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Emerging infectious diseases2006; 12(10); 1559-1561; doi: 10.3201/eid1210.060852

West Nile virus isolation from equines in Argentina, 2006.

Abstract: West Nile virus (WNV) was isolated from the brains of 3 horses that died from encephalitis in February 2006. The horses were from different farms in central Argentina and had not traveled outside the country. This is the first isolation of WNV in South America.
Publication Date: 2006-12-21 PubMed ID: 17176571PubMed Central: PMC3290965DOI: 10.3201/eid1210.060852Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research is focused on the first-ever isolation of the West Nile virus (WNV) from horses in Argentina in 2006, who died from encephalitis and didn’t travel outside the country.

Research Focus

  • The paper primarily focuses on the isolation of the West Nile virus (WNV) from equines, specifically, horses that died from encephalitis in Argentina in 2006.
  • Considering these horses had never traveled outside the country, this instance marks the first isolation and presence of WNV in South America.

Methodology

  • The researchers isolated the virus from the brains of 3 horses. This process presumably involves collecting and analyzing the brain tissue to identify and separate the virus.
  • These horses were all from different farms in central Argentina, which suggests that the virus has dispersed in the area, not confined to a single location.

Significance of the Findings

  • This study’s findings represent a significant development in understanding the spread of the West Nile virus in a region where it has never been identified before.
  • Isolating the virus will allow for more extensive studies on its characteristics and how it interacts with the equines, which is crucial in developing preventative measures and treatments for infected animals in the future.
  • The observation of WNV in these horses might signal an impending outbreak in the region. Hence, understanding its presence could aid in prevention efforts.

Cite This Article

APA
Morales MA, Barrandeguy M, Fabbri C, Garcia JB, Vissani A, Trono K, Gutierrez G, Pigretti S, Menchaca H, Garrido N, Taylor N, Fernandez F, Levis S, Enría D. (2006). West Nile virus isolation from equines in Argentina, 2006. Emerg Infect Dis, 12(10), 1559-1561. https://doi.org/10.3201/eid1210.060852

Publication

ISSN: 1080-6040
NlmUniqueID: 9508155
Country: United States
Language: English
Volume: 12
Issue: 10
Pages: 1559-1561

Researcher Affiliations

Morales, María Alejandra
  • Instituto Nacional de Enfermedades Virales Humanas, Dr. Julio I. Malztegui, Pergainino, Buenos Aires, Argentina. malemor@yahoo.com.ar
Barrandeguy, María
    Fabbri, Cintia
      Garcia, Jorge B
        Vissani, Aldana
          Trono, Karina
            Gutierrez, Gerónimo
              Pigretti, Santiago
                Menchaca, Hernán
                  Garrido, Nelson
                    Taylor, Nora
                      Fernandez, Fernando
                        Levis, Silvana
                          Enría, Delia

                            MeSH Terms

                            • Animals
                            • Argentina / epidemiology
                            • Base Sequence / genetics
                            • Brain / virology
                            • Horse Diseases / epidemiology
                            • Horse Diseases / virology
                            • Horses
                            • Molecular Sequence Data
                            • Phylogeny
                            • Reverse Transcriptase Polymerase Chain Reaction
                            • West Nile Fever / epidemiology
                            • West Nile Fever / veterinary
                            • West Nile Fever / virology
                            • West Nile virus / genetics
                            • West Nile virus / isolation & purification

