Treatment with continuous intrasynovial antimicrobial infusion for septic synovitis in horses: 31 cases (2000-2003).
Abstract: OBJECTIVE-To determine clinical findings, complications, and outcome of septic synovitis in which continuous intrasynovial antimicrobial infusion (CIAI) was used for local antimicrobial delivery in horses. DESIGN-Retrospective case series. Animals-22 adult horses and 9 foals (horses7 days) in nature, 15 had been refractory to standard treatments, and 13 synovial infections had associated osteomyelitis. Mean duration from infection to initiation of CIAI was 19.7 days, and mean duration of CIAI was 6.1 days. Temporary discharge from the catheter site at the time of removal was evident in 8 horses. Dysfunction of the infusion system occurred in 2 horses and was corrected during the course of treatment. No long-term complications were reported. Thirty-nine (93%) synovial infections in 29 (94%) horses were resolved. Twenty adult horses and 8 foals were discharged from the hospital, and 19 of 24 horses with long-term follow-up performed their intended use. CONCLUSIONS AND CLINICAL RELEVANCE-CIAI was a useful adjunctive treatment for septic synovitis and allowed intrasynovial antimicrobial delivery into a variety of synovial cavities.
Publication Date: 2006-06-21 PubMed ID: 16784387DOI: 10.2460/javma.228.12.1922Google Scholar: Lookup
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- Journal Article
Summary
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This research explores the effectiveness of continuous intrasynovial antimicrobial infusion (CIAI) in treating septic synovitis, a joint infection in horses. Most cases responded well with high survival and recovery rates noted.
Methods
- For this research, the team examined the records of 31 horses treated for septic synovitis using CIAI.
- The sample included 22 adult horses and 9 foals, young horses less than one year old.
- The clinical variables were evaluated to determine their correlation with the performance of horses after treatment.
Findings
- Out of 42 synovial cavities treated with CIAI, 29 were chronic infections that were present for over seven days, 15 had not responded to other forms of treatment, and 13 also had osteomyelitis, an accompanying bone infection.
- The average delay between infection detection and the start of the CIAI treatment was approximately 20 days and the average duration of the CIAI treatment was a little over six days.
- Irritation was observed in several horses at the area where the catheter was inserted but no long term complications were reported.
- Treatment system malfunctions were experienced by two horses but they were corrected during the course of the treatment.
Conclusions
- A large majority, 93% of the infections were successfully treated, meaning 94% of the horses recovered.
- Of the 28 horses that were discharged from the hospital, the majority were able to fulfill their intended usage based on long-term follow-ups.
- It was concluded that using CIAI for treating septic synovitis is highly effective and can be used to deliver antimicrobials into different synovial cavities.
Cite This Article
APA
Lescun TB, Vasey JR, Ward MP, Adams SB.
(2006).
Treatment with continuous intrasynovial antimicrobial infusion for septic synovitis in horses: 31 cases (2000-2003).
J Am Vet Med Assoc, 228(12), 1922-1929.
https://doi.org/10.2460/javma.228.12.1922 Publication
Researcher Affiliations
- Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47909-1248, USA.
MeSH Terms
- Animals
- Animals, Newborn
- Anti-Bacterial Agents / administration & dosage
- Anti-Bacterial Agents / therapeutic use
- Female
- Horse Diseases / drug therapy
- Horses
- Infusion Pumps / veterinary
- Infusions, Intralesional / instrumentation
- Infusions, Intralesional / veterinary
- Male
- Retrospective Studies
- Synovial Membrane
- Synovitis / drug therapy
- Synovitis / veterinary
- Treatment Outcome
Citations
This article has been cited 4 times.- Crosby DE, Labens R, Hughes KJ, Nielsen S, Hilbert BJ. Factors Associated With Survival and Return to Function Following Synovial Infections in Horses. Front Vet Sci 2019;6:367.
- Nieto JE, Trela J, Stanley SD, Yamout S, Snyder JR. Pharmacokinetics of a combination of amikacin sulfate and penicillin G sodium for intravenous regional limb perfusion in adult horses. Can J Vet Res 2016 Jul;80(3):230-5.
- Elmas CR, Koenig JB, Bienzle D, Cribb NC, Cernicchiaro N, Coté NM, Weese JS. Evaluation of a broad range real-time polymerase chain reaction (RT-PCR) assay for the diagnosis of septic synovitis in horses. Can J Vet Res 2013 Jul;77(3):211-7.
- Loppnow Z, Kersh K, Wang C, Spaethe S, Troy J. Clinical use of antimicrobial regional limb perfusion in adult horses diagnosed with synovial sepsis or penetrating synovial wounds at a single equine referral hospital in the Midwest United States-163 cases (2010-2020). Front Vet Sci 2025;12:1504486.
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