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Equine veterinary journal2004; 36(2); 130-134; doi: 10.2746/0425164044868594

Why are certain premises at increased risk of equine grass sickness? A matched case-control study.

Abstract: Equine grass sickness (EGS) occurs repeatedly on certain premises over time. Few studies have sought, or identified, the determinants of this phenomenon in order to inform advice on disease prevention strategies. Objective: Premises-level risk factors are important determinants of whether EGS occurs. Methods: A matched case-control study was undertaken. Sixty premises giving rise to one or more histologically confirmed case of EGS and 120 time-matched control premises were sampled. Data were collected on pasture management, soil nutrient content, pasture nutrient content and local weather conditions for 2 weeks prior to the onset of disease. Data were analysed by conditional logistic regression. Results: Multivariable modelling identified an association between EGS and increased soil nitrogen content, pasture disturbance and previous occurrence of EGS on the premises. None of the meteorological variables recorded in this study were significantly associated with EGS occurrence. No relationship between certain management practices (e.g. harrowing, fertilisation, reseeding) and the risk of EGS was detected. Conclusions: This information is useful in understanding the causal pathway of EGS and may be used in the formulation of evidence-based disease avoidance strategies.
Publication Date: 2004-03-25 PubMed ID: 15038435DOI: 10.2746/0425164044868594Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

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The research investigates why certain places are more susceptible to Equine Grass Sickness (EGS), a disease affecting horses. It uncovers that factors like soil nutrient content, pasture disturbance, and previous instances of EGS contribute to increased vulnerability.

Research Methods:

The researchers carried out a matched case-control study. They used a sample of:

  • Sixty premises where there had been at least one instance of EGS confirmed through histology
  • 120 control premises that were matched in terms of time

Data was collected on aspects such as:

  • Pasture management techniques
  • Soil nutrient content
  • Pasture nutrient content
  • Local weather conditions two weeks before a disease outbreak

The researchers then analyzed this data using conditional logistic regression.

Results of the Study:

After analyzing the data through multi-variable modelling, researchers uncovered that the occurrence of EGS was linked with:

  • Higher soil nitrogen content
  • Disturbances in pasture
  • Previous instances of EGS in the same location

However, they found no significant links between local meteorological variables and EGS occurrence. Certain management practices like harrowing, fertilization, or reseeding were also not associated with an increased risk of EGS.

Conclusion:

This study provides valuable insights to understand the causes behind EGS and potentially how to mitigate its occurrence. The knowledge gained can be used to devise evidence-based strategies to prevent this disease in horses. The research highlights the importance of looking at local factors like soil content and history of the disease while developing such preventative measures.

Cite This Article

APA
McCarthy HE, French NP, Edwards GB, Miller K, Proudman CJ. (2004). Why are certain premises at increased risk of equine grass sickness? A matched case-control study. Equine Vet J, 36(2), 130-134. https://doi.org/10.2746/0425164044868594

Publication

ISSN: 0425-1644
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 36
Issue: 2
Pages: 130-134

Researcher Affiliations

McCarthy, H E
  • Faculty of Veterinary Science, University of Liverpool, Leahurst, Neston, Wirral CH64 7TE, UK.
French, N P
    Edwards, G B
      Miller, K
        Proudman, C J

          MeSH Terms

          • Animal Husbandry / methods
          • Animals
          • Autonomic Nervous System Diseases / epidemiology
          • Autonomic Nervous System Diseases / etiology
          • Autonomic Nervous System Diseases / veterinary
          • Case-Control Studies
          • Horse Diseases / epidemiology
          • Horse Diseases / etiology
          • Horses
          • Incidence
          • Logistic Models
          • Multivariate Analysis
          • Nitrogen / adverse effects
          • Nitrogen / analysis
          • Risk Factors
          • Seasons
          • Soil / analysis
          • Soil Microbiology
          • Surveys and Questionnaires

          Citations

          This article has been cited 4 times.
          1. Randleff-Rasmussen PK, Leblond A, Cappelle J, Bontemps J, Belluco S, Popoff MR, Marcillaud-Pitel C, Tapprest J, Tritz P, Desjardins I. Development of a clinical prediction score for detection of suspected cases of equine grass sickness (dysautonomia) in France.. Vet Res Commun 2018 Mar;42(1):19-27.
            doi: 10.1007/s11259-017-9704-ypubmed: 29204821google scholar: lookup
          2. McGorum BC, Pirie RS, Glendinning L, McLachlan G, Metcalf JS, Banack SA, Cox PA, Codd GA. Grazing livestock are exposed to terrestrial cyanobacteria.. Vet Res 2015 Feb 25;46:16.
            doi: 10.1186/s13567-015-0143-xpubmed: 25828258google scholar: lookup
          3. Edwards SE, Martz KE, Rogge A, Heinrich M. Edaphic and Phytochemical Factors as Predictors of Equine Grass Sickness Cases in the UK.. Front Pharmacol 2010;1:122.
            doi: 10.3389/fphar.2010.00122pubmed: 21833167google scholar: lookup
          4. Archer DC, Pinchbeck GL, Proudman CJ, Clough HE. Is equine colic seasonal? Novel application of a model based approach.. BMC Vet Res 2006 Aug 24;2:27.
            doi: 10.1186/1746-6148-2-27pubmed: 16930473google scholar: lookup