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Topic:Disease Treatment
Disease treatment in horses encompasses a range of medical interventions and management strategies aimed at addressing various health conditions affecting equine species. These treatments can include pharmacological approaches, such as the administration of antibiotics, anti-inflammatory drugs, and antiparasitic medications, as well as non-pharmacological methods like physical therapy, dietary adjustments, and surgical procedures. The selection of appropriate treatments depends on the specific disease, its severity, and the individual needs of the horse. This topic brings together peer-reviewed research studies and scholarly articles that explore the efficacy, safety, and advancements in therapeutic options for equine diseases, providing insights into best practices and emerging trends in equine veterinary medicine.
Renal medullary crest necrosis associated with phenylbutazone therapy in horses. Thirty-five cases of renal medullary crest necrosis morphologically similar to the renal papillary necrosis of analgesic nephropathy as described in man and rats are reported in horses receiving maintenance dosages of phenylbutazone. The primary lesion is a well-demarcated focal medullary necrosis resulting in sequestration of fragments of the renal crest. Renal cortical lesions are considered secondary to the medullary necrosis and consist of segmental pallor as a result of tubular dilatation, filtrate retention, and interstitial edema. Ischemia in concert with phenylbutazone is suggested as ...
Surgical treatment of paraphimosis in a pony. Circumcision (or reefing operation) was performed on an aged pony stallion to remove excessive granulation tissue involving the preputial integument following an injury and subsequent paraphimosis. Postoperative swelling of the penis and prepuce was reduced daily with gentle massage. Initially, an improvised suspensory was used to support the penis postoperatively. The pony was able to voluntarily retract its penis six months following surgery.
Survey of 79 referral colic cases. The clinical, surgical and/or necropsy diagnosis of 79 horses admitted to a referral clinic for evaluation of colic are reported. Twenty-one horses were presented with conditions amenable to medical treatment and all were subsequently discharged. Exploratory laparotomies were performed on 44 horses during the present study, in some cases as a diagnostic procedure preceding euthanasia. In general, in surgical cases the mortality rate was highest for problems involving the small intestine, followed by those affecting the large colon and then the small colon. Postoperative sequelae included perit...
Prognosis in equine colic: a study of individual variables used in case assessment. The individual merit of the use of 43 variables to assess the prognosis of equine colic cases was examined. The following variables revealed highly significant (P less than 0.001) differences between cases which survived and those which died: blood pressure; heart rate; oral mucosal capillary refill time; degree of mental depression; venous haemoglobin concentration, haematocrit, erythrocyte count, urea concentration and lactate concentration; peritoneal fluid lactate concentration; and haematocrit/plasma protein and serum protein concentration ratios. Thus, in general, variables which assesse...
Use of an autogenous cancellous bone graft in the treatment of subchondral bone cysts in the medial femoral condyle of the horse. The clinical features, diagnosis and radiological findings of eight cases of a subchondral bone cyst involving the medial condyle of the femur are described. Surgical treatment, which comprised performing an arthrotomy of the femorotibial joint, curetting and packing the cystic cavity with an autogenous cancellous bone graft, is described.
Giant cell tumor of soft parts in six horses. Giant cell tumor of soft parts was diagnosed in 6 horses 3 to 12 years old (mean, 6.8 +/- 3.5 years): 3 Quarter Horse geldings, 2 Standardbred mares, and 1 Standardbred stallion. The neoplasms developed as raised, solitary masses, approximately 1 to 4 cm in diameter, which were firmly attached to subcutaneous tissue of the neck (1 horse), shoulder (1 horse), thigh (2 horses), or stifle (2 horses). Excision was followed by local recurrence in 3 horses within 1 to 1 1/2 months. The neoplasms were firm and cut with resistance. On cut surface, they were white, with mottled red hemorrhagic areas.
Leptospiral infection in aborted equine foetuses. During an investigation of equine abortion, leptospiral infection was demonstrated in nine out of 22 foetuses examined by immunofluorescence and culture. Strains belonging to four serogroups (Australis, Pomona, Hebdomadis and Icterohaemorrhagiae) were isolated. The age of leptospira infected foetuses ranged from six months to term.
Transfer of adult Strongylus vulgaris via stomach tube. Patent infections with Strongylus vulgaris were established in 6 of 8 helminth-free ponies given 41 to 101 adult worms via nasogastric tube. The parasites were removed from the cecum and ventral colon and transferred within 1 to 2 hours of the death of the donor horses. Eggs were found in the feces of the recipients in 2 or 3 days; egg counts reached maximum, 28 eggs per gram of feces, at 4 weeks after ponies were inoculated. In 6 ponies euthanatized 3 to 7 weeks after parasitic transfers were done, 28% of the inoculated worms were found alive at necropsy. A 7th pony was maintained as a donor ...
Phagocytosis and intracellular killing of the contagious equine metritis organism by equine neutrophils in genital secretions. Equine neutrophils were combined with contagious equine metritis organism (CEMO) or Escherichia coli in vitro in the presence of seminal plasma, uterine flushings, or Hank's balanced salt solution (HBSS). Phagocytosis and intracellular killing were estimated by bacterial culture and light and electron microscopy. With lysed neutrophils, the numbers of colony-forming units of CEMO and E coli increased in seminal plasma and uterine flushings. Numbers of CEMO decreased in HBSS. The numbers of CEMO increased more in the presence of seminal plasma than the other media. When neutrophils were in the ...