                            References

                            This article includes 9 references
                            1. Petersen LR, Roehrig JT. West Nile virus: a reemerging global pathogen.. Emerg Infect Dis 2001 Jul-Aug;7(4):611-4.
                              doi: 10.3201/eid0704.010401pmc: PMC2631751pubmed: 11585520google scholar: lookup
                            2. Beaty BJ, Calisher CH, Shope RS. Arboviruses. In: Schmidt NJ, Emmons RW, editors. Diagnostic procedures for viral, rickettsial and chlamydial infections. 6th ed. Washington: American Public Health Association; 1989. p. 797–856.
                            3. Riggs JL. Immunofluorescent staining. In: Lennette EH, Schmidt NJ, editors. Diagnostic procedures for viral, rickettsial and chlamydial infections. 5th ed. Washington: American Public Health Association; 1979. p. 141–51.
                            4. Shi PY, Kauffman EB, Ren P, Felton A, Tai JH, Dupuis AP 2nd, Jones SA, Ngo KA, Nicholas DC, Maffei J, Ebel GD, Bernard KA, Kramer LD. High-throughput detection of West Nile virus RNA.. J Clin Microbiol 2001 Apr;39(4):1264-71.
                            5. Johnson DJ, Ostlund EN, Pedersen DD, Schmitt BJ. Detection of North American West Nile virus in animal tissue by a reverse transcription-nested polymerase chain reaction assay.. Emerg Infect Dis 2001 Jul-Aug;7(4):739-41.
                              doi: 10.3201/eid0704.010425pmc: PMC2631755pubmed: 11585541google scholar: lookup
                            6. Goloboff P, Farris S, Nixon K. TNT (tree analysis using new technology) (BETA) version 1.0. Tucuman, Argentina. Published by the authors; 2000.
                            7. Komar N, Clark GG. West Nile virus activity in Latin America and the Caribbean.. Rev Panam Salud Publica 2006 Feb;19(2):112-7.
                            8. Mattar S, Edwards E, Laguado J, González M, Alvarez J, Komar N. West Nile virus antibodies in Colombian horses.. Emerg Infect Dis 2005 Sep;11(9):1497-8.
                              pmc: PMC3310636pubmed: 16673523doi: 10.3201/eid1109.050426google scholar: lookup
                            9. van der Meulen KM, Pensaert MB, Nauwynck HJ. West Nile virus in the vertebrate world.. Arch Virol 2005 Apr;150(4):637-57.
                              doi: 10.1007/s00705-004-0463-zpubmed: 15662484google scholar: lookup

