Update on treatments for endotoxemia.
Abstract: Endotoxemia is a major cause of morbidity and mortality in horses affected by colic. This article briefly reviews the pathogenesis of endotoxemia in horses with colic, reviews current established treatments, and describes new advances in the treatment of endotoxemia.
Publication Date: 2009-07-08 PubMed ID: 19580938DOI: 10.1016/j.cveq.2009.04.012Google Scholar: Lookup
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- Journal Article
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Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research article is about the latest developments in treating endotoxemia, a significant cause of illness and death in colicky horses. It gives an overview of how endotoxemia affects horses suffering from colic, discusses existing treatments, and introduces recent advancements in dealing with the disease.
Understanding Endotoxemia in Horses
- The research commences by explaining the disease process of endotoxemia in colicky horses. As such, it provides a comprehensive perspective on how endotoxemia is initiated and progresses in afflicted animals.
- The researchers delve into the biological and physiological processes implicated in the development and exacerbation of endotoxemia. This information provides a scientific background for understanding the disease’s etiology.
Current Established Treatments
- The research proceeds to discuss the currently established methods of treating endotoxemia. It might include details about the types of treatments, their efficacy, side effects, and the time it takes for patients to respond to these treatments.
- The researchers highlight both pharmacological and non-pharmacological interventions. They might also explore the reasons behind the effectiveness of these treatments to shed more light on the mechanisms of endotoxemia.
New Advances in Endotoxemia Treatment
- Lastly, the article introduces new advancements in treating endotoxemia, offering promising solutions to improving the health and survival outcomes in colicky horses. The new advances could be innovative drugs or therapies that enhance the efficiency of disease management.
- The authors might present new scientific evidence and experimental results that back the efficacy of these new treatments. The discussions would provide medical professionals with up-to-date knowledge and propel further research in endotoxemia treatment.
Cite This Article
APA
Kelmer G.
(2009).
Update on treatments for endotoxemia.
Vet Clin North Am Equine Pract, 25(2), 259-270.
https://doi.org/10.1016/j.cveq.2009.04.012 Publication
Researcher Affiliations
- Large Animal Department, Koret Veterinary Teaching Hospital, Hebrew University of Jerusalem, Rehovot, Israel. kelmerg@agri.huji.ac.il
MeSH Terms
- Animals
- Colic / complications
- Colic / veterinary
- Endotoxemia / complications
- Endotoxemia / drug therapy
- Endotoxemia / prevention & control
- Endotoxemia / veterinary
- Horse Diseases / pathology
- Horses
Citations
This article has been cited 13 times.- van Spijk JN, Beckmann K, Wehrli Eser M, Stirn M, Steuer AE, Saleh L, Schoster A. Preliminary Investigation of Side Effects of Polymyxin B Administration in Hospitalized Horses. Antibiotics (Basel) 2023 May 5;12(5).
- van Spijk JN, Beckmann K, Wehrli Eser M, Boxler M, Stirn M, Rhyner T, Kaelin D, Saleh L, Schoster A. Adverse effects of polymyxin B administration to healthy horses. J Vet Intern Med 2022 Jul;36(4):1525-1534.
- Bauquier J, Tudor E, Bailey S. Effect of the p38 MAPK inhibitor doramapimod on the systemic inflammatory response to intravenous lipopolysaccharide in horses. J Vet Intern Med 2020 Sep;34(5):2109-2116.
- Mendoza Garcia FJ, Gonzalez-De Cara C, Aguilera-Aguilera R, Buzon-Cuevas A, Perez-Ecija A. Meloxicam ameliorates the systemic inflammatory response syndrome associated with experimentally induced endotoxemia in adult donkeys. J Vet Intern Med 2020 Jul;34(4):1631-1641.
- Dik B, Sonmez G, Faki HE, Bahcivan E. Sulfasalazine treatment can cause a positive effect on LPS-induced endotoxic rats. Exp Anim 2018 Nov 1;67(4):403-412.
- Dou ZF, Guo YR, Liu JC, Li N, Chai B, Li XQ, Fu R, Wang XJ. Ameliorative effects of glycine in an experimental nonalcoholic steatohepatitis and its correlation between TREM-1 and TREM-2. Am J Transl Res 2016;8(2):284-97.
- Rodes L, Saha S, Tomaro-Duchesneau C, Prakash S. Microencapsulated Bifidobacterium longum subsp. infantis ATCC 15697 favorably modulates gut microbiota and reduces circulating endotoxins in F344 rats. Biomed Res Int 2014;2014:602832.
- Davis HA, Munsterman A. Ileal impaction and jejunal enterotomy in a 4-month-old Arabian filly. Can Vet J 2012 Jan;53(1):71-4.
- Urayama S, Muko R, Muranaka M, Mita H, Ohta M, Matsuda H, Tanaka A. Differential effects of flunixin meglumine and meloxicam on TNF- α production in LPS-stimulated equine neutrophils in vitro. Vet Anim Sci 2025 Dec;30:100513.
- Uslu M, Corum O, Yazar E. Effect of Meloxicam on the Pharmacokinetics of Cefquinome in Endotoxemic Sheep. Vet Med Sci 2025 Sep;11(5):e70462.
- Hardefeldt L, Thomas K, Page S, Norris J, Browning G, El Hage C, Stewart A, Gilkerson J, Muscatello G, Verwilghen D, van Galen G, Bauquier J, Cuming R, Reynolds B, Whittaker C, Wilkes E, Clulow J, Burden C, Begg L. Antimicrobial prescribing guidelines for horses in Australia. Aust Vet J 2025 Dec;103(12):781-889.
- Mendoza FJ, Buzon-Cuevas A, Aguilera-Aguilera R, Gonzalez-De Cara CA, De Las Heras A, Perez-Ecija A. Hemodynamic Response to Lipopolysaccharide Infusion and Effect of Meloxicam Administration on Cardiac Function in Donkeys. Animals (Basel) 2024 Dec 18;14(24).
- Zou R, Shi W, Chen M, Zhang M, Wu D, Li H, Zhou H, Li Y, Lu W, Li C, Fan X. Phosphoglycerate mutase 1-mediated dephosphorylation and degradation of Dusp1 disrupt mitochondrial quality control and exacerbate endotoxemia-induced myocardial dysfunction. Theranostics 2024;14(19):7488-7504.
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