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Animals : an open access journal from MDPI2020; 10(4); doi: 10.3390/ani10040697

Undenatured Type II Collagen (UC-II) in Joint Health and Disease: A Review on the Current Knowledge of Companion Animals.

Abstract: OA is quite common in companion animals, especially in large breed dogs and horses. Collagen, the most abundant protein of mammals, has specific connective tissue types for skin, bones, reticulate, basal lamina, bones, cell surfaces, while type II collagen (UC-II) forms the main structure of cartilage tissue. Even at the smaller dosages, UC-II has also been reported to be more effective than the glucosamine and chondroitin sulfate supplements, which are the supplements most frequently used in the market. In this review, we summarize the effects of UC-II on joint health and function in health and disease conditions in companion animals.
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Publication Date: 2020-04-17 PubMed ID: 32316397PubMed Central: PMC7222752DOI: 10.3390/ani10040697Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article reviews the benefits of undenatured Type II Collagen (UC-II) for joint health in pets, especially large breed dogs and horses, and suggests its effectiveness could outweigh traditional supplements such as glucosamine and chondroitin sulfate.

Understanding the Role of UC-II Collagen in Joint Health

  • Undenatured Type II Collagen (UC-II) is a significant form of collagen that forms the main structure of cartilage tissue in mammals. This cartilage tissue is crucial to joint health as it provides cushion and support for movement.
  • This review discusses how smaller doses of UC-II have been found to be more effective than traditional joint supplements used on the market, namely glucosamine and chondroitin sulfate. This comparison refers to studies where UC-II supplementation led to an improvement in joint pain and mobility in animals.
  • UC-II is particularly useful in managing conditions like Osteoarthritis (OA), which is common in large breed dogs and horses. Osteoarthritis involves the deterioration of cartilage in the joints, often causing pain and limiting movement.

UC-II Collagen and Comparative Effectiveness

  • The researchers highlight that the effectiveness of UC-II, even at smaller doses, suggests its potential in treating joint diseases in animals.
  • Existing options such as glucosamine and chondroitin sulfate supplements have been widely used but may not be as effective as UC-II. These supplements also aid in maintaining and repairing cartilage but research suggests UC-II may offer superior results.
  • The favorable comparison of UC-II to traditional joint supplements opens up new possibilities for animal treatments.

The Relevance of UC-II Collagen Research in Animal Health

  • This review emphasizes the crucial role UC-II could play in the health and well-being of companion animals, particularly those susceptible to joint diseases such as large breed dogs and horses.
  • The evidence suggesting UC-II can improve joint health even in smaller doses presents a significant potential cost advantage, as lower amounts would be needed to achieve the same or even better results compared to other supplements.
  • Future research into UC-II can reveal more about its role and effects in joint health, disease management, and overall animal healthcare protocols.

Cite This Article

APA
Gencoglu H, Orhan C, Sahin E, Sahin K. (2020). Undenatured Type II Collagen (UC-II) in Joint Health and Disease: A Review on the Current Knowledge of Companion Animals. Animals (Basel), 10(4). https://doi.org/10.3390/ani10040697

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 10
Issue: 4

Researcher Affiliations

Gencoglu, Hasan
  • Department of Biology, Faculty of Science, Firat University, Elazig (+90) 424, Turkey.
Orhan, Cemal
  • Department of Animal Nutrition, Faculty of Veterinary Medicine, Firat University, Elazig (+90) 424, Turkey.
Sahin, Emre
  • Department of Animal Nutrition, Faculty of Veterinary Medicine, Firat University, Elazig (+90) 424, Turkey.
Sahin, Kazim
  • Department of Animal Nutrition, Faculty of Veterinary Medicine, Firat University, Elazig (+90) 424, Turkey.

Grant Funding

  • 2019-2 / Türkiye Bilimler Akademisi

Conflict of Interest Statement

The authors declare no conflict of interest.

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