                            Citations

                            This article has been cited 68 times.
                            1. Lorenz C, Chiaravalloti-Neto F. Why are there no human West Nile virus outbreaks in South America?. Lancet Reg Health Am 2022 Aug;12:100276.
                              doi: 10.1016/j.lana.2022.100276pubmed: 36776433google scholar: lookup
                            2. Chalhoub FLL, Horta MAP, Alcantara LCJ, Morales A, Dos Santos LMB, Guerra-Campos V, Rodrigues CDS, Santos CC, Mares-Guia MAM, Pauvolid-Corrêa A, de Filippis AMB. Serological Evidence of Exposure to Saint Louis Encephalitis and West Nile Viruses in Horses of Rio de Janeiro, Brazil. Viruses 2022 Nov 6;14(11).
                              doi: 10.3390/v14112459pubmed: 36366557google scholar: lookup
                            3. Fritsch H, Pereira FM, Costa EA, Fonseca V, Tosta S, Xavier J, Levy F, Oliveira C, Menezes G, Lima J, Santos L, Silva L, Nardy V, Astete MKG, Santos BSÁDS, Aguiar NR, Guedes MIMC, Faria GC, Furtini R, Drumond SRM, Cunha GM, Souza MSPL, Jesus R, Guimarães SAF, Nuno IC, Santana ICB, Sá JEU, Santos GR, Silva WS, Guedes TF, Araújo ELL, Said RFDC, Albuquerque CFC, Peterka CRL, Romano APM, Cunha RVD, Filippis AMB, Leal E Silva de Mello A, Giovanetti M, Alcantara LCJ. Retrospective Investigation in Horses with Encephalitis Reveals Unnoticed Circulation of West Nile Virus in Brazil. Viruses 2022 Jul 14;14(7).
                              doi: 10.3390/v14071540pubmed: 35891521google scholar: lookup
                            4. Mansilla AP, Grande JM, Diaz A. Effect of Agroecosystems on Seroprevalence of St. Louis Encephalitis and West Nile Viruses in Birds, La Pampa, Argentina, 2017-2019. Emerg Infect Dis 2022 Jul;28(7):1393-1402.
                              doi: 10.3201/eid2807.211485pubmed: 35731160google scholar: lookup
                            5. Salgado R, Hawks SA, Frere F, Vázquez A, Huang CY, Duggal NK. West Nile Virus Vaccination Protects against Usutu Virus Disease in Mice. Viruses 2021 Nov 23;13(12).
                              doi: 10.3390/v13122352pubmed: 34960621google scholar: lookup
                            6. Carrillo-Bilbao G, Martin-Solano S, Saegerman C. Zoonotic Blood-Borne Pathogens in Non-Human Primates in the Neotropical Region: A Systematic Review. Pathogens 2021 Aug 10;10(8).
                              doi: 10.3390/pathogens10081009pubmed: 34451473google scholar: lookup
                            7. de Oliveira-Filho EF, Fischer C, Berneck BS, Carneiro IO, Kühne A, de Almeida Campos AC, Ribas JRL, Netto EM, Franke CR, Ulbert S, Drexler JF. Ecologic Determinants of West Nile Virus Seroprevalence among Equids, Brazil. Emerg Infect Dis 2021 Sep;27(9):2466-2470.
                              doi: 10.3201/eid2709.204706pubmed: 34424166google scholar: lookup
                            8. Costa ÉA, Giovanetti M, Silva Catenacci L, Fonseca V, Aburjaile FF, Chalhoub FLL, Xavier J, Campos de Melo Iani F, da Cunha E Silva Vieira MA, Freitas Henriques D, Medeiros DBA, Guedes MIMC, Senra Álvares da Silva Santos B, Gonçalves Silva AS, de Pino Albuquerque Maranhão R, da Costa Faria NR, Farinelli de Siqueira R, de Oliveira T, Ribeiro Leite Jardim Cavalcante K, Oliveira de Moura NF, Pecego Martins Romano A, Campelo de Albuquerque CF, Soares Feitosa LC, Martins Bayeux JJ, Bertoni Cavalcanti Teixeira R, Lisboa Lobato O, da Costa Silva S, Bispo de Filippis AM, Venâncio da Cunha R, Lourenço J, Alcantara LCJ. West Nile Virus in Brazil. Pathogens 2021 Jul 15;10(7).
                              doi: 10.3390/pathogens10070896pubmed: 34358046google scholar: lookup
                            9. Weber MN, Mosena ACS, Baumbach LF, da Silva MS, Canova R, Dos Santos DRL, Budaszewski RDF, de Oliveira LV, Soane MM, Saraiva NB, Bellucco FT, Mazurek BA, Diehl GN, Gil LHVG, Borba MR, Corbellini LG, Canal CW. Serologic evidence of West Nile virus and Saint Louis encephalitis virus in horses from Southern Brazil. Braz J Microbiol 2021 Jun;52(2):1021-1027.
