Analyze Diet
Equine veterinary journal2010; 42(2); 174-180; doi: 10.2746/042516409X480395

A review of tendon injury: why is the equine superficial digital flexor tendon most at risk?

Abstract: Tendon injury is one of the most common causes of wastage in the performance horse; the majority of tendon injuries occur to the superficial digital flexor tendon (SDFT) whereas few occur to the common digital extensor tendon. This review outlines the epidemiology and aetiology of equine tendon injury, reviews the different functions of the tendons in the equine forelimb and suggests possible reasons for the high rate of failure of the SDFT. An understanding of the mechanisms leading to matrix degeneration and subsequent tendon gross failure is the key to developing appropriate treatment and preventative measures.
Publication Date: 2010-02-17 PubMed ID: 20156256DOI: 10.2746/042516409X480395Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
  • Journal Article
  • Research Support
  • Non-U.S. Gov't
  • Review

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article is an in-depth analysis into tendon injuries in horses, particularly in the superficial digital flexor tendon (SDFT), to unravel the reasons behind its high rate of failure, and the potential preventive measures that could be implemented based on the understanding of its degeneration mechanisms.

Research Overview

  • The research begins with an exploration into the epidemiology and etiology of equine tendon injuries. These are injuries to the tendons in horses which are seen as one of the leading causes of performance reduction in the animal. The study notes that the majority of these tendon injuries occur to the superficial digital flexor tendon (SDFT), and few to the common digital extensor tendon. As such, the research dives deep into why the SDFT is the most affected.

Functions of Tendons in Equine Forelimb

  • The research provides a detailed review of the different functions of the tendons in the equine forelimb. It outlines the role of these tendons in relation to the horse’s biomechanics, the forces acting on them, and their response to these forces.

Investigating the High Rate of SDFT failure

  • The article then raises the key question around the high rate of failure of the SDFT and proposes potential reasons behind this. It discuss the structural makeup of the SDFT, its mechanical load, and the horse’s exercise regime, noting that a combination of these factors may contribute to the observed high rate of SDFT injuries.

Matrix Degeneration and Tendon Failure

  • The research goes on to explore the mechanisms that lead to matrix degeneration and subsequent tendon failure. It elucidates how overstraining the tendon, cumulative micro-traumas, and suboptimal management practices can lead to progressive matrix degeneration and finally to visible tendon injuries.

Preventive Measures and Treatments

  • Finally, the research provides insight into the possible preventive measures and treatments that could be explored based on an understanding of the degeneration mechanisms. It underscores the importance of early diagnosis, appropriate management strategies, and innovative therapeutic interventions to tackle equine tendon injuries.

Cite This Article

APA
Thorpe CT, Clegg PD, Birch HL. (2010). A review of tendon injury: why is the equine superficial digital flexor tendon most at risk? Equine Vet J, 42(2), 174-180. https://doi.org/10.2746/042516409X480395

Publication

ISSN: 0425-1644
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 42
Issue: 2
Pages: 174-180

Researcher Affiliations

Thorpe, C T
  • University College London, Division of Surgery and Interventional Science, Institute of Orthopaedics and Musculoskeletal Science, Stanmore Campus, Royal National Orthopaedic Hospital, Stanmore, London HA7 4LP.
Clegg, P D
    Birch, H L

      MeSH Terms

      • Animals
      • Forelimb / injuries
      • Forelimb / pathology
      • Horse Diseases / pathology
      • Horses / injuries
      • Tendon Injuries / pathology
      • Tendon Injuries / veterinary

