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Topic:Diagnosis
Diagnosis in horses involves the systematic identification of diseases and conditions affecting equine health. This process relies on a combination of clinical evaluations, laboratory tests, imaging techniques, and other diagnostic tools to assess the health status of horses. Veterinarians utilize these methods to identify symptoms, determine the underlying causes of health issues, and formulate appropriate treatment plans. Diagnostic procedures in equine medicine can include blood tests, ultrasound, radiography, endoscopy, and more specialized tests such as genetic screening or advanced imaging modalities like MRI and CT scans. This page aggregates peer-reviewed research studies and scholarly articles that explore various diagnostic techniques, their applications, and advancements in the field of equine veterinary medicine.
The distribution of Anoplocephala perfoliata in the intestine of the horse and associated pathological changes. The intestinal tracts of 130 horses were examined for infection with Anoplocephala perfoliata at necropsy. Fifty horses (38.5%) harboured the tapeworm, and the site of attachment of each worm was recorded using predetermined anatomical landmarks. The worms were attached in four regions of the gastrointestinal tract: 17% of the worms were found at the ileocaecal junction, 81% on the caecal wall, 1.7% in the terminal ileum and 0.2% in the ventral colon. The severity of lesions produced at the sites of attachment was related to the number of worms attached. Due to the small area of the ileocaecal...
Foals raised on pasture with or without daily pyrantel tartrate feed additive: comparison of parasite burdens and host responses following experimental challenge with large and small strongyle larvae. Three groups of foals were raised under different management programs in this study: Group 1 (n = 6) and Group 2 (n = 6) were raised with their dams on pasture; Group 3 foals (n = 5) were raised under parasite-free conditions. Mares and foals of Group 1 received daily pyrantel tartrate (PT) treatment with their pelleted feed ration, whereas mares and foals of Groups 2 and 3 received only the pelleted ration. Pasture-reared foals were weaned and moved to a heavily contaminated pasture for 5 weeks. Group 1 foals continued to receive daily PT treatment whereas Group 2 foals received only the pell...
Parasites of stomach and small intestine of 70 horses slaughtered in The Netherlands. The prevalence of metazoan parasites in the stomach and small intestine was investigated in 70 horses slaughtered in the period February 1994-July 1994. Most horses were young (1.5-3 years) and in good condition. Trichostrongylus axei was the most prevalent parasite species in the stomach (51.4%), followed by Gasterophilus intestinalis (41.4%) and Habronema spp. (4.3%). In the small intestine, Parascaris equorum (28.6%) and Paranoplocephala mamillana (1.4%) were found. The mean worm burden of T. axei was 957 (max. 8502), of G. intestinalis 21 (max. 84), of Habronema spp. 3 (max. 5), and of P. ...
Videoendoscopic assessment of dynamic laryngeal function during exercise in horses with grade-III left laryngeal hemiparesis at rest: 26 cases (1992-1995). To evaluate laryngeal function by means of videoendoscopy during high-speed treadmill exercise in racehorses with grade-III left laryngeal hemiparesis at rest and to determine outcome of treatment. Methods: Retrospective study. Methods: 26 racehorses. Methods: Videoendoscopy of the larynx was performed while horses were at rest and exercising on a treadmill. Horses were classified as having grade-IIIA, -IIIB, or -IIIC laryngeal hemiparesis on the basis of the degree of arytenoid cartilage abduction maintained during exercise. Postoperative racing performance was determined by evaluating race r...
Treatment of a chronic comminuted fracture of the fibula in a horse. A four-year-old Standardbred gelding was examined because of vague right hind limb lameness of 3 to 4 months' duration. Results of physical examination, radiography, and scintigraphy were indicative of a chronic comminuted fracture of the proximal portion of the right fibula. A cancellous bone graft was placed in the fracture site, and 3 months later, the fracture appeared to be healed radiographically. Fractures of the fibula are rare in horses and should not be confused with normal anatomic discontinuities that result in a bi- or tripartite appearance of the fibula on radiographs. Because th...
