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Topic:Pathology

Pathology in horses involves the study of diseases and abnormalities affecting equine health, encompassing a range of conditions that can impact various systems within the horse's body. This field examines the causes, mechanisms, and effects of diseases, as well as the structural and functional changes they induce in equine tissues and organs. Common pathological conditions in horses include laminitis, colic, equine infectious anemia, and respiratory disorders. Understanding these diseases involves evaluating clinical signs, diagnostic methods, and treatment options. This page compiles peer-reviewed research studies and scholarly articles that explore the etiology, pathogenesis, and clinical implications of pathological conditions in horses.
Microvascular permeability and endothelial cell morphology associated with low-flow ischemia/reperfusion injury in the equine jejunum.
American journal of veterinary research    May 1, 1995   Volume 56, Issue 5 639-648 
Dabareiner RM, Snyder JR, White NA, Pascoe JR, Harmon FA, Gardner I, Woliner MJ, Pinney D, Sullins KE.Microvascular permeability of the jejunum of clinically normal equids and microvascular permeability associated with 60 minutes of ischemia (25% baseline blood flow) and subsequent reperfusion were investigated. Eight adult horses were randomly allotted to 2 equal groups: normal and ischemic/reperfusion injury. Lymphatic flow rates, mesenteric blood flow, and lymph and plasma protein concentrations were determined at 15-minute intervals throughout the study. Microvascular permeability was determined by estimates of the osmotic reflection coefficient, which was determined when the ratio of lymp...
Systemic and colonic venous plasma eicosanoid and endotoxin concentrations, and colonic venous serum tumor necrosis factor and interleukin-6 activities in horses during low-flow ischemia and reperfusion of the large colon.
American journal of veterinary research    May 1, 1995   Volume 56, Issue 5 656-663 
Moore RM, Muir WW, Cawrse M, Bertone AL, Beard WL.Twenty-four horses were randomly allocated to 3 groups. Horses were anesthetized, subjected to a ventral midline celiotomy, and the large colon was exteriorized and instrumented. Group-1 horses served as sham-operated controls. Group-2 horses were subjected to 6 hours of low-flow colonic arterial ischemia, and group-3 horses were subjected to 3 hours of ischemia and 3 hours of reperfusion. Baseline (BL) samples were collected, then low-flow ischemia was induced by reducing ventral colonic arterial blood flow to 20% of BL. All horses were monitored for 6 hours after BL data were collected. Bloo...
An overview of equine dermatoses characterized by scaling and crusting.
The Veterinary clinics of North America. Equine practice    April 1, 1995   Volume 11, Issue 1 43-51 doi: 10.1016/s0749-0739(17)30330-9
Fadok VA.Scaling and/or crusting are common clinical findings associated with equine skin diseases. Scaling and crusting may be associated with pruritic or nonpruritic dermatoses. This article focuses on those conditions that are usually nonpruritic in horses. They include the infectious dermatoses, the keratinization/seborrheic disorders, photosensitization, and the immunologic/inflammatory disorders, including pemphigus foliaceus, equine exfoliative eosinophilic dermatitis and stomatitis, and equine histiocytic dermatitis (sarcoidosis). Clinical signs that help differentiate the various disorders are...
Is specific antifungal therapy necessary for the treatment of guttural pouch mycosis in horses?
Equine veterinary journal    March 1, 1995   Volume 27, Issue 2 151-152 doi: 10.1111/j.2042-3306.1995.tb03053.x
Speirs VC, Harrison IW, van Veenendaal JC, Baumgartner T, Josseck HH, Reutter H.No abstract available
Isolation of obligate anaerobic bacteria from clinical specimens.
The Canadian veterinary journal = La revue veterinaire canadienne    March 1, 1995   Volume 36, Issue 3 173 
Hariharan H, Lamey K, Heaney S.No abstract available
Iridium-192 interstitial brachytherapy for equine periocular tumours: treatment results and prognostic factors in 115 horses.