                              doi: 10.1007/s42770-021-00474-7pubmed: 33797731google scholar: lookup
                            10. Albrieu-Llinás G, Gallardo R, Konigheim BS, Quaglia AI, Mariño B, Curiotti J, Mazzini R, Contigiani MS. Arbovirus serosurvey (Orthobunyavirus, Flavivirus, and Alphavirus) in a draft horse population from Santa Fe, Argentina (2013-2016). Arch Virol 2021 Mar;166(3):881-884.
                              doi: 10.1007/s00705-020-04929-4pubmed: 33433694google scholar: lookup
                            11. Morel AP, Webster A, Zitelli LC, Umeno K, Souza UA, Prusch F, Anicet M, Marsicano G, Bandarra P, Trainini G, Stocker J, Giani D, Fortes FB, Goenaga S, Reck J. Serosurvey of West Nile virus (WNV) in free-ranging raptors from Brazil. Braz J Microbiol 2021 Mar;52(1):411-418.
                              doi: 10.1007/s42770-020-00393-zpubmed: 33108590google scholar: lookup
                            12. Goenaga S, Goenaga J, Boaglio ER, Enria DA, Levis SDC. Superinfection exclusion studies using West Nile virus and Culex flavivirus strains from Argentina. Mem Inst Oswaldo Cruz 2020;115:e200012.
                              doi: 10.1590/0074-02760200012pubmed: 32520074google scholar: lookup
                            13. Cardo MV, Rubio A, Vezzani D, Carbajo AE. Assessment of Culex pipiens bioforms in the world's southernmost distribution limit. Mem Inst Oswaldo Cruz 2020;115:e190390.
                              doi: 10.1590/0074-02760190390pubmed: 32049099google scholar: lookup
                            14. Byas AD, Ebel GD. Comparative Pathology of West Nile Virus in Humans and Non-Human Animals. Pathogens 2020 Jan 7;9(1).
                              doi: 10.3390/pathogens9010048pubmed: 31935992google scholar: lookup
                            15. Gomes FA, Jansen AM, Machado RZ, Jesus Pena HF, Fumagalli MJ, Silva A, Alves BF, Roque ALR, Moraes Figueiredo LT. Serological evidence of arboviruses and coccidia infecting horses in the Amazonian region of Brazil. PLoS One 2019;14(12):e0225895.
                              doi: 10.1371/journal.pone.0225895pubmed: 31830142google scholar: lookup
                            16. Hadfield J, Brito AF, Swetnam DM, Vogels CBF, Tokarz RE, Andersen KG, Smith RC, Bedford T, Grubaugh ND. Twenty years of West Nile virus spread and evolution in the Americas visualized by Nextstrain. PLoS Pathog 2019 Oct;15(10):e1008042.
                              doi: 10.1371/journal.ppat.1008042pubmed: 31671157google scholar: lookup
                            17. de Oliveira AS, Gazolla PAR, Oliveira AFCDS, Pereira WL, de S Viol LC, Maia AFDS, Santos EG, da Silva ÍEP, Mendes TAO, da Silva AM, Dias RS, da Silva CC, Polêto MD, Teixeira RR, de Paula SO. Discovery of novel West Nile Virus protease inhibitor based on isobenzonafuranone and triazolic derivatives of eugenol and indan-1,3-dione scaffolds. PLoS One 2019;14(9):e0223017.
                              doi: 10.1371/journal.pone.0223017pubmed: 31557229google scholar: lookup
                            18. Flores FS, Zanluca C, Guglielmone AA, Duarte Dos Santos CN, Labruna MB, Diaz A. Vector Competence for West Nile Virus and St. Louis Encephalitis Virus (Flavivirus) of Three Tick Species of the Genus Amblyomma (Acari: Ixodidae). Am J Trop Med Hyg 2019 May;100(5):1230-1235.
                              doi: 10.4269/ajtmh.18-0134pubmed: 30887949google scholar: lookup
                            19. Martins LC, Silva EVPD, Casseb LMN, Silva SPD, Cruz ACR, Pantoja JAS, Medeiros DBA, Martins Filho AJ, Cruz EDRMD, Araújo MTF, Cardoso JF, Cunha MACRD, Almada GL, Romano APM, Santos MGDP, Rodrigues GAP, Chiang JO, Quaresma JAS, Carvalho VL, Vasconcelos PFDC. First isolation of West Nile virus in Brazil. Mem Inst Oswaldo Cruz 2019 Jan 17;114:e180332.
                              doi: 10.1590/0074-02760180332pubmed: 30672980google scholar: lookup