      Citations

      This article has been cited 69 times.
      1. Abdelhakiem MAH, Hussein A, Seleim SM, Abdelbaset AE, Abd-Elkareem M. Silver nanoparticles and platelet-rich fibrin accelerate tendon healing in donkey. Sci Rep 2023 Feb 28;13(1):3421.
        doi: 10.1038/s41598-023-30543-wpubmed: 36854886google scholar: lookup
      2. Duddy HR, Schoonover MJ, Hague BA. Outcome following local injection of a liquid amnion allograft for treatment of equine tendonitis or desmitis - 100 cases. BMC Vet Res 2022 Nov 7;18(1):391.
        doi: 10.1186/s12917-022-03480-5pubmed: 36345002google scholar: lookup
      3. Sander IL, Dvorak N, Stebbins JA, Carr AJ, Mouthuy PA. Advanced Robotics to Address the Translational Gap in Tendon Engineering. Cyborg Bionic Syst 2022;2022:9842169.
        doi: 10.34133/2022/9842169pubmed: 36285305google scholar: lookup
      4. Supokawej A, Korchunjit W, Wongtawan T. The combination of BMP12 and KY02111 enhances tendon differentiation in bone marrow-derived equine mesenchymal stromal cells (BM-eMSCs). J Equine Sci 2022 Jul;33(2):19-26.
        doi: 10.1294/jes.33.19pubmed: 35847484google scholar: lookup
      5. Hobbs SJ, Clayton HM. The Olympic motto through the lens of equestrian sports. Anim Front 2022 Jun;12(3):45-53.
        doi: 10.1093/af/vfac025pubmed: 35711501google scholar: lookup
      6. Ribbans WJ, September AV, Collins M. Tendon and Ligament Genetics: How Do They Contribute to Disease and Injury? A Narrative Review. Life (Basel) 2022 Apr 29;12(5).
        doi: 10.3390/life12050663pubmed: 35629331google scholar: lookup
      7. Rampin A, Skoufos I, Raghunath M, Tzora A, Diakakis N, Prassinos N, Zeugolis DI. Allogeneic Serum and Macromolecular Crowding Maintain Native Equine Tenocyte Function in Culture. Cells 2022 May 5;11(9).
        doi: 10.3390/cells11091562pubmed: 35563866google scholar: lookup
      8. Ellis I, Schnabel LV, Berglund AK. Defining the Profile: Characterizing Cytokines in Tendon Injury to Improve Clinical Therapy. J Immunol Regen Med 2022 May;16.
        doi: 10.1016/j.regen.2022.100059pubmed: 35309714google scholar: lookup
      9. Melotti L, Carolo A, Elshazly N, Boesso F, Da Dalt L, Gabai G, Perazzi A, Iacopetti I, Patruno M. Case Report: Repeated Intralesional Injections of Autologous Mesenchymal Stem Cells Combined With Platelet-Rich Plasma for Superficial Digital Flexor Tendon Healing in a Show Jumping Horse. Front Vet Sci 2022;9:843131.
        doi: 10.3389/fvets.2022.843131pubmed: 35252428google scholar: lookup
      10. Lu V, Tennyson M, Zhang J, Khan W. Mesenchymal Stem Cell-Derived Extracellular Vesicles in Tendon and Ligament Repair-A Systematic Review of In Vivo Studies. Cells 2021 Sep 27;10(10).
        doi: 10.3390/cells10102553pubmed: 34685532google scholar: lookup
      11. Horan K, Coburn J, Kourdache K, Day P, Harborne D, Brinkley L, Carnall H, Hammond L, Peterson M, Millard S, Pfau T. Influence of Speed, Ground Surface and Shoeing Condition on Hoof Breakover Duration in Galloping Thoroughbred Racehorses. Animals (Basel) 2021 Sep 3;11(9).
        doi: 10.3390/ani11092588pubmed: 34573553google scholar: lookup
      12. Busse NI, Gonzalez ML, Krason ML, Johnson SE. β-Hydroxy β-methylbutyrate supplementation to adult Thoroughbred geldings increases type IIA fiber content in the gluteus medius. J Anim Sci 2021 Oct 1;99(10).
