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Home / Equine Research Bank / Vaccine / Vaccination against equine influenza: quid novi?
Vaccine2006; 24(19); 4047-4061; doi: 10.1016/j.vaccine.2006.02.030

Vaccination against equine influenza: quid novi?

Abstract: Equine influenza virus is a leading cause of respiratory disease in the horse. Equine influenza vaccines containing inactivated virus were first developed in the 1960s. Despite their intensive use, equine influenza outbreaks still continue to occur and therefore new strategies of vaccination are necessary to improve vaccine efficacy. Numerous methods of vaccination have been evaluated and commercialised in the horse, the most recent being the cold-adapted influenza virus and poxvirus-based vaccines. As a large animal model, the horse is also a useful species in which to evaluate the potential of new generations of influenza vaccine such as live-attenuated influenza virus engineered by reverse genetics. This report details the equine immune responses conferring protection against influenza. It then undertakes a selective review of different strategies of vaccination against equine influenza that have been developed over the last two decades and discusses factors that may influence the efficacy of vaccination. Finally it outlines progress in the development of a novel vaccination strategy against equine influenza using reverse genetics.
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Publication Date: 2006-02-28 PubMed ID: 16545507DOI: 10.1016/j.vaccine.2006.02.030Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article discusses the ongoing challenges in preventing equine influenza, a common respiratory disease in horses. It explores the limitations of current vaccination strategies and delves into the potential of novel vaccination methods, including live-attenuated influenza virus produced by reverse genetics.

Understanding Equine Influenza and the Need for Effective Vaccination

  • The study begins by recognizing equine influenza as a prominent cause of respiratory disease among horses. Despite having vaccines that contain deactivated viruses developed as early as the 1960s, outbreaks of the disease still occur. This scenario underlines the need for more efficient vaccination strategies.
  • The horse serves as a large animal model for studying potential improvements to influenza vaccines, making advancements in this field relevant to broader virology research.
  • The research outlines the immune responses in horses that provide protection against influenza, providing necessary context for evaluating the efficacy of different vaccination methods.

Evaluating Different Vaccination Strategies against Equine Influenza

  • The paper then moves on to review the various vaccination methods that have been explored and brought to market for horses. These include the recent cold-adapted influenza virus and poxvirus-based vaccines.
  • These innovative vaccination strategies are evaluated for their potential effectiveness against equine influenza. The discussion also considers factors that may influence the efficacy of these vaccination strategies, offering a more comprehensive view of the challenges and opportunities in improving equine influenza prevention.

Prospects of a Novel Vaccination Strategy Using Reverse Genetics

  • Finally, the article provides an overview of progress in the development of a unique vaccination strategy for equine influenza that uses reverse genetics.
  • This method involves creating a live-attenuated (weakened) influenza virus, which could potentially provide a more robust and longer-lasting immune response against the disease. This novel approach represents a promising avenue for improving equine influenza vaccination and could also have implications for human influenza vaccines.

Cite This Article

APA
Paillot R, Hannant D, Kydd JH, Daly JM. (2006). Vaccination against equine influenza: quid novi? Vaccine, 24(19), 4047-4061. https://doi.org/10.1016/j.vaccine.2006.02.030

Publication

Vaccine
ISSN: 0264-410X
NlmUniqueID: 8406899
Country: Netherlands
Language: English
Volume: 24
Issue: 19
Pages: 4047-4061

Researcher Affiliations

Paillot, R
  • Animal Health Trust, Centre for Preventive Medicine, Lanwades Park, Newmarket, Suffolk CB8 7UU, UK. romain.paillot@aht.org.uk
Hannant, D
    Kydd, J H
      Daly, J M

        MeSH Terms

        • Age Factors
        • Animals
        • Antibodies, Viral / biosynthesis
        • Female
        • Genetic Vectors
        • Horse Diseases / immunology
        • Horse Diseases / prevention & control
        • Horses
        • Immunity, Cellular
        • Immunity, Maternally-Acquired
        • Influenza A Virus, H3N8 Subtype / classification
        • Influenza A Virus, H3N8 Subtype / genetics
        • Influenza A Virus, H3N8 Subtype / immunology
        • Influenza Vaccines / genetics
        • Influenza Vaccines / pharmacology
        • Models, Immunological
        • Molecular Epidemiology
        • Orthomyxoviridae Infections / immunology
        • Orthomyxoviridae Infections / prevention & control
        • Orthomyxoviridae Infections / veterinary
        • Pregnancy
        • Vaccines, Attenuated / pharmacology
        • Vaccines, DNA / genetics
        • Vaccines, DNA / pharmacology
        • Vaccines, Inactivated / pharmacology
        • Vaccines, Subunit / genetics
        • Vaccines, Subunit / pharmacology
        • Vaccines, Synthetic / genetics
        • Vaccines, Synthetic / pharmacology

