Omneity® Pellets
All-In-One Vitamin & Mineral Pellet
Topic:Clinical Study
Clinical studies in equine research involve the systematic investigation of health and disease in horses through structured scientific methods. These studies aim to evaluate the safety and efficacy of treatments, understand disease mechanisms, and improve veterinary care practices. Clinical studies can include randomized controlled trials, observational studies, and case-control studies. They may focus on various aspects such as pharmacokinetics, therapeutic interventions, and diagnostic techniques. This page compiles peer-reviewed research studies and scholarly articles that explore the design, implementation, and findings of clinical studies in equine medicine, providing insights into their impact on horse health and veterinary practices.
Critical tests of morantel-trichlorfon paste formulation against internal parasites of the horse. Critical tests were completed on six horses to evaluate the antiparasitic activity of a paste formulation mixture of morantel citrate and trichlorfon, administered intraorally at the dose rate of 6 mg morantel base kg-1 and trichlorfon at 30 mg kg-1. Aggregate average removals were: 78% for two horses infected with 2nd instar Gasterophilus intestinalis; 100% for one infected with 2nd instar G. nasalis; 96% for six infected with 3rd instar G. intestinalis; 100% for four infected with 3rd instar G. nasalis; 100% for five infected with Parascaris equorum; 100% for one infected with mature Oxyuris...
Hyaluronic acid concentration in synovial fluid from normal and arthritic joints of horses. A method previously described was used to determine the hyaluronic acid concentration in synovia from normal and arthritic horse joints. The concentration of hyaluronic acid in the synovia from arthritic joints was found to be significantly lower than the concentration in fluid from normal joints.
Acupuncture for treatment of chronic back pain in the horse. Fifteen horses with chronic back pain for 1/2 to 9 years, who could not function normally, who did not obtain any lasting improvement from other previous treatments, were treated with acupuncture. The treatments were 20 minutes of manual acupuncture. The average number of treatments was 7.9 times administered at weekly intervals. After the acupuncture treatments were completed, 13 of the 15 horses were able to function normally.
Experiences in diagnostic and surgical arthroscopy in the horse. This paper reviews the current status of diagnostic and surgical arthroscopy in the horse. Arthroscopy has been used as a diagnostic aid since 1974 and is useful for evaluation of abnormalities in synovial membrane and articular cartilage. Surgical arthroscopy is a more recent advance that has replaced conventional arthrotomy in 90 per cent of the author's cases. Clinical conditions currently being treated using arthroscopic techniques rather than arthrotomy include all chip fractures in the carpus, chip fractures of the first phalanx, chronic proliferative synovitis in the fetlock and osteoch...
Hyperglycemia and hypoinsulinemia during xylazine-ketamine anesthesia in Thoroughbred horses. Plasma glucose and serum insulin concentrations in Thoroughbreds administered xylazine hydrochloride (1.1 mg/kg; IV) and ketamine hydrochloride (2.2 mg/kg; IV) at dosages sufficient to induce short periods of recumbency and anesthesia were measured. Samples of blood were collected from 6 adult horses before, during, and after the anesthetic period. Plasma glucose (mg/dl) was significantly increased above control (-30 minute concentration) from 15 to 150 minutes after xylazine administration with the peak value occurring at 30 minutes. Serum insulin (microU/ml) was significantly decreased from ...
Survey of resting blood pressure values in clinically normal horses. Resting coccygeal blood pressure values were measured, indirectly, on 296 horses (97 Thoroughbreds, 97 Standardbreds and 102 hacks). Blood pressure was found to vary with the class of horse examined; on average Thoroughbreds had significantly higher values than Standardbreds and hacks, whereas blood pressures of the last two groups were not significantly different. There was no demonstrable effect of sex, height or heart rate on blood pressure, but temperature and age did influence the value recorded. Mean (+/- sd) (n = 296) coccygeal uncorrected values (systolic pressure/diastolic pressure) w...
Effects of placement of intravaginal sponges on LH, FSH, estrus and ovarian activity in mares during the nonbreeding season. Eight seasonally anestrous mares were administered intravaginal polyurethane sponges on December 15 and then weekly thereafter until February 1. Control mares received no sponges or genital contact. Sponge insertion caused an immediate surge in follicle-stimulating hormone (FSH) concentrations in jugular plasma in 50% of treated mares whereas no control mares had surges in FSH (P less than .05). The effect of treatment on luteinizing hormone (LH) concentrations was much less dramatic and only three treated mares appeared to have positive responses. Sponge-treated mares exhibited positive respo...