        doi: 10.1093/jas/skab264pubmed: 34516615google scholar: lookup
      13. Rouette J, Cockram MS, Sanchez J, MacMillan KM. Musculoskeletal injuries in Standardbred racehorses on Prince Edward Island. Can Vet J 2021 Sep;62(9):987-993.
        pubmed: 34475585
      14. Janczarek I, Kędzierski W, Tkaczyk E, Kaczmarek B, Łuszczyński J, Mucha K. Thermographic Analysis of the Metacarpal and Metatarsal Areas in Jumping Sport Horses and Leisure Horses in Response to Warm-Up Duration. Animals (Basel) 2021 Jul 6;11(7).
        doi: 10.3390/ani11072022pubmed: 34359150google scholar: lookup
      15. Wagner FC, Reese S, Gerlach K, Böttcher P, Mülling CKW. Cyclic tensile tests of Shetland pony superficial digital flexor tendons (SDFTs) with an optimized cryo-clamp combined with biplanar high-speed fluoroscopy. BMC Vet Res 2021 Jun 25;17(1):223.
        doi: 10.1186/s12917-021-02914-wpubmed: 34172051google scholar: lookup
      16. Oreff GL, Fenu M, Vogl C, Ribitsch I, Jenner F. Species variations in tenocytes' response to inflammation require careful selection of animal models for tendon research. Sci Rep 2021 Jun 14;11(1):12451.
        doi: 10.1038/s41598-021-91914-9pubmed: 34127759google scholar: lookup
      17. Wagner FC, Gerlach K, Geiger SM, Gittel C, Böttcher P, Mülling CKW. Biplanar High-Speed Fluoroscopy of Pony Superficial Digital Flexor Tendon (SDFT)-An In Vivo Pilot Study. Vet Sci 2021 May 27;8(6).
        doi: 10.3390/vetsci8060092pubmed: 34072030google scholar: lookup
      18. Logan AA, Nielsen BD. Training Young Horses: The Science behind the Benefits. Animals (Basel) 2021 Feb 9;11(2).
        doi: 10.3390/ani11020463pubmed: 33572461google scholar: lookup
      19. Godinho MS, Thorpe CT, Greenwald SE, Screen HRC. Elastase treatment of tendon specifically impacts the mechanical properties of the interfascicular matrix. Acta Biomater 2021 Mar 15;123:187-196.
        doi: 10.1016/j.actbio.2021.01.030pubmed: 33508509google scholar: lookup
      20. Ribitsch I, Oreff GL, Jenner F. Regenerative Medicine for Equine Musculoskeletal Diseases. Animals (Basel) 2021 Jan 19;11(1).
        doi: 10.3390/ani11010234pubmed: 33477808google scholar: lookup
      21. Aimaletdinov A, Mindubaeva G, Khalikova S, Kabwe E, Salmakova A, Alexandrova N, Rutland C, Rizvanov A, Zakirova E. Application of gene therapy in the treatment of superficial digital flexor tendon injury in horses. Open Vet J 2020 Oct;10(3):261-266.
        doi: 10.4314/ovj.v10i3.3pubmed: 33282696google scholar: lookup
      22. Haythorn A, Young M, Stanton J, Zhang J, Mueller POE, Halper J. Differential gene expression in skin RNA of horses affected with degenerative suspensory ligament desmitis. J Orthop Surg Res 2020 Oct 7;15(1):460.
        doi: 10.1186/s13018-020-01994-ypubmed: 33028365google scholar: lookup
      23. Bukowska J, Szóstek-Mioduchowska AZ, Kopcewicz M, Walendzik K, Machcińska S, Gawrońska-Kozak B. Adipose-Derived Stromal/Stem Cells from Large Animal Models: from Basic to Applied Science. Stem Cell Rev Rep 2021 Jun;17(3):719-738.
        doi: 10.1007/s12015-020-10049-ypubmed: 33025392google scholar: lookup
