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Parasites & vectors2020; 13(1); 323; doi: 10.1186/s13071-020-04192-1

Trypanosome infections in naturally infected horses and donkeys of three active sleeping sickness foci in the south of Chad.

Abstract: Equine trypanosomiases are complex infectious diseases with overlapping clinical signs defined by their mode of transmission. Despite their economic impacts, these diseases have been neglected by the scientific community, the veterinary authorities and regulatory organizations. To fill the observed knowledge gap, we undertook the identification of different trypanosome species and subspecies naturally infecting horses and donkeys within the Chadian sleeping sickness focus. The objective of the study was to investigate the potential role of these domestic animals as reservoirs of the human-infective Trypanosoma brucei gambiense. Methods: Blood samples were collected from 155 donkeys and 131 horses in three human African trypanosomiasis (HAT) foci in Chad. Rapid diagnostic test (RDT) and capillary tube centrifugation (CTC) test were used to search for trypanosome infections. DNA was extracted from each blood sample and different trypanosome species and subspecies were identified with molecular tools. Results: From 286 blood samples collected, 54 (18.9%) and 36 (12.6%) were positive for RDT and CTC, respectively. PCR revealed 101 (35.3%) animals with trypanosome infections. The Cohen's kappa coefficient used to evaluate the concordance between the diagnostic methods were low; ranging from 0.09 ± 0.05 to 0.48 ± 0.07. Trypanosomes of the subgenus Trypanozoon were the most prevalent (29.4%), followed by T. congolense forest (11.5%), Trypanosoma congolense savannah (4.9%) and Trypanosoma vivax (4.5%). Two donkeys and one horse from the Maro HAT focus were found with T. b. gambiense infections. No significant differences were observed in the infection rates of different trypanosomes between animal species and HAT foci. Conclusions: This study revealed several trypanosome species and subspecies in donkeys and horses, highlighting the existence of AAT in HAT foci in Chad. The identification of T. b. gambiense in donkeys and horses suggests considering these animals as potential reservoir for HAT in Chad. The presence of both human-infective and human non-infective trypanosomes species highlights the need for developing joint control strategies for HAT and AAT.
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Publication Date: 2020-06-23 PubMed ID: 32576240PubMed Central: PMC7310289DOI: 10.1186/s13071-020-04192-1Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research paper centered on the study of Trypanosome infections in horses and donkeys in Chad, Africa, aiming to recognize their potential role as reservoirs for a type of Trypanosome (T. brucei gambiense) that affects humans. The study collected and analyzed blood samples from the animals using several diagnostic methods, revealing multiple species of Trypanosomes present and indicating the need for a joint control strategy against these diseases in the region.

Understanding the Research

  • The main subject of the study was Trypanosome infections in equines. Trypanosomes are microscopic parasites transmitted by tsetse flies, causing an infectious disease known as Trypanosomiasis.
  • The research was conducted in Chad, a country in Africa where Trypanosomiasis, also known as sleeping sickness, is prevalent.
  • The study focused on horses and donkeys as these animals, often neglected by the scientific community despite their economic significance, are potential reservoirs for the Trypanosoma brucei gambiense, an infectious species of Trypanosome that targets humans.

Methodology of the Research

  • Blood samples were collected from 155 donkeys and 131 horses in the three human African trypanosomiasis (HAT) foci in Chad.
  • The samples were tested for trypanosome infections through a rapid diagnostic test (RDT) and capillary tube centrifugation (CTC).
  • DNA extractions from the blood samples were also conducted. This enabled the identification of different trypanosome species and subspecies through the use of molecular tools.

Results of the Research

  • Out of the 286 samples, 54 (18.9%) and 36 (12.6%) turned out positive for RDT and CTC, respectively.
  • Using PCR, 101 (35.3%) samples revealed trypanosome infections. However, there was a low concordance between the different diagnostic methods used as per the Cohen’s kappa coefficient used for evaluation.
  • The detection of different trypanosome species and subspecies was notably the most prevalent of the subgenus Trypanozoon, followed by T. congolense forest, Trypanosoma congolense savannah, and Trypanosoma vivax.
  • Three animals, two donkeys and one horse, were found with T. b. gambiense infections. The detection of this infective species indicates a potential pathway for human infection.

