A journey through horse cloning.
Abstract: Interest in equine somatic cell nuclear transfer technology has increased significantly since the first equid clones were produced in 2003. This is demonstrated by the multiple commercial equine cloning companies having produced numerous cloned equids to date; worldwide, more than 370 cloned horses have been produced in at least six different countries. Equine cloning can be performed using several different approaches, each with different rates of success. In this review we cover the history and applications of equine cloning and summarise the major scientific advances in the development of this technology in horses. We explain the advantages and disadvantages of different procedures to produce cloned equine embryos and describe the current status of equine clone commercialisation, along with observations of differences in regional breed association registration regulations.
Publication Date: 2017-01-01 PubMed ID: 29539299DOI: 10.1071/RD17374Google Scholar: Lookup
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- Historical Article
- Journal Article
- Review
Summary
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The research article covers the evolution and adoption of horse cloning technology since its inception in 2003, discussing various methods, their success rates, implications of this technology, as well as looking at the commercialization and regional regulations associated with equine cloning.
Introduction: The Emergence of Equine Cloning
- Equine cloning technology has escalated in significance since the creation of the first equid clones in 2003. This growing interest is portrayed by the growth of commercial horse cloning companies and the number of cloned horses produced worldwide, with over 370 instances of successful cloning in at least six different countries.
Cloning Methods and Their Efficiency
- There are multiple methods to clone horses, each yielding different degrees of success. The article does not detail these methods, but it notes that some are more efficient than others, contributing to varying rates of success in the reproduction of cloned equine embryos.
Progressive Developments in Horse Cloning
- The authors recount the historical progression and improvements made in horse cloning technology. They take us through the major leaps in scientific advancements that have facilitated the development and perfection of this technology in horses over the years.
Pros and Cons of Different Cloning Procedures
- They explore the advantages and setbacks of different techniques used to produce cloned horse embryos. Different cloning processes may have respective strengths and drawbacks, affecting the efficiency, cost, ethical implications, and overall feasibility of equine cloning.
State of Commercialization and Regulation
- The article also inspects the current standing of commercializing horse cloning. It considers the operation of various companies in the field and how they have influenced the direction of the industry.
- Regional breed association registration regulations and their impact on equine cloning are spotlighted. It underlines the regulatory differences across various regions and how these regulations might influence the future direction of equine cloning technology.
Cite This Article
APA
Gambini A, Maserati M.
(2017).
A journey through horse cloning.
Reprod Fertil Dev, 30(1), 8-17.
https://doi.org/10.1071/RD17374 Publication
Researcher Affiliations
- Laboratory of Animal Biotechnology, Agriculture Faculty, University of Buenos Aires, Av. San Martin 4453, C1417DSE, Ciudad Autonóma de Buenos Aires, Buenos Aires, Argentina.
- Clonagem Animal S/A, Rod SP 340, Km 166, (Cx Postal 238), Mogi Mirim, Sao Pablo, Brasil.
MeSH Terms
- Animals
- Cloning, Organism / history
- Cloning, Organism / methods
- Cloning, Organism / veterinary
- Embryo, Mammalian
- History, 21st Century
- Horses / embryology
- Nuclear Transfer Techniques / history
- Nuclear Transfer Techniques / trends
- Nuclear Transfer Techniques / veterinary
Citations
This article has been cited 5 times.- Laseca N, Molina A, Ramón M, Valera M, Azcona F, Encina A, Demyda-Peyrás S. Fine-Scale Analysis of Runs of Homozygosity Islands Affecting Fertility in Mares.. Front Vet Sci 2022;9:754028.
- Rahbaran M, Razeghian E, Maashi MS, Jalil AT, Widjaja G, Thangavelu L, Kuznetsova MY, Nasirmoghadas P, Heidari F, Marofi F, Jarahian M. Cloning and Embryo Splitting in Mammalians: Brief History, Methods, and Achievements.. Stem Cells Int 2021;2021:2347506.
- Angel-Velez D, De Coster T, Azari-Dolatabad N, Fernandez-Montoro A, Benedetti C, Bogado Pascottini O, Woelders H, Van Soom A, Smits K. New Alternative Mixtures of Cryoprotectants for Equine Immature Oocyte Vitrification.. Animals (Basel) 2021 Oct 28;11(11).
- Antczak DF, Allen WRT. Placentation in Equids.. Adv Anat Embryol Cell Biol 2021;234:91-128.
- Gambini A, Duque Rodríguez M, Rodríguez MB, Briski O, Flores Bragulat AP, Demergassi N, Losinno L, Salamone DF. Horse ooplasm supports in vitro preimplantation development of zebra ICSI and SCNT embryos without compromising YAP1 and SOX2 expression pattern.. PLoS One 2020;15(9):e0238948.
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