      24. Pechanec MY, Boyd TN, Baar K, Mienaltowski MJ. Adding exogenous biglycan or decorin improves tendon formation for equine peritenon and tendon proper cells in vitro. BMC Musculoskelet Disord 2020 Sep 23;21(1):627.
        doi: 10.1186/s12891-020-03650-2pubmed: 32967653google scholar: lookup
      25. Citeroni MR, Ciardulli MC, Russo V, Della Porta G, Mauro A, El Khatib M, Di Mattia M, Galesso D, Barbera C, Forsyth NR, Maffulli N, Barboni B. In Vitro Innovation of Tendon Tissue Engineering Strategies. Int J Mol Sci 2020 Sep 14;21(18).
        doi: 10.3390/ijms21186726pubmed: 32937830google scholar: lookup
      26. Ribitsch I, Baptista PM, Lange-Consiglio A, Melotti L, Patruno M, Jenner F, Schnabl-Feichter E, Dutton LC, Connolly DJ, van Steenbeek FG, Dudhia J, Penning LC. Large Animal Models in Regenerative Medicine and Tissue Engineering: To Do or Not to Do. Front Bioeng Biotechnol 2020;8:972.
        doi: 10.3389/fbioe.2020.00972pubmed: 32903631google scholar: lookup
      27. Riasat K, Bardell D, Goljanek-Whysall K, Clegg PD, Peffers MJ. Epigenetic mechanisms in Tendon Ageing. Br Med Bull 2020 Oct 14;135(1):90-107.
        doi: 10.1093/bmb/ldaa023pubmed: 32827252google scholar: lookup
      28. Horstmeier C, Ahrberg AB, Berner D, Burk J, Gittel C, Hillmann A, Offhaus J, Brehm W. In Vivo Magic Angle Magnetic Resonance Imaging for Cell Tracking in Equine Low-Field MRI. Stem Cells Int 2019;2019:5670106.
        doi: 10.1155/2019/5670106pubmed: 31933650google scholar: lookup
      29. Kornicka-Garbowska K, Pędziwiatr R, Woźniak P, Kucharczyk K, Marycz K. Microvesicles isolated from 5-azacytidine-and-resveratrol-treated mesenchymal stem cells for the treatment of suspensory ligament injury in horse-a case report. Stem Cell Res Ther 2019 Dec 18;10(1):394.
        doi: 10.1186/s13287-019-1469-5pubmed: 31852535google scholar: lookup
      30. Ribitsch I, Gueltekin S, Keith MF, Minichmair K, Peham C, Jenner F, Egerbacher M. Age-related changes of tendon fibril micro-morphology and gene expression. J Anat 2020 Apr;236(4):688-700.
        doi: 10.1111/joa.13125pubmed: 31792963google scholar: lookup
      31. Zhang C, Zhu J, Zhou Y, Thampatty BP, Wang JH. Tendon Stem/Progenitor Cells and Their Interactions with Extracellular Matrix and Mechanical Loading. Stem Cells Int 2019;2019:3674647.
        doi: 10.1155/2019/3674647pubmed: 31737075google scholar: lookup
      32. Greco-Otto P, Bond S, Sides R, Bayly W, Leguillette R. Conditioning equine athletes on water treadmills significantly improves peak oxygen consumption. Vet Rec 2020 Feb 29;186(8):250.
        doi: 10.1136/vr.104684pubmed: 31511399google scholar: lookup
      33. Shojaee A, Parham A. Strategies of tenogenic differentiation of equine stem cells for tendon repair: current status and challenges. Stem Cell Res Ther 2019 Jun 18;10(1):181.
        doi: 10.1186/s13287-019-1291-0pubmed: 31215490google scholar: lookup
      34. Tsang AS, Dart AJ, Biasutti SA, Jeffcott LB, Smith MM, Little CB. Effects of tendon injury on uninjured regional tendons in the distal limb: An in-vivo study using an ovine tendinopathy model. PLoS One 2019;14(4):e0215830.
        doi: 10.1371/journal.pone.0215830pubmed: 31013317google scholar: lookup