Equine veterinary journal    March 1, 1995   Volume 27, Issue 2 117-121 doi: 10.1111/j.2042-3306.1995.tb03046.x
Théon AP, Pascoe JR.One hundred and fifteen horses with periocular tumours were treated with iridium-192 interstitial brachytherapy. Tumours included squamous cell carcinomas (n = 52) and sarcoids (n = 63). All horses were scheduled to receive 60 Gy (minimal tumour dose) given at a low dose rate (0.034 +/- 0.010 Gy/h). The mean and median follow-up times to last contact or death were 24 and 16 months, respectively. Chronic radiation reactions included palpebral fibrosis (10.4%), cataract (7.8%), keratitis and corneal ulceration (6.9%). Cosmetic changes included permanent epilation (21.7%) and hair dyspigmentation...
Treatment of superficial tumours on horses with dimethyl sulfoxide and cisplatin.
Australian veterinary journal    February 1, 1995   Volume 72, Issue 2 76-77 doi: 10.1111/j.1751-0813.1995.tb15343.x
Peaston A, Maddison J.No abstract available
Infection of horses by Tyzzer’s bacillus.
Equine veterinary journal    January 1, 1995   Volume 27, Issue 1 1-3 doi: 10.1111/j.2042-3306.1995.tb03020.x
Chanter N.No abstract available
Interstitial pneumonia in the horse: a fledgling morphological entity with mysterious causes.
Equine veterinary journal    January 1, 1995   Volume 27, Issue 1 4-5 doi: 10.1111/j.2042-3306.1995.tb03021.x
Buergelt CD.No abstract available
Fibrosing granulomas in the equine liver and peritoneum: a retrospective morphologic study. Buergelt CD, Greiner EC.Fibrosing granulomas were found in the liver and occasionally on the intestinal and diaphragmatic serosae and in the lung of 11 horses submitted for necropsy. Although these granulomas were considered incidental findings in most of the horses, they had caused liver failure in 1 horse. The granulomas typically were characterized by a dense collagenous core that frequently was mineralized. The periphery contained a rim of inflammatory cells. Only in 1 of the 11 horses was there evidence of an egg shell suggestive of schistosomes. Schistosomal eggs were not detected in the feces of the horses. Th...
The equine enteric nervous system–neuron characterization and distribution in adults and juveniles.
Veterinary research communications    January 1, 1995   Volume 19, Issue 6 433-449 doi: 10.1007/BF01839331
Doxey DL, Pearson GT, Milne EM, Gilmour JS, Chisholm HK.A study of myenteric and submucosal plexuses was undertaken in the jejunum and ileum of horses and ponies in which no clinical or pathological evidence of intestinal abnormality was apparent. Complete transverse sections of the intestine, stained by a modified haematoxylin and eosin method, were examined using up to 20 sequential sections per animal. Information was gathered from adult, juvenile and fetal equidae. In adults, the longitudinal muscle layers were thinner than the circular muscle layers and the ileum had thicker layers compared to the jejunum. In adults, the submucosal plexus had ...
Morphologic and morphometric characterization of lung collagen content in clinically normal adult thoroughbreds in race training.
American journal of veterinary research    January 1, 1995   Volume 56, Issue 1 11-18 
Lakritz J, Wisner ER, Finucane T, O'Brien TR, Tyler WS, Pascoe JR, Plopper CG.Interstitial and bronchointerstitial pulmonary patterns are commonly observed in thoracic radiographs of Thoroughbreds. Prominent interstitial and bronchointerstitial pulmonary patterns are observed in clinically normal horses, and in horses with respiratory tract disease. Until recently, the relevance of these pulmonary patterns was not known. Previous studies indicated that bronchiolitis, bronchiolar epithelial hyperplasia, epithelial metaplasia, and bronchial arteriolar recruitment correlated strongly with the prominence of the interstitial and bronchointerstitial pulmonary patterns observe...
Case report: acute joint destabilization in the equine demonstrating early pathology in osteoarthritis.
