Endocrinology.
Publisher:
Association for the Study of Internal Secretions,. New York : Oxford University Press (2017)
Frequency: Monthly
Country: United States
Language: English
Author(s):
Association for the Study of Internal Secretions (U.S.), Endocrine Society.
Start Year:1917 -
ISSN:
0013-7227 (Print)
1945-7170 (Electronic)
0013-7227 (Linking)
1945-7170 (Electronic)
0013-7227 (Linking)
Impact Factor
4.8
2022
| NLM ID: | 0375040 |
| (DNLM): | E07180000(s) |
| (OCoLC): | 01567879 |
| Coden: | ENDOAO |
| LCCN: | sg 39000030 |
| Classification: | W1 EN396S |
The estrogens of the pregnant mare. The urinary ketonic estrogens were studied at monthly intervals in five pregnant mares. Estrone and equilin appear to be the principal components and equilenin a minor constituent of the mares’ estrogens. The levels of equilin rise from the 4–5th months to equal and in some instances exceed those of estrone in the late months of pregnancy. A partition chromatographic method for the separation of the ketonic phenolic steroids of pregnant mares’ urine is described.
Metabolism of estrogens in the pregnant mare. The biosynthetic origins of the ring-B unsaturated estrogens, equilin and cquilcnin
have been the subject of considerable speculation. Girard and associates (1,2) first iso-
lated these compounds, in addition to estrone, from the urine of pregnant marcs, and
observed that their proportions increased during the latter months of pregnancy, at a
time when the total estrogen (estrone) content of the urine diminished (2,3). Heard and
associates (4) reported that estrone-C14 administered to a pregnant marc was not trans-
formed to equilin nor equilenin (5). We have explored in the mare the pos...
The inactivation of pregnant mares’ serum gonadotrophin by hydroquinones and quinones. Pregnant mares' serum (PMS) when incubated in vitro with hydroquinones and quinones loses its gonadotrophic activity. The influence of the incubation conditions on this process has been examined. Hydroquinones did not inactivate PMS unless they were first allowed to oxidize to the corresponding quinones. Þ-Benzoquinone was found to be more active than mono-substituted quinones and the di- and tetra-substituted quinones had little or no activity. The amorphous polymer “humic acid” formed by “ageing” p-benzoquinone solutions partially inactivated PMS but itwas much less active than the ...
The demonstration of a non-estrogenic uterine stimulating and estrogen augmenting substance in pregnant mares’ urine. THE occurrence of substances, in the extracts of human urine and of testes, that are capable of augmenting the effects of estrogens or androgens has been postulated and demonstrated by various workers. Freud and co-workers (1933, 1935) obtained factors from extracts of testes and human urine that augmented the effects of androgens, although possessing no androgenic activity themselves. Emmens (1938) described the presence of substances in the phenolic fraction of normal human female urine which in themselves were non-estrogenic, but when given orally, increased the potency of estriol injected ...