      35. Beerts C, Suls M, Broeckx SY, Seys B, Vandenberghe A, Declercq J, Duchateau L, Vidal MA, Spaas JH. Tenogenically Induced Allogeneic Peripheral Blood Mesenchymal Stem Cells in Allogeneic Platelet-Rich Plasma: 2-Year Follow-up after Tendon or Ligament Treatment in Horses. Front Vet Sci 2017;4:158.
        doi: 10.3389/fvets.2017.00158pubmed: 29018808google scholar: lookup
      36. Godinho MSC, Thorpe CT, Greenwald SE, Screen HRC. Elastin is Localised to the Interfascicular Matrix of Energy Storing Tendons and Becomes Increasingly Disorganised With Ageing. Sci Rep 2017 Aug 30;7(1):9713.
        doi: 10.1038/s41598-017-09995-4pubmed: 28855560google scholar: lookup
      37. Wu F, Nerlich M, Docheva D. Tendon injuries: Basic science and new repair proposals. EFORT Open Rev 2017 Jul;2(7):332-342.
        doi: 10.1302/2058-5241.2.160075pubmed: 28828182google scholar: lookup
      38. Ashraf Kharaz Y, Zamboulis D, Sanders K, Comerford E, Clegg P, Peffers M. Comparison between chaotropic and detergent-based sample preparation workflow in tendon for mass spectrometry analysis. Proteomics 2017 Jul;17(13-14).
        doi: 10.1002/pmic.201700018pubmed: 28547889google scholar: lookup
      39. Thorpe CT, Riley GP, Birch HL, Clegg PD, Screen HRC. Fascicles and the interfascicular matrix show decreased fatigue life with ageing in energy storing tendons. Acta Biomater 2017 Jul 1;56:58-64.
        doi: 10.1016/j.actbio.2017.03.024pubmed: 28323176google scholar: lookup
      40. Roth SP, Glauche SM, Plenge A, Erbe I, Heller S, Burk J. Automated freeze-thaw cycles for decellularization of tendon tissue - a pilot study. BMC Biotechnol 2017 Feb 14;17(1):13.
        doi: 10.1186/s12896-017-0329-6pubmed: 28193263google scholar: lookup
      41. Linderman SW, Gelberman RH, Thomopoulos S, Shen H. Cell and Biologic-Based Treatment of Flexor Tendon Injuries. Oper Tech Orthop 2016 Sep;26(3):206-215.
        doi: 10.1053/j.oto.2016.06.011pubmed: 28042226google scholar: lookup
      42. Kharaz YA, Tew SR, Peffers M, Canty-Laird EG, Comerford E. Proteomic differences between native and tissue-engineered tendon and ligament. Proteomics 2016 May;16(10):1547-56.
        doi: 10.1002/pmic.201500459pubmed: 27080496google scholar: lookup
      43. Padaliya NR, Ranpariya JJ, Kumar D, Javia CB, Barvalia DR. Ultrasonographic assessment of the equine palmar tendons. Vet World 2015 Feb;8(2):208-12.
      44. Williamson KA, Lee KJ, Humphreys WJ, Comerford EJ, Clegg PD, Canty-Laird EG. Restricted differentiation potential of progenitor cell populations obtained from the equine superficial digital flexor tendon (SDFT). J Orthop Res 2015 Jun;33(6):849-58.
        doi: 10.1002/jor.22891pubmed: 25877997google scholar: lookup
      45. Burk J, Gittel C, Heller S, Pfeiffer B, Paebst F, Ahrberg AB, Brehm W. Gene expression of tendon markers in mesenchymal stromal cells derived from different sources. BMC Res Notes 2014 Nov 20;7:826.
        doi: 10.1186/1756-0500-7-826pubmed: 25412928google scholar: lookup
      46. Takahashi T, Mukai K, Ohmura H, Aida H, Hiraga A. In vivo measurements of flexor tendon and suspensory ligament forces during trotting using the thoroughbred forelimb model. J Equine Sci 2014;25(1):15-22.
        doi: 10.1294/jes.25.15pubmed: 24834009google scholar: lookup
