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Epidemiology and infection2016; 144(15); 3176-3183; doi: 10.1017/S0950268816001400

Twenty years of Hendra virus: laboratory submission trends and risk factors for infection in horses.

Abstract: Hendra virus (HeV) was first described in 1994 in an outbreak of acute and highly lethal disease in horses and humans in Australia. Equine cases continue to be diagnosed periodically, yet the predisposing factors for infection remain unclear. We undertook an analysis of equine submissions tested for HeV by the Queensland government veterinary reference laboratory over a 20-year period to identify and investigate any patterns. We found a marked increase in testing from July 2008, primarily reflecting a broadening of the HeV clinical case definition. Peaks in submissions for testing, and visitations to the Government HeV website, were associated with reported equine incidents. Significantly differing between-year HeV detection rates in north and south Queensland suggest a fundamental difference in risk exposure between the two regions. The statistical association between HeV detection and stockhorse type may suggest that husbandry is a more important risk determinant than breed per se. The detection of HeV in horses with neither neurological nor respiratory signs poses a risk management challenge for attending veterinarians and laboratory staff, reinforcing animal health authority recommendations that appropriate risk management strategies be employed for all sick horses, and by anyone handling sick horses or associated biological samples.
Publication Date: 2016-06-30 PubMed ID: 27357144PubMed Central: PMC9150281DOI: 10.1017/S0950268816001400Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

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The research article mainly focuses on the analysis of cases related to ‘Hendra virus‘ (HeV) in horses over the last 20 years. The researchers seemed to be looking for patterns and risk factors to better understand and manage the infection.

Research Context:

  • The Hendra virus (HeV) is a pathogen that was first discovered in Australia in 1994. It is known to cause severe diseases not only in horses but also in humans.
  • Over the past two decades, periodic cases of HeV in horses continue to be recorded. However, the factors contributing to these infections remain largely unclear.

Research Methodology:

  • The study carried out an analysis of equine cases that were tested for HeV in a Queensland government veterinary reference laboratory over a period of 20 years.
  • The intent behind this investigation was to identify any discernable patterns in the HeV infection cases among horses, and boost understanding of the virus.

Research Findings:

  • A significant increase in testing from July 2008 was observed, mainly due to an extension of the clinical case definition of HeV.
  • Researchers found that peaks in testing submissions and visits to the government’s HeV website corresponded with reported equine incidents, indicating public concern and engagement.
  • A critical finding was the notable variation in HeV detection rates between northern and southern parts of Queensland. This pattern might indicate a fundamental difference in risk exposure between the two regions.

Connections and Implications:

  • The researchers also found a statistical pointer towards ‘stockhorse-type’ horses getting infected more often with HeV, suggesting that the husbandry practices may be a more prominent risk factor than the breed itself.
  • Interestingly, HeV was also discovered in horses that did not display the usual neurological or respiratory signs, posing a risk management challenge. This finding reinforces recommendations from animal health authorities that adequate risk management strategies should be implemented for all sick horses and by anyone handling these animals.

Cite This Article

APA
Smith CS, McLAUGHLIN A, Field HE, Edson D, Mayer D, Ossedryver S, Barrett J, Waltisbuhl D. (2016). Twenty years of Hendra virus: laboratory submission trends and risk factors for infection in horses. Epidemiol Infect, 144(15), 3176-3183. https://doi.org/10.1017/S0950268816001400

Publication

ISSN: 1469-4409
NlmUniqueID: 8703737
Country: England
Language: English
Volume: 144
Issue: 15
Pages: 3176-3183

Researcher Affiliations

Smith, C S
  • Biosecurity Queensland,Department of Agriculture and Fisheries,Brisbane,Queensland,Australia.
McLAUGHLIN, A
  • Biosecurity Queensland,Department of Agriculture and Fisheries,Brisbane,Queensland,Australia.
Field, H E
  • Biosecurity Queensland,Department of Agriculture and Fisheries,Brisbane,Queensland,Australia.
Edson, D
  • Biosecurity Queensland,Department of Agriculture and Fisheries,Brisbane,Queensland,Australia.
Mayer, D
  • Biosecurity Queensland,Department of Agriculture and Fisheries,Brisbane,Queensland,Australia.
Ossedryver, S
  • Biosecurity Queensland,Department of Agriculture and Fisheries,Brisbane,Queensland,Australia.
Barrett, J
  • Biosecurity Queensland,Department of Agriculture and Fisheries,Brisbane,Queensland,Australia.
Waltisbuhl, D
  • Biosecurity Queensland,Department of Agriculture and Fisheries,Brisbane,Queensland,Australia.

MeSH Terms

  • Animals
  • Hendra Virus / physiology
  • Henipavirus Infections / epidemiology
  • Henipavirus Infections / veterinary
  • Henipavirus Infections / virology
  • Horse Diseases / epidemiology
  • Horse Diseases / virology
  • Horses
  • Prevalence
  • Queensland / epidemiology
  • Risk Factors

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