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ACS Pharmacol Transl Sci

Overview of the Current Osteoarthritis Treatment in Veterinary Medicine and Future Directions.
ACS pharmacology & translational science    April 14, 2026   Volume 9, Issue 5 1037-1054 doi: 10.1021/acsptsci.5c00706
Quintão NLM, Moffa EB, Kroier M, Goldoni RC, Bundgaard L, Jensen AL, Fernandes ES.Osteoarthritis (OA) is a chronic and progressive joint disease that can cause permanent loss of joint function. OA is highly prevalent in horses, dogs, and cats, affecting different joints and leading to reduced mobility and chronic pain. Different risk factors for animal OA have been identified, including trauma and breed. Inflammation is a hallmark of the disease, with various underlying mechanisms such as cyclooxygenase and metalloproteinase activation, nerve growth factor, cytokine, and prostaglandin upregulation, among others. Although disease complexity makes OA difficult to treat, eno...