                            20. Morales MA, Fabbri CM, Zunino GE, Kowalewski MM, Luppo VC, Enría DA, Levis SC, Calderón GE. Detection of the mosquito-borne flaviviruses, West Nile, Dengue, Saint Louis Encephalitis, Ilheus, Bussuquara, and Yellow Fever in free-ranging black howlers (Alouatta caraya) of Northeastern Argentina. PLoS Negl Trop Dis 2017 Feb;11(2):e0005351.
                              doi: 10.1371/journal.pntd.0005351pubmed: 28187130google scholar: lookup
                            21. Diaz LA, Quaglia AI, Konigheim BS, Boris AS, Aguilar JJ, Komar N, Contigiani MS. Activity Patterns of St. Louis Encephalitis and West Nile Viruses in Free Ranging Birds during a Human Encephalitis Outbreak in Argentina. PLoS One 2016;11(8):e0161871.
                              doi: 10.1371/journal.pone.0161871pubmed: 27564679google scholar: lookup
                            22. Van Hoeven N, Joshi SW, Nana GI, Bosco-Lauth A, Fox C, Bowen RA, Clements DE, Martyak T, Parks DE, Baldwin S, Reed SG, Coler RN. A Novel Synthetic TLR-4 Agonist Adjuvant Increases the Protective Response to a Clinical-Stage West Nile Virus Vaccine Antigen in Multiple Formulations. PLoS One 2016;11(2):e0149610.
                              doi: 10.1371/journal.pone.0149610pubmed: 26901122google scholar: lookup
                            23. Caraballo EV, Hunsperger E, Martínez I. Characterization of Puerto Rican West Nile Virus isolates in mice. Virol J 2015 Sep 11;12:137.
                              doi: 10.1186/s12985-015-0363-8pubmed: 26357867google scholar: lookup
                            24. López RH, Soto SU, Gallego-Gómez JC. Evolutionary relationships of West Nile virus detected in mosquitoes from a migratory bird zone of Colombian Caribbean. Virol J 2015 May 20;12:80.
                              doi: 10.1186/s12985-015-0310-8pubmed: 25989901google scholar: lookup
                            25. Chancey C, Grinev A, Volkova E, Rios M. The global ecology and epidemiology of West Nile virus. Biomed Res Int 2015;2015:376230.
                              doi: 10.1155/2015/376230pubmed: 25866777google scholar: lookup
                            26. Zanluca C, Mazzarotto GA, Bordignon J, Duarte Dos Santos CN. Development, characterization and application of monoclonal antibodies against Brazilian Dengue virus isolates. PLoS One 2014;9(11):e110620.
                              doi: 10.1371/journal.pone.0110620pubmed: 25412181google scholar: lookup
                            27. Quaglia AI, Diaz LA, Argibay H, Contigiani MS, Saggese MD. West Nile and st. Louis encephalitis viruses antibodies surveillance in captive and free-ranging birds of prey from Argentina. Ecohealth 2014 Dec;11(4):603-9.
                              doi: 10.1007/s10393-014-0956-5pubmed: 25106849google scholar: lookup
                            28. Eastwood G, Goodman SJ, Hilgert N, Cruz M, Kramer LD, Cunningham AA. Using avian surveillance in Ecuador to assess the imminence of West Nile virus incursion to Galápagos. Ecohealth 2014;11(1):53-62.
                              doi: 10.1007/s10393-014-0911-5pubmed: 24796792google scholar: lookup
                            29. Elizondo-Quiroga D, Elizondo-Quiroga A. West nile virus and its theories, a big puzzle in Mexico and latin america. J Glob Infect Dis 2013 Oct;5(4):168-75.
                              doi: 10.4103/0974-777X.122014pubmed: 24672180google scholar: lookup
                            30. Burgueño A, Spinsanti L, Díaz LA, Rivarola ME, Arbiza J, Contigiani M, Delfraro A. Seroprevalence of St. Louis encephalitis virus and West Nile virus (Flavivirus, Flaviviridae) in horses, Uruguay. Biomed Res Int 2013;2013:582957.
                              doi: 10.1155/2013/582957pubmed: 24490165google scholar: lookup
                            31. Ciota AT, Kramer LD. Vector-virus interactions and transmission dynamics of West Nile virus. Viruses 2013 Dec 9;5(12):3021-47.
                              doi: 10.3390/v5123021pubmed: 24351794google scholar: lookup
                            32. Mann BR, McMullen AR, Swetnam DM, Barrett AD. Molecular epidemiology and evolution of West Nile virus in North America. Int J Environ Res Public Health 2013 Oct 16;10(10):5111-29.