Significance and Conclusions

  • This research demonstrates the presence of multiple species of Trypanosomes in horses and donkeys within the HAT foci in Chad, indicating the existence of the animal form of the disease (AAT).
  • The discovery of T. b. gambiense in these animals suggests them as potential reservoirs for HAT.
  • The presence of both human-infective and non-infective species of Trypanosomes points out the need for a joint control strategy against the vector diseases.

Cite This Article

APA
Vourchakbé J, Tiofack AAZ, Mbida M, Simo G. (2020). Trypanosome infections in naturally infected horses and donkeys of three active sleeping sickness foci in the south of Chad. Parasit Vectors, 13(1), 323. https://doi.org/10.1186/s13071-020-04192-1

Publication

Parasites & vectors
ISSN: 1756-3305
NlmUniqueID: 101462774
Country: England
Language: English
Volume: 13
Issue: 1
Pages: 323
PII: 323

Researcher Affiliations

Vourchakbé, Joël
  • Molecular Parasitology and Entomology Unit, Department of Biochemistry, Faculty of Science, University of Dschang, PO Box 67, Dschang, Cameroon.
  • Department of Chemistry-Biology-Geology, Faculty of Science and Technology, University of Doba, PO Box 03, Doba, Chad.
Tiofack, Arnol Auvaker Z
  • Molecular Parasitology and Entomology Unit, Department of Biochemistry, Faculty of Science, University of Dschang, PO Box 67, Dschang, Cameroon.
Mbida, Mpoame
  • Laboratory of Applied Biology and Ecology (LABEA), Department of Animal Biology, Faculty of Science, University of Dschang, PO Box 067, Dschang, Cameroon.
Simo, Gustave
  • Molecular Parasitology and Entomology Unit, Department of Biochemistry, Faculty of Science, University of Dschang, PO Box 67, Dschang, Cameroon. gsimoca@yahoo.fr.

MeSH Terms

  • Animals
  • Animals, Domestic
  • Antibodies, Protozoan / blood
  • Chad / epidemiology
  • Disease Reservoirs / parasitology
  • Equidae / parasitology
  • Genome, Protozoan / genetics
  • Horses / parasitology
  • Trypanosoma / classification
  • Trypanosoma / genetics
  • Trypanosoma / immunology
  • Trypanosoma / isolation & purification
  • Trypanosomiasis, African / diagnosis
  • Trypanosomiasis, African / epidemiology
  • Trypanosomiasis, African / transmission
  • Trypanosomiasis, African / veterinary

Conflict of Interest Statement

The authors declare that they have no competing interests.