Osteoarthritis and cartilage    December 1, 1994   Volume 2, Issue 4 281-283 doi: 10.1016/s1063-4584(05)80080-9
Attenburrow DP, Goss VA.A case of acute destabilization of the right stifle joint associated with rupture of the anterior cruciate ligament and avulsion fracture of the tibial spine in a horse is reported. The diagnosis was obtained by scintigraphy and radiography. Post mortem investigations 6 weeks after injury demonstrated fibrillation of surface cartilage in regions unprotected by tibial menisci. No pathological change was demonstrated in the subchondral bone of the tibia in regions associated with loss of cartilage integrity.
Testicular degeneration in 3 stallions.
Equine veterinary journal    November 1, 1994   Volume 26, Issue 6 507-510 doi: 10.1111/j.2042-3306.1994.tb04060.x
Watson ED, Clarke CJ, Else RW, Dixon PM.No abstract available
Lipofuscin and abnormalities in colloid in the equine thyroid gland in relation to age.
Journal of comparative pathology    November 1, 1994   Volume 111, Issue 4 389-399 doi: 10.1016/s0021-9975(05)80097-0
Dalefield RR, Palmer DN, Jolly RD.Lipofuscin accumulation and other histological changes in thyroid tissue, previously reported to be age-related, were studied in 31 horses aged up to 35 years. The number of lipofuscin granules relative to thyrocytes increased from birth to 5 years of age. There was a wide individual variation in the number of lipofuscin granules in thyrocytes in mature horses, but this was not directly related to age. Several abnormalities were identified in thyroid colloid. The prevalence of spherites, lipofuscin granules, nucleated cells and shreds of colloid increased with age, but the prevalence of calciu...
Distribution of equid herpesvirus-1 (EHV-1) in the respiratory tract of ponies: implications for vaccination strategies.
Equine veterinary journal    November 1, 1994   Volume 26, Issue 6 466-469 doi: 10.1111/j.2042-3306.1994.tb04051.x
Kydd JH, Smith KC, Hannant D, Livesay GJ, Mumford JA.Twelve adult ponies and 2 conventional foals were exposed to 10(6.6) TCID50 of Equid herpesvirus-1 (EHV-1), strain Ab4 and samples of respiratory tract tissues were recovered. Infectious virus in tissue homogenates was detected using susceptible cell monolayers and expression of viral antigens was monitored using indirect immunoperoxidase histochemistry of paraffin sections. The results illustrated the rapid dissemination of EHV-1 throughout the respiratory tract, with early replication in the lungs one day after exposure. Endothelial cell infection was prominent in all areas of the nasopharyn...
Effect of prior lavage on bronchoalveolar lavage fluid cell population of lavaged and unlavaged lung segments in horses.
American journal of veterinary research    November 1, 1994   Volume 55, Issue 11 1501-1504 
Sweeney CR, Rossier Y, Ziemer EL, Lindborg SR.Bronchoalveolar lavage (BAL) was performed on 16 horses to determine whether it caused local or diffuse inflammation in the lungs. In 7 horses, BAL was performed in both lungs twice, 48 hours apart. Although total cell counts of the BAL samples did not change significantly, there were increased numbers and percentage of neutrophils in the second lavage fluid samples. In 5 horses, BAL was performed in 1 lung and repeated 48 hours later in the same lung and in the corresponding airway in the contralateral lung. The absolute cell count and percentage of neutrophils were significantly (P = < 0....
Effects of 0.05% chlorhexidine lavage on the tarsocrural joints of horses.
Veterinary surgery : VS    November 1, 1994   Volume 23, Issue 6 442-447 doi: 10.1111/j.1532-950x.1994.tb00505.x
Wilson DG, Cooley AJ, MacWilliams PS, Markel MD.In six horses, a 0.05% solution of chlorhexidine diacetate was used to lavage one tarsocrural joint; the contralateral control joint was lavaged with lactated Ringer's solution. Horses were evaluated daily for lameness. Synovial fluid samples were collected on days 1, 4, and 8 for determination of protein concentration, total and differential leukocyte counts, and mucin clot formation. After death on day 8, synovium and osteochondral samples were collected from the tarsocrural joints for examination of morphology and proteoglycan staining. Lavage with chlorhexidine solution caused lameness tha...