Times of appearance and disappearance of colostral IgG in the mare. Pre- and postpartum colostral samples collected from 14 Arabian and 22 Thoroughbred mares were examined for color, consistency, and immunoglobulin (Ig)G concentration. Initial samples, obtained 3 to 28 days before mares had foaled, contained greater than 1,000 mg of IgG/dl. Mean concentration of IgG in colostrum of the Arabian mares at the time of parturition (T0) was 9,691 mg/dl and was significantly (P less than 0.05) higher than the average, 4,608 mg/dl, for the Thoroughbreds. Average times lapsed from T0 until the colostral IgG decreased to 1,000 mg/dl (T1,000) was 19.1 hours for the Arabi...
Muscle perfusion in the horse. Muscle perfusion was studied in conscious and anaesthetised horses by monitoring the clearance of a locally injected bolus of saline containing radioactive xenon (133Xe). The mean of all the measurements made from the brachiocephalicus and semimembranosus muscles in conscious subjects was 1.29 ml/min/100 g while in anaesthetised subjects it was 0.40 ml/min/100 g. The significance of these results is discussed in relation to the clinical occurrence of post anaesthetic myositis.
Method of selective and non-selective angiocardiography for the horse. A practical and safe method of angiocardiography for the horse is described. The technique involved the rapid injection of 50 to 150 ml contrast agent via catheters in the right and left heart, pulmonary artery and aorta. The examination was carried out with the horse in the standing position or under general anaesthesia. Angiocardiograms were performed on 10 normal horses and satisfactory pictures of the right and left ventricles, pulmonary arteries, aorta and coronary circulation were obtained. The technique was also used in a foal with severe congenital heart disease. The most practical met...
[Diagnosis and therapy of guttural pouch diseases in horses]. Using a fibreoptic endoscope ("small gastroscope" with outside diameter of 9.3 mm) a simple and sparing inspection of the guttural pouch is performed. The flap-type tube cover is opened by means of medial leverage with a guidance probe shifted through the work duct of the endoscope. The same procedure is used in diagnostic specimen collection and therapeutical measures such as irrigations. Guttural pouch topography and pathological disorders are illustrated by endoscopic photography. The different diseases such as follicular hyperplasia, ascending pharyngeal catarrh, perforating abscesses of t...
The elimination of equine strongyles and hematological and pathological consequences following larvicidal doses of thiabendazole. Twelve horses were divided into three groups and given various doses of a mixed species strongyle inoculum, representing light, moderate, and heavy infections. Three weeks after the larval inoculations, three animals from each group were given larvicidal doses of thiabendazole (TBZ) (440 mg kg-1 on two consecutive days); one animal from each group served as a non-medicated control. Treatment was repeated three weeks later. One treated animal from each group was designated for long-term study; others were necropsied to study adult and larval parasite loads. Six of the twelve animals with strong...
Cervical vertebral interbody fusion in the horse: a comparative study of bovine xenografts and autografts supported by stainless steel baskets. A modified form of the Cloward technique for anterior cervical fusion in human beings was used in the application of different grafts for evaluation of their effectiveness in stabilizing equine cervical vertebrae. Results of bovine xenograft implants in 8 horses were compared with results of stainless steel baskets (SSB) packed with cancellous autogenous bone in 8 horses. Graft material was incorporated in all cases. Evidence of graft rejection was not present. Both forms of implants decreased the mobility of the intervertebral space in which they were implanted. A fibrous connective tissue un...
Horse haemoglobin phenotyping by agarose gel isoelectric focusing comparison of Thoroughbreds with other Equidae. By using isoelectric focusing in thin agarose slab gels 1049 Thoroughbred, 82 Nooitgedachter, 45 Percheron and 244 horses of other breeds were examined. The numbers of other Equidae tested were 107 donkeys, 50 mules, 4 common zebras (Equus burchelli boehmi) and 8 mountain zebras (Equus zebra hartmannae). Phenotypic data are presented for all tested animals and gene frequencies are calculated for the horses.
Effects of environmental control on pulmonary function of horses affected with chronic obstructive pulmonary disease. The effects of environmental control on horses affected with chronic obstructive pulmonary disease was assessed by clinical examination and pulmonary function tests, ie, maximum change in intrathoracic pressure, tidal volume, minute volume, non-elastic work of breathing, dynamic compliance, inspiratory and expiratory flow rates and arterial blood gas analysis. A controlled environment (ie, bedding horses on shredded paper and feeding a complete cubed diet) caused symptomatic COPD affected horses to become asymptomatic within four to 24 days (mean +/- sd 8.4 +/- 4.8 days). When asymptomatic, th...
Detection of equine infectious anemia virus in horse leukocyte cultures derived from horses in various stages of equine infectious anemia viral infection. The enzyme-linked immunosorbent assay (ELISA) antigen-positive and agar-gel immunodiffusion test (AGID)-negative horses do not have infective equine infectious anemia (EIA) virus. The ELISA testing of horse leukocyte culture (HLC) supernatants did detect EIA virus in a HLC that was infected with the Wyoming strain of EIA virus and in HLC derived from horses in febrile, acute, or subacute stages of EIA infection. In supernatants of HLC derived from chronic and inapparent carrier horses, EIA virus was not detected with ELISA. Direct fluorescent antibody tests detected EIA virus in HLC infected w...