References

This article includes 53 references
  1. Büscher P, Cecchi G, Jamonneau V, Priotto G. Human African trypanosomiasis.. Lancet 2017 Nov 25;390(10110):2397-2409.
    pubmed: 28673422doi: 10.1016/s0140-6736(17)31510-6google scholar: lookup
  2. Büscher P, Bart JM, Boelaert M, Bucheton B, Cecchi G, Chitnis N, Courtin D, Figueiredo LM, Franco JR, Grébaut P, Hasker E, Ilboudo H, Jamonneau V, Koffi M, Lejon V, MacLeod A, Masumu J, Matovu E, Mattioli R, Noyes H, Picado A, Rock KS, Rotureau B, Simo G, Thévenon S, Trindade S, Truc P, Van Reet N. Do Cryptic Reservoirs Threaten Gambiense-Sleeping Sickness Elimination?. Trends Parasitol 2018 Mar;34(3):197-207.
    pmc: PMC5840517pubmed: 29396200doi: 10.1016/j.pt.2017.11.008google scholar: lookup
  3. Fèvre EM, Wissmann BV, Welburn SC, Lutumba P. The burden of human African trypanosomiasis.. PLoS Negl Trop Dis 2008;2(12):e333.
    pmc: PMC2602597pubmed: 19104653doi: 10.1371/journal.pntd.0000333google scholar: lookup
  4. Welburn SC, Maudlin I, Simarro PP. Controlling sleeping sickness - a review.. Parasitology 2009 Dec;136(14):1943-9.
    pubmed: 19691861doi: 10.1017/s0031182009006416google scholar: lookup
  5. WHO. Accelerating work to overcome neglected tropical diseases: a roadmap for implementation.. Geneva: World Health Organization; 2012.
  6. Dhollander S, Jallow A, Mbodge K, Kora S, Sanneh M, Gaye M, Bos J, Leak S, Berkvens D, Geerts S. Equine trypanosomosis in the Central River Division of The Gambia: a study of veterinary gate-clinic consultation records.. Prev Vet Med 2006 Aug 17;75(3-4):152-62.
    pubmed: 16814418doi: 10.1016/j.prevetmed.2005.11.009google scholar: lookup
  7. Pinchbeck GL, Morrison LJ, Tait A, Langford J, Meehan L, Jallow S, Jallow J, Jallow A, Christley RM. Trypanosomosis in The Gambia: prevalence in working horses and donkeys detected by whole genome amplification and PCR, and evidence for interactions between trypanosome species.. BMC Vet Res 2008 Feb 20;4:7.
    pmc: PMC2263031pubmed: 18289378doi: 10.1186/1746-6148-4-7google scholar: lookup
  8. Snow WF, Wacher TJ, Rawlings P. Observations on the prevalence of trypanosomosis in small ruminants, equines and cattle, in relation to tsetse challenge, in The Gambia.. Vet Parasitol 1996 Nov 1;66(1-2):1-11.
    pubmed: 8988551doi: 10.1016/s0304-4017(96)01003-5google scholar: lookup
  9. Shaw AP, Cecchi G, Wint GR, Mattioli RC, Robinson TP. Mapping the economic benefits to livestock keepers from intervening against bovine trypanosomosis in Eastern Africa.. Prev Vet Med 2014 Feb 1;113(2):197-210.
    pubmed: 24275205doi: 10.1016/j.prevetmed.2013.10.024google scholar: lookup
  10. Raftery AG, Jallow S, Rodgers J, Sutton DGM. Safety and efficacy of three trypanocides in confirmed field cases of trypanosomiasis in working equines in The Gambia: a prospective, randomised, non-inferiority trial.. PLoS Negl Trop Dis 2019 Mar;13(3):e0007175.
    pmc: PMC6447232pubmed: 30901321doi: 10.1371/journal.pntd.0007175google scholar: lookup
  11. Simo G, Asonganyi T, Nkinin SW, Njiokou F, Herder S. High prevalence of Trypanosoma brucei gambiense group 1 in pigs from the Fontem sleeping sickness focus in Cameroon.. Vet Parasitol 2006 Jun 30;139(1-3):57-66.
    pubmed: 16567049doi: 10.1016/j.vetpar.2006.02.026google scholar: lookup
  12. Njiokou F, Simo G, Nkinin SW, Laveissière C, Herder S. Infection rate of Trypanosoma brucei s.l., T. vivax, T. congolense "forest type", and T. simiae in small wild vertebrates in south Cameroon.. Acta Trop 2004 Oct;92(2):139-46.
    pubmed: 15350866doi: 10.1016/j.actatropica.2004.04.011google scholar: lookup