Equine motor neuron disease.
The Veterinary record    October 22, 1994   Volume 135, Issue 17 416 doi: 10.1136/vr.135.17.416-a
Prendergast M, Bassett HF, Cummings JF.No abstract available
Histopathologic evidence of reperfusion injury in the large colon of horses after low-flow ischemia.
American journal of veterinary research    October 1, 1994   Volume 55, Issue 10 1434-1443 
Moore RM, Bertone AL, Muir WW, Stromberg PC, Beard WL.Effects of low-flow ischemia and reperfusion of the large colon on mucosal architecture were determined in horses. Twenty-four adult horses were randomly allocated to 3 groups: sham-operated (n = 6), 6 hours of ischemia (n = 9), and 3 hours of ischemia and 3 hours of reperfusion (n = 9). Low-flow ischemia was induced in horses of groups 2 and 3 by reducing colonic arterial blood flow to 20% of baseline values. Systemic hemodynamic and metabolic variables were maintained constant and in a normal physiologic range. Full-thickness biopsy specimens were obtained from the left ventral colon for his...
Survey in central Kentucky for prevalence of Anoplocephala perfoliata in horses at necropsy in 1992.
Veterinary parasitology    October 1, 1994   Volume 55, Issue 1-2 81-86 doi: 10.1016/0304-4017(94)90057-4
Benton RE, Lyons ET.A total of 118 horses was examined at necropsy in central Kentucky for the tapeworm Anoplocephala perfoliata. The examination period was between 28 August and 21 December 1992. Prevalence was 64% for Thoroughbreds (n = 81 examined) and 54% for non-Thoroughbreds (n = 37 examined). The number of tapeworms per infected horse varied from one to 853. Data on infections are categorized by breed, sex (n = 38 males, 8 geldings, and 72 females), age (1-31 years), and month of necropsy of the horses.
Neurological manifestation of cholesterinic granulomas in three horses.
The Veterinary record    September 3, 1994   Volume 135, Issue 10 228-230 doi: 10.1136/vr.135.10.228
Jackson CA, deLahunta A, Dykes NL, Divers TJ.Cholesterinic granulomas have been previously reported as an incidental post mortem in horses. Three adult horses with diencephalic dysfunction due to cholesterinic granulomas are described. All the horses exhibited profound depression, somnolence and reluctance to move. One horse experienced generalised seizures. Cerebrosinal fluid was xanthochromic with an elevated total protein in two of the cases evaluated. The large cholesterinic granulomas caused expansion of the lateral ventricle and secondary hydrocephalus due to the build up of cerebrospinal fluid behind the mass. Cholesterinic granul...
Pituitary abscess and basilar empyema in 4 horses.
Equine veterinary journal    September 1, 1994   Volume 26, Issue 5 424-426 doi: 10.1111/j.2042-3306.1994.tb04414.x
Reilly L, Habecker P, Beech J, Johnston J, Sweeney C, Hamir A.Abscess of the pituitary gland is a rare condition which has been described in man (Domingue and Wilson 1977; Ahmed et al. 1989), ruminants (Taylor and Meads 1963; Moriwaki er al. 1973; Lomas and Hazell 1983; Perdrizet and Dinsmore 1986) and one horse (Rumbaugh 1977). The some of infection may be either direct extension from an adjacent focus or haematogenous spread from a site elsewhere in the body. In man, pituitary abscess may result from meningitis, sphenoid sinusitis (Selose et al. 1980), and osteomyelitis (Rongetti and Daniels 1950). A review of 20 cases of pituitary abscess in ...
[Sporotrichosis in a horse].
