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Topic:Clinical Study
Clinical studies in equine research involve the systematic investigation of health and disease in horses through structured scientific methods. These studies aim to evaluate the safety and efficacy of treatments, understand disease mechanisms, and improve veterinary care practices. Clinical studies can include randomized controlled trials, observational studies, and case-control studies. They may focus on various aspects such as pharmacokinetics, therapeutic interventions, and diagnostic techniques. This page compiles peer-reviewed research studies and scholarly articles that explore the design, implementation, and findings of clinical studies in equine medicine, providing insights into their impact on horse health and veterinary practices.
Subchondral cystic and related lesions affecting the equine pedal bone and stifle. Twenty-nine horses were examined over a period of 8 years and found to have cystic lesions in the stifle (14 cases) or pedal bone (15 cases). The lesions are described and illustrated with radiographs. In the stifle 12 lesions were found on the femoral condyles (11 medially and one laterally) and 10 were typical subchondral cysts. One lesion was observed in the tibia and 3 in the patella. Bone cysts wee found unilaterally in the pedal bone (14 in the forelimbs and one in the hindlimb). All but 2 of the horses with lesions in the stifle or pedal bone were lame. The only treatment was rest. For ...
Glucocorticoid suppression of oestrus, follicles, LH and ovulation in the mare. Dexamethasone, a synthetic glucocorticoid, was administered (30 mg/day) from Day 10 after ovulation to assess the involvement of the adrenal glands in the ovulatory cycle. Only 1 of 8 mares treated in this way exhibited behavioural oestrus, compared to 7 of 8 control mares. Mean maximum LH concentration and follicle size were significantly reduced. Ovulation occurred in 1 and possibly in 2 other treated mares, compared to all 8 control mares. The results demonstrated that dexamethasone can interfere with ovulation and associated events in the mare, but the mechanism of action is uncertain.
Time relationship between the respiratory cycle and limb cycle in the horse. Techniques developed for the detection and simultaneous recording of certain events in the respiratory and limb cycles are presented. The respiratory cycle and limb cycle were found to be in-phase only at the canter and gallop. The significance of any time relationship between events in respiration and in locomotion is discussed.
Isolation and some properties of equine alpha 1-antitrypsin. 1. Equine alpha 1-antitrypsin was isolated from horse plasma by a combination of ammonium sulfate and acidification precipitation followed by ion-exchange chromatography on DEAE-cellulose, molecular sieve chromatography on Sephadex G-200 and affinity chromatography on Cibacron Blue-agarose. 2. The purified protein showed a single precipitin arc on immunoelectrophoresis in agarose but gave two bands on discontinuous polyacrylamide gel electrophoresis (PAGE). 3. Both bands appeared to interact equally with trypsin and were thought to represent two isoinhibitors of equine alpha 1-AT.
The repeatability of seminal characteristics of stallions. Fifteen seminal characteristics were measured in ejaculates from 4 laboratory stallions and from 164 commercial stud stallions. Complete field and laboratory data were available from 536 and 531 ejaculates, respectively. These were obtained over 4 breeding seasons (1974/75-1977/78) and 9 breeds were represented. Stallions at commercial studs produced 1-13 ejaculates at intervals of approximately 4 weeks and ranging from 1 h to 1 year apart. Intra-class correlations or 'repeatability' of each seminal characteristic were calculated. Significant between-stallion variation occurred in all characte...
Colic in a mare caused by a colonic neurofibroma. A 16 year old Thoroughbred mare was presented to the Ontario Veterinary College because of an acute episode of colic. An exploratory laparotomy was performed and a neurofibroma was identified and successfully removed from the small colon. The clinical and pathological features of this case are discussed.
Anthelmintic efficacy of ivermectin given intramuscularly in horses. The anthelmintic activity of ivermectin was evaluated in 18 female horses with naturally acquired parasitic infections. Horses were treated once (IM) with vehicle only (n = 6), 200 microgram/kg of body weight (n = 6), and 300 microgram/kg (n = 6). Efficacy of both dosages of ivermectin was greater than 99% against Gasterophilus spp, 100% against Trichostrongylus axei, Habronema muscae, H majus, and Draschia megastoma, 98% to 99% against adult cyathostomes, 86% to 97% against 4th-stage cyathostomes, and 100% against adult large strongyles. Although ivermectin was incomplete in its activity agai...
Results of concurrent bacteriological and cytological examinations of the endometrium of mares in routine stud farm practice 1978-1981. The results of 4024 concurrent endometrial swab and smear tests taken from maiden, barren and post-parturient mares during early oestrus, before coitus demonstrated the practical value of these tests in routine stud farm practice. The use of cytological examinations provided a more direct diagnostic test for acute endometritis and this increased the accuracy of interpretation of the bacteriological findings.
Fertility of frozen equine semen. Semen of 16 stallions collected by the fractionated method and frozen in liquid nitrogen was used to inseminate 175 mares of different ages and in various reproductive conditions. Pregnancy was recorded in 91 mares of which 72 delivered a foal. Pregnancy followed by resorption occurred in another 10 mares and 9 aborted. The best results were obtained in the young primiparous and in older mares inseminated in the oestrous cycle that followed the post-partum oestrus. Overall, 64% of mares became pregnant and 56% gave birth to a living foal. The highest occurrence of fetal death and resorption we...
Enzyme-linked immunosorbent assay for detection of antibody to Pseudomonas aeruginosa and measurement of antibody titer in horse serum. Enzyme-linked immunosorbent assay (ELISA) was used for detection of immunoglobulin (Ig) M and IgG antibodies against a serologically common antigen (original endotoxin protein), protease, and elastase of Pseudomonas aeruginosa. The P aeruginosa antibody in horse sera was measured, using ELISA. Horseradish peroxidase-labeled rabbit anti-horse IgM and IgG antibodies were used for enzyme-labeled antibody conjugate. 5-Aminosalicylic acid and H2O2 were used for substrate. Sera collected from a vaccinated horse, a newborn foal, and 72 healthy racehorses were investigated for antibodies against P aer...