  13. Jamonneau V, Ravel S, Koffi M, Kaba D, Zeze DG, Ndri L, Sane B, Coulibaly B, Cuny G, Solano P. Mixed infections of trypanosomes in tsetse and pigs and their epidemiological significance in a sleeping sickness focus of Côte d'Ivoire.. Parasitology 2004 Dec;129(Pt 6):693-702.
    pubmed: 15648692doi: 10.1017/s0031182004005876google scholar: lookup
  14. Nimpaye H, Njiokou F, Njine T, Njitchouang GR, Cuny G, Herder S, Asonganyi T, Simo G. Trypanosoma vivax, T. congolense "forest type" and T. simiae: prevalence in domestic animals of sleeping sickness foci of Cameroon.. Parasite 2011 May;18(2):171-9.
    pmc: PMC3671417pubmed: 21678793doi: 10.1051/parasite/2011182171google scholar: lookup
  15. Cordon-Obras C, Berzosa P, Ndong-Mabale N, Bobuakasi L, Buatiche JN, Ndongo-Asumu P, Benito A, Cano J. Trypanosoma brucei gambiense in domestic livestock of Kogo and Mbini foci (Equatorial Guinea).. Trop Med Int Health 2009 May;14(5):535-41.
    pubmed: 19320872doi: 10.1111/j.1365-3156.2009.02271.xgoogle scholar: lookup
  16. Cordon-Obras C, García-Estébanez C, Ndong-Mabale N, Abaga S, Ndongo-Asumu P, Benito A, Cano J. Screening of Trypanosoma brucei gambiense in domestic livestock and tsetse flies from an insular endemic focus (Luba, Equatorial Guinea).. PLoS Negl Trop Dis 2010 Jun 8;4(6):e704.
    pmc: PMC2882337pubmed: 20544031doi: 10.1371/journal.pntd.0000704google scholar: lookup
  17. Burn CC, Dennison TL, Whay HR. Relationships between behaviour and health in working horses, donkeys, and mules in developing countries.. Appl Anim Behav Sci 2010;126:109–118.
  18. Stringer A, Lunn DP, Reid S. Science in brief: Report on the first Havemeyer workshop on infectious diseases in working equids, Addis Ababa, Ethiopia, November 2013.. Equine Vet J 2015 Jan;47(1):6-9.
    pubmed: 25257182doi: 10.1111/evj.12359google scholar: lookup
  19. OIE—World Organisation for Animal Health. Manual of diagnostic tests and vaccines for terrestrial Animals.. 2018.
  20. Stringer A. Improving animal health for poverty alleviation and sustainable livelihoods.. Vet Rec 2014 Nov 29;175(21):526-9.
    pubmed: 25431381doi: 10.1136/vr.g6281google scholar: lookup
  21. Pritchard JC. Animal traction and transport in the 21st century: getting the priorities right.. Vet J 2010 Dec;186(3):271-4.
    pubmed: 20833088doi: 10.1016/j.tvjl.2010.08.004google scholar: lookup
  22. Admassu B, Shiferaw Y. Donkeys, horses and mules—their contribution to people’s livelihoods in Ethiopia.. .
  23. Coetzer JAW, Tustin RC. Infectious diseases of livestock. 2.. Oxford: Oxford University Press; 2005.
  24. Büscher P, Gonzatti MI, Hébert L, Inoue N, Pascucci I, Schnaufer A, Suganuma K, Touratier L, Van Reet N. Equine trypanosomosis: enigmas and diagnostic challenges.. Parasit Vectors 2019 May 15;12(1):234.
    pmc: PMC6518633pubmed: 31092285doi: 10.1186/s13071-019-3484-xgoogle scholar: lookup
  25. Bureau P. Historique et évolution de la maladie du sommeil au Tchad.. Bull Liais Doc OCEAC 1996;29:90–98.
  26. Peka M, Kohagne TL, Ndjeleje N, Louis FJ, Hassane MH. Transmission concomitante de Trypanosomose humaine et animale: le foyer du Mandoul au Tchad.. Rév Elev Med Vét Pays Trop 2014;67:5–12.
  27. Franco JR, Cecchi G, Priotto G, Paone M, Diarra A, Grout L, Simarro PP, Zhao W, Argaw D. Monitoring the elimination of human African trypanosomiasis: Update to 2016.. PLoS Negl Trop Dis 2018 Dec;12(12):e0006890.
    pmc: PMC6283345pubmed: 30521525doi: 10.1371/journal.pntd.0006890google scholar: lookup
  28. Magrin G. Le sud du Tchad en mutation: des champs de coton aux sirènes de l’or noir.. CIRAD, PRASAC, SEPLA; 2001.
