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Topic:Veterinary Research
Veterinary research in horses encompasses the study of diseases, health management, and medical treatments specific to equine species. This field investigates various aspects of horse health, including infectious diseases, metabolic disorders, and musculoskeletal conditions. Researchers focus on understanding the pathophysiology of equine ailments, developing diagnostic tools, and evaluating therapeutic interventions. The study of horse health also involves examining preventive measures such as vaccination protocols and nutritional management to promote overall well-being. This page collects peer-reviewed research studies and scholarly articles that explore the diverse areas of veterinary science related to horses, providing insights into disease mechanisms, treatment strategies, and advancements in equine healthcare.
An epidemic of Getah virus infection among racehorses: isolation of the virus. During the autumn of 1978 a disease characterised by fever and occasionally by exanthema and/or oedema of the limbs was seen in approximately 13 per cent of horses in a training stable in the Kanto district of Japan. A virus was isolated by the intracerebral inoculation of one-day-old mice from blood and nasal swabs taken from naturally and experimentally infected horses. The virus was subsequently passaged in two monkey kidney cell lines in which it produced complete cytopathic changes. Infected horses developed neutralising, complement fixing and haemagglutinin inhibiting antibodies to the v...
On the natural history and comparative pathology of the blue naevus. In man the epidermis is the final destination for most of the melanocytes which are of neural crest origin, and they migrate to a variety of sites. Dermal melanocytic distribution, conspicuous in some lower animals, has a very restricted normal distribution in man, and of the variety of anomalies which exist the blue naevus is the most frequently encountered. It is comparable to the common melanocytoma of dog and hamster. More widespread dermal melanocytoses are rare, and a unique case in which death from melanoma supervened, recently recorded by the author, is an example of a syndrome the onl...
Intestinal atresia and stenosis in animals: a report of 34 cases. Intestinal atresia was found in 29 animals and stenosis in five. Atresia was found in the duodenum in one pup; in the jejunum in nine calves, two lambs and one piglet; in the ileum in one pup, one lamb and one piglet; and in the colon in one foal, seven calves, one lamb, one piglet and three kittens. Stenosis was found in the duodenum of a foal, in the jejunum in two calves and one pup, and in both the ileum and the colon of a kitten. One lamb showed ileal atresia as well as ileal stenosis. We classified the atresia as type 1, membrane atresia (four cases); type 2, cord atresia (six cases); an...
Critical tests of new benzothiazole anthelmintic tioxidazole in the horse. The basic-dose confirmation tests of tioxidazole for removal of susceptible populations of gastrointestinal parasites of the horse were made in 10 naturally infected horses, using the critical test method (experiment A). A single dose of toxidazole, given at the rate of 11 mg/kg of body weight, was administered to 5 horses by stomach tube and to 5 horses by mixing the drug with the daily grain ration. In the 5 horses given the drug by stomach tube, aggregate average removals were 90% or more for 5 horses infected with Stronglyus vulgaris, 5 infected with S edentatus, 5 infected with small stro...
Studies on the physiopathology of chronic obstructive pulmonary disease in the horse. II. Right heart haemodynamics. Pressure curves obtained by cardiac catheterization of the pulmonary artery, right ventricle and right atrium of 9 horses and ponies with chronic obstructive pulmonary disease (COPD) were compared with those similarly recorded from 6 clinically normal control subjects. The mean pulmonary peak systolic, pulmonary minimum diastolic and ventricular peak systolic pressures of the COPD subjects were significantly higher (P less than 0,01) than the corresponding mean pressures of the clinically normal control subjects. The mean pressure calculated from pressure curves obtained from 8 Thoroughbreds i...
Ontogeny of lymphocyte function in the equine fetus. The capacity of cells from thymus, liver, spleen, mesenteric lymph nodes, peripheral blood, and bone marrow to respond to in vitro phytolectin and allogeneic lymphocyte-stimulation was determined in 16 pony fetuses 61 to 200 days old (gestational age). Phytolectin-responsive cells were detected in the thymus at the 80th gestational day, peripheral blood at 120 days, lymph node at 160 days, and spleen at 200 days. Mixed lymphocyte culture-responsive cells were detected in thymus at 100 days and in the spleen at 200 days (gestational age). Immunoglobulins (Ig) M and IgG were quantitated by radio...
