English
French
American journal of respiratory and critical care medicine.
Publisher:
American Lung Association,. New York, NY : American Thoracic Society (2000)
Frequency: Semimonthly, 2002-
Country: United States
Language: English
Author(s):
American Thoracic Society., American Lung Association.
Start Year:1994 -
ISSN:
1073-449X (Print)
1535-4970 (Electronic)
1073-449X (Linking)
1535-4970 (Electronic)
1073-449X (Linking)
Impact Factor
24.7
| NLM ID: | 9421642 |
| (DNLM): | SR0080213(s) |
| (OCoLC): | 29407978 |
| Coden: | AJCMED |
| LCCN: | sn 93003167 |
| Classification: | W1 AM521NF |
Neutrophilic airway inflammation in horses with heaves is characterized by a Th2-type cytokine profile. Heaves in horses shares many similarities with human asthma, including lower airway inflammation, reversible airway obstruction, and bronchial hyperresponsiveness. Extrinsic asthma is an allergic response to environmental allergens and a similar immunologic mechanism may be implicated in heaves. It is now recognized that a Th2 subset of CD4+ lymphocytes is associated with allergic diseases such as atopic asthma. The purpose of this study was to determine whether airway inflammation in heaves is associated with a pattern of expression of cytokine suggestive of a Th2 type response. The expressio...
Correlation between nuclear factor-kappaB activity in bronchial brushing samples and lung dysfunction in an animal model of asthma. Asthma is a chronic inflammatory disease of the airways, in which many inflammatory genes are overexpressed. Transcription factor, nuclear factor-kappaB (NF-kappaB), which is thought to control the transcriptional initiation of inflammatory genes, has been poorly investigated in asthma. In the present report, bronchial cells (BCs), recovered by bronchial brushing in healthy and heaves-affected horses (i.e., an animal model of asthma), were assessed for NF-kappaB activity. Small amounts of active NF-kappaB were present in BCs of healthy horses, whereas high levels of NF-kappaB activity was foun...
Acetylcholine release from airway cholinergic nerves in horses with heaves, an airway obstructive disease. The present study was conducted to determine if acetylcholine (ACh) release from airway cholinergic nerves is increased and if modulation of ACh release by prejunctional receptors is altered in horses with heaves, an obstructive airway disease characterized by airway inflammation and bronchospasm. Trachealis strips and bronchial segments of normal horses and horses affected with heaves were suspended in 2-ml tissue baths. ACh release was induced by electrical field stimulation and the bath ACh content was measured by high performance liquid chromatography (HPLC) with electrochemical detection....