Efficacy of ivermectin in injectable and oral paste formulations against eight-week-old Strongylus vulgaris larvae in ponies. A controlled test method was used to evaluate the efficacy of injectable micelle and oral paste formulations of ivermectin (22,23-dihydroavermectin B1) against 8-week-old Strongylus vulgaris larvae in experimentally infected pony foals. The dosage level of the drug in both formulations tested was 0.2 mg/kg. Ponies were euthanatized and necropsied 5 weeks after treatment. Based on the recovery of live vs dead S vulgaris from mesenteric arteries, both formulations were greater than 99% effective. Increased weight gains and marked reductions in the severity of arterial lesions were observed in tr...
[An attempt at demonstrating the participation of autoaggressive processes in the pathogenesis of periodic eye inflammation in horses]. In the studies attempts were to demonstrate the occurrence of immunological reactivity against antigens of the lens and tunica vascularis of the eye in periodical inflammation of eyes in horses. For this purpose antigens from the lens and tunica vascularis of the eye, prepared in our laboratory, were used in the experiments. The reactivity of horses with monthly symptoms of blindness against the above antigens was determined in vivo (skin tests and PCA) and in vitro (ID reaction). The results obtained mainly in skin tests account for its occurrence in some percentage of diseased animals, becau...
Analysis of propionylpromazine and its metabolites in horse urine. The metabolism of propionylpromazine in the horse was studied. Although propionylpromazine is not currently approved or recommended for use in horses, it has been used illegally to alter their performance. Propionylpromazine hydrochloride was administered intramuscularly at clinical and subclinical doses. Three metabolites were detected in urine. The major metabolite was identified as 2-(1-hydroxypropyl) promazine sulfoxide. The detection of this metabolite in routine drug testing has been described.
Quantitation of serum phospholipase A2 by enzyme-diffusion in lecithin agar gels. A comparative study in man and animals. A sensitive gel-diffusion assay for determination of phospholipase A was developed. PLA standards, serum, faecal and pancreas homogenate samples with PLA-activity were allowed to diffuse from wells into agar-gels containing lecithin-membranes. The turbidity cleared radially upon PLA-activity. The diameters of the cleared zones showed a linear relationship with the log of the enzyme concentration. Serum samples resulted in some turbidity within the cleared zones. This interference originating from serum lipoproteins could be abolished by hydrophobic absorption. The gel-diffusion method was comp...
[Leptospirosis on the Island of Reunion. II. Animal leptospiroses]. Bovine leptospirosis is a typical form in the island of Reunion. It appears during the second part of the rain season. The clinical picture of equine leptospirosis is acute hepatonephritis. About 10 serogroups are found in bovines, with greater frequency for Sejroë and Hebdomadis. In horses, the prevailing serogroups are Autumnalis, Ballum, Icterohaemorrhagiae, Australis, Grippotyphosa.
Isolation and partial characterization of equine alveolar macrophages. A device was constructed from an equine nasogastric tube, polyethylene tubing, and a 3-way stopcock and used to lavage the lungs of anesthetized ponies. The technique was safe and atraumatic in that 6.4 to 19.7 X 10(7) purified alveolar macrophages were removed from the lungs without harm to the ponies or contamination of the samples with blood. Studies of these highly purified cell suspensions revealed a mean viability of 85% as assessed by eosin dye exclusion with a mean recovery (+/- SD) of 12.5 +/- 4.8 X 10(7) pulmonary alveolar macrophages/pony.
Reduction of the red blood cell mass of horses: toxic effect of heparin anticoagulant therapy. This study was designed to test the efficacy of heparin anticoagulant therapy in the horse and its effect on the formed elements of blood. Nine clinically normal, nontraumatized adult horses were subjected to 4 different heparin maintenance regimens (dosages of 320, 240, 160, and 40 U/kg of body weight). Porcine intestinal mucosa heparin (20,000 U/ml) was injected subcutaneously every 12 hours for 96 hours (total 9 times). A loading dose of one-third the maintenance dose was given IV just before the first heparin injection. Three control horses were given an equivalent volume of 0.9% saline so...
Increased susceptibility of fibroblasts from horses with severe combined immunodeficiency to growth inhibition by 2′-deoxyadenosine. The effect of adenosine, deoxyadenosine, guanosine, and deoxyguanosine on the growth rate of fibroblasts derived from normal horses, horses heterozygous for the severe combined immunodeficiency (SCID) trait (heterozygotes), and horses with SCID was studied. All four purines were found to inhibit growth in a dose-dependent manner, but only adenosine and deoxyadenosine were inhibitory at concentrations of less than 100 microM. No statistical difference in sensitivity to adenosine was detected between normal and SCID fibroblasts. Fibroblasts from SCID horses were, however, more sensitive to the g...
