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Cells2020; 9(6); 1453; doi: 10.3390/cells9061453

Veterinary Regenerative Medicine for Musculoskeletal Disorders: Can Mesenchymal Stem/Stromal Cells and Their Secretome Be the New Frontier?

Abstract: Regenerative medicine aims to restore the normal function of diseased or damaged cells, tissues, and organs using a set of different approaches, including cell-based therapies. In the veterinary field, regenerative medicine is strongly related to the use of mesenchymal stromal cells (MSCs), which belong to the body repair system and are defined as multipotent progenitor cells, able to self-replicate and to differentiate into different cell types. This review aims to take stock of what is known about the MSCs and their use in the veterinary medicine focusing on clinical reports on dogs and horses in musculoskeletal diseases, a research field extensively reported in the literature data. Finally, a perspective regarding the use of the secretome and/or extracellular vesicles (EVs) in the veterinary field to replace parental MSCs is provided. The pharmaceuticalization of EVs is wished due to the realization of a Good Manufacturing Practice (GMP product suitable for clinical trials.
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Publication Date: 2020-06-11 PubMed ID: 32545382PubMed Central: PMC7349187DOI: 10.3390/cells9061453Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't
  • Review

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article is about exploring the use of mesenchymal stromal cells (MSCs) and their secretome as part of regenerative medicine in veterinary care, particularly in treating musculoskeletal diseases in dogs and horses. It also discusses the potential of using extracellular vesicles (EVs) in the field.

Overview and Aim

The article begins with an overview of regenerative medicine, emphasizing that its primary goal is to restore the function of damaged or diseased cells, tissues, and organs using varying approaches, including cell-based therapies. It then explains that in the field of veterinary medicine, the focus of regenerative medicine primarily falls on mesenchymal stromal cells (MSCs), a type of cell that plays a critical role in the body’s natural repair mechanism.

The purpose of the review article is to evaluate current knowledge on the use of MSCs in veterinary medicine, with an emphasis on their application in treating musculoskeletal diseases in dogs and horses. These cases were chosen due to the extensive literature data available on them.

Mesenchymal Stromal Cells (MSCs)

  • The article describes MSCs as multipotent progenitor cells. This means they have the ability to self-replicate and differentiate into various cell types, lending them a significant role in natural repair processes.
  • These cells are believed to be particularly beneficial in veterinary medicine, and there is considerable research investigating their application.

Use of MSCs in Veterinary Medicine

  • The paper highlights the application of MSCs in treating musculoskeletal diseases in dogs and horses. This is an extensively researched area, making it an ideal focus for the review.

The Secretome and Extracellular Vesicles (EVs)

  • Apart from MSCs, the review foresees the potential use of the secretome and/or extracellular vesicles (EVs) in regenerative medicine. The secretome refers to the release of substances by cells, which can include EVs—tiny structures that can carry proteins, lipids, and nucleic acids between cells.
  • These entities hold appealing prospects to the point that a shift from the use of parental MSCs to using EVs as therapeutic tools is suggested in the review. This shift could lead to improved, more effective therapies.
  • The authors express their wishes for the pharmaceuticalization of EVs, indicating a need for standardizing guidelines and creating Good Manufacturing Practice (GMP)-compliant products for clinical trials. This denotes the importance of ensuring the safety, efficacy, and quality of potential EV-based therapies.

Cite This Article

APA
Mocchi M, Dotti S, Bue MD, Villa R, Bari E, Perteghella S, Torre ML, Grolli S. (2020). Veterinary Regenerative Medicine for Musculoskeletal Disorders: Can Mesenchymal Stem/Stromal Cells and Their Secretome Be the New Frontier? Cells, 9(6), 1453. https://doi.org/10.3390/cells9061453

Publication

Cells
ISSN: 2073-4409
NlmUniqueID: 101600052
Country: Switzerland
Language: English
Volume: 9
Issue: 6
PII: 1453

Researcher Affiliations

Mocchi, Michela
  • Department of Drug Sciences, University of Pavia, 27100 Pavia, Italy.
Dotti, Silvia
  • Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, 25124 Brescia, Italy.
Bue, Maurizio Del
  • Freelance Veterinary Medical Doctor, 43121 Parma, Italy.
Villa, Riccardo
  • Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, 25124 Brescia, Italy.
Bari, Elia
  • Department of Drug Sciences, University of Pavia, 27100 Pavia, Italy.
Perteghella, Sara
  • Department of Drug Sciences, University of Pavia, 27100 Pavia, Italy.
  • PharmaExceed S.r.l., 27100 Pavia, Italy.
Torre, Maria Luisa
  • Department of Drug Sciences, University of Pavia, 27100 Pavia, Italy.
  • PharmaExceed S.r.l., 27100 Pavia, Italy.
Grolli, Stefano
  • Department of Veterinary Medical Science, University of Parma, 43121 Parma, Italy.

MeSH Terms

  • Animals
  • Cryopreservation
  • Disease Models, Animal
  • Mesenchymal Stem Cells / cytology
  • Musculoskeletal Diseases / therapy
  • Musculoskeletal Diseases / veterinary
  • Regenerative Medicine
  • Veterinary Medicine

Conflict of Interest Statement

M.L.T., and S.P. are co-founders and members of the advisory board of PharmaExceed S.r.l.

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