  29. Seignobos C. Le poney du Logone et les derniers peuples cavaliers: essai dʼapproche historique. Maisons-Alfort, Institut dʼélevage et de médecine vétérinaire des pays tropicaux, Centre de coopération internationale et recherche agronomique pour le développement; 1987.
  30. Woo PT. The haematocrit centrifuge technique for the diagnosis of African trypanosomiasis.. Acta Trop 1970;27(4):384-6.
    pubmed: 4396363
  31. Matovu E, Kitibwa A, Picado A, Biéler S, Bessell PR, Ndung'u JM. Serological tests for gambiense human African trypanosomiasis detect antibodies in cattle.. Parasit Vectors 2017 Nov 3;10(1):546.
    pmc: PMC5670715pubmed: 29100526doi: 10.1186/s13071-017-2487-8google scholar: lookup
  32. Sternberg JM, Gierliński M, Biéler S, Ferguson MA, Ndung'u JM. Evaluation of the diagnostic accuracy of prototype rapid tests for human African trypanosomiasis.. PLoS Negl Trop Dis 2014 Dec;8(12):e3373.
    pmc: PMC4270746pubmed: 25521120doi: 10.1371/journal.pntd.0003373google scholar: lookup
  33. Jamonneau V, Camara O, Ilboudo H, Peylhard M, Koffi M, Sakande H, N'Dri L, Sanou D, Dama E, Camara M, Lejon V. Accuracy of individual rapid tests for serodiagnosis of gambiense sleeping sickness in West Africa.. PLoS Negl Trop Dis 2015 Feb;9(2):e0003480.
    pmc: PMC4314185pubmed: 25642701doi: 10.1371/journal.pntd.0003480google scholar: lookup
  34. Bisser S, Lumbala C, Nguertoum E, Kande V, Flevaud L, Vatunga G, Boelaert M, Büscher P, Josenando T, Bessell PR, Biéler S, Ndung'u JM. Sensitivity and Specificity of a Prototype Rapid Diagnostic Test for the Detection of Trypanosoma brucei gambiense Infection: A Multi-centric Prospective Study.. PLoS Negl Trop Dis 2016 Apr;10(4):e0004608.
    pmc: PMC4825971pubmed: 27058033doi: 10.1371/journal.pntd.0004608google scholar: lookup
  35. Ravel S, Mediannikov O, Bossard G, Desquesnes M, Cuny G, Davoust B. A study on African animal trypanosomosis in four areas of Senegal.. Folia Parasitol (Praha) 2015 Aug 18;62.
    pubmed: 26370150doi: 10.14411/fp.2015.044google scholar: lookup
  36. Masiga DK, Smyth AJ, Hayes P, Bromidge TJ, Gibson WC. Sensitive detection of trypanosomes in tsetse flies by DNA amplification.. Int J Parasitol 1992 Nov;22(7):909-18.
    pubmed: 1459784doi: 10.1016/0020-7519(92)90047-ogoogle scholar: lookup
  37. Majiwa PA, Thatthi R, Moloo SK, Nyeko JH, Otieno LH, Maloo S. Detection of trypanosome infections in the saliva of tsetse flies and buffy-coat samples from antigenaemic but aparasitaemic cattle.. Parasitology 1994 Apr;108 ( Pt 3):313-22.
    pubmed: 8022657doi: 10.1017/s0031182000076150google scholar: lookup
  38. Radwanska M, Claes F, Magez S, Magnus E, Perez-Morga D, Pays E, Büscher P. Novel primer sequences for polymerase chain reaction-based detection of Trypanosoma brucei gambiense.. Am J Trop Med Hyg 2002 Sep;67(3):289-95.
    pubmed: 12408669doi: 10.4269/ajtmh.2002.67.289google scholar: lookup
  39. Morrison LJ, Tait A, McCormack G, Sweeney L, Black A, Truc P, Likeufack AC, Turner CM, MacLeod A. Trypanosoma brucei gambiense Type 1 populations from human patients are clonal and display geographical genetic differentiation.. Infect Genet Evol 2008 Dec;8(6):847-54.
    pubmed: 18790085doi: 10.1016/j.meegid.2008.08.005google scholar: lookup
  40. Cohen J. A coefficient of agreement for nominal scales.. Educ Psychol Meas 1960;20:37–46.
  41. Altman DG. Practical statistics for medical research.. London: Chapman and Hall CRC; 1991.
  42. Faye D, Pereira de Almeida PJ, Goossens B, Osaer S, Ndao M, Berkvens D, Speybroeck N, Nieberding F, Geerts S. Prevalence and incidence of trypanosomosis in horses and donkeys in the Gambia.. Vet Parasitol 2001 Nov 5;101(2):101-14.
