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Topic:Diagnosis
Diagnosis in horses involves the systematic identification of diseases and conditions affecting equine health. This process relies on a combination of clinical evaluations, laboratory tests, imaging techniques, and other diagnostic tools to assess the health status of horses. Veterinarians utilize these methods to identify symptoms, determine the underlying causes of health issues, and formulate appropriate treatment plans. Diagnostic procedures in equine medicine can include blood tests, ultrasound, radiography, endoscopy, and more specialized tests such as genetic screening or advanced imaging modalities like MRI and CT scans. This page aggregates peer-reviewed research studies and scholarly articles that explore various diagnostic techniques, their applications, and advancements in the field of equine veterinary medicine.
Use of physiologic and arterial blood gas variables to predict short-term survival in horses with large colon volvulus. To determine if preoperative physical examination and blood work values, intraoperative physiologic variables, and intraoperative treatments can be correlated with survival to anesthetic recovery and short-term survival to hospital discharge in horses that undergo exploratory celiotomy for large colon volvulus (LCV) with and without colon resection. Methods: Retrospective case series. Methods: Horses (n = 156) undergoing exploratory celiotomy for correction of LCV ≥ 360(ο) . Methods: Medical records (January 2000-December 2009) of horses that had surgical correction of LCV ≥ 360(ο) were ...
Investigation of a progressive facial deformity and stridor in an adult horse with a bone sequestrum and subsequent sinonasal abscess. Advanced diagnostic imaging and histopathological investigation were performed in an adult horse with chronic facial swelling due to a bone sequestrum and abscessation. In contrast to other cases, there were no draining tracts, difficulty eating, weight loss, head shaking, or fistula formation between the oral cavity and the maxillary sinus. Une investigation d’imagerie diagnostique avancée et un examen histopathologique ont été réalisés chez un cheval adulte présentant de l’enflure faciale chronique attribuable à un séquestre osseux et à une abcédation. Par contraste à d’aut...
Insulin-like growth factor I: could it be a marker of prematurity in the foal? Insulin-like growth factor (IGF)-I represents one of the most important growth regulators, playing a central role in fetal and neonatal growth. Plasma IGF-I levels increase rapidly after birth, and they are influenced by numerous factors, including sex, age, nutritional state, and premature birth. The aims of this study were: (1) to evaluate the IGF-I plasma profile in healthy newborn foals during the first 2 weeks of life; (2) to assess the possible influence of sex and birth weight on this hormone; (3) to analyze the percentage increment of IGF-I values in healthy foals; (4) to evaluate the ...
Tenoscopic surgical treatment of tears of the manica flexoria in 53 horses. To determine typical clinical features associated with tears of the manica flexoria (MF) and prognosis for return to athletic function after surgical resection. Methods: Case series. Methods: Medical records (January 2001-December 2011) of horses that underwent tenoscopic surgical treatment of MF tears were reviewed and outcome obtained by telephone questionnaire of owners. Results: Fifty three horses (65 MF tears) were treated; 83% were cobs or ponies. Injuries occurred more frequently in hindlimbs (85%) and effusion of the digital flexor tendon sheath was associated with all MF tears. Follow...
A histological study of peripheral dental caries of equine cheek teeth. Peripheral caries of equine cheek teeth is a poorly described disorder and, in particular little is known of its histopathology. Histological examinations of decalcified sections of 21 equine peripheral caries-affected cheek teeth showed two different patterns of cemental lesions; including progressive enlargement of focal, flask-like lesions leading to breakdown of the adjacent cementum, and secondly; a more generalized flaking-off of thin layers of under-run, surface cementum. A thick layer of plaque and food material usually lay on the surface of affected cementum and also within cemental d...
Traditional and quantitative assessment of acid-base and shock variables in horses with atypical myopathy. Descriptions of acid-base disturbances in atypical myopathy (AM) are limited. Objective: Describe and compare traditional and quantitative acid-base abnormalities and cardiovascular shock status in horses with AM at admission. Methods: 34 horses with AM, 15 healthy controls. Methods: Retrospective case-control study. Records were searched for shock variables (packed cell volume [PCV], blood urea nitrogen [BUN], heart and respiratory rate) and acid-base variables (venous blood gas analysis, electrolytes, total protein, lactate) on admission. Base excess (BE) of free water (BEfw), chloride (BEcl...
