Accelerometric Evaluation of the Locomotor Pattern After Administration of Morphine in Conscious Healthy Horses.

This research study aimed to understand the changes in the gait of healthy horses post-injection of a saline solution or a blend of morphine and saline solution. It found that the administration of morphine had minimal effects on the horses’ locomotor activity, indicating its potential safe use for pain relief.

Objective of the Research

• The purpose was to analyse, using accelerometry, the alterations in the walking patterns of healthy horses after being administered with morphine (0.2 mg/kg).

Methods Employed

• Six mature horses were used, each receiving two different treatments with at least a two-week interval in between.
• The treatments involved a single dose of either 10 ml saline solution or 0.2 mg/kg of morphine diluted in 10 ml saline solution.
• Using a 3D acceleration device, data was continuously collected while the horses walked.
• The walking trial was conducted 10 minutes before injection, and then at varying intervals post-injection (up to 3 hours).

Variables Considered

• A total of eight variables were considered, comprising stride kinematic, coordination and energetic factors.
• Additionally, the acceleration force and three parts of the power were calculated.

Results and Findings

• Stride length and propulsion power showed significant variation, with decreased values noted after morphine administration.
• Compared to baseline values, stride length was significantly shorter for 80 minutes and again 110 minutes post-morphine injection.
• The propulsion power experienced a noticeable decrease at intervals of 5, 15, 20, 30 and 40 minutes following the injection.

Conclusion

• The study concluded that the quantity of morphine administered had limited effects on the horses’ gait pattern.
• Locomotor activities produced minimal effects with this dosage, hence it was considered safe to use for pain relief in clinical contexts.