        Citations

        This article has been cited 38 times.
        1. Olufemi OT, Edeh ER, Isyaku MS, Haliru M, Samaila S, Mshelia PW, Owolodun OA, Newton JR, Daly JM. Seroprevalence of Equine Influenza and Its Associated Risk Factors in Northwest Nigeria. Pathogens 2022 Nov 17;11(11).
          doi: 10.3390/pathogens11111372pubmed: 36422623google scholar: lookup
        2. Ahearne MM, Pentzke-Lemus LL, Romano AM, Larsen ED, Watson AM, O'Fallon EA, Landolt GA. Disease progression, pathologic, and virologic findings of an equine influenza outbreak in rescue donkeys. J Vet Intern Med 2022 Nov;36(6):2230-2237.
          doi: 10.1111/jvim.16563pubmed: 36205917google scholar: lookup
        3. El-Hage C, Hartley C, Savage C, Watson J, Gilkerson J, Paillot R. Assessment of Humoral and Long-Term Cell-Mediated Immune Responses to Recombinant Canarypox-Vectored Equine Influenza Virus Vaccination in Horses Using Conventional and Accelerated Regimens Respectively. Vaccines (Basel) 2022 May 26;10(6).
          doi: 10.3390/vaccines10060855pubmed: 35746463google scholar: lookup
        4. Skarlupka AL, Ross TM. Inherent Serum Inhibition of Influenza Virus Neuraminidases. Front Vet Sci 2021;8:677693.
          doi: 10.3389/fvets.2021.677693pubmed: 34409085google scholar: lookup
        5. Mathew MK, Virmani N, Bera BC, Anand T, Kumar R, Balena V, Sansanwal R, Pavulraj S, Sundaram K, Virmani M, Tripathi BN. Protective efficacy of inactivated reverse genetics based equine influenza vaccine candidate adjuvanted with Montanide(TM) Pet Gel in murine model. J Vet Med Sci 2019 Dec 18;81(12):1753-1762.
          doi: 10.1292/jvms.19-0399pubmed: 31656240google scholar: lookup
        6. Blanco-Lobo P, Rodriguez L, Reedy S, Oladunni FS, Nogales A, Murcia PR, Chambers TM, Martinez-Sobrido L. A Bivalent Live-Attenuated Vaccine for the Prevention of Equine Influenza Virus. Viruses 2019 Oct 11;11(10).
          doi: 10.3390/v11100933pubmed: 31614538google scholar: lookup
        7. Singh RK, Dhama K, Karthik K, Khandia R, Munjal A, Khurana SK, Chakraborty S, Malik YS, Virmani N, Singh R, Tripathi BN, Munir M, van der Kolk JH. A Comprehensive Review on Equine Influenza Virus: Etiology, Epidemiology, Pathobiology, Advances in Developing Diagnostics, Vaccines, and Control Strategies. Front Microbiol 2018;9:1941.
          doi: 10.3389/fmicb.2018.01941pubmed: 30237788google scholar: lookup
        8. Paillot R, Marcillaud Pitel C, D'Ablon X, Pronost S. Equine Vaccines: How, When and Why? Report of the Vaccinology Session, French Equine Veterinarians Association, 2016, Reims. Vaccines (Basel) 2017 Dec 4;5(4).
          doi: 10.3390/vaccines5040046pubmed: 29207516google scholar: lookup
        9. Paillot R, Rash NL, Garrett D, Prowse-Davis L, Montesso F, Cullinane A, Lemaitre L, Thibault JC, Wittreck S, Dancer A. How to Meet the Last OIE Expert Surveillance Panel Recommendations on Equine Influenza (EI) Vaccine Composition: A Review of the Process Required for the Recombinant Canarypox-Based EI Vaccine. Pathogens 2016 Nov 25;5(4).
          doi: 10.3390/pathogens5040064pubmed: 27897990google scholar: lookup
        10. Paillot R, El-Hage CM. The Use of a Recombinant Canarypox-Based Equine Influenza Vaccine during the 2007 Australian Outbreak: A Systematic Review and Summary. Pathogens 2016 Jun 10;5(2).
          doi: 10.3390/pathogens5020042pubmed: 27294963google scholar: lookup
        11. Paillot R. A Systematic Review of Recent Advances in Equine Influenza Vaccination. Vaccines (Basel) 2014 Nov 14;2(4):797-831.
          doi: 10.3390/vaccines2040797pubmed: 26344892google scholar: lookup
        12. Nishiyama S, Ikegami T. Temperature-sensitive mutations for live-attenuated Rift Valley fever vaccines: implications from other RNA viruses. Front Microbiol 2015;6:787.
          doi: 10.3389/fmicb.2015.00787pubmed: 26322023google scholar: lookup