Idiopathic hypocalcemia in foals. Five thoroughbred foals (4 fillies and 1 colt), all in good to excellent body condition, ranging in age from 4 days to 5 weeks at the time of onset of signs, were presented to 2 Kentucky equine hospitals from 1992 through 1996. All 5 foals presented with tachycardia, hyperhidrosis, diarrhea or a recent history of diarrhea, and muscle rigidity or stiff gait. Four of the 5 foals presented for recumbency, seizure-like activity with opisthotonos, or pronounced extensor muscle rigidity. All 5 foals were hypocalcemic. All foals either died or had euthanasia performed. None responded to oral calcium ...
[Demonstration of immunoglobulin isotypes in the vitreous body as a contribution to the etiology of recurrent equine uveitis]. The functional properties of different immunoglobulin isotypes in equine recurrent uveitis (ERU) has not been investigated yet. Here, we describe the quantitative determination of total immunoglobulin levels and isotype differentiation in the vitreous of four horses with ERU as compared to that of seven healthy horses. In contrast to almost equal amounts of total immunoglobulin in the vitreous of both groups, remarkable differences were found: All four of the horses with ERU had significantly higher IgA contents in their vitreous as compared to the control group. However, the other isotypes mo...
Emericella nidulans as an agent of guttural pouch mycosis in a horse. A case is reported in a 9-year-old Anglo-Arab horse with guttural pouch mycosis caused by Emericella nidulans. Acute death occurred by exsanguination following erosion of the external carotid artery. Histopathological examination of the mycotic plaque demonstrated septate hyphae, conidial heads, hülle cells and mature cleistothecia containing characteristic ascospores. Specific identification was confirmed by culture. In accordance with previous reports, Emericella nidulans should be considered as the major agent of guttural pouch mycosis in Equidae.
Detection of Trichinella spiralis in a horse during routine examination in Italy. Routine examination for Trichinella infection by artificial digestion of 5-g samples of muscle tissue revealed the presence of muscle larvae in one out of 28 horses imported from Romania to an abattoir in Italy. The parasite, identified as Trichinella spiralis by the polymerase chain reaction, showed a reproductive capacity index of 68 in Swiss mice. Light microscope examination of 200 nurse cell-larva complexes showed that 22% of them were calcified and that the capsules of the non-calcified nurse cells were 17.5-27.5 microns (s = 22.67 microns) thick and had very few cellular infiltrates. Th...
Strains of Actinobacillus spp. from diseases of animals and ostriches in Zimbabwe. Among the Actinobacillus spp. only A. lignieresii represents a homogenous and well studied taxon. However, haemolytic and non-haemolytic strains of A. equuli and A. suis are also isolated from a wide range of diseases in a variety of hosts. These isolates often pose problems in definitive identification. Consequently, several studies have been published, emphasizing the need for detailed studies to reclassify various members of this genus and also to assess their disease significance. We isolated 48 strains of Actinobacillus from clinical cases in horses, cattle, sheep, cat, pigs and ostrich. ...
Ocular tuberculosis in a horse. This paper is the first report of systemic tuberculosis involving the eyes in a horse. The animal lost condition and gradually became increasingly blind in both eyes; it was eventually euthanased. The pathological findings included bilateral, mycobacterial granulomatous uveitis with unilateral retinal detachment and necrosis, and disseminated, mycobacterial granulomatous foci in the myocardium, lungs, bronchial lymph nodes, kidneys, liver, pancreas, colon and visceral serosal surfaces, with the most extensive lesions in the myocardium. The mycobacteria were identified as Mycobacterium avium.
Association of deficiency in antibody response to vaccine and heterogeneity of Ehrlichia risticii strains with Potomac horse fever vaccine failure in horses. Ehrlichia risticii is the causative agent of Potomac horse fever (PHF), which continues to be an important disease of horses. Commercial inactivated whole-cell vaccines are regularly used for immunization of horses against the disease. However, PHF is occurring in large numbers of horses in spite of vaccination. In a limited study, 43 confirmed cases of PHF occurred between the 1994 and 1996 seasons; of these, 38 (89%) were in horses that had been vaccinated for the respective season, thereby clearly indicating vaccine failure. A field study of horses vaccinated with two PHF vaccines indicated...