Alternate grazing of horses and sheep as control for gastro-intestinal helminthiasis in horses. Gastro-intestinal helminth infections of a group of three yearling mare Shetland ponies, which were set-stocked on a small pasture from February until September, were compared with those of a similar group of ponies, which grazed a similar pasture from February to July and subsequently was removed to a pasture which had been grazed by sheep from April to July. In addition both groups were treated with cambendazole when the latter group was removed to the sheep pasture. Pasture larval counts and worm counts demonstrated that the group grazed after the sheep acquired considerably smaller burdens...
Modulation of equine platelet function by diethylcarbamazine (DEC). Equine platelets, when treated with the anthelmintic drug diethylcarbamazine (DEC), gave a dose-dependent release of radiolabeled serotonin without concomitant aggregation. At levels of the drug that gave only minimal release of radiolabel, marked dose-dependent inhibition of platelet aggregation to three of four platelet agonists tested--adenosine diphosphate (ADP), collagen, and arachidonic acid--was observed. With ADP, inhibition was observed to be reversed by removal of DEC prior to agonist challenge. However, with collagen, inhibition was only partially reduced by prior removal of DEC; wh...
Phenoxymethyl penicillin in the horse: an alternative to parenteral administration of penicillin. This preliminary study evaluated phenoxymethyl penicillin (Penicillin V) as an alternative to parenteral administration of penicillin in horses. Penicillin V was administered orally to five horses at two different doses and plasma levels of the drug were determined at timed intervals. The results were evaluated by regression analysis. Following the administration of penicillin V at a dose of 66,000 IU/kg or 110,000 IU/kg, the mean peak plasma levels obtained were 1.55 micrograms/mL and 2.34 micrograms/mL respectively. A plasma level two to four times above the minimal inhibitory concentration ...
Assessment of the efficacy of an abductor muscle prosthesis for treatment of laryngeal hemiplegia in horses. Four variations of abductor muscle prosthesis for treating laryngeal hemiplegia were evaluated in 153 horses by questionnaire, and in the 100 Thoroughbred racehorses in this group survival analysis was used to compare their racing performances and earnings with those of 400 control horses. The questionnaire indicated that the technique which included a ventriculectomy and 2 prostheses was regarded as being the most successful (P less than 0.01) and resulted in the least residual stertor (P less than 0.001). Survival analysis showed that there was no significant difference between the treated g...
Treatment of equine cutaneous neoplasia by radiotherapy using iridium 192 linear sources. The treatment of equine cutaneous tumours by conventional or cryosurgical techniques can be limited where the position of the tumour makes radical excision or freezing impractical or dangerous. Radiotherapy provides an effective and practical alternative. The use of iridium pins with guide needles allows accurate positioning of sources and uniform radiation fields to be achieved. The subsequent removal of the pins reduces the period of incapacity and reduces the radiation risk when compared to permanently implanted sources. Twenty-seven tumours on 26 horses were treated by this method with a 1...
Segmental epidural and subarachnoid analgesia in conscious horses: a comparative study. Six adult horses were used to compare the effects of segmental epidural analgesia (SEA) and segmental subarachnoid analgesia (SSA). A 17-gauge Huber point directional needle was used to place a catheter with stylet into the epidural space or the subarachnoid space at the lumbosacral intervertebral junction and to catheterize the thoracolumbar epidural or subarachnoid space. The position of the catheter was confirmed radiographically. A 2% solution of mepivacaine hydrochloride was used at average doses of 80 mg (4 ml) to produce SEA and 30 mg (1.5 ml) to produce SSA. Onset of analgesia in respo...
[Experiences with half-closed castration in stallions]. The half-closed method of castration involves ligation of the spermatic cord enclosed in the vaginal tunic, the testicle itself lying outside the opened vaginal tunic. Of 497 horses and ponies admitted to the Department of Large Animal Surgery and castrated using this technique, 68.6 per cent recovered without complications. Although the most serious postoperative complications such as intestinal eventration and haemorrhage of the spermatic cord may be reduced to a minimum by this approach, normal healing cannot be guaranteed under the circumstances in which this method was used.
Surgical correction of angular limb deformities in foals: a retrospective study. The outcome of surgical treatment of angular limb deformities in 29 foals was evaluated through long-term monitoring of athletic performance. Foals were placed into 1 of 2 groups, depending on the site of the angular limb deformity. In group 1 foals, the deformity involved the carpus of distal end of the radius. In group 2 foals, the deformity involved the distal end of the 3rd metacarpal or metatarsal bone. Group 1 contained 20 foals and group 2 contained 11 foals. Two foals were in both groups. Sixteen foals in group 1 and 4 foals in group 2 progressed to some form of athletic use. The under...
Management of umbilical hernias in cattle and horses. The medical records of 60 cattle and 47 horses treated for umbilical hernia at the Western College of Veterinary Medicine over a 3-year period were studied retrospectively. Age, hernia size, physical signs at admission, reducibility, method of repair, prevalence, and types of complications were evaluated. Most patients were less than 6 months old, with hernias less than 10 cm long. Affected cattle had a higher prevalence of organic diseases associated with umbilical hernias and more postsurgical complications than did affected horses.
A new analgesic drug combination in the horse. A xylazine and butorphanol drug combination produced minimal and transient hemodynamic effects and no significant respiratory depression when administered to 6 healthy horses. Combining xylazine and butorphanol produced a synergistic analgesic effect and provided good chemical restraint for a standing surgical procedure.