Advances in equine computed tomography and use of contrast media. Advances in equine computed tomography have been made as a result of improvements in software and hardware and an increasing body of knowledge. Contrast media can be administered intravascularly or intrathecally. Contrast media is useful to differentiate between tissues of similar density. Equine computed tomography can be used for many different clinical conditions, including lameness diagnosis, fracture identification and characterization, preoperative planning, and characterization of skull diseases.
Imaging of the equine proximal suspensory ligament. Injury to the suspensory ligament can result in significant lameness. Multiple imaging modalities may be required to fully characterize injury to the suspensory ligament. Ultrasonography of the suspensory ligament is challenging, due to the normal anatomy. This article describes imaging of the proximal suspensory ligament in the front and hind limbs of the horse.
Biochemical evaluation of equine articular cartilage through imaging. The use of molecular imaging of cartilage is the next vital step in understanding, treating, and training the equine athlete. Because of the logistics of precontrast and postcontrast medium imaging, the clinical usefulness of the examination has come into question. With the large number of horses undergoing high-field magnetic resonance imaging, the use of contrast medium administration and T1 mapping or T2 imaging precontrast and postcontrast medium administration may add a limited amount of time to the scan and has the potential to provide more detailed information about the chemical composi...
The basics of musculoskeletal magnetic resonance imaging: terminology, imaging sequences, image planes, and descriptions of basic pathologic change. The usefulness of magnetic resonance (MR) imaging in the diagnosis of equine lameness is unquestionable. As with most imaging modalities, advances in technology happen quickly, and the information that can be obtained can seem limitless. An understanding of MR sequences, expected signal intensity of normal tissues, and the role of multiplanar imaging is the foundation for interpreting MR images. The rapid development of new techniques and sequences and the potential for biochemical changes to be indirectly assessed using MR spectroscopy offer possibilities for the continued development of this...
Association of oxidative stress with motor neuron disease in horses. To investigate the influence of oxidative stress in terms of antioxidant capacity and lipid peroxidation on the probability of motor neuron disease (MND) in horses. Methods: 88 horses with MND (cases) and 49 controls. Methods: Blood samples were collected from all horses enrolled, and RBCs and plasma were harvested. Activity of the enzyme erythrocytic superoxide dismutase 1 (SOD1) was determined in the RBCs. Plasma concentrations of α-tocopherols and β-carotenes and activity of glutathione peroxidase were also evaluated. Degree of lipid peroxidation was measured by determining plasma concent...
Evaluation of squeeze-induced somnolence in neonatal foals. To test the hypothesis that application of a rope restraint device would result in behavioral, electroencephalographic, and humoral changes consistent with sleep and analgesia in neonatal foals. Methods: 8 healthy neonatal foals. Methods: Following acclimatization to experimental conditions, each foal underwent a series of assessments before and during or at the end of a period of restraint via application of a restraint device (soft linen rope). Assessments included measurements of heart and respiratory rates, rectal temperature, and circulating β-endorphin and steroid hormone concentrations...
Cryptosporidium spp. infection in mares and foals of the northwest region of São Paulo State, Brazil. The present study aimed to analyze the occurrence of infection by Cryptosporidium spp. in mares and their respective foals. This study was carried out in 11 farms located in the municipalities of Araçatuba, Birigui, Guararapes and Santo Antônio do Aracangua, in the northwest region of the State of Sao Paulo, from November 2010 to March 2011. A total of 98 mares and 98 foals of several breeds were analyzed; among foals, 59 were males and 39 females, aged from three to 330 days. Feces were collected directly from the rectal ampulla, purified and processed according to modified Kinyoun stain. O...
Pedigree analysis and exclusion of alpha-tocopherol transfer protein (TTPA) as a candidate gene for neuroaxonal dystrophy in the American Quarter Horse. Equine neuroaxonal dystrophy/equine degenerative myeloencephalopathy (NAD/EDM) is a neurodegenerative disorder affecting young horses of various breeds that resembles ataxia with vitamin E deficiency in humans, an inherited disorder caused by mutations in the alpha-tocopherol transfer protein gene (TTPA). To evaluate variants found upon sequencing TTPA in the horse, the mode of inheritance for NAD/EDM had to be established. Objective: NAD/EDM in the American Quarter Horse (QH) is caused by a mutation in TTPA. Methods: 88 clinically phenotyped (35 affected [ataxia score ≥2], 53 unaffected) QH...
