English
French
Arthritis & rheumatology.
Publisher:
Wiley,
Frequency: Monthly
Country: United States
Language: English
Author(s):
American College of Rheumatology,
Start Year:2014 -
ISSN:
2326-5191 (Print)
2326-5205 (Electronic)
2326-5191 (Linking)
2326-5205 (Electronic)
2326-5191 (Linking)
Impact Factor
1.3
2022
| NLM ID: | 101623795 |
| (OCoLC): | 826899584 |
| LCCN: | 2013200527 |
| Classification: | W1 AR95163 |
Disease-Modifying Osteoarthritis Treatment With Interleukin-1 Receptor Antagonist Gene Therapy in Small and Large Animal Models. Gene therapy holds great promise for the treatment of osteoarthritis (OA) because a single intraarticular injection can lead to long-term expression of therapeutic proteins within the joint. This study was undertaken to investigate the use of a helper-dependent adenovirus (HDAd)-mediated intraarticular gene therapy approach for long-term expression of interleukin-1 receptor antagonist (IL-1Ra) as sustained symptomatic and disease-modifying therapy for OA. In mouse models of OA, efficacy of HDAd-IL-1Ra was evaluated by histologic analysis, micro-computed tomography (micro-CT), and hot plate ana...
Transcriptome-wide analysis of messenger RNA decay in normal and osteoarthritic human articular chondrocytes. Messenger RNA (mRNA) decay rates control not only gene expression levels, but also responsiveness to altered transcriptional input. We undertook this study to examine transcriptome-wide posttranscriptional regulation in both normal and osteoarthritic (OA) human articular chondrocytes. Methods: Human articular chondrocytes were isolated from normal or OA tissue. Equine articular chondrocytes were isolated from young or old horses at a commercial abattoir. RNA decay was measured across the transcriptome in human cells by microarray analysis following an actinomycin D chase. Messenger RNA levels ...