      47. Dakin SG, Dudhia J, Smith RK. Resolving an inflammatory concept: the importance of inflammation and resolution in tendinopathy. Vet Immunol Immunopathol 2014 Apr 15;158(3-4):121-7.
        doi: 10.1016/j.vetimm.2014.01.007pubmed: 24556326google scholar: lookup
      48. Shepherd JH, Legerlotz K, Demirci T, Klemt C, Riley GP, Screen HR. Functionally distinct tendon fascicles exhibit different creep and stress relaxation behaviour. Proc Inst Mech Eng H 2014 Jan;228(1):49-59.
        doi: 10.1177/0954411913509977pubmed: 24285289google scholar: lookup
      49. Gittel C, Brehm W, Burk J, Juelke H, Staszyk C, Ribitsch I. Isolation of equine multipotent mesenchymal stromal cells by enzymatic tissue digestion or explant technique: comparison of cellular properties. BMC Vet Res 2013 Oct 29;9:221.
        doi: 10.1186/1746-6148-9-221pubmed: 24168625google scholar: lookup
      50. Birch HL, Thorpe CT, Rumian AP. Specialisation of extracellular matrix for function in tendons and ligaments. Muscles Ligaments Tendons J 2013 Jan;3(1):12-22.
        doi: 10.11138/mltj/2013.3.1.012pubmed: 23885341google scholar: lookup
      51. Burk J, Erbe I, Berner D, Kacza J, Kasper C, Pfeiffer B, Winter K, Brehm W. Freeze-thaw cycles enhance decellularization of large tendons. Tissue Eng Part C Methods 2014 Apr;20(4):276-84.
        doi: 10.1089/ten.TEC.2012.0760pubmed: 23879725google scholar: lookup
      52. Muttini A, Salini V, Valbonetti L, Abate M. Stem cell therapy of tendinopathies: suggestions from veterinary medicine. Muscles Ligaments Tendons J 2012 Jul;2(3):187-92.
        pubmed: 23738296
      53. Youngstrom DW, Barrett JG, Jose RR, Kaplan DL. Functional characterization of detergent-decellularized equine tendon extracellular matrix for tissue engineering applications. PLoS One 2013;8(5):e64151.
        doi: 10.1371/journal.pone.0064151pubmed: 23724028google scholar: lookup
      54. Thorpe CT, Birch HL, Clegg PD, Screen HR. The role of the non-collagenous matrix in tendon function. Int J Exp Pathol 2013 Aug;94(4):248-59.
        doi: 10.1111/iep.12027pubmed: 23718692google scholar: lookup
      55. Södersten F, Hultenby K, Heinegård D, Johnston C, Ekman S. Immunolocalization of collagens (I and III) and cartilage oligomeric matrix protein in the normal and injured equine superficial digital flexor tendon. Connect Tissue Res 2013;54(1):62-9.
        doi: 10.3109/03008207.2012.734879pubmed: 23020676google scholar: lookup
      56. Kavaguchi De Grandis A, Boulocher C, Viguier E, Roger T, Sawaya S. Ultrasonograph and clinical quantitative characterization of tendinopathy by modified splitting in a goat model. ScientificWorldJournal 2012;2012:472023.
        doi: 10.1100/2012/472023pubmed: 22997496google scholar: lookup
      57. Spaas JH, Guest DJ, Van de Walle GR. Tendon regeneration in human and equine athletes: Ubi Sumus-Quo Vadimus (where are we and where are we going to)?. Sports Med 2012 Oct 1;42(10):871-90.
        doi: 10.1007/BF03262300pubmed: 22963225google scholar: lookup
      58. Zhang Z, Yang Y, Ma Y, Mai Z, Fu H, Wang X, Cao X, Li T, Li J, Guo Q. Clinical Diagnosis, Treatment, and Outcome Analysis of a Horse with Proximal Sesamoid Bone Fracture Complicated by Flexor Tendinitis. Vet Sci 2026 Jan 2;13(1).