Pyrosequencing of 16S rRNA genes in fecal samples reveals high diversity of hindgut microflora in horses and potential links to chronic laminitis. The nutrition and health of horses is closely tied to their gastrointestinal microflora. Gut bacteria break down plant structural carbohydrates and produce volatile fatty acids, which are a major source of energy for horses. Bacterial communities are also essential for maintaining gut homeostasis and have been hypothesized to contribute to various diseases including laminitis. We performed pyrosequencing of 16S rRNA bacterial genes isolated from fecal material to characterize hindgut bacterial communities in healthy horses and those with chronic laminitis. Results: Fecal samples were collected...
Monitoring of equine health in Denmark: the importance, purpose, research areas and content of a future database. The plentiful data on Danish horses are currently neither organized nor easily accessible, impeding register-based epidemiological studies on Danish horses. A common database could be beneficial. In principle, databases can contain a wealth of information, but no single database can serve every purpose. Hence the establishment of a Danish equine health database should be preceded by careful consideration of its purpose and content, and stakeholder attitudes should be investigated. The objectives of the present study were to identify stakeholder attitudes to the importance, purpose, research ar...
Clonal transmission of a rare methicillin-resistant Staphylococcus aureus genotype between horses and staff at a veterinary teaching hospital. Methicillin-resistant Staphylococcus aureus (MRSA) infection or colonization has become a serious emerging condition in equine hospitals. Following the detection of MRSA in asymptomatic hospitalized horses and in two horses with post-operative wound infections, an investigation was conducted. Twelve of 84 horses (14.3%) and 16 of 139 personnel (11.5%) were MRSA carriers. The profile of the dominant MRSA strain common to horses and staff was multi-drug-resistant, spa-type t535, SCCmec type V, pvl-negative. MLST of a representative isolate yielded sequence type (ST) 5. The risk of MRSA carriage ...
Persistence and chronic urinary shedding of the aphthovirus equine rhinitis A virus. Equine rhinitis A virus (ERAV) is a member of the Aphthovirus genus, and has many physical and structural similarities to the prototype Aphthovirus foot-and-mouth disease virus (FMDV). The pathogenesis of FMDV has been extensively studied, however, the similarities in the pathogenesis of ERAV and FMDV disease has not been well documented. This study describes and compares the pathogenesis of ERAV both in the natural host and a small animal model alternative (CBA mice). Distinct parallels in the pathogenesis of the acute infection of these two viruses are described where infection in the upper ...
Nonprimate hepaciviruses in domestic horses, United kingdom. Although the origin of hepatitis C virus infections in humans remains undetermined, a close homolog of this virus, termed canine hepacivirus (CHV) and found in respiratory secretions of dogs, provides evidence for a wider distribution of hepaciviruses in mammals. We determined frequencies of active infection among dogs and other mammals in the United Kingdom. Samples from dogs (46 respiratory, 99 plasma, 45 autopsy samples) were CHV negative by PCR. Screening of 362 samples from cats, horses, donkeys, rodents, and pigs identified 3 (2%) positive samples from 142 horses. These samples were gene...
Surgical lesions of the small colon and post operative survival in a UK hospital population. There is limited information about risk factors and survival associated with disorders of the small colon requiring surgical management. Objective: 1) To document the types of surgical lesion in horses where pathology of the small (descending) colon was the primary cause of abdominal pain, 2) to describe the short- and long-term survival of these cases and identify factors associated with survival and 3) to identify preoperative variables associated with localisation of a lesion to the small colon. Methods: Clinical data and long-term follow-up were obtained for horses that underwent explorato...
[The prevalence of liver trematodes in equines in different cities of Turkey]. This study was carried out between March 2004- April 2005 to determine the prevalance of liver trematode infections of equids in different cities of Turkey. Methods: A total of 117 equids (72 horses, 39 donkeys and 6 mules) in Ankara were examined for liver parasites after the slaugthering process. On the other hand, a total of 620 feces of horses in Bursa, Gemlik, Malatya, Eskişehir and Ankara provinces were detected for determining liver trematodes in live equines. The fecal samples of horses were examined for liver fluke infection by Benedect's sedimentation methods. Results: Of these 117 ...
