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Topic:Diagnosis
Diagnosis in horses involves the systematic identification of diseases and conditions affecting equine health. This process relies on a combination of clinical evaluations, laboratory tests, imaging techniques, and other diagnostic tools to assess the health status of horses. Veterinarians utilize these methods to identify symptoms, determine the underlying causes of health issues, and formulate appropriate treatment plans. Diagnostic procedures in equine medicine can include blood tests, ultrasound, radiography, endoscopy, and more specialized tests such as genetic screening or advanced imaging modalities like MRI and CT scans. This page aggregates peer-reviewed research studies and scholarly articles that explore various diagnostic techniques, their applications, and advancements in the field of equine veterinary medicine.
The concept of osmolality: its use in the evaluation of “dehydration” in the horse. Osmolality is an indication of the osmotic pressure of plasma and depends on the amount of solute and solvent (water) present. The mean (+sd) plasma osmolality of 100 clinically normal animals was 282 (+6) mOsm/kg using lithium heparin as anticoagulant. The equation, osmolality=1.86 (sodium + potassium) +glucose +blood urea nitrogen + 9, was found to predict only crudely plasma osmolality. The plasma sodium: osmolality ratio was 0.49. Water and electrolyte disorders are classified into 3 types based on the measurement of electrolytes and osmolality: (1) Hypertonic dehydration (true dehydration...
Effect of intra-articular injection of orgotein and saline solution on equine synovia. Orgotein was injected into the right intercarpal joint of each of 8 horses; the corresponding left joint was left alone (not injected) or was given an injection of normal saline solution. Injection with orgotein caused a transient, marked inflammatory response, evidenced by clinical signs and by increased leukocytes and total protein in the synovia (synovial fluid). Leukocyte numbers and total protein concentration were increased (P less than 0.010) in the orgotein-injected joints within 24 hours. However, saline solution alone also elicited a marked inflammatory response, manifested by increa...
Experimental subacute foal pneumonia induced by aerosol administration of Corynebacterium equi. Subacute pyogranulomatous pneumonia was experimentally induced in 3 neonatal foals following multiple challenge with aerosols containing Corynebacterium equi. On each of 7 consecutive days the foals were exposed to approximately 3.5 X 10(7) viable C equi in droplets small enough to reach the terminal airways. Clinical, pathological and bacteriological features of the induced syndrome were indistinguishable from those exhibited by cases with spontaneous subacute C equi foal pneumonia. Radiographic evidence of advanced pulmonary damage preceded the appearance of clinical signs and ante mortem cu...
Paradoxic hypercalcemia and hypophosphatemia associated with chronic renal failure in horses. Chronic renal failure associated with hypercalcemia and hypophosphatemia was diagnosed in 6 horses. The renal lesions in 5 of the horses were classified as chronic glomerulonephritis and in the sixth, as chronic interstitial nephritis/pyelonephritis. There was no evidence of primary hyperparathyroidism or pseudohyperparathyroidism, thus suggesting that hypercalcemia associated with advanced renal failure in horses is related to a unique role of the equine kidney in calcium homeostasis.
Complications of cleft palate repair in large animals. Seven foals, 2 horses, and 2 calves were presented to the George D. Widener Hospital for Large Animals at New Bolton Center and the Large Animal Clinic at Auburn University for surgical repair of cleft palate. All animals had preexisting pneumonia. Initial repair of cleft palate in 6 foals, 2 horses, and 2 calves was performed via mandibular symphysiotomy. Primary repair of cleft soft palate in a foal was attempted through a pharyngotomy incision after fracture of the basal hyoid bone; however, exposure was inadequate and mandibular symphysiotomy had to be done. Dehiscence of a portion of the ...
Deuteromethylation of dimethylxanthines: a gas chromatographic mass spectrometric method for confirmatory analysis in horse urine extracts. The methylated xanthines caffeine and/or theobromine are commonly encountered in drug-positive samples from racehorses and their metabolism and excretion in the horse and their analysis in urinary extracts has been of particular interest in this laboratory. Due to their polar nature the dimethylxanthines theobromine, theophylline and paraxanthine give unsatisfactory gas chromatographic performance and require derivatization prior to analysis by gas chromatography mass spectrometry. The present paper describes a simple deuteromethylation procedure to render the compounds amenable to analysis by...
Isolation of an adenovirus antigenically distinct from equine adenovirus type 1 from diarrheic foal feces. Adenovirus was isolated in equine fetal kidney cell cultures from the feces of 2 foals with diarrhea that also had large numbers (greater than 10(6)/g) of rotavirus particles in their feces. Unlike equine adenovirus type 1 (EAdV1), the fecal EAdV did not hemagglutinate human O, rhesus macaque, or equine RBC. By serum neutralization, the fecal viruses were identical with each other, but showed no relationship to EAdV1. Antiserum prepared against the fecal viruses did not contain hemagglutination-inhibiting antibody to EAdV1. It is proposed that the fecal viruses be considered prototypic of EAdV...
Proopiolipomelanocortin peptides in normal pituitary, pituitary tumor, and plasma of normal and Cushing’s horses. Using RIAs for six regions within proopiolipomelanocortin (proOLMC), gel filtration, and electrophoresis, we studied pituitary peptides in a normal horse and one with Cushing's disease caused by a pars intermedia adenoma. Almost all immunoreactive (IR) ACTH (78%) was 4,500 mol wt (4.5K) ACTH in normal pars distalis, but it was almost 100% corticotropin-like intermediate lobe peptide (CLIP) in normal pars intermedia. alpha MSH and beta MSH were found mainly in pars intermedia: equal concentrations of the beta MSH precursors, beta-lipotropin (beta LPH) and gamma LPH, were found in pars distalis....