        doi: 10.3390/vetsci13010040pubmed: 41600695google scholar: lookup
      59. Tommasa SD, Raspe S, Farí G, Imperante A, Brehm W. Autologous conditioned serum IRAP efficacy for tendon and ligament injuries in horses: An observational study. Open Vet J 2025;15(8):3787-3793.
        doi: 10.5455/OVJ.2025.v15.i8.43pubmed: 41036008google scholar: lookup
      60. Vachkova E, Arnhold S, Petrova V, Heimann M, Koynarski T, Simeonova G, Piperkov P. Transcriptional Factors Related to Cellular Kinetics, Apoptosis, and Tumorigenicity in Equine Adipose-Derived Mesenchymal Stem Cells (ASCs) Are Influenced by the Age of the Donors. Animals (Basel) 2025 Jun 28;15(13).
        doi: 10.3390/ani15131910pubmed: 40646808google scholar: lookup
      61. Heidenberger J, Hangel R, Reihs EI, Strauss J, Liskova P, Alphonsus J, Brunner C, Döring K, Gerner I, Jenner F, Windhager R, Toegel S, Rothbauer M. The modulating role of uniaxial straining in the IL-1β and TGF-β mediated inflammatory response of human primary ligamentocytes. Front Bioeng Biotechnol 2024;12:1469238.
        doi: 10.3389/fbioe.2024.1469238pubmed: 39720167google scholar: lookup
      62. Puchalska M, Witkowska-Piłaszewicz O. Gene doping in horse racing and equine sports: Current landscape and future perspectives. Equine Vet J 2025 Mar;57(2):312-324.
        doi: 10.1111/evj.14418pubmed: 39267222google scholar: lookup
      63. Ditton DM, Marchus CR, Bozeman AL, Martes AC, Brumley MR, Schiele NR. Visualization of rat tendon in three dimensions using micro-Computed Tomography. MethodsX 2024 Jun;12:102565.
        doi: 10.1016/j.mex.2024.102565pubmed: 38292310google scholar: lookup
      64. Jacklin BD, Hanousek K, Gillespie S, Liedtke A, Tucker R, Fiske-Jackson A, Smith RK. Validation of a novel clinical tool for monitoring distal limb stiffness. Front Vet Sci 2023;10:1271036.
        doi: 10.3389/fvets.2023.1271036pubmed: 38249548google scholar: lookup
      65. Mienaltowski MJ, Callahan M, Gonzales NL, Wong A. Examining the Potential of Vitamin C Supplementation in Tissue-Engineered Equine Superficial Digital Flexor Tendon Constructs. Int J Mol Sci 2023 Dec 4;24(23).
        doi: 10.3390/ijms242317098pubmed: 38069418google scholar: lookup
      66. Vlahos TP. Percutaneous ultrasonic debridement of equine tendinopathy and desmopathy: A report of 10 cases. Open Vet J 2023 Sep;13(9):1141-1149.
        doi: 10.5455/OVJ.2023.v13.i9.10pubmed: 37842115google scholar: lookup
      67. Pechanec MY, Mienaltowski MJ. Decoding the transcriptomic expression and genomic methylation patterns in the tendon proper and its peritenon region in the aging horse. BMC Res Notes 2023 Oct 11;16(1):267.
        doi: 10.1186/s13104-023-06562-1pubmed: 37821884google scholar: lookup
      68. Luo J, Wang Z, Tang C, Yin Z, Huang J, Ruan D, Fei Y, Wang C, Mo X, Li J, Zhang J, Fang C, Li J, Chen X, Shen W. Animal model for tendinopathy. J Orthop Translat 2023 Sep;42:43-56.
        doi: 10.1016/j.jot.2023.06.005pubmed: 37637777google scholar: lookup
      69. Shojaee A. Equine tendon mechanical behaviour: Prospects for repair and regeneration applications. Vet Med Sci 2023 Sep;9(5):2053-2069.
        doi: 10.1002/vms3.1205pubmed: 37471573google scholar: lookup