Neonatal alloimmune thrombocytopenia in a quarter horse foal. Neonatal alloimmune thrombocytopenia is recognized as a spontaneous disease of human infants, piglets, and possibly mules, but it has not been previously reported in horses. A 1-day-old Quarter Horse foal presented to Michigan State University Large Animal Clinic with severe thrombocytopenia of unknown origin. Immunoglobulins that bound to the foal's platelets were identified in the mare's plasma, serum, and milk by indirect assays. The immunoglobulins were further shown to recognize platelets from the foal's full brother, born 1 year earlier. These findings, coupled with the clinical course o...
Severe mitral regurgitation in horses: clinical, echocardiographic and pathological findings. Forty-three horses with mitral regurgitation (MR) and congestive heart failure were examined, using M-mode, 2-dimensional real-time and Doppler echocardiography. There was no breed or sex predisposition when compared to the general hospital population. The mean +/- s.d. age of affected horses was 7.6 +/- 8.1 years. Horses with MR and congestive heart failure had significant increases in mean values for left ventricular chamber size, left atrial size and heart rate and significant decreases in interventricular septal and left ventricular free wall thickness. Significant increases in pulmonary a...
Elevation of cytokines associated with the thrombocytopenia of equine infectious anaemia. Thrombocytopenia is a common finding in infection with equine infectious anaemia virus (EIAV), a lentivirus with some homology to human immunodeficiency virus (HIV). The thrombocytopenia of EIA, like that in some HIV patients, appears to have a multifactorial pathogenesis. To investigate the decreased platelet production seen in experimental EIA, the levels of three potential negative regulators of platelet production--tumour necrosis factor-alpha (TNF-alpha), transforming growth factor-beta (TGF-beta) and interferon-alpha (IFN-alpha)--were measured in serum and bone marrow of six severe combi...
[Program for early detection of illness level in foals during the first 24 hours of life]. Basing on exact investigations of normal behaviour and abnormalities in newborn and up to 24 hours old foals a program for evaluation, comprehending exogeniously judgable criteria, was developed. It aims at a quick recognition of aberrations in behaviour. The program includes a score, which allows early diagnosis of even subtile abnormalities. As a result, a veterinary surgeon should be consulted if the score exposes a critical situation, so that therapy can be started in time. Furthermore informations about investigations on blood-glucose- and immunoglobulin-G-concentration in relation to neo...
Isolation of virulent Rhodococcus equi from transtracheal aspirates of foals serodiagnosed by enzyme-linked immunosorbent assay. Although isolation of Rhodococcus equi from tracheobronchial aspirates is thought to be a definitive diagnosis of R. equi pneumonia in foals, virulence of isolates from the aspirates of infected foals remains obscure. In the present study, transtracheal aspirates were collected from thirty-one 1- to 6-month-old foals, which showed clinical signs of respiratory tract infection, and R. equi isolates were analyzed for the presence of virulence plasmids and virulence-associated antigens. Moreover, this method was compared with a serodiagnosis by an enzyme-linked immunosorbent assay (ELISA) to eval...
Genetic variation of envelope gp90 gene of equine infectious anemia virus isolated from an experimentally infected horse. Six strains of equine infectious anemia virus (EIAV) were recovered from febrile and non-febrile stages of a horse experimentally infected with the P337-V70 strain given once to a horse. The env gp90 genes of the isolates, the P337-V70 and P337-V26, avirulent virus derived from the P337-V70 strain, were sequenced. A comparison of the gp90 gene sequences revealed that amino acid variations among the viruses tested showed as high as 8.2 to 11.5%. In addition, the comparison also indicated that the isolates that recovered from the non-febrile stage were contained in nucleotide insertions in the p...
A modified teniotomy technique for facilitated removal of descending colon enteroliths in horses. To describe a method for facilitating movement of enteroliths obstructing the proximal portion of the descending colon. Methods: Prospective report. Methods: 15 horses. Methods: A seromuscular incision through the antimesenteric taenia of the proximal portion of the descending colon was used to facilitate movement of enteroliths. Results: Teniotomy allowed proximal descending colon enteroliths located within the abdomen or close to the abdominal wall to be advanced 4 to 15 cm in an aboral direction so that they could be exteriorized for safe removal. Conclusions: Teniotomy is a feasible method...