Retropulsion-propulsion in equine large colon. The circular and longitudinal muscle coats of equine "midcolon" were found to be directly electrically coupled. They appear to act in concert, in healthy animals, as a pacemaker in the area of the large colon pelvic flexure, for retropulsive-propulsive myoelectrical events. The retropulsive events keep the cecum and right ventral and left ventral divisions of the colon filled, imposing a delay time for fermentation of cellulose and for bacterial protein synthesis. Point-to-point involvement of adjacent colon sections was slowed by cooling the intestinal contents with no adverse clinical signs....
Chemotaxis of radiolabeled equine neutrophils. A method for the isolation of equine neutrophils was developed using metrizamide cushions. A purity of greater than 95% was routinely obtained with greater than 90% viability. These cells were radiolabeled and tested for their chemotactic response in Boyden chambers to zymosan-activated equine serum, the partially purified equine complement component C5a, and formyl-L-methionyl-L-leucyl-L-phenylalanine. The time and ionic requirements for chemotaxis of radiolabeled equine neutrophils were investigated and maximal movement was observed at 2 hours' incubation and 1.0 mM Ca and 0.5 mM Mg. Dinitro...
Controlled tests of fenbendazole against migrating Strongylus vulgaris in ponies. Sixteen pony foals were reared worm-free and inoculated with Strongylus vulgaris. On day 7 after inoculation, 12 ponies were given a fenbendazole 10% suspension at dose rate of 50 mg/kg of body weight by stomach tube. On day 8 after inoculation, 8 of these ponies were given the 2nd treatment of the anthelmintic and on day 9, 4 of these ponies were given the 3rd treatment. (The other 4 of the 16 ponies were given only tap water, as controls.) The ponies were necropsied at death or on day 28 after inoculation. Fenbendazole was effective in minimizing the appearance of clinical signs associated w...
Pulmonary atresia with dextroposition of the aorta and ventricular septal defect in three Arabian foals. Three Arabian males foals were presented with cyanosis, heart murmur, and exercise intolerance, Results of clinical evaluation suggested a tentative diagnosis of ventricular septal defect in conjunction with malformations of the great arteries. Each foal had a poor prognosis and was killed at the owners' requests. At necropsy, the malformed hearts of the three foals were virtually identical. Each heart had a large defect in the upper interventricular septum. The aorta originated from the hypertrophied right ventricle and partially overrode the ventricular septal defect. The aortic ostium was g...
Purification of horse eosinophil peroxidase. Eosinophil peroxidase (donor: hydrogen-peroxidase oxidoreductase, EC 1.11.1.7) was isolated in a highly purified form (415/280 nm ratio, 1.05) from horse peripheral blood eosinophil. Eosinophil peroxidase was extracted from intact eosinophils (98-100% purity) or isolated eosinophil granules with 0.05 M acetate buffer (pH 4.7)/0.18 M NaCl and purified by chromatography on Sephadex G-200 and carboxymethylcellulose. Final elution was with 0.05 M acetate buffer (pH 4.7)/ 1 M NaCl. Horse eosinophil peroxidase is a strongly basic protein with bacterial properties when combined with H2O2 and iodide, ...
Use of a gold compound for the treatment of pemphigus foliaceus in a foal. A 4-month-old foal was examined because of generalized exfoliative dermatitis, with thick scales, extensive crusting, and oozing of serum. A diagnosis of pemphigus foliaceus was made by histologic and immunopathologic examinations of skin biopsy specimens. The foal was treated with a gold compound, aurothioglucose (1 mg/kg once weekly for 14 weeks). For the initial 5 weeks, high-dose glucocorticoid treatments also was used. The skin disorder resolved entirely after 12 weeks of treatment.
Renal dysfunction in a case of purpura haemorrhagica in a horse. A four-year-old thoroughbred was presented with clinical manifestations of purpura haemorrhagica. Evidence of renal involvement consistent with glomerulopathy and nephrotic syndrome, characterised by heavy proteinuria and azotaemia, became apparent and may have been exacerbated by diuretic therapy. Autopsy revealed membrano- and mesangial proliferative glomerulonephritis and chronic pleuritis. Circulating immune complexes may have been responsible for the renal diseases and the purpura.
Detection of equine infectious anemia virus in a horse with an equivocal agar gel immunodiffusion test reaction. A horse whose serum reacted equivocally in the agar gel immunodiffusion (AGID) test for equine infectious anemia was studied over a 3-year period. The horse remained afebrile and virus was detected in only 1 of 6 horse inoculation tests. The intensity of AGID test reactions increased temporarily following this evidence for virus. Although the AGID test reaction was equivocal and 5 of the 6 transmission attempts failed, the 1 successful transmission proved the horse was infected.
Rn for treatment of periocular fibrous connective tissue sarcomas in the horse. Twelve periocular fibrous connective tissue sarcomas in 11 horses were treated with 222Rn. Follow-up periods ranged from 1 to 6 years; the overall nonrecurrence rate at 12 months after therapy was 92%. Two lesions recurred 2 years after treatment, and 1 after 3 years. One of the former lesions has not recurred after a 2nd 222Rn treatment.
A mild form of strangles caused by an atypical Streptococcus equi. A mild form of strangles caused by an atypical Streptococcus equi was recognized on a large horse breeding farm. The organism differed from most S equi isolates by disappearance of the mucoid capsule by 24 hours of culture, leaving a matt-type colony. Typically, the clinical signs were a transient (24-48 hour) fever, profuse nasal discharge, and anorexia. In about half the affected animals, there was moderate mandibular lymph node enlargement, and these glands usually ruptured or were drained. The use of a passive hemagglutination antibody test showed that subclinical infection was widespread ...