    pubmed: 11587839doi: 10.1016/s0304-4017(01)00503-9google scholar: lookup
  43. Desquesnes M, Dávila AM. Applications of PCR-based tools for detection and identification of animal trypanosomes: a review and perspectives.. Vet Parasitol 2002 Nov 11;109(3-4):213-31.
    pubmed: 12423934doi: 10.1016/s0304-4017(02)00270-4google scholar: lookup
  44. Büscher P, Mertens P, Leclipteux T, Gilleman Q, Jacquet D, Mumba-Ngoyi D, Pyana PP, Boelaert M, Lejon V. Sensitivity and specificity of HAT Sero-K-SeT, a rapid diagnostic test for serodiagnosis of sleeping sickness caused by Trypanosoma brucei gambiense: a case-control study.. Lancet Glob Health 2014 Jun;2(6):e359-63.
    pubmed: 25103304doi: 10.1016/s2214-109x(14)70203-7google scholar: lookup
  45. Jackson AP, Sanders M, Berry A, McQuillan J, Aslett MA, Quail MA, Chukualim B, Capewell P, MacLeod A, Melville SE, Gibson W, Barry JD, Berriman M, Hertz-Fowler C. The genome sequence of Trypanosoma brucei gambiense, causative agent of chronic human african trypanosomiasis.. PLoS Negl Trop Dis 2010 Apr 13;4(4):e658.
    pmc: PMC2854126pubmed: 20404998doi: 10.1371/journal.pntd.0000658google scholar: lookup
  46. Sistrom M, Evans B, Benoit J, Balmer O, Aksoy S, Caccone A. De Novo Genome Assembly Shows Genome Wide Similarity between Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense.. PLoS One 2016;11(2):e0147660.
    pmc: PMC4766357pubmed: 26910229doi: 10.1371/journal.pone.0147660google scholar: lookup
  47. Salim B, Bakheit MA, Sugimoto C. Molecular detection of equine trypanosomes in the Sudan.. Vet Parasitol 2014 Mar 1;200(3-4):246-50.
    pubmed: 24439848doi: 10.1016/j.vetpar.2013.09.002google scholar: lookup
  48. Desquesnes M, Dia ML. Trypanosoma vivax: mechanical transmission in cattle by one of the most common African tabanids, Atylotus agrestis.. Exp Parasitol 2003 Jan-Feb;103(1-2):35-43.
    pubmed: 12810044doi: 10.1016/s0014-4894(03)00067-5google scholar: lookup
  49. Simarro PP, Cecchi G, Franco JR, Paone M, Diarra A, Priotto G, Mattioli RC, Jannin JG. Monitoring the Progress towards the Elimination of Gambiense Human African Trypanosomiasis.. PLoS Negl Trop Dis 2015;9(6):e0003785.
    pmc: PMC4461311pubmed: 26056823doi: 10.1371/journal.pntd.0003785google scholar: lookup
  50. Rayaisse JB, Esterhuizen J, Tirados I, Kaba D, Salou E, Diarrassouba A, Vale GA, Lehane MJ, Torr SJ, Solano P. Towards an optimal design of target for tsetse control: comparisons of novel targets for the control of Palpalis group tsetse in West Africa.. PLoS Negl Trop Dis 2011 Sep;5(9):e1332.
    pmc: PMC3176748pubmed: 21949896doi: 10.1371/journal.pntd.0001332google scholar: lookup
  51. Herder S, Simo G, Nkinin S, Njiokou F. Identification of trypanosomes in wild animals from southern Cameroon using the polymerase chain reaction (PCR).. Parasite 2002 Dec;9(4):345-9.
    pubmed: 12514949doi: 10.1051/parasite/2002094345google scholar: lookup
  52. Simo G, Njiokou F, Mbida Mbida JA, Njitchouang GR, Herder S, Asonganyi T, Cuny G. Tsetse fly host preference from sleeping sickness foci in Cameroon: epidemiological implications.. Infect Genet Evol 2008 Jan;8(1):34-9.
    pubmed: 17977803doi: 10.1016/j.meegid.2007.09.005google scholar: lookup
  53. Njiokou F, Laveissière C, Simo G, Nkinin S, Grébaut P, Cuny G, Herder S. Wild fauna as a probable animal reservoir for Trypanosoma brucei gambiense in Cameroon.. Infect Genet Evol 2006 Mar;6(2):147-53.
    pubmed: 16236560doi: 10.1016/j.meegid.2005.04.003google scholar: lookup