        13. Short KR, Richard M, Verhagen JH, van Riel D, Schrauwen EJ, van den Brand JM, Mänz B, Bodewes R, Herfst S. One health, multiple challenges: The inter-species transmission of influenza A virus. One Health 2015 Dec 1;1:1-13.
          doi: 10.1016/j.onehlt.2015.03.001pubmed: 26309905google scholar: lookup
        14. Hughes HR, Vincent AL, Brockmeier SL, Gauger PC, Pena L, Santos J, Braucher DR, Perez DR, Loving CL. Oral Fluids as a Live-Animal Sample Source for Evaluating Cross-Reactivity and Cross-Protection following Intranasal Influenza A Virus Vaccination in Pigs. Clin Vaccine Immunol 2015 Oct;22(10):1109-20.
          doi: 10.1128/CVI.00358-15pubmed: 26291090google scholar: lookup
        15. Margine I, Krammer F. Animal models for influenza viruses: implications for universal vaccine development. Pathogens 2014 Oct 21;3(4):845-74.
          doi: 10.3390/pathogens3040845pubmed: 25436508google scholar: lookup
        16. Baz M, Paskel M, Matsuoka Y, Zengel J, Cheng X, Treanor JJ, Jin H, Subbarao K. A live attenuated equine H3N8 influenza vaccine is highly immunogenic and efficacious in mice and ferrets. J Virol 2015 Feb;89(3):1652-9.
          doi: 10.1128/JVI.02449-14pubmed: 25410860google scholar: lookup
        17. Pouwels HG, Van de Zande SM, Horspool LJ, Hoeijmakers MJ. Efficacy of a non-updated, Matrix-C-based equine influenza subunit-tetanus vaccine following Florida sublineage clade 2 challenge. Vet Rec 2014 Jun 21;174(25):633.
          doi: 10.1136/vr.101993pubmed: 24795071google scholar: lookup
        18. Galvin P, Gildea S, Arkins S, Walsh C, Cullinane A. The evaluation of a nucleoprotein ELISA for the detection of equine influenza antibodies and the differentiation of infected from vaccinated horses (DIVA). Influenza Other Respir Viruses 2013 Dec;7 Suppl 4(Suppl 4):73-80.
          doi: 10.1111/irv.12195pubmed: 24224822google scholar: lookup
        19. Baz M, Paskel M, Matsuoka Y, Zengel J, Cheng X, Jin H, Subbarao K. Replication and immunogenicity of swine, equine, and avian h3 subtype influenza viruses in mice and ferrets. J Virol 2013 Jun;87(12):6901-10.
          doi: 10.1128/JVI.03520-12pubmed: 23576512google scholar: lookup
        20. Scott S, Molesti E, Temperton N, Ferrara F, Böttcher-Friebertshäuser E, Daly J. The use of equine influenza pseudotypes for serological screening. J Mol Genet Med 2012;6:304-8.
          pubmed: 23515229
        21. Sajid M, Ahmad MU, Khan MA, Anjum MA, Mushtaq MH. Investigation of equine influenza virus in two geographical regions of Pakistan. Trop Anim Health Prod 2013 Feb;45(2):693-4.
          doi: 10.1007/s11250-012-0247-5pubmed: 22923059google scholar: lookup
        22. Firestone SM, Cogger N, Ward MP, Toribio JA, Moloney BJ, Dhand NK. The influence of meteorology on the spread of influenza: survival analysis of an equine influenza (A/H3N8) outbreak. PLoS One 2012;7(4):e35284.
          doi: 10.1371/journal.pone.0035284pubmed: 22536366google scholar: lookup
        23. Ault A, Zajac AM, Kong WP, Gorres JP, Royals M, Wei CJ, Bao S, Yang ZY, Reedy SE, Sturgill TL, Page AE, Donofrio-Newman J, Adams AA, Balasuriya UB, Horohov DW, Chambers TM, Nabel GJ, Rao SS. Immunogenicity and clinical protection against equine influenza by DNA vaccination of ponies. Vaccine 2012 Jun 6;30(26):3965-74.
          doi: 10.1016/j.vaccine.2012.03.026pubmed: 22449425google scholar: lookup
        24. Pena L, Vincent AL, Ye J, Ciacci-Zanella JR, Angel M, Lorusso A, Gauger PC, Janke BH, Loving CL, Perez DR. Modifications in the polymerase genes of a swine-like triple-reassortant influenza virus to generate live attenuated vaccines against 2009 pandemic H1N1 viruses. J Virol 2011 Jan;85(1):456-69.
          doi: 10.1128/JVI.01503-10pubmed: 20962084google scholar: lookup
        25. Cullinane A, Elton D, Mumford J. Equine influenza - surveillance and control. Influenza Other Respir Viruses 2010 Nov;4(6):339-44.
          doi: 10.1111/j.1750-2659.2010.00176.xpubmed: 20958927google scholar: lookup