                              doi: 10.3390/ijerph10105111pubmed: 24135819google scholar: lookup
                            33. Díaz-Nieto LM, Maciá A, Parisi G, Farina JL, Vidal-Domínguez ME, Perotti MA, Berón CM. Distribution of mosquitoes in the south east of Argentina and first report on the analysis based on 18S rDNA and COI sequences. PLoS One 2013;8(9):e75516.
                              doi: 10.1371/journal.pone.0075516pubmed: 24098700google scholar: lookup
                            34. Silva JR, Medeiros LC, Reis VP, Chavez JH, Munhoz TD, Borges GP, Soares OA, Campos CH, Machado RZ, Baldani CD, Silva ML, Faria JL, Silva EE, Figueiredo LT. Serologic survey of West Nile virus in horses from Central-West, Northeast and Southeast Brazil. Mem Inst Oswaldo Cruz 2013 Nov;108(7):921-3.
                            35. Angenvoort J, Brault AC, Bowen RA, Groschup MH. West Nile viral infection of equids. Vet Microbiol 2013 Nov 29;167(1-2):168-80.
                              doi: 10.1016/j.vetmic.2013.08.013pubmed: 24035480google scholar: lookup
                            36. Cargnelutti JF, Brum MC, Weiblen R, Flores EF. Stable expression and potential use of west nile virus envelope glycoproteins preM/E as antigen in diagnostic tests. Braz J Microbiol 2011 Jul;42(3):1161-6.
                            37. Mann BR, McMullen AR, Swetnam DM, Salvato V, Reyna M, Guzman H, Bueno R Jr, Dennett JA, Tesh RB, Barrett AD. Continued evolution of West Nile virus, Houston, Texas, USA, 2002-2012. Emerg Infect Dis 2013;19(9):1418-27.
                              doi: 10.3201/eid1909.130377pubmed: 23965756google scholar: lookup
                            38. Micieli MV, Matacchiero AC, Muttis E, Fonseca DM, Aliota MT, Kramer LD. Vector competence of Argentine mosquitoes (Diptera: Culicidae) for West Nile virus (Flaviviridae: Flavivirus). J Med Entomol 2013 Jul;50(4):853-62.
                              doi: 10.1603/me12226pubmed: 23926785google scholar: lookup
                            39. Osorio JE, Ciuoderis KA, Lopera JG, Piedrahita LD, Murphy D, Levasseur J, Carrillo L, Ocampo MC, Hofmeister E. Characterization of West Nile viruses isolated from captive American Flamingoes (Phoenicopterus ruber) in Medellin, Colombia. Am J Trop Med Hyg 2012 Sep;87(3):565-72.
                              doi: 10.4269/ajtmh.2012.11-0655pubmed: 22802436google scholar: lookup
                            40. Jiménez-Clavero MÁ. Animal viral diseases and global change: bluetongue and West Nile fever as paradigms. Front Genet 2012;3:105.
                              doi: 10.3389/fgene.2012.00105pubmed: 22707955google scholar: lookup
                            41. Ciota AT, Kramer LD. Insights into arbovirus evolution and adaptation from experimental studies. Viruses 2010 Dec;2(12):2594-617.
                              doi: 10.3390/v2122594pubmed: 21994633google scholar: lookup
                            42. Brault AC, Langevin SA, Ramey WN, Fang Y, Beasley DW, Barker CM, Sanders TA, Reisen WK, Barrett AD, Bowen RA. Reduced avian virulence and viremia of West Nile virus isolates from Mexico and Texas. Am J Trop Med Hyg 2011 Oct;85(4):758-67.
                              doi: 10.4269/ajtmh.2011.10-0439pubmed: 21976584google scholar: lookup
                            43. Eastwood G, Kramer LD, Goodman SJ, Cunningham AA. West Nile virus vector competency of Culex quinquefasciatus mosquitoes in the Galapagos Islands. Am J Trop Med Hyg 2011 Sep;85(3):426-33.
                              doi: 10.4269/ajtmh.2011.10-0739pubmed: 21896799google scholar: lookup
                            44. Ledgerwood JE, Pierson TC, Hubka SA, Desai N, Rucker S, Gordon IJ, Enama ME, Nelson S, Nason M, Gu W, Bundrant N, Koup RA, Bailer RT, Mascola JR, Nabel GJ, Graham BS. A West Nile virus DNA vaccine utilizing a modified promoter induces neutralizing antibody in younger and older healthy adults in a phase I clinical trial. J Infect Dis 2011 May 15;203(10):1396-404.