Citations

This article has been cited 6 times.
  1. Vourchakbé J, Tiofack AAZ, Kante ST, Barka PA, Simo G. Prevalence of pathogenic trypanosome species in naturally infected cattle of three sleeping sickness foci of the south of Chad.. PLoS One 2022;17(12):e0279730.
    doi: 10.1371/journal.pone.0279730pubmed: 36584086google scholar: lookup
  2. Geerts M, Chen Z, Bebronne N, Savill NJ, Schnaufer A, Büscher P, Van Reet N, Van den Broeck F. Deep kinetoplast genome analyses result in a novel molecular assay for detecting Trypanosoma brucei gambiense-specific minicircles.. NAR Genom Bioinform 2022 Dec;4(4):lqac081.
    doi: 10.1093/nargab/lqac081pubmed: 36285287google scholar: lookup
  3. Boundenga L, Mombo IM, Augustin MO, Barthélémy N, Nzassi PM, Moukodoum ND, Rougeron V, Prugnolle F. Molecular Identification of Trypanosome Diversity in Domestic Animals Reveals the Presence of Trypanosoma brucei gambiense in Historical Foci of Human African Trypanosomiasis in Gabon.. Pathogens 2022 Aug 30;11(9).
    doi: 10.3390/pathogens11090992pubmed: 36145424google scholar: lookup
  4. Somda MB, Kaboré J, Karambiri SM, Dama E, Dabiré D, Compaoré CFA, Salou EW, Ilboudo H, Houaga I, Courtin F, Belem AMG, Jamonneau V, Bengaly Z. Evaluation of the Re-emergence Risk of Human African Trypanosomiasis in the Southwestern Burkina Faso, A Gold-Bearing Mutation Area.. Acta Parasitol 2022 Jun;67(2):714-722.
    doi: 10.1007/s11686-021-00512-2pubmed: 35029802google scholar: lookup
  5. Traoré BM, Koffi M, N'Djetchi MK, Kaba D, Kaboré J, Ilboudo H, Ahouty BA, Koné M, Coulibaly B, Konan T, Segard A, Kouakou L, De Meeûs T, Ravel S, Solano P, Bart JM, Jamonneau V. Free-ranging pigs identified as a multi-reservoir of Trypanosoma brucei and Trypanosoma congolense in the Vavoua area, a historical sleeping sickness focus of Côte d'Ivoire.. PLoS Negl Trop Dis 2021 Dec;15(12):e0010036.
    doi: 10.1371/journal.pntd.0010036pubmed: 34937054google scholar: lookup
  6. Vourchakbé J, Tiofack ZAA, Kante TS, Mpoame M, Simo G. Molecular identification of Trypanosoma brucei gambiense in naturally infected pigs, dogs and small ruminants confirms domestic animals as potential reservoirs for sleeping sickness in Chad.. Parasite 2020;27:63.
    doi: 10.1051/parasite/2020061pubmed: 33206595google scholar: lookup
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