Pericarditis in horses: 18 cases (1986-1995). To determine clinical signs of pericarditis in horses and to determine whether there were any relationships among clinical signs, echocardiographic findings, treatment, and outcome. Methods: Retrospective study. Methods: 18 horses. Results: Physical examination was performed on 16 horses. Cardiovascular abnormalities included tachycardia (n = 16), pericardial friction rub (10), venous distention (7), murmur (7), muffled heart sounds (6), weak arterial pulse (6), jugular pulse (6), and edema (5). Twelve horses also had respiratory abnormalities; the most common was dull lung sounds, ventrally, ...
Effect of platelet-activating factor antagonist L-691,880 on low-flow ischemia-reperfusion injury of the large colon in horses. To determine the effect of platelet-activating factor (PAF) antagonist L-691,880 on low-flow ischemia and reperfusion (I-R) of the large colon in horses. Methods: 12 adult horses. Methods: Horses were anesthetized, and the large colon was exteriorized through a ventral median celiotomy and instrumented. Colonic arterial blood flow was reduced to 20% of baseline (BL) and maintained for 3 hours; flow was then restored, and the colon was reperfused for 3 hours. One of two solutions was administered intravenously 30 minutes before reperfusion: group 1, 10 mL/kg 0.9% NaCl; and group 2, 5 mg/kg PAF ...
Erythroid hypoplasia and anemia following administration of recombinant human erythropoietin to two horses. A Standardbred gelding and a colt were examined because of poor performance and anemia. Each horse had been given recombinant human erythropoietin (rhEPO; 4,000 IU) at least twice within the preceding 2 to 4 months. The horses had an Het of 16 and 24%, serum iron concentrations of 210 and 304 micrograms/dl (reference range, 73 to 140 micrograms/dl), total iron binding capacities of 239 and 321 micrograms/dl (reference range, 266 to 364 micrograms/dl), values for the percentage saturation of transferrin by iron of 87.9 and 94% (reference range, 20 to 52%), and serum ferritin concentrations of 2...
Biomechanical comparison of the Herbert and AO cortical bone screws for compression of an equine third carpal bone dorsal plane slab osteotomy. To assess feasibility of insertion of 4.5-mm Herbert cannulated bone screws (HS) using fluoroscopic guidance and compare the mechanical shear strength of these HS and 4.5-mm AO cortical bone screws (AO) for fixation of dorsal plane slab osteotomies in equine cadaver third carpal bones (C3). Methods: Eight equine cadavers. Methods: Bone mineral composition and density of contralateral C3 were confirmed to be equivalent using dual-energy x-ray absorptiometry. A standard 10-mm C3 slab osteotomy was reduced using HS or AO instrumentation under fluoroscopic guidance. Specimens were loaded in shear ...
Treatment of superficial ulcerative squamous cell carcinoma in three horses with topical 5-fluorouracil. Three horses with superficial ulcerative squamous cell carcinoma were successfully treated with topical 5-fluorouracil. Two of them remain in remission after a single course of treatment and the third case is controlled by the application of the cream for seven days every six weeks. No systemic side-effects were observed but there was a localised inflammatory reaction in the skin in each case.
Venereal infection of mares by equine arteritis virus and use of killed vaccine against the infection. Venereal infection with equine arteritis virus (EAV) was established in each of seven mares by inoculation via the cervix with 20 ml of viral suspension (> or = 8 x 10(6) plaque-forming units; PFU), following treatment with prostaglandin and oestradiol. A dose of < or = 8 x 10(5) PFU produced infection in only five of eight mares. Serum neutralizing antibody developed in mares manifesting clinical signs of equine viral arteritis (EVA), and a weak antibody was detectable in one apparently healthy mare inoculated with 8 x 10(5) PFU. Virus isolation was demonstrated not only in the buffy coat but...
In vitro responses to noradrenaline of small intestine taken from normal and grass sickness-affected horses. Small intestine was taken from the caudal flexure of the duodenum and the terminal ileum proximal to the ileocaecal fold of 25 horses, 9 with acute grass sickness (AGS), 12 with subacute grass sickness (SAGS) and 12 with chronic grass sickness (CGS). The motility in the samples was measured isometrically either within 1 h of death or after storage for 24 h at 4 degree C. In control tissue, noradrenaline produced contractions of muscle strips which did not involve a muscarinic cholinergic mechanism and which were unaffected by the alpha 1 antagonist prazosin but were blocked by the alpha 2 anta...