                              doi: 10.1093/infdis/jir054pubmed: 21398392google scholar: lookup
                            45. Murray KO, Mertens E, Despres P. West Nile virus and its emergence in the United States of America. Vet Res 2010 Nov-Dec;41(6):67.
                              doi: 10.1051/vetres/2010039pubmed: 21188801google scholar: lookup
                            46. Forshey BM, Guevara C, Laguna-Torres VA, Cespedes M, Vargas J, Gianella A, Vallejo E, Madrid C, Aguayo N, Gotuzzo E, Suarez V, Morales AM, Beingolea L, Reyes N, Perez J, Negrete M, Rocha C, Morrison AC, Russell KL, Blair PJ, Olson JG, Kochel TJ. Arboviral etiologies of acute febrile illnesses in Western South America, 2000-2007. PLoS Negl Trop Dis 2010 Aug 10;4(8):e787.
                              doi: 10.1371/journal.pntd.0000787pubmed: 20706628google scholar: lookup
                            47. Jiang D, Weidner JM, Qing M, Pan XB, Guo H, Xu C, Zhang X, Birk A, Chang J, Shi PY, Block TM, Guo JT. Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections. J Virol 2010 Aug;84(16):8332-41.
                              doi: 10.1128/JVI.02199-09pubmed: 20534863google scholar: lookup
                            48. Weaver SC, Reisen WK. Present and future arboviral threats. Antiviral Res 2010 Feb;85(2):328-45.
                            49. Hunsperger EA, McElroy KL, Bessoff K, Colón C, Barrera R, Muñoz-Jordán JL. West Nile virus from blood donors, vertebrates, and mosquitoes, Puerto Rico, 2007. Emerg Infect Dis 2009 Aug;15(8):1298-300.
                              doi: 10.3201/eid1508.090333pubmed: 19751597google scholar: lookup
                            50. Ma D, Jiang D, Qing M, Weidner JM, Qu X, Guo H, Chang J, Gu B, Shi PY, Block TM, Guo JT. Antiviral effect of interferon lambda against West Nile virus. Antiviral Res 2009 Jul;83(1):53-60.
                            51. Chang J, Wang L, Ma D, Qu X, Guo H, Xu X, Mason PM, Bourne N, Moriarty R, Gu B, Guo JT, Block TM. Novel imino sugar derivatives demonstrate potent antiviral activity against flaviviruses. Antimicrob Agents Chemother 2009 Apr;53(4):1501-8.
                              doi: 10.1128/AAC.01457-08pubmed: 19223639google scholar: lookup
                            52. Ciota AT, Lovelace AO, Jia Y, Davis LJ, Young DS, Kramer LD. Characterization of mosquito-adapted West Nile virus. J Gen Virol 2008 Jul;89(Pt 7):1633-1642.
                              doi: 10.1099/vir.0.2008/000893-0pubmed: 18559933google scholar: lookup
                            53. Adrián Diaz L, Komar N, Visintin A, Dantur Juri MJ, Stein M, Lobo Allende R, Spinsanti L, Konigheim B, Aguilar J, Laurito M, Almirón W, Contigiani M. West Nile virus in birds, Argentina. Emerg Infect Dis 2008 Apr;14(4):689-91.
                              doi: 10.3201/eid1404.071257pubmed: 18394305google scholar: lookup
                            54. Martin JE, Pierson TC, Hubka S, Rucker S, Gordon IJ, Enama ME, Andrews CA, Xu Q, Davis BS, Nason M, Fay M, Koup RA, Roederer M, Bailer RT, Gomez PL, Mascola JR, Chang GJ, Nabel GJ, Graham BS. A West Nile virus DNA vaccine induces neutralizing antibody in healthy adults during a phase 1 clinical trial. J Infect Dis 2007 Dec 15;196(12):1732-40.
                              doi: 10.1086/523650pubmed: 18190252google scholar: lookup
                            55. Tenorio A. [New viruses, old viruses]. Enferm Infecc Microbiol Clin 2007 Nov;25(9):559-60.
                              doi: 10.1157/13111180pubmed: 17953894google scholar: lookup
                            56. Ciota AT, Lovelace AO, Jones SA, Payne A, Kramer LD. Adaptation of two flaviviruses results in differences in genetic heterogeneity and virus adaptability. J Gen Virol 2007 Sep;88(Pt 9):2398-2406.
                              doi: 10.1099/vir.0.83061-0pubmed: 17698648google scholar: lookup
                            57. Gleiser RM, Zygadlo JA. Insecticidal properties of essential oils from Lippia turbinata and Lippia polystachya (Verbenaceae) against Culex quinquefasciatus (Diptera: Culicidae). Parasitol Res 2007 Oct;101(5):1349-54.
