Acta veterinaria Scandinavica2007; 49(1); 17; doi: 10.1186/1751-0147-49-17

Vitamin E deficiency and risk of equine motor neuron disease.

Abstract: Equine motor neuron disease (EMND) is a spontaneous neurologic disorder of adult horses which results from the degeneration of motor neurons in the spinal cord and brain stem. Clinical manifestations, pathological findings, and epidemiologic attributes resemble those of human motor neuron disease (MND). As in MND the etiology of the disease is not known. We evaluated the predisposition role of vitamin E deficiency on the risk of EMND. Methods: Eleven horses at risk of EMND were identified and enrolled in a field trial at different times. The horses were maintained on a diet deficient in vitamin E and monitored periodically for levels of antioxidants--alpha-tocopherols, vitamins A, C, beta-carotene, glutathione peroxidase (GSH-Px), and erythrocytic superoxide dismutase (SOD1). In addition to the self-control another parallel control group was included. Survival analysis was used to assess the probability of developing EMND past a specific period of time. Results: There was large variability in the levels of vitamins A and C, beta-carotene, GSH-Px, and SOD1. Plasma vitamin E levels dropped significantly over time. Ten horses developed EMND within 44 months of enrollment. The median time to develop EMND was 38.5 months. None of the controls developed EMND. Conclusions: The study elucidated the role of vitamin E deficiency on the risk of EMND. Reproducing this disease in a natural animal model for the first time will enable us to carry out studies to test specific hypotheses regarding the mechanism by which the disease occurs.
Publication Date: 2007-07-02 PubMed ID: 17605810PubMed Central: PMC1950518DOI: 10.1186/1751-0147-49-17Google Scholar: Lookup
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  • Journal Article
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  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research discusses the link between vitamin E deficiency and the risk of equine motor neuron disease (EMND), a neurologic disorder in adult horses. It was found that a vitamin E deficient diet in horses correlated with a significant development of EMND.

Research Methodology

  • The researchers identified eleven horses that were at risk of developing EMND and were enrolled into a field trial at different stages.
  • These horses were put on a diet deficient in vitamin E. Their antioxidant levels were monitored over time, specifically for alpha-tocopherols, vitamins A and C, beta-carotene, glutathione peroxidase (GSH-Px), and erythrocytic superoxide dismutase (SOD1).
  • Alongside these test subjects, there was also a parallel control group which was kept under similar conditions but without the vitamin E deficiency.
  • A survival analysis was used to assess the likelihood of the horses developing EMND.

Results and Findings

  • There was considerable fluctuation in the levels of vitamins A and C, beta-carotene, GSH-Px, and SOD1 among different subjects.
  • However, over time, it was observed that the plasma vitamin E levels notably dropped in the test group horses.
  • A significant finding was that out of the eleven at-risk horses that were put on a vitamin E deficient diet, ten developed EMND within 44 months of the trial period with a median time of 38.5 months.
  • None of the horses from the control group developed the disease, indicating a possible direct link between vitamin E deficiency and EMND.

Conclusions and Future Implications

  • The research proved a relationship between vitamin E deficiency and the risk of developing EMND in horses.
  • This study is the first to reproduce EMND in a natural animal model, helping understand its mechanism of development in relation with Vitamin E.
  • Such findings open avenues for further studies to test specific hypotheses about the mechanism of the disease and perhaps lead to potential preventative measures or treatments.

Cite This Article

APA
Mohammed HO, Divers TJ, Summers BA, de Lahunta A. (2007). Vitamin E deficiency and risk of equine motor neuron disease. Acta Vet Scand, 49(1), 17. https://doi.org/10.1186/1751-0147-49-17

Publication

ISSN: 1751-0147
NlmUniqueID: 0370400
Country: England
Language: English
Volume: 49
Issue: 1
Pages: 17

Researcher Affiliations

Mohammed, Hussni O
  • Department of Population Medicine and Diagnostic Science, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. hom1@cornell.edu
Divers, Thomas J
    Summers, Brian A
      de Lahunta, Alexander

        MeSH Terms

        • Animal Nutritional Physiological Phenomena
        • Animals
        • Breeding
        • Female
        • Horse Diseases / blood
        • Horse Diseases / epidemiology
        • Horse Diseases / etiology
        • Horses
        • Male
        • Motor Neuron Disease / blood
        • Motor Neuron Disease / epidemiology
        • Motor Neuron Disease / etiology
        • Motor Neuron Disease / veterinary
        • Risk Factors
        • Vitamin E / blood
        • Vitamin E Deficiency / complications
        • Vitamin E Deficiency / veterinary

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