        26. Morens DM, Taubenberger JK. Historical thoughts on influenza viral ecosystems, or behold a pale horse, dead dogs, failing fowl, and sick swine. Influenza Other Respir Viruses 2010 Nov;4(6):327-37.
          doi: 10.1111/j.1750-2659.2010.00148.xpubmed: 20958926google scholar: lookup
        27. van der Meer FJ, Orsel K, Barkema HW. The new influenza A H1N1 virus: balancing on the interface of humans and animals. Can Vet J 2010 Jan;51(1):56-62.
          pubmed: 20357942
        28. Bryant NA, Paillot R, Rash AS, Medcalf E, Montesso F, Ross J, Watson J, Jeggo M, Lewis NS, Newton JR, Elton DM. Comparison of two modern vaccines and previous influenza infection against challenge with an equine influenza virus from the Australian 2007 outbreak. Vet Res 2010 Mar-Apr;41(2):19.
          doi: 10.1051/vetres/2009067pubmed: 19863903google scholar: lookup
        29. Patel JR, Heldens JG. Immunoprophylaxis against important virus disease of horses, farm animals and birds. Vaccine 2009 Mar 13;27(12):1797-1810.
          doi: 10.1016/j.vaccine.2008.12.063pubmed: 19402200google scholar: lookup
        30. Chambers TM, Quinlivan M, Sturgill T, Cullinane A, Horohov DW, Zamarin D, Arkins S, García-Sastre A, Palese P. Influenza A viruses with truncated NS1 as modified live virus vaccines: pilot studies of safety and efficacy in horses. Equine Vet J 2009 Jan;41(1):87-92.
          doi: 10.2746/042516408x371937pubmed: 19301588google scholar: lookup
        31. Olafsdóttir G, Svansson V, Ingvarsson S, Marti E, Torsteinsdóttir S. In vitro analysis of expression vectors for DNA vaccination of horses: the effect of a Kozak sequence. Acta Vet Scand 2008 Nov 4;50(1):44.
          doi: 10.1186/1751-0147-50-44pubmed: 18983656google scholar: lookup
        32. Rosas C, Van de Walle GR, Metzger SM, Hoelzer K, Dubovi EJ, Kim SG, Parrish CR, Osterrieder N. Evaluation of a vectored equine herpesvirus type 1 (EHV-1) vaccine expressing H3 haemagglutinin in the protection of dogs against canine influenza. Vaccine 2008 May 2;26(19):2335-43.
          doi: 10.1016/j.vaccine.2008.02.064pubmed: 18407383google scholar: lookup
        33. Gagnon CA, Elahi SM, Tremblay D, Lavoie JP, Bryant NA, Elton DM, Carman S, Elsener J. Genetic relatedness of recent Canadian equine influenza virus isolates with vaccine strains used in the field. Can Vet J 2007 Oct;48(10):1028-30.
          pubmed: 17987964
        34. Meeusen EN, Walker J, Peters A, Pastoret PP, Jungersen G. Current status of veterinary vaccines. Clin Microbiol Rev 2007 Jul;20(3):489-510, table of contents.
          doi: 10.1128/CMR.00005-07pubmed: 17630337google scholar: lookup
        35. Song H, Nieto GR, Perez DR. A new generation of modified live-attenuated avian influenza viruses using a two-strategy combination as potential vaccine candidates. J Virol 2007 Sep;81(17):9238-48.
          doi: 10.1128/JVI.00893-07pubmed: 17596317google scholar: lookup
        36. Gonzalez-Obando J, Jaimes-Dueñez J, Zuluaga-Cabrera A, Forero JE, Diaz A, Rojas-Arbeláez C, Ruiz-Saenz J. Seroprevalence of Equine Influenza Virus Antibodies in Horses from Four Localities in Colombia. Viruses 2025 Jul 16;17(7).
          doi: 10.3390/v17070999pubmed: 40733615google scholar: lookup
        37. Witkowska-Piłaszewicz O, Malin K, Dąbrowska I, Grzędzicka J, Ostaszewski P, Carter C. Immunology of Physical Exercise: Is Equus caballus an Appropriate Animal Model for Human Athletes?. Int J Mol Sci 2024 May 10;25(10).
          doi: 10.3390/ijms25105210pubmed: 38791248google scholar: lookup
        38. Lim SI, Kim MJ, Kim MJ, Lee SK, Yang HS, Kwon M, Lim EH, Ouh IO, Kim EJ, Hyun BH, Lee YH. Assessment of Equine Influenza Virus Status in the Republic of Korea from 2020 to 2022. Viruses 2023 Oct 23;15(10).
          doi: 10.3390/v15102135pubmed: 37896912google scholar: lookup
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