Genetic characterization by composite sequence analysis of a new pathogenic field strain of equine infectious anemia virus from the 2006 outbreak in Ireland. Equine infectious anemia virus (EIAV), the causative agent of equine infectious anaemia (EIA), possesses the least-complex genomic organization of any known extant lentivirus. Despite this relative genetic simplicity, all of the complete genomic sequences published to date are derived from just two viruses, namely the North American EIAV(WYOMING) (EIAV(WY)) and Chinese EIAV(LIAONING) (EIAV(LIA)) strains. In 2006, an outbreak of EIA occurred in Ireland, apparently as a result of the importation of contaminated horse plasma from Italy and subsequent iatrogenic transmission to foals. This EIA out...
Complete genome sequence of equine herpesvirus type 9. Equine herpesvirus type 9 (EHV-9), which we isolated from a case of epizootic encephalitis in a herd of Thomson's gazelles (Gazella thomsoni) in 1993, has been known to cause fatal encephalitis in Thomson's gazelle, giraffe, and polar bear in natural infections. Our previous report indicated that EHV-9 was similar to the equine pathogen equine herpesvirus type 1 (EHV-1), which mainly causes abortion, respiratory infection, and equine herpesvirus myeloencephalopathy. We determined the genome sequence of EHV-9. The genome has a length of 148,371 bp and all 80 of the open reading frames (ORFs) fo...
A pilot study comparing the development of EIAV Env-specific antibodies induced by DNA/recombinant vaccinia-vectored vaccines and an attenuated Chinese EIAV vaccine. Data from successful attenuated lentiviral vaccine studies indicate that fully mature Env-specific antibodies characterized by high titer, high avidity, and the predominant recognition of conformational epitopes are associated with protective efficacy. Although vaccination with a DNA prime/recombinant vaccinia-vectored vaccine boost strategy has been found to be effective in some trials with non-human primate/simian/human immunodeficiency virus (SHIV) models, it remains unclear whether this vaccination strategy could elicit mature equine infectious anemia virus (EIAV) Env-specific antibodies, ...
Early detection of Trypanosoma evansi infection and monitoring of antibody levels by ELISA following treatment. In present communication, we report an outbreak of Trypanosoma evansi in equine herd n = 30 (horse and mules) which, were reared in fly proof stables as well as in open paddock maintained under semi-intensive system of management, and its effective control using trypanocidal drug. The infection was monitored by antibody ELISA up to 180 days post-treatment (PT). A total of 8 out of 14 equines (57.14 %) which were maintained only in open paddocks were found positive with T. evansi infection parasitologically. The infected animals were treated with quinapyramine methyl sulphate and chloride c...
Role of KCNQ2 and KCNQ3 genes in juvenile idiopathic epilepsy in Arabian foals. Juvenile idiopathic epilepsy (JIE) in Arabian foals resembles benign-familial neonatal convulsion (BFNC) syndrome, a rare idiopathic epilepsy of new-born humans. BFNC syndrome exhibits genetic heterogeneity, as has been hypothesised to occur in Arabian foals, and is known to be caused by mutations in the voltage-gated potassium channel subunit KCNQ2 and KCNQ3 genes. The close phenotypic characteristics of both Arabian foals and children suggest these epileptic syndromes are caused by the same genetic disorder. In horses, the KCNQ2 and KCNQ3 genes are located on the terminal region of chromosom...
Changes in Borrelia burgdorferi ELISA antibody over time in both antibiotic treated and untreated horses. Changes in ELISA serology are frequently used to determine antibiotic treatment success for Lyme disease in horses. This concept was based upon a previous report showing a marked decline in ELISA values in experimentally infected and antibiotic-treated ponies. Changes in Lyme serology following antibiotic treatment in naturally infected horses have not been reported. The objective of this study was to compare Borrelia ELISA antibody concentrations in naturally exposed horses both before and following antibiotic treatment for Lyme disease. A retrospective study was performed comparing oxytetrac...
A case of umbilical cord teratoma in an aborted foal. A 16-year-old primiparous mare aborted an apparently normal fetus at 240 days of gestation. A large, oval mass, measuring approximately 20 cm × 30 cm × 20 cm, was detected attached to the umbilical cord of the fetus. On the cut surface, the mass showed multifocal cystic structures, foci of mineralization, and diffuse hemorrhages. Histological examination of the mass revealed haphazardly arranged cartilage, bone, mesenchymal stroma, adipose tissue, vascular structures, smooth muscle, ciliated epithelium, squamous cornifying epithelium, and undifferentiated germ cells with areas of necrosis an...