                              doi: 10.1007/s00436-007-0647-zpubmed: 17616850google scholar: lookup
                            58. Kitai Y, Shoda M, Kondo T, Konishi E. Epitope-blocking enzyme-linked immunosorbent assay to differentiate west nile virus from Japanese encephalitis virus infections in equine sera. Clin Vaccine Immunol 2007 Aug;14(8):1024-31.
                              doi: 10.1128/CVI.00051-07pubmed: 17596430google scholar: lookup
                            59. Bosch I, Herrera F, Navarro JC, Lentino M, Dupuis A, Maffei J, Jones M, Fernández E, Pérez N, Pérez-Emán J, Guimarães AE, Barrera R, Valero N, Ruiz J, Velásquez G, Martinez J, Comach G, Komar N, Spielman A, Kramer L. West Nile virus, Venezuela. Emerg Infect Dis 2007 Apr;13(4):651-3.
                              doi: 10.3201/eid1304.061383pubmed: 17561567google scholar: lookup
                            60. Ciota AT, Ngo KA, Lovelace AO, Payne AF, Zhou Y, Shi PY, Kramer LD. Role of the mutant spectrum in adaptation and replication of West Nile virus. J Gen Virol 2007 Mar;88(Pt 3):865-874.
                              doi: 10.1099/vir.0.82606-0pubmed: 17325359google scholar: lookup
                            61. Bruno L, Nappo MA, Frontoso R, Perrotta MG, Di Lecce R, Guarnieri C, Ferrari L, Corradi A. West Nile Virus (WNV): One-Health and Eco-Health Global Risks. Vet Sci 2025 Mar 19;12(3).
                              doi: 10.3390/vetsci12030288pubmed: 40266979google scholar: lookup
                            62. Matta NE, Gaitán-Albarracín FA, Fuentes-Rodríguez GA, Rodríguez-Fandiño ÓA, Calixto-Botía IF, Correa-Higuera LJ. Survey of West Nile virus infection in wildlife species in the Orinoquia region of Colombia. Front Microbiol 2025;16:1548538.
                              doi: 10.3389/fmicb.2025.1548538pubmed: 40071208google scholar: lookup
                            63. Brüssow H, Figuerola J. The Spread of the Mosquito-Transmitted West Nile Virus in North America and Europe. Microb Biotechnol 2025 Mar;18(3):e70120.
                              doi: 10.1111/1751-7915.70120pubmed: 40035176google scholar: lookup
                            64. Vissani MA, Alamos F, Tordoya MS, Minatel L, Schammas JM, Dus Santos MJ, Trono K, Barrandeguy ME, Balasuriya UBR, Carossino M. Outbreak of Western Equine Encephalitis Virus Infection Associated with Neurological Disease in Horses Following a Nearly 40-Year Intermission Period in Argentina. Viruses 2024 Oct 10;16(10).
                              doi: 10.3390/v16101594pubmed: 39459927google scholar: lookup
                            65. Cardo MV, Rubio A, Carbajo AE, Vezzani D. Exploring the range of Culex mosquitoes in Western Argentinean Patagonia, unveiling the presence of Culex pipiens bioform pipiens in South America. Parasitol Res 2024 Mar 5;123(3):151.
                              doi: 10.1007/s00436-024-08166-5pubmed: 38441704google scholar: lookup
                            66. Rucci KA, Arias-Builes DL, Visintin AM, Diaz A. Serological survey reveals enzootic circulation of St. Louis encephalitis and West Nile viruses in semiarid Monte ecosystem of Argentina. Sci Rep 2024 Feb 29;14(1):4994.
                              doi: 10.1038/s41598-024-55723-0pubmed: 38424362google scholar: lookup
                            67. Alvial IE, Hernández-P R, Suazo MJ, González CR, Véliz D, Benítez HA. Unraveling biotypes of the northern house mosquito, Culex pipiens s.l. (Diptera: Culicidae): molecular differentiation and morphometric analysis. J Insect Sci 2024 Jan 1;24(1).
                              doi: 10.1093/jisesa/ieae006pubmed: 38340048google scholar: lookup
                            68. Garrigós M, Garrido M, Panisse G, Veiga J, Martínez-de la Puente J. Interactions between West Nile Virus and the Microbiota of Culex pipiens Vectors: A Literature Review. Pathogens 2023 Oct 27;12(11).
                              doi: 10.3390/pathogens12111287pubmed: 38003752google scholar: lookup