Thermography in the diagnosis of inflammatory processes in the horse. To evaluate the use of thermography in equine medicine, a three-phase study was conducted. In the first phase, six horses were examined thermographically, before and after exercise, to determine a normal thermal pattern. In the second phase, nine horses with acute and chronic inflammatory processes were examined thermographically. In the third phase, thermography was used to evaluate the effectiveness of anti-inflammatory drugs on chemically induced inflammatory reactions. All normal horses tested had similar infrared emission patterns. There was a high degree of symmetry between right and lef...
Crystalline inclusions in erythrocytes parasitized with Babesia equi following treatment of ponies with imidocarb. Four splenectomized Welsh ponies were infected with Babesia equi. Two ponies were treated with imidocarb dipropionate, and two were not treated. By light microscopic examination, 1% to 2% of the parasitized erythrocytes of treated ponies contained crystalline inclusions. The crystals were rectangular, diamond, or burr shaped. They occupied most of the erythrocytic cytoplasm, and, as a result, the remainder of the pale staining cytoplasm was inconspicuous in Wright-Giemsa-stained blood smears. The size and shape of intraerythrocytic inclusions varied when examined by electron microscopy, but in...
Thermography: a technique for subclinical diagnosis of osteoarthritis. Thermographic and radiographic evaluations of the tarsus (hock) were done on 20 Standardbred racehorses before and after exercise at three consecutive 6-week intervals. All horses were from the same stable and given the same care and training under identical schedules and conditions. Normal thermographic patterns were established before and after exercise. These patterns corresponded to the underlying tarsal vasculature. Postexercise thermal patterns indicated a warming trend, and the increases were uniform. Abnormal thermal patterns were more localized and did not conform to the normal underl...
Thermographic diagnosis of Horner’s syndrome in the horse. Lateral and frontal thermographic patterns of the head of normal horses before and after exercise were characterized to aid the diagnosis of diseases of the head. Surgical induction of Horner's syndrome was done in four horses by isolation and transection of the vagosympathetic trunk. One clinical case and the surgically induced cases of Horner's syndrome were evaluated clinically. Thermographic findings of the clinical case were similar to the experimental cases.
Response of plasma LH and FSH to gonadotropin-releasing hormone in pony foals and ovariectomized pony mares. Plasma FSH and LH response to a synthetic GnRH analog was measured in adult ovariectomized pony mares (OVX) and in pony foals (<70 days of age) during late spring (May-June). FSH and LH responded in a similar fashion (200% increase) in the OVX mare, which is different from other reports for intact mares. There was a greater mean response to a comparable dose of GnRH in the prepubertal foal for both FSH (500%) and LH (900%) than in the OVX mare. There was a positive correlation between age and the maximum FSH response to GnRH in male and female foals. The LH response was positively correlate...
Evidence for Sarcocystis as the etiologic agent of equine protozoal myeloencephalitis. Equine protozoal myeloencephalitis (EPM) was diagnosed in 10 horses. By electron microscopy, schizonts were found in intact host cells of the spinal cords or, more frequently, free in the extracellular spaces. Developmental stages of schizonts differed morphologically, and the late stage of schizogony was characterized by endopolygeny. These findings permitted tentative identification of the protozoon as a Sarcocystis sp. Free merozoites were present in the extracellular spaces or in cells of the spinal cord. Pericytes of capillaries were most frequently parasitized by merozoites were present ...
Maturation of equine epididymal spermatozoa. Spermatozoa from four regions of the epididymis and from ejaculated semen were evaluated for their resistance to cold shock, progressive motility, and structural stability. Spermatozoa were incubated at 38 C and their percentage of eosinophilia was compared with that of spermatozoa cooled to 0 C in 2 minutes, 10 C in 12 minutes, or 4 C in 22 minutes. Spermatozoa motility was estimated visually under phase-contrast microscopy and was recorded by cinematography. Structural stability of spermatozoa incubated in 0.05 M sodium borate buffer, 0.035 M sodium dodecyl sulfate (SDS), 0.002 M dithiothrei...
The complete amino acid sequence of horse muscle acylphosphatase. The amino acid sequence of horse muscle acylphosphatase is given in the present paper. The carboxymethylated enzyme consists of a single polypeptide chain of 98 amino acid residues with an acetyl group blocking the NH2 terminus and a tyrosine at the COOH terminus. The calculated molecular weight of the native protein, a mixed disulfide with glutathione, is 11,365. The carboxymethylated protein was cleaved by cyanogen bromide. The three expected fragments were purified; moreover, an additional fragment, derived from a partial failure of cleavage at methionine-24, was purified and characterized....
Limitations in equine fetal electrocardiography. Technical and interpretive limitations of equine fetal electrocardiography were evaluated in recordings obtained from 45 pregnant mares. Technical limitations were related to the small amplitude of the fetal electrocardiogram and the variability in the lead configuration providing the best recording. It was found that recording the fetal electrocardiogram at high sensitivity and high base-line fidelity in several different leads was necessary to obtain satisfactory tracings. Interpretive limitations were related in part to the small amplitude of the fetal electrocardiogram and to the marked va...
[Use of trichlorfon as an anthelmintic in horses (author’s transl)]. The use of trichlorfon as an anthelmintic in horses has increased since it was combined with mebendazole and febantel, and became commercially available as Telmin-trichlorfon and Rintal-plus respectively. Field studies showed that these combined preparations frequently gave rise to cases of poisoning. Mild to severe colic was observed up to six hours after treatment, diarrhoea and/or anorexia continuing to be present for one to six days after administration. The 'horse weight measurer' introduced by Janssen Pharmaceutica is not sufficiently accurate to prevent overdosage. It is advisable only ...
The slap test for laryngeal adductory function in horses with suspected cervical spinal cord damage. The paper describes the assessment and practical implications of a laryngeal adductory reflex in a series of 30 ataxic and 64 non-ataxic horses. The reflex was evoked by slapping the saddle region just caudal to the withers. In normal horses this produced a flickering adductory movement of the contralateral arytenoid cartilage which was observed endoscopically. Abolition of the laryngeal response was encountered in in 3 situations:--(1) Disruption of the afferent impulse occurred in those horses in which there was significant spinal cord pathology affecting the pathway from the cranial thoraci...
Myoblastoma. Equine granular cell tumor. A unilateral pulmonary granular cell tumor occurred in a Thoroughbred mare with longstanding respiratory disease wrongly attributed to chronic obstructive pulmonary disease. The clinical features, radiology and endoscopic appearance permitted an accurate diagnosis, which was supported by subsequent necropsy and histologic examination. Obstructive pulmonary disease was ruled out after measurement of arterial blood gases and maximum intrathoracic pressure changes, and after microscopic examination of the lung.
Electromagnetic measurements of metacarpal blood flow in nonanesthetized horses. Blood flow (milliliter/minute) was measured in the medial palmar artery of 12 horses, using electromagnetic flow equipment. Extraluminal flow probes were surgically placed around the artery and base-line blood flows were recorded during surgical manipulation. After horses had recovered from anesthesia, blood flows were recorded each day for 11 days. According to mean average blood flows, horses were allotted to two groups: group 1--those with predominately normal flow characteristics, and group 2--those horses with predominately abnormal flow features. Average daily mean blood flows in the med...
Natural rigaidity of the horse’s backbone. The functional anatomy of the thoracolumbar (TL) spine is considered in relation to the horse's ability to perform at speed and to jump. The morphological features quite clearly show the relative inflexibility of the equine back and this was confirmed by some experimental studies. Fresh post mortem specimens from 5 Thoroughbreds were used to estimate the limits of dorsoventral movement of the TL spine from mid-thoracic to the cranial lumbar (T10-L2). The individual spinous processes could be moved a mean 1.1-6.0 mm on maximum ventroflexion and 0.8-3.8 mm on dorsiflexion. The overall flexibilit...
