields.
Abstract: Irreversible electroporation is a proven ablation modality for local ablation of soft tissue tumors in animals and humans. However, the strong muscle contractions associated with the electrical impulses (duration, 50-100 μs) requires the use of general anesthesia and, in most situations, application of neuromuscular blockade. As such, this technology is not used in an outpatient setting for ablating common cutaneous tumors (e.g., squamous cell carcinoma or melanoma) in humans or animals. Recently, high-frequency irreversible electroporation (H-FIRE) technology has been developed to enable electroporation of tumors without stimulation of nearby skeletal muscle. H-FIRE administers bursts of electrical pulses (duration, 0.5-2 μs) through bipolar electrodes placed in tumor parenchyma. We hypothesized that H-FIRE could be used to safely ablate superficial tumors in standing, awake horses without the need for general anesthesia. Here, we describe the treatment of superficial tumors in five horses using this novel ablation therapy without the need for general anesthesia. In each case, H-FIRE therapy predictably ablated tumor volume. All patients tolerated the procedure, no complications developed, and veterinary personnel safety was maintained. The H-FIRE treatment may be useful for treatment in veterinary and human patients in an outpatient setting without the need for hospitalization, general anesthesia, and advanced monitoring techniques.
Publication Date: 2019-08-14 PubMed ID: 31475163PubMed Central: PMC6705183DOI: 10.3389/fvets.2019.00265Google Scholar: Lookup
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Summary
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The research article investigates the use of a novel high-frequency pulsed electrical fields (H-FIRE) technology to safely remove superficial tumors in standing, awake horses without needing general anesthesia.
Background of the Study
- The researchers focused on testing a method of tumor removal known as irreversible electroporation, which is recognized for its effectiveness in both animals and humans in local removal of soft tissue tumors.
- One of the main challenges of traditional irreversible electroporation is that it often stimulates strong muscle contractions due to the electrical impulses it produces. This usually necessitates the use of general anesthesia and neuromuscular blockade.
- Because of these requirements, this technology cannot be conveniently used in an outpatient setting to ablate common skin tumors in patients, whether human or animal.
The New High-Frequency Irreversible Electroporation (H-FIRE) Technology
- The high-frequency irreversible electroporation (H-FIRE) technology has been developed to help bypass the limitations of the traditional irreversible electroporation method.
- H-FIRE uses short bursts of electrical pulses delivered through bipolar electrodes placed in tumor tissue, allowing for the electroporation of tumors without stimulating the nearby skeletal muscle.
- The short duration of the electrical pulses (0.5 to 2 microseconds) makes it more feasible for use on patients without subjecting them to general anesthesia.
Study Method and Findings
- In this study, the H-FIRE technique was used to treat superficial tumors in five awake, standing horses, keeping away the need for general anesthesia.
- The results of the study showed that not only could H-FIRE dependably ablate tumor volume in each case, but all horses also tolerated the procedure well, no complications arose, and the safety of the veterinary personnel was ensured throughout the process.
Implications of the Study
- This research indicates that H-FIRE could potentially be a beneficial treatment for both veterinary and human patients in an outpatient setting, without requiring hospitalization, general anesthesia, or advanced monitoring techniques.
- The successful application of this technology could revolutionize how superficial tumors are treated, making the process more comfortable for the patient and easier to administer for healthcare providers.
Cite This Article
APA
Byron CR, DeWitt MR, Latouche EL, Davalos RV, Robertson JL.
(2019).
Treatment of Infiltrative Superficial Tumors in Awake Standing Horses Using Novel High-Frequency Pulsed Electrical Fields.
Front Vet Sci, 6, 265.
https://doi.org/10.3389/fvets.2019.00265 Publication
Researcher Affiliations
- Department of Large Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, United States.
- Virginia Tech-Wake Forest School of Biomedical Engineering and Science, College of Engineering, Virginia Tech, Blacksburg, VA, United States.
- Virginia Tech-Wake Forest School of Biomedical Engineering and Science, College of Engineering, Virginia Tech, Blacksburg, VA, United States.
- Virginia Tech-Wake Forest School of Biomedical Engineering and Science, College of Engineering, Virginia Tech, Blacksburg, VA, United States.
- Virginia Tech-Wake Forest School of Biomedical Engineering and Science, College of Engineering, Virginia Tech, Blacksburg, VA, United States.
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