Tijdschrift voor diergeneeskunde    September 1, 1994   Volume 119, Issue 17 500-502 
Greydanus-van der Putten SW, Klein WR, Blankenstein B, de Hoog GS, Koeman J.A 9-year old male Arabian horse was referred to the Department of Large Animal Surgery of the University of Utrecht because of multiple nodules on the inner side of the right hind leg. The nodules seemed to follow a cutaneolymphatic pattern. Histopathology of a nodule showed a granulomatous inflammation with the presence of multinucleated giant cells. In PAS- and Grocott-stained sections, spheroid yeast-like organisms with some budding were found throughout the tissue. A preliminary diagnosis of sporotrichosis was made. A fresh nodule was cultured and the presence of Sporothrix c.f. schenckii ...
Effect of betamethasone and exercise on equine carpal joints with osteochondral fragments.
Veterinary surgery : VS    September 1, 1994   Volume 23, Issue 5 369-376 doi: 10.1111/j.1532-950x.1994.tb00497.x
Foland JW, McIlwraith CW, Trotter GW, Powers BE, Lamar CH.Osteochondral fragments were created arthroscopically on the distal aspect of both radial carpal bones in 12 horses. On day 14 after surgery, one middle carpal joint of each horse was injected with 2.5 mL Betavet Soluspan (3.9 mg betamethasone sodium phosphate and 12 mg betamethasone acetate per milliliter) and the contralateral joint was injected with 2.5 mL saline as a control. Intra-articular treatments were repeated on day 35. On day 17, six horses began exercising 5 days per week on a high-speed treadmill. The other six horses were kept in box stalls throughout the study as nonexercised c...
Ataxia due to a vertebral haemangiosarcoma in a horse.
The Veterinary record    August 20, 1994   Volume 135, Issue 8 182-184 doi: 10.1136/vr.135.8.182
Newton-Clarke MJ, Guffoy MR, Dykes NL, Divers TJ.A haemangiosarcoma in a horse resulted in ataxia affecting all four legs, a low head carriage and a reluctance to flex the neck. Ancillary diagnostic procedures included the analysis of cerebrospinal fluid, standing lateral cervical radiographs and a myelogram. Post mortem a tumour was found which involved the body of the second cervical vertebra and the associated hypaxial muscles, with secondary intravertebral extradural infiltration and focal compressive myelopathy. A histological examination showed that the tumour was a haemangiosarcoma.
Recurrence of avulsion fractures.
Journal of the American Veterinary Medical Association    August 15, 1994   Volume 205, Issue 4 534 
Blikslager AT, Bristol DG.No abstract available
Motor neuron disease in a quarter horse from Nova Scotia.
The Canadian veterinary journal = La revue veterinaire canadienne    August 1, 1994   Volume 35, Issue 8 507-509 
Lofstedt J, Ikede BO.No abstract available
Morphologic characteristics of equine endometrium classified as Kenney categories I, II, and III, using light and scanning electron microscopy.
American journal of veterinary research    August 1, 1994   Volume 55, Issue 8 1060-1065 
Ferreira-Dias G, Nequin LG, King SS.Pathologic changes in the endometrium of mares may be rated according to Kenney's method of classification. Category I endometrium contains healthy tissue with no or few widely scattered pathologic changes. At the opposite end, severe widespread pathologic changes are associated with category III. Uterine biopsy specimens were collected aseptically from 16 mares during the estrous and diestrous stages of the cycle. Pathologic changes were evaluated, using light microscopy, and endometrium was classified as Kenney's category I, II, or III. Endometrial tissue of category I (n = 5 mares in estrus...
[Morphologic and molecular biologic studies of the etiology of equine sarcoid].
Tierarztliche Praxis    August 1, 1994   Volume 22, Issue 4 368-376 
Teifke JP.From 932 equine skin lesions 421 were diagnosed as sarcoids (about 45%). The most common locations were the ventral body regions, head, neck and sites of thin skin. Most often the fibroblastic type, less frequently the mixed type and most infrequent the verrucous type of sarcoid were diagnosed. Detection of BPV-DNA was performed by polymerase chain reaction (PCR) using an oligonucleotide primer pair located in the E5-open reading frame. DNA of BPV 1 and BPV 2 could be differentiated by digestion with restriction endonucleases. In 97 out of 108 sarcoids BPV-DNA was detected